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Neurological consequences of human calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： helene H.Jensen Anders Olsen Medical Biotechnology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

When calcium ions enter the cytosol,it is a stimulatory signal for cellular events.The calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction partners.In this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and apoptosis.That is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell types.Moreover,throughout vertebrate evolution,the protein sequence has remained completely unchanged.

关键词： consequences unchanged calmodulin

Bacterial plant pathogens affect the locomotor behavior of the insect vector:a case study of Citrus volkameriana-Triozae erytreae-Candidatus Liberibacter asiaticus system

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Insect Science 2024年第3期31卷 901-910页

作者： Arnaud Ameline Alain Karkach Thomas Denoirjean Martial Grondin Florencia Molinari Patrick Turpin helene Delatte Bernard Reynaud UMR CNRS 7058 EDYSAN(Ecologie et Dynamique des Systemes Anthropises) Universite de Picardie Jules VerneAmiensCedexFrance UMR PVBMT(Peuplements végétaux et bioagresseurs en milieu tropical) Universitéde la RéunionSaint PierreLa RéunionFrance

Plant pathogens can alter the behavior of their insect vectors as well as their survival and reproduction.The African psyllid,Trioza erytreae,is one of the vectors of Huanglongbing,a citrus disease caused mainly by"Candidatus Liberibacter asiaticus"(CLas).The purpose of this study was to characterize the effects of CLas on the psyllid,T.erytreae using Citrus volkamerina plants as the study system.The study focused more specifically on the CLas effects prior to and after its acquisition by the psyllid T.erytreae.Our results did not support the hypothesis that CLas effects psyllid probing behavior prior to acquisition;few differences were observed between uninfected T.erytrea feeding on CLas-infected versus control plants.On the other hand,compared to psyllids that had completed their development on control plants,the ones that had completed their development on a CLas-infected plant exhibited changes in their behavior(greater velocity),physiology(smaller mass)and biochemistry(lower water and lipid content).Altogether,our results confirm the existence of a marked postacquisition effect on the vector locomotor behavior and a minor preacquisition effect of CLas on the vector behavior,which can be partially explained by physiological and biochemical changes.

关键词： electrical penetration graph Huanglongbing locomotory behavior lipid biomass probing behavior vector manipulation

Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells

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World Journal of Stem Cells 2024年第5期16卷 551-559页

作者： Amani Yehya Joseph Azar Mohamad Al-Fares helene Boeuf Wassim Abou-Kheir Dana Zeineddine Ola Hadadeh Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Inserm BiotisU1026University BordeauxBordeaux F-33000France Rammal Rammal Lab Physio-Toxicity Environmental TeamFaculty of SciencesLebanese UniversityNabatieh 0000Lebanon

BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos.ESCs exhibit a unique combination of self-renewal potency,unlimited proliferation,and pluripotency.The latter is evident by the ability of the isolated cells to differ-entiate spontaneously into multiple cell lineages,representing the three primary embryonic germ layers.Multiple regulatory networks guide ESCs,directing their self-renewal and lineage-specific differentiation.Apoptosis,or programmed cell death,emerges as a key event involved in sculpting and forming various organs and structures ensuring proper embryonic development.How-ever,the molecular mechanisms underlying the dynamic interplay between diffe-rentiation and apoptosis remain poorly understood.AIM To investigate the regulatory impact of apoptosis on the early differentiation of ESCs into cardiac cells,using mouse ESC(mESC)models-mESC-B-cell lym-phoma 2(BCL-2),mESC-PIM-2,and mESC-metallothionein-1(MET-1)-which overexpress the anti-apoptotic genes Bcl-2,Pim-2,and Met-1,respectively.METHODS mESC-T2(wild-type),mESC-BCL-2,mESC-PIM-2,and mESC-MET-1 have been used to assess the effect of potentiated apoptotic signals on cardiac differentiation.The hanging drop method was adopted to generate embryoid bodies(EBs)and induce terminal differentiation of mESCs.The size of the generated EBs was measured in each condition compared to the wild type.At the functional level,the percentage of cardiac differentiation was measured by calculating the number of beating cardiomyocytes in the manipulated mESCs compared to the control.At the molecular level,quantitative reverse transcription-polymerase chain reaction was used to assess the mRNA expression of three cardiac markers:Troponin T,GATA4,and NKX2.5.Additionally,troponin T protein expression was evaluated through immunofluorescence and western blot assays.RESULTS Our findings showed that the upregulation of Bcl-2,Pim-2,and Met-1 genes led to a reduction in th

关键词： Mouse embryonic stem cells Self-renewal Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1

Cardiac Malformations in Congenital Hypothyroidism: A Case Report

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Open Journal of Pediatrics 2024年第2期14卷 279-284页

作者： Suzanne Sap Gaelle Ntsoli Jocelyn Tony Ritha Mbono helene Kamo David Chelo Mother and Child Center of Chantal Biya Foundation Yaounde Cameroon University of Yaounde I Yaounde Cameroon Laquintinie Hospital University of Douala Douala Cameroon General Hospital of Garoua University of Garoua Garoua Cameroon

Introduction: Congenital hypothyroidism is the most common causes of preventable mental retardation. It is associated with other births defects like cardiac malformations. Descriptions in Sub Saharan Africa are rare, justifying the present report. Case Report: We reported the cases of 3 female patients, diagnosed with hypothyroidism, presenting in addition pulmonary stenosis. The diagnosis was late in all the patients and we noticed clinical improvement under levothyroxine. Conclusion: Association congenital hypothyroidism and cardiac defect is not rare. Our patients are female with no history of consanguinity, presenting congenital hypothyroidism with a gland in situ associated with pulmonary stenosis. Systematic screening of other births defects is thus recommended in affected patients.

关键词： Congenital Hypothyroidism Cardiac Malformations Children

Understanding intrarenal backflow: Intrarenal pressure during ureteroscopy and beyond

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Asian Journal of Urology 2024年第2期11卷 139-142页

作者： Palle J.S.Osther Susanne S.Osther Maria P.Hesselholt Sofia Byllov Søren K.Lildal Louise F.Øbro helene Jung Urological Research Center Department of UrologyVejle Hospital(a part of Lillebaelt Hospital)University Hospital of Southern DenmarkVejleDenmark Department of Regional Health Research University of Southern DenmarkOdenseDenmark

The number of ureterorenoscopic procedures for upper urinary tract stone management has increased dramatically during recent years worldwide[1].Developments in flexible ureteroscope and laser technology have made it possible to successfully address larger and more complex stone scenarios retrogradely.On the other hand,this means that more and more patients are exposed to the potential adverse effects of ureteroscopy[2].In general,ureteroscopy is considered a safe procedure.However,serious complications and even deaths do occur,and these events are most likely underreported[3,4].

关键词： beyond likely ureter

A Rare Cause of Leukocoria in Children: Persistent Hyperplastic Primary Vitreous

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Open Journal of Ophthalmology 2024年第1期14卷 63-68页

作者： Prudence Ada Assoumou Davy Alex Mouinga Abayi Yoan Mboussou Annick Kougou Ntoutoume helene Nyinko Aboughe Olive Matsanga Tatiana Harly Mba Aki Emmanuel Mve Mengome Owendo University Hospital Center Department of Surgery at the Faculty of Medicine of the University of Health Sciences Libreville Gabon Omar Bongo Ondimba Military Instructions Hospital Department of Surgery at the Faculty of Medicine of the University of Health Sciences Libreville Gabon Médivision Clinic Libreville Gabon Jeanne Ebori Foundation Mother and Child University Hospital Center Department of Surgery at the Faculty of Medicine of the University of Health Sciences Libreville Gabon

Introduction: Leukocoria, a whitish pupillary reflection, is a common warning sign of various pediatric ocular pathologies, including Persistent hyperplastic primary vitreous (PHVP). This case report describes the observation of a 3-year-old child with melanoderma, presenting with a white spot in the left eye since birth. Observation: Uncorrected distance visual acuity was 2/10 in the right eye and hand movements were perceived at 2 meters in the left eye. Examination of the anterior segment in the left eye revealed leukocoria and microphthalmia. The fundus examination was normal in the right eye but revealed a white mass extending from the center of the optic disc towards the temporal region in the left eye. Ocular imaging, including ocular ultrasound and optical coherence tomography, confirmed the diagnosis of PHVP, illustrated by a residual white mass at the center of the optic disc in the left eye. Conclusion: PHVP should be considered in the presence of leukocoria in a child, with urgent exclusion of retinoblastoma. This observation underscores the importance of early diagnosis for appropriate management. .

关键词： PHVP Leukocoria Amblyopia Ocular Imaging Childhood

AHORA: a Spanish language tool to identify acute stroke symptoms

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Stroke & Vascular Neurology 2022年第2期7卷 176-178页

作者： Paul Banerjee helene Koumans Madison Danielle Weech Maricela Wilson Mark Rivera-Morales Latha Ganti Fire Rescue Polk County FloridaBartowFloridaUSA Department of Emergency Medicine University of Central Florida College of MedicineOrlandoFloridaUSA Osceola Regional Medical Center KissimmeeFloridaUSA Department of Biology and Medicine Brown UniversityProvidenceRhode IslandUSA Department of Biology University of FloridaGainesvilleFloridaUSA Stroke Community Outreach Seton Healthcare FamilyAustinTexasUSA Department of Neurology University of Central Florida College of MedicineOrlandoFloridaUSA

Objective To develop a Spanish language tool for acute stroke identification.Methods A Spanish language translation of the Balance-Eyes-Face-Arm-Speech-Time tool was developed within our emergency medical services agency.Results The authors present a new prehospital stroke tool,Andar,Hablar,Ojos,Rostro and Ambos Brazos o Piernas(AHORA)(which means now in Spanish)to help combat the language barrier and reinforce the necessity to call 9-1-1 as soon as any stroke symptoms are noted.Conclusion AHORA is a Spanish language tool that aims to help Spanish-speaking individuals to identify an acute stroke and obtain prompt help.

关键词： And Spanish prompt

Gastrointestinal tumors in transplantation: Two case reports and review of literature

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World Journal of Gastroenterology 2022年第34期28卷 5076-5085页

作者： Romain Stammler Dany Anglicheau Bruno Landi Tchao Meatchi Emilia Ragot Eric Thervet helene Lazareth Department of Nephrology Georges Pompidou European HospitalParis 75015France Department of Renal Transplantation Necker-Enfants Malades InstituteFrench National Institutes of Health and Medical Research U1151Paris 75015France Universite Paris Cite Assistance Publique des Hôpitaux de ParisParis 75001France Department of Gastroenterology and Digestive Oncology Georges Pompidou European HospitalParis 75015France Department of Pathology Georges Pompidou European HospitalParis 75015France Department of Digestive Surgery Georges Pompidou European HospitalParis 75015France

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract.As most of them harbor a KIT mutation(75%),selective kinase inhibitors are the therapeutic option and show a sustained objective response among patients with metastatic or unresectable GISTs.A wellknown higher risk of neoplasm has been described among renal transplant recipients(RTRs).Nevertheless,only few cases of GIST onset among transplant patients have been reported in the literature.CASE SUMMARY Here,we describe 2 cases of gastric GIST occurring during the follow-up of RTRs.We also review the existing literature concerning GIST occurrence in transplant patients.In total and in association with our 2 cases,16 patients have been reported.The median age was 59.5 years and 69%were male.With a median tumor size of 45 mm,no patient displayed metastatic dissemination at diagnosis.Time from transplantation to diagnosis was highly variable between 5 mo and 21 years.Histopathological data mostly revealed high risk of progression(43%).Death increased to 29%during follow-up.Surgical treatment was systematically performed when the tumor was operable(94%).The use of adjuvant therapy was uncommon(19%).CONCLUSION GISTs represent rare but potentially severe malignant complication among transplant patients.

关键词： Gastrointestinal stromal tumors Imatinib mesylate Transplantation Kidney transplantation Proto-oncogene protein c-KIT Case report

New insights into intergeneric relationships of Hickeliinae(Poaceae:Bambusoideae) revealed by complete plastid genomes

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Plant Diversity 2023年第2期45卷 125-132页

作者： Rivontsoa A.Rakotonasolo Soejatmi Dransfield Thomas Haevermans helene Ralimanana Maria S.Vorontsova Meng-Yuan Zhou De-Zhu Li Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201China Department Flore Parc Botanique et Zoologique de TsimbazazaAntananarivo101Madagascar Kew Madagascar Conservation Center Antananarivo101Madagascar Comparative Plant and Fungal Biology Royal Botanic Gardens KewRichmondSurreyUK Institut de Systématiqueévolution Biodiversité(ISYEB) Muséum National d'Histoire NaturelleCentre National de La Recherche Scientifiqueécole Pratique des HautesétudesUniversitédes AntillesSorbonne Université45 Rue BuffonCP 5075005ParisFrance University of Chinese Academy of Sciences Beijing100049China

The Hickeliinae(Poaceae:Bambusoideae) is an ecologically and economically significant subtribe of tropical bamboos restricted to Madagascar,Comoros,Reunion Island,and a small part of continental Africa(Tanzania).Because these bamboos rarely flower,field identification is challenging,and inferring the evolutionary history of Hickeliinae from herbarium specimens is even more so.Molecular phylogenetic work is critical to understanding this group of bamboos.Here,comparative analysis of 22 newly sequenced plastid genomes showed that members of all genera of Hickeliinae share evolutionarily conserved plastome structures.We also determined that Hickeliinae plastome sequences are informative for phylogenetic reconstructions.Phylogenetic analysis showed that all genera of Hickeliinae are monophyletic,except for Nastus,which is paraphyletic and forms two distant clades.The type species of Nastus(Clade Ⅱ) is endemic to Reunion Island and is not closely related to other sampled species of Nastus endemic to Madagascar(Clade Ⅵ).Clade Ⅵ(Malagasy Nastus) is sister to the Sokinochloa+Hitchcockella clade(Clade Ⅴ),and both clades have a clumping habit with short-necked pachymorph rhizomes.The monotypic Decaryochloa is remarkable in having the longest floret in Bambuseae and forms a distinct Clade Ⅳ.Clade Ⅲ,which has the highest generic diversity,consists of Cathariostachys,Perrierbambus,Sirochloa,and Valiha,which are also morphologically diverse.This work provides significant resources for further genetic and phylogenomic studies of Hickeliinae,an understudied subtribe of bamboo.

关键词： Bamboo Hickeliinae Madagascar Paleotropical Phylogenomics Plastome