Molecularly defined adult-type hypolactasia in school-aged children with a previous history of cow's milk allergy

作     者：Heli Rasinper Kristiina Saarinen Anna Pelkonen Irma Jrvel Erkki Savilahti Kaija-Leena Kolho 

作者机构：Department of Medical Genetics University of HelsinkiFinland Hospital for Children and Adolescents University of HelsinkiFinland Department of Allergology Skin and Allergy HospitalHelsinki University Central HospitalHelsinkiFinland Department of Medical Genetics University of HelsinkiFinland Laboratory of Molecular GeneticsHelsinki University HospitalHelsinkiFinland 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第14期

页      面：2264-2268页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Supported by The Sigrid Juselius Foundation  Helsinki  Finland The Helsinki University Hospital Research Funding  Helsinki  Finland The Helsinki University Science Foundation  Helsinki  Finland and The Foundation of Nutrition Research  Helsinki  Finland 

主　　题：Adult-type hypolactasia Primary lactose malabsorption Genetic testing Cow's milk allergy 

摘      要：AIM： To assess the role of lactase non-persistence/per- sistence in school-aged children and their milk-related symptoms. METHODS： The genotypes for the C/T-13910 variant associated with lactase non-persistence/ persistence were determined using PCR-minisequencing in a group of 172 children with a mean age of 8.6 years （SE = 0.02, 93 boys） participating in a follow-up study for cow＇s milk allergy. The parents were asked to assess their children＇s milk consumption and abdominal symptoms. RESULTS： The presence of allergy to cow＇s milk was not associated with the C/C-13910 genotype related with a decline of lactase enzyme activity during childhood （lactase non-persistence）. The frequency of the C/C-13910 genotype （16%） was similar to published figures for the prevalence of adult-type hypolactasia in Finland. The majority of the children （90%） in this series consumed milk but 26% of their families suspected that their children had milk-related symptoms. Forty-eight percent of the children with the C/C-13910 genotype did not drink milk at all or consumed a low lactose containing diet prior to the genotyping （P〈 0.004 when compared to the other genotypes）. CONCLUSION： Analysis of the C/T-13910 polymorphism is an easy and reliable method for excluding adult-type hypolactasia in children with milk-related symptoms. Genotyping for this variant can be used to advise diets for children with a previous history of cow＇s milk allergy.