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Hepatic veins as a site of clot formation following liver resection

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World Journal of Gastroenterology 2011年第3期17卷 403-406页

作者： Emmanuel Buc Safi Dokmak Magaly Zappa Marie helene Denninger Dominique Charles Valla Jacques Belghiti Olivier Farges Department of Hepato-Biliary Surgery Hpital BeaujonAssistance-Publique Hpitaux de ParisUniversity Paris 7 Department of Radiology Hpital Beaujon Assistance-Publique Hpitaux de ParisUniversity Paris 7 Department of Biological Hematology Hpital Beaujon Assistance-Publique Hpitaux de ParisUniversity Paris 7 Department of Hepatology Hpital BeaujonAssistance-Publique Hpitaux de ParisUniversity Paris 7

Pulmonary embolism occurs more frequently after hepatectomy than previously thought but is infrequently associated with peripheral deep vein thrombosis. In this paper, we report 2 cases of postoperative hepatic vein thrombosis after liver resection. Both patients had undergone major hepatectomy of a non-cirrhotic liver largely exposing the middle hepatic vein. Clots were incidentally found in the middle hepatic vein 4 and 17 d after surgery despite routine systemic thrombo-prophylaxis with low molecular weight heparin. Coagulation of the transition plan in a context of mutation of the prothrombin gene and inflammation induced biloma were the likely predisposing conditions. Clots disappeared following curative anticoagulation. We conclude that thrombosis of hepatic veins may occur after liver resection and is a potential source of pulmonary embolism.

关键词： Hepatectomy Hepatic veins Thrombosis Pulmonary embolism Anticoagulants

Species and endosymbiont diversity of Bemisia tabaci （Homoptera： Aleyrodidae） on vegetable crops in Senegal

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Insect Science 2015年第3期22卷 386-398页

作者： Delatte helene Baudin Remy Becker Nathalie Girard Anne-Laure Ramatoulaye Sidebe Traore Lett Jean-Michel Reynaud Bernard CIRAD UMR PVBMT F-97410 Saint-Pierre La Reunion France Museum National d'Histoire Naturelle Institut de Systematique Evolution Biodiversite ISYEB UMR 7205 CNRS UPMC EPHE 75005 Paris France TECHNISEM Zone d'activite Anjou Actiparc de Jumelles 49160 Longue-Jumelles France

Bemisia tabaci-transmitted geminiviruses are one of the major threats on cassava and vegetable crops in Africa. However, to date, few studies are available on the diversity orB. tabaci and their associated endosymbionts in Africa. More than 28 species have been described in the complex ofB. tabaci cryptic species; among them, 2 are invasive pests worldwide： MED and MEAM1. In order to assess the species diversity orB. tabaci in vegetable crops in Senegal, several samplings in different localities, hosts and seasons were collected and analyzed with nuclear （microsatellite） and mitochondrial （COI） markers. The bacterial endosymbiont community was also studied for each sample. Two species were detected： MED Q1 and MEAM1 B. Patterns of MED Q1 （dominance on most of the samples and sites, highest nuclear and mitochondrial diversity and broader secondary endosymbiont community： Hamiltonella, Cardinium, Wolbachia and Rickettsia）, point toward a predominant resident begomovirus vector group for MED Q 1 on market gardening crops. Furthermore, the lower prevalence of the second species MEAM1 B, its lower nuclear and mitochondrial diversity and a narrower secondary endosymbiont community （Hamiltonella/Rickettsia）, indicate that this genetic group is exotic and results from a recent invasion in this area.

关键词： begomovirus vectors endosymbionts diversity MED and MEAM 1 species microsatellites mtCOI phylogeny whitefly

Current trends in management of hepatitis B virus reactivation in the biologic therapy era

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World Journal of Gastroenterology 2011年第34期17卷 3881-3887页

作者： Claudio M Mastroianni Miriam Lichtner Rita Citton Cosmo Del Borgo Angela Rago helene Martini Giuseppe Cimino Vincenzo Vullo Infectious Diseases Unit Fondazione Eleonora Lorillard Spencer Cenci Sapienza University SM Goretti Hospital Hematology Unit Sapienza University SM Goretti Hospital Department of Public Health and Infectious Diseases Sapienza University Policlinico Umberto I

Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk ofHBV reactivation is heightened by the use monoclonalantibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and longlasting immunosuppression. Emerging data indicatethat HBV reactivation could also develop following theuse of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is di-agnosed, it is mandatory to suspend biologic treatmentand start antiviral agents immediately. However, preemptive antiviral therapy prior to monoclonal antibodyadministration is crucial in preventing HBV reactivationand its clinical consequences. Several lines of evidencehave shown that risk of HBV reactivation is greatlyreduced by the identifi cation of high-risk patients andthe use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists.

关键词： Hepatitis B virus Virus reactivation Rituximab Tumor necrosis factor-α antagonists Biologic agents Antiviral drugs

New insights into intergeneric relationships of Hickeliinae(Poaceae:Bambusoideae) revealed by complete plastid genomes

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Plant Diversity 2023年第2期45卷 125-132页

作者： Rivontsoa A.Rakotonasolo Soejatmi Dransfield Thomas Haevermans helene Ralimanana Maria S.Vorontsova Meng-Yuan Zhou De-Zhu Li Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201China Department Flore Parc Botanique et Zoologique de TsimbazazaAntananarivo101Madagascar Kew Madagascar Conservation Center Antananarivo101Madagascar Comparative Plant and Fungal Biology Royal Botanic Gardens KewRichmondSurreyUK Institut de Systématiqueévolution Biodiversité(ISYEB) Muséum National d'Histoire NaturelleCentre National de La Recherche Scientifiqueécole Pratique des HautesétudesUniversitédes AntillesSorbonne Université45 Rue BuffonCP 5075005ParisFrance University of Chinese Academy of Sciences Beijing100049China

The Hickeliinae(Poaceae:Bambusoideae) is an ecologically and economically significant subtribe of tropical bamboos restricted to Madagascar,Comoros,Reunion Island,and a small part of continental Africa(Tanzania).Because these bamboos rarely flower,field identification is challenging,and inferring the evolutionary history of Hickeliinae from herbarium specimens is even more *** phylogenetic work is critical to understanding this group of ***,comparative analysis of 22 newly sequenced plastid genomes showed that members of all genera of Hickeliinae share evolutionarily conserved plastome *** also determined that Hickeliinae plastome sequences are informative for phylogenetic *** analysis showed that all genera of Hickeliinae are monophyletic,except for Nastus,which is paraphyletic and forms two distant *** type species of Nastus(Clade Ⅱ) is endemic to Reunion Island and is not closely related to other sampled species of Nastus endemic to Madagascar(Clade Ⅵ).Clade Ⅵ(Malagasy Nastus) is sister to the Sokinochloa+Hitchcockella clade(Clade Ⅴ),and both clades have a clumping habit with short-necked pachymorph *** monotypic Decaryochloa is remarkable in having the longest floret in Bambuseae and forms a distinct Clade Ⅳ.Clade Ⅲ,which has the highest generic diversity,consists of Cathariostachys,Perrierbambus,Sirochloa,and Valiha,which are also morphologically *** work provides significant resources for further genetic and phylogenomic studies of Hickeliinae,an understudied subtribe of bamboo.

关键词： Bamboo Hickeliinae Madagascar Paleotropical Phylogenomics Plastome

Severe steroid refractory gastritis induced by Nivolumab: A case report

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World Journal of Gastroenterology 2020年第16期26卷 1971-1978页

作者： helene Hjorth Vindum JØrgen S Agnholt Anders Winther Moelby Nielsen Mette Bak Nielsen Henrik Schmidt Department of Oncology Aarhus University HospitalAarhus 8200Denmark Department of Gastroenterology Aarhus University HospitalAarhus 8200Denmark Department of Pathology Aarhus University HospitalAarhus 8200Denmark

BACKGROUND Immune checkpoint inhibitors are widely used for treatment of many advanced *** gastrointestinal(GI)side effects,such as diarrhea and colitis,are common,but upper GI side effects are rarely ***,the correct treatment of upper GI adverse events has been less frequently *** SUMMARY We describe a case of a 16-year-old woman with stage IIIb malignant melanoma treated with adjuvant monotherapy using *** patient developed severe gastritis after six series of Nivolumab with weight loss,nausea,and *** was no effect of intravenous steroids,but the patient′s condition resolved after administration of *** This case report supports the same treatment for gastritis as for colitis,which is in line with current guidelines.

关键词： Gastritis Immune checkpoint inhibitors Nivolumab Case report Immune-related adverse events Infliximab

Teaching Gallo at School

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Sino-US English Teaching 2014年第5期11卷 342-349页

作者： Cecile helene Christiane Rey University of Virginia Charlottesville United States

This study explores the origins and current status of the Gallo language at school--a minority language spoken in the eastern part of Brittany--among older speakers （group 1-41 informants） and students of Gallo （group 2-17 informants）. The paper discusses different pedagogical methods, learning materials, and learners＇ status. The most important mission of schools is to increase public awareness about their linguistic environment which helps reassert minority identity through language acquisition and linguistic maintenance. Implementing an educational language curriculum for regional languages constitutes a main step towards the preservation of linguistic minorities. According to the informants interviewed during the fieldwork, both groups express positive reactions towards the presence of Gallo at school （group 1--80%; group 2--92.9%）. However, in follow-up discussions, a certain number of older speakers seem to be more reluctant, because the variety of Gallo taught at school is different from the one which was transmitted to them. In conclusion, bilingual and immersion programs are increasingly successful in Brittany and could lead to a wider recognition of Eastern Brittany＇s language and culture.

关键词： language acquisition representations language transmission language preservation

Tale of Two Alopecias: Alopecia Areata and Central Centrifugal Cicatricial Alopecia Occurring in the Same Patient

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International Journal of Dermatology and Venereology 2022年第1期5卷 45-49页

作者： Sharlene helene C.See Timothy L.Tan Oyinade Aderibigbe Pedram Yazdan Department of Pathology Northwestern University Feinberg School of MedicineChicagoIL 60611USA Consolidated Pathology Consultants LibertyvilleIL 60048USA Department of Dermatology Division of DermatopathologyNorthwestern University Feinberg School of MedicineChicagoIL 60611USA

Introduction:Scarring and non-scarring alopecias have rarely been described to occur together in the same *** these two different types of alopecia is important as treatment and prognosis can be *** presentation:Here,we report the first case of simultaneous alopecia areata(AA)and central centrifugal cicatricial alopecia(CCCA)in a 35-year-old *** alopecic patches were noted on her frontal and vertex *** of the frontal scalp revealed miniaturized hair follicles and dense lymphocytic infiltrate surrounding the hair bulbs,consistent with AA;while biopsy of the vertex scalp revealed decreased hair follicles,perifollicular fibroplasia with eccentric atrophy of the follicular epithelium,and premature desquamation of the inner root sheath at the level of the lower isthmus,consistent with ***:Proposed mechanisms of these two alopecia types occurring together include loss of immune privilege,genetic predisposition,as well as unknown external factors that trigger an autoimmune lymphocytic *** recently,the peptidylarginine deiminase type III gene has been implicated in both *** treatment options can overlap between thetwo diseases,treatment response can differ and CCCA tendsto have a worse ***:Awareness of this concomitant presentation of two alopecic types is important for appropriate treatment and prognostication.

关键词： alopecia areata central centrifugal cicatricial alopecia non-scarring alopecia scarring alopecia peptidylarginine deiminase type III gene

Clozapine is strongly associated with the risk of pneumonia and inflammation

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General Psychiatry 2020年第2期33卷 66-72页

作者： Jose de Leon Can-Jun Ruan helene Verdoux Chuanyue Wang University of Kentucky Mental Health Research Center Eastern State HospitalLexingtonKentuckyUSA Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalBeijingChina Inserm Bordeaux Population Health Research CenterUniversity of Bordeaux Faculty of Medical SciencesBordeauxAquitaineFrance

Clinicians need to remember that(1)systemic inflammations can increase clozapine level;(2)clozapine,by itself,can cause inflammation,particularly during titration that is too rapid for that patient;(3)clozapine may increase the risk of infection;and(4)more specifically,clozapine may be particularly strongly associated with the risk of *** appears to be associated with high mortality in clozapine patients around the *** who are alert to the risk of pneumonia in clozapine patients may significantly decrease mortality in clozapine *** is no data on COVID-19 infections in clozapine patients,but based on what we know about clozapine pharmacology,we can hypothesise that clozapine,possibly by impairing immunological mechanisms,may increase the risk of pneumonia in infected *** importantly,once fever and/or pneumonia develops,the clozapine dose should be cut in half to decrease the risk of clozapine *** there is any doubt that in spite of halving the dose there are still signs of clozapine intoxication,completely stopping clozapine may be *** the signs of inflammation and fever have disappeared,the clozapine dose can be increased to the prior dosage level.

关键词： inflammation pneumonia mortality

Occurrence and ecological risk assessment of pharmaceutical products in the Kadicha river in Lebanon

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Emerging Contaminants 2021年第1期7卷 196-203页

作者： Fatme Merhabi Elena Gomez Nancy Ariza Castro Helmieh Amine David Rosain Jalal Halwani helene Fenet Hydrosciences Montpellier IRDCNRSUniversity of MontpellierMontpellierFrance Water&Environment Science Laboratory Faculty of Public Health(FSP III)Lebanese UniversityTripoli1300Lebanon Escuela de Química Instituto Tecnologico de Costa RicaCartago 159-7050Costa Rica

Contamination of aquatic systems with pharmaceutical products represents a rising *** Kadicha river in Northern Lebanon is an illustrative example of a small Mediterranean river affected by rapid urbanization and population *** paper reports the first study on occurrence and ecological risk assessments on selected pharmaceuticals and their metabolites within the Kadicha *** this purpose,surface water samples were collected over two sampling campaigns from twelve sites impacted by urban,rural,and mixed land uses(residential and agricultural zones)within the Kadicha river *** the studied pharmaceuticals,six compounds(carbamazepine,diclofenac,acetaminophen,sulfamethoxazole,ofloxacin,and atenolol)were detected with detection frequencies and concentrations that vary according to the sampling *** was the most frequently detected compound and showed the highest concentrations(not detected-290 ng/L).The presence of pharmaceuticals carbamazepine,ofloxacin(not detected-190 ng/L),and atenolol(not detected-93 ng/L)was related to raw wastewater inputs in the water body,while the presence of sulfamethoxazole(not detected-23 ng/L)was associated with its usage in specific sites with livestock ***,the presence of acetaminophen(not detected-242 ng/L)and diclofenac(not detected-1055 ng/L)can be affected by their degradation properties in river *** highest concentrations were observed in the urbanized downstream area,while the lowest concentrations were within the rural upstream ***,the urbanized downstream area presents the highest potential risks for aquatic ***,ofloxacin may pose high ecotoxicological risks in this *** levels of contamination with pharmaceuticals do not exceed the concentrations reported in the ***,the levels of carbamazepine,diclofenac,and acetaminophen were more similar to sites receiving raw wastewaters,while the concentration levels of sulfamethoxazo

关键词： Kadicha river Pharmaceuticals Surface waters Wastewaters Potential risk Urbanization