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State-of-the-Art in Electrophilic Trifluoromethylthiolation Reagents

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Chinese Journal of Chemistry 2016年第5期34卷 445-454页

作者： helene Chachignon Dominique Cahard Normandie UniversitY CNRS UMR 6014 COBRA et FR 3038 Universite de Rouen INSA Rouen. 1 rue Tesniere 76821 Mont Saint-Aignan Cedex France

The trifluoromethylthio group （SCF3） is a fluorine chemotype that has experienced a strong acceleration of in- terest in the recent years. It is particularly true of the construction of new fluorinated architectures by electrophilic trifluoromethylthiolation. The spread of knowledge was already very active in this research domain in the sixties; however, gaseous and highly toxic trifluoromethanesulfenyl chloride （CF3SC1） was the only reagent available at that time. Nowadays, one really can speak of a revival in the field thanks to the rapid development of a wide pano- ply of reagents that are stable and easy to handle. This review provides a historical perspective of the development of shelf-stable electrophilic trifluoromethylthiolation reagents.

关键词： fluorine sulfur electrophilic addition synthetic methods

Salt Stress in Arabidopsis： Lipid Transfer Protein AZI1 and Its Control by Mitogen-Activated Protein Kinase MPK3

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Molecular Plant 2014年第4期7卷 722-738页

作者： Andrea Pitzschke Sneha Datta helene Persak Department of Applied Genetics and Cell Biology University of Natural Resources and Life Sciences Muthgasse 18 1190 Vienna Austria

A plant＇s capability to cope with environmental challenges largely relies on signal transmission through mitogen-activated protein kinase （MAPK） cascades. In Arabidopsis thaliana, MPK3 is particularly strongly associated with numerous abiotic and biotic stress responses. Identification of MPK3 substrates is a milestone towards improving stress resistance in plants. Here, we characterize AZI1, a lipid transfer protein （LTP）-related hybrid proline-rich protein （HyPRP）, as a novel target of MPK3. AZI1 is phosphorylated by MPK3 in vitro. As documented by co-immunoprecipitation and bimolecular fluorescence complementation experiments, AZI1 interacts with MPK3 to form protein complexes in planta. Furthermore, null mutants of azil are hypersensitive to salt stress, while AZIl-overexpressing lines are markedly more tolerant. AZI1 overexpression in the mpk3 genetic background partially alleviates the salt-hypersensitive phenotype of this mutant, but functional MPK3 appears to be required for the full extent of AZIl-conferred robustness. Notably, this robustness does not come at the expense of normal development. Immunoblot and RT-PCR data point to a role of MPK3 as positive regulator of AZI1 abundance.

关键词： salt stress Arabidopsis MAPK MPK3 lipid transfer protein AZI1 phosphorylation in vivo interaction.

CO_2 Capture technologies: Current status and new directions using supported ionic liquid phase (SILP) absorbers

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Science China Chemistry 2012年第8期55卷 1648-1656页

作者： KOLDING helene FEHRMANN Rasmus RIISAGER Anders Centre for Catalysis and Sustainable Chemistry Department of Chemistry Building 207 Technical University of Denmark2800 Kgs. Lyngby Denmark

Current state-of-the-art techniques for COz capture are presented and discussed, Post-combustion capture of CO2 by absorption is the technology most easily retrofitted to existing installations, but at present this is not economically viable to install and run. Using ionic liquids instead of aqueous amine solutions overcomes the major thermodynamic issues. By applying SILP tech- nology further advances, in terms of ease of handling and sorption dynamics, are obtained. Initial experimental studies showed that ionic liquids such as tetrahexylammonium prolinate, [N6666][Pro], provide a good candidate for CO2 absorption using SILP technology. Thus a solid SILP absorber comprised of 40 wt% [N6666][Pro] loaded on precalcined silica quantitatively takes up about 1.2 mole CO2 per mole of ionic liquid in consecutive absorption-desorption cycles in a flow-experiment per- formed with 0.09 bar of CO2 （9% CO2 in He）.

关键词： CO2 capture absorption ionic liquids SILP absorber

Neurological consequences of human calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： helene H.Jensen Anders Olsen Medical Biotechnology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

When calcium ions enter the cytosol,it is a stimulatory signal for cellular *** calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction *** this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and *** is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell ***,throughout vertebrate evolution,the protein sequence has remained completely unchanged.

关键词： consequences unchanged calmodulin

The Nature of “Natural Disasters”: Survivors’ Explanations of Earthquake Damage

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International Journal of Disaster Risk Science 2019年第3期10卷 293-305页

作者： Alessandro Massazza Chris R.Brewin helene Joffe Department of Clinical Educational and Health PsychologyUniversity College London

The distinction between natural and human-made disasters is ingrained in everyday language. Disaster scientists have long been critical of this dichotomy. Nonetheless,virtually no attention has been paid to how disaster survivors conceptualize the causes of the disasters they experience. In this mixed-methods longitudinal study, 112 survivors of the2016–2017 Central Italy earthquakes completed questionnaires 3 and 16 months following the earthquakes, with the aim of assessing attributions of blame for the earthquake damage. In-depth interviews were also conducted with 52 participants at the 3-month mark to explore representations of causation for the earthquake damage. The distinction between disasters caused by nature and disasters caused by humans was not supported by survivors of the earthquake. In the longitudinal surveys, building firms and the State were assigned as much blame as nature for the earthquake damage, at both 3 months and 16 months after the *** this complexity, in the interviews, the causes of the earthquake damage, rather than being understood as purely natural, were perceived as a complex mosaic composed of political, technological, natural, and moral *** empirical work shows that disaster survivors combine both nature-based and human-based explanations of disasters, rather than subscribing to one or the other. These findings have practical implications for disaster risk reduction and response.

关键词： Amatrice Attributions Disaster causes Disaster survivors Human-made disasters Natural disasters 2016–2017 Central Italy earthquakes

Human neural stem cell transplants to address multiple pathologies associated with traumatic brain injury

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Neural Regeneration Research 2019年第10期14卷 1699-1700页

作者： helene Clervius Mirza Baig Anil Mahavadi Shyam Gajavelli University of Miami Miller School of Medicine

Traumatic brain injury (TBI), an unmet need: TBI is an alteration in brain function caused by an external force with evidence of brain pathology. It could be from a bump, blow, blast or jolt to the head including penetrating the cranium. TBI is a public health concern worldwide due to its economic impact. Most TBIs are survivable, do not need hospitalization but may influence productivity. A smaller percentage of TBI due to falls or penetrating TBI (PTBI) needs hospitalization and accounts for largest fraction of TBI care costs.

关键词： Traumatic brain injury(TBI) function caused by an external largest fraction of TBI care costs

Micro-Differential Boundary Conditions Modelling the Absorption of Acoustic Waves by 2D Arbitrarily-Shaped Convex Surfaces

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Communications in Computational Physics 2012年第2期11卷 674-690页

作者： helene Barucq Julien Diaz Veronique Duprat INRIA Bordeaux-Sud Ouest Team-project MAGIQUE-3D LMA CNRS UMR 5142University of PauFrance

We propose a new Absorbing Boundary Condition(ABC)for the acoustic wave equation which is derived from a micro-local diagonalization process formerly defined by *** and which does not depend on the geometry of the surface bearing the *** considering the principal symbol of the wave equation both in the hyperbolic and the elliptic regions,we show that a second-order ABC can be constructed as the combination of an existing first-order ABC and a Fourier-Robin *** compare the new ABC with other ABCs and we show that it performs well in simple configurations and that it improves the accuracy of the numerical solution without increasing the computational burden.

关键词： Wave equation micro-local diagonalization absorbing boundary condition finite element formulation

FullApertureReconstruction of theAcoustic Far-Field Pattern from Few Measurements

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Communications in Computational Physics 2012年第2期11卷 647-659页

作者： helene Barucq Chokri Bekkey Rabia Djellouli INRIA Bordeaux Sud-Ouest Research Center Team Project Magique-3D&LMA/CNRS UMR 5142Universite de Pau et des Pays de l’AdourFrance Faculte des Sciences de Monastir Tunisia Department of Mathematics California State University Northridge&Interdisciplinary Research Institute for the SciencesIRISUSA

We propose a numerical procedure to extend to full aperture the acoustic farfield pattern(FFP)when measured in only few observation *** reconstruction procedure is a multi-step technique that combines a total variation regularized iterative method with the standard Tikhonov regularized *** proposed approach distinguishes itself from existing solution methodologies by using an exact representation of the total variation which is crucial for the stability and robustness of Newton *** present numerical results in the case of two-dimensional acoustic scattering problems to illustrate the potential of the proposed procedure for reconstructing the full aperture of the FFP from very few noisy data such as backscattering synthetic measurements.

关键词： Acoustic scattering problem limited aperture inverse obstacle problem ill-posed problem total variation Tikhonov regularization Newton method

Planning for Community Relocations Due to Climate Change in Fiji

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International Journal of Disaster Risk Science 2015年第3期6卷 315-319页

作者： Karen E.Mc Namara helene Jacot Des Combes School of Geography Planning and Environmental ManagementThe University of Queensland Pacific Centre for Environment and Sustainable Development University of the South Pacific

As a consequence of the impacts of climate change, some households and entire communities across the Pacific are making the complex and challenging decision to leave their homelands and relocate to new environments that can sustain their livelihoods. This short article charts how the residents of Vunidogoloa village in Fiji relocated in early 2014 to reduce their vulnerability to encroaching sea level and inundation events that regularly devastated the community. As a consequence of the Vunidogoloa relocation, this article also explores how the Fiji Government is planning for similar resettlement transitions, including vulnerability and adaptation assessments to develop a list of potential community relocations and the development of national relocation guidelines. This study draws from key informant interviews(n = 8) with government officials, as well as representatives from intergovernmental and local nongovernmental organizations,who are involved in the relocation issue. Given the speed at which these national, top-down initiatives are being forged and especially in light of the absence of any mention of relocation in Fiji’s 2012 climate change policy, careful and inclusive engagement across all scales and stakeholders,including communities 'earmarked' for relocation, is paramount.

关键词： Climate change Community relocation Fiji Risk planning Sea level rise