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The Impact of the Block Freeze Concentration Process on Human Milk Properties Intended for Feeding Newborns

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Food and Nutrition Sciences 2017年第4期8卷 402-418页

作者： Ana Claudia Berenhauser Maria helena machado Canella Isabella de Bona Munoz Elane Schwinden Prudencio J.Vladimir Oliveira Jane Mara Block Maternity Ward of UFSC UFSCFlorianópolisBrazil Department of Food Science and Technology UFSCFlorianópolisBrazil Department of Chemical and Food Engineering UFSCFlorianópolisBrazil

Human milk is the ideal nutritional support for premature neonates. Considering the need for aggregating nutritional value to human milk provided to such vulnerable group of infants, human milk was concentrated by the block freeze concentration technique. The effects of freeze concentration on the physicochemical properties, the efficiency of the process, color parameters, and the density and dynamic viscosity of human milk were assessed. The freeze concentration technology was used to successfully concentrate human milk to a factor equal to 180.48% and 72% of total solid retention in the second stage of freeze concentration. The values observed in the concentrates for the biochemical properties showed that the fraction of concentrated fluid human milk of the second stage (C2) presented elevated amounts of carbohydrates, protein and energy. The elevated caloric value observed in the ice fraction of the first stage (I1) refers to the retention of lipids in it. When added to human milk, C2 and I1 may satisfy the special requisites of nutrients and energy to guarantee the growth and development of preterm neonates.

关键词： Freeze Concentration Human Milk Human Milk Fortifier Premature Neonate

Non-alcoholic fatty liver disease: What the clinician needs to know

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World Journal of Gastroenterology 2014年第36期20卷 12956-12980页

作者： Mariana Verdelho machado helena Cortez-Pinto Departamento de Gastrenterologia Laboratório de Nutri??o Hospital Universitário de Santa Maria Lisbon 1649-035 Portugal

Non-alcoholic fatty liver disease(NAFLD) is the most frequent cause of liver disease in the Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic. Though highly frequent, only about one fifth of affected subjects are at risk of developing the progressive form of the disease, non-alcoholic steatohepatitis with fibrosis. Even in the latter, liver disease is slowly progressive, though, since it is so prevalent, it is already the third cause of liver transplantation in the United States, and it is predicted to get to the top of the ranking in few years. Of relevance, fatty liver is also associated with increased overall mortality and particularly increased cardiovascular mortality. The literature and amount of published papers on NAFLD is increasing as fast as its prevalence, which makes it difficult to keep updated in this topic. This review aims to summarize the latest knowledge on NAFLD, in order to help clinicians understanding its pathogenesis and advances on diagnosis and treatment.

关键词： Non-alcoholic fatty liver disease Metabolic syndrome Insulin resistance Epidemiology Pathogenesis Genetics Diagnosis Prognosis Management

Iron homeostasis and H63D mutations in alcoholics with and without liver disease

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World Journal of Gastroenterology 2009年第1期15卷 106-111页

作者： Mariana Verdelho machado Paula Ravasco Alexandra Martins Maria Rosário Almeida Maria Ermelinda Camilo helena Cortez-Pinto Unidade de Nutrio e Metabolismo Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa1649-035 Departamento de Gastrenterologia do Hospital de Santa Maria 1649-035 Lisboa Portugal Genomed Instituto de Medicina Molecular1649-035 Portugal

MM： To evaluate the prevalence of HFE gene mutation and indices of disturbed iron homeostasis in alcoholics with and without liver disease. METHODS： One hundred and fifty-three heavy drinkers （defined as alcohol consumption 〉 80 g/d for at least 5 years） were included in the study. These comprised 78 patients with liver disease [liver disease alcoholics （LDA）] in whom the presence of liver disease was confirmed by liver biopsy or clinical evidence of hepatic decompensation, and 75 subjects with no evidence of liver disease, determined by normal liver tests on two occasions [non-liver disease alcoholics （NLDA）], were consecutively enrolled. Serum markers of iron status and HFE C282Y and H63D mutations were determined. HFE genotyping was compared with data obtained in healthy blood donors from the same geographical area. RESULTS： Gender ratio was similar in both study groups. LDA patients were older than NLDA patients （52 ± 10 years vs 48 ± 11 years, P = 0.03）. One third and one fifth of the study population had serum transferrin saturation （TS） greater than 45% and 60% respectively. Serum iron levels were similar in both groups. However, LDA patients had higher TS （51 ± 27 vs 36 ± 13, P 〈 0.001） and ferritin levels （559 ± 607 ng/mL vs 159 ± 122 ng/mL, P 〈 0.001）, and lower total iron binding capacity （TIBC）（241 ± 88 μg/dL vs 279 ± 40 μg/dL, P = 0.001）. The odds ratio for having liver disease with TS greater than 45% was 2.20 （95% confidence interval （CI）： 1.37-3.54）. There was no difference in C282Y allelic frequency between the two groups. However, H63D was more frequent in LDA patients （0.25 vs 0.16, P = 0.03）. LDA patients had a greater probability of carrying at least one HFE mutation than NLDA patients （49.5% vs 31.6%, P = 0.02）. The odds ratio for LDA in patients with H63D mutation was 1.57 （95% CI： 1.02-2.40）. CONCLUSION： The present study confirms the presence of iron overload in alcoholics, which was more severe in the subset of subjects with liver disease,

关键词： Alcoholic liver disease Iron lIFE gene H63D Hemochromatosis

Ground peach pits: alternative substrate component for seedling production

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Journal of Forestry Research 2019年第5期30卷 1779-1791页

作者： Patricia Mieth Maristela machado Araujo Maria helena Fermino Suelen Carpenedo Aimi Daniele Rodrigues Gomes Juliana de Marques Vilella Department of Forest Sciences Federal University of Santa MariaSanta MariaBrazil FEPAGRO–Agricultural Research Foundation of the State of Rio Grande do Sul Porto AlegreBrazil Federal University of Rio Grande do Sul Porto AlegreBrazil

The exploitation of agro-industrial wastes is a strategy to add value to seedling production and reduce environmental *** production chain for processed peaches generates,approximately,21,000 tons of fruit worldwide,and the pits are used mainly to generate *** objective of the study was to investigate the use of different proportions of ground peach pits(GPP)as a substrate component for seedling growth of Eucalyptus dunnii in the nursery and *** proportions of GPP mixed with either commercial substrate(CS)or with brown peat(BP)were *** physical and chemical properties of the substrates,the morphological and physiological attributes of the seedlings and their correlation with substrate properties were *** GPP increased the density,aeration space and pH and reduced total porosity,liquid retention and electric conductivity of the *** use of this component resulted in hormesis,a biphasic dose–response model in which low levels of exposure to this component stimulated biological performance of plants and high levels of exposure inhibited *** improved seedling growth in the nursery and adequate post-planting development of ***,GPP with CS is recommended at 20%of the total substrate and with BP between 15 and 30%.

关键词： Organic waste Prunus persica Eucalyptus dunnii Tree species Morphological attributes

Pancreatic neuroendocrine tumor liver metastasisin a patient with previously diagnosed pancreatic adenocarcinoma: an unexpected diagnosis

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 69-74页

作者： Mario Fontes-Sousa helena Magalhaes Bianca machado Olga Sousa Manuela machado Department of Medical Oncology Portuguese Oncology Institute-PortoPorto 4200-072Portugal Pathology Department Portuguese Oncology Institute-PortoPorto 4200-072Portugal Radioncology Department Portuguese Oncology Institute-PortoPorto 4200-072Portugal

Locally advanced pancreatic carcinoma has an usually poor prognosis despite multimodal approaches and sequential *** authors present a case of a long-term survivor with stage III pancreatic adenocarcinoma achieving partial response after a multimodal approach including local and systemic ***,three years after diagnosis and amidst several episodes of cholangitis,hepatic metastasis were *** pancreatic adenocarcinoma being the obvious culprit for metastization,a hepatic biopsy was considered at that time given a stable primary disease and presenting three years since the initial *** this point,a biopsy could have specific diagnostic,prognostic and therapeutic implications and after it was performed,an unexpected diagnosis of pancreatic neuroendocrine tumor was ***,we urge clinicians to consider hepatic biopsy in similar cases-generally when it may change prognosis and treatment strategies-and perform histological confirmation of metastatic disease whenever feasible,even if the answer may seem obvious at first impression.

关键词： Neoplasm metastasis pancreatic cancer neuroendocrine tumors biomarkers survivorship chemoradiotherapy

Perioperative Treatment in Gastric Cancer—Developments in Patient Selection

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Journal of Cancer Therapy 2018年第2期9卷 101-105页

作者： Manuela machado helena Magalhaes Mário Fontes-Sousa Medical Oncology Department Portuguese Institute of Oncology of Porto(IPO Porto)PortoPortugal

Gastric cancer (GC) is a major public health issue. It is considered the 5th most common cancer diagnosed worldwide and it is one of the main causes of malignant disease-associated morbidity and mortality. The cornerstone of curative treatment is still surgery, and since the rate of relapse is high, a multidisciplinary approach is warranted in most developed countries. And while there have been recent developments in the perioperative scenario namely the FLOT regimen, little has advanced considering patient selection. We have reviewed the major trials in this setting and provide some insights from recently reported microsatellite instability (MSI) in a subgroup analysis in the MAGIC trial patients that seem to suggest an opportunity to patient selection. Furthermore, GC subtyping may prove helpful selecting candidates to immunotherapy or even multimodal therapy in the future. As the paradigm is moving towards a precision oncology model, GC patient selection remains one the biggest challenges in oncology but seems closer to clinical practice reality as new developments are being reported.

关键词： Gastric Cancer Perioperative Chemotherapy Molecular Classification of Gastric Cancer MSI

Proposal of a Conceptual Model to Analyse the Influence of LARG Practices on Manufacturing Supply Chain Performance

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Journal of Modern Accounting and Auditing 2012年第2期8卷 174-184页

作者： Susana G. Azevedo helena Carvalho V. Cruz-machado University of Beira Interior Portugal Universidade Nova de Lisboa Portugal

The main objective of this paper is to propose a conceptual model about the influence of lean, agile, resilient, and green （LARG） practices on supply chain operational, economic and environmental performance. This model is based on the literature review about the four supply chain management paradigms and also performance measurement systems. This paper contributes to the literature by introducing a new model to improve the leanness, agility, resilience, and greenness of manufacturing supply chains. Among the suggested LARG practices, the ones influencing more the supply chain performance are the just in time and also the supplier relationships. Also the supply chain performance measures with more LARG practices influencing them are the inventory levels and the time, that is, the supply chain＇s operational performance is the most affected by the simultaneous paradigms deployment in the supply chain.

关键词： performance measurement LARG (lean agile resilient and green) supply chain manufacturing supplychain

A New Era in the Adjuvant Treatment of Pancreatic Adenocarcinoma

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Journal of Cancer Therapy 2019年第12期10卷 915-919页

作者： Manuela machado Maria Leitao Mário Fontes e Sousa Magalhaes e helena Oncologia Medica IPO PortoPortoPortugal Oncologia Medica Centro Hospitalar Lisboa Ocidental(CHLO)LisboaPortugal Oncologia Medica Unidade Local de Saude de MatosinhosHospital Pedro HispanoMatosinhosPortugal

Pancreatic adenocarcinoma is currently a major public health problem, being the 7th cause of death worldwide. Incidence is increasing and unfortunately nowadays the incidence is almost overlapping to mortality. The cornerstone of curative treatment is still surgery, but adjuvant treatment is critical to decreasing the risk of recurrence.

关键词： Pancreatic Adenocarcinoma Adjuvant Chemotherapy Positive Clinical Trials

Individual factors related to chronic condition in Portuguese adolescents: Highlights from the HBSC/WHO study

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Health 2013年第11期5卷 25-34页

作者： Teresa Santos Margarida Gaspar de Matos Maria Celeste Simoes helena Fonseca Maria do Ceu machado Faculdade de Motricidade Humana(“Social Adventure”Team) Universidade de LisboaLisboaPortugal Centro de Malaria e Doencas Tropicais/IHMT Universidade Nova de LisboaLisboaPortugal Departamento de Pediatria do Hospital de Santa Maria

Background: Adolescence includes a period (10 to 19 years) of profound biopsychosocial changes, constituting potentially difficult challenges, which may become more pronounced in the presence of a chronic condition and its limitations. Responses are not homogeneous and can be quite variable, depending on various specific individual factors. Research comparing adolescents with or without chronic illness, or comparing across different conditions, has been contradictory, not confirming a direct relationship between the degree of suffering and the chronic condition. Objective: To characterize and assess the impact of 1) having a chronic condition (CC) and 2) how CC affects school participation;and its association with life satisfaction and perception of wellness, controlling for demographic factors: age, gender and family socioeconomic status (SES). Methods: 5050 Portuguese adolescents with an average age of 14 years participated in the Health Behaviour in School-aged Children/WHO (HBSC). Results: The majority of the adolescents with CC reported that their conditions did not affect school participation. Adolescents with CC who indicated that CC affected school participation felt more frequently unwell and presented lower life satisfaction. Being a boy, younger and having high family socio economic status (SES) were identified as predictors of higher life satisfaction;on the other hand, being a girl, older, having lower SES, living with CC and feeling that CC affects school participation are predictors for feeling more frequently unwell. Conclusions: These adolescents showed an increased vulnerability, presenting internalized symptoms and lower life satisfaction. Furthermore, when there was simultaneous occurrence of living with CC and that CC affected school participation, the impact was even higher. Thus, it is crucial that future interventions should include the identified predictors, combined with “listen to the voice” of adolescents, throughout the adaptation proces

关键词： Adolescent Health Chronic Condition Health Promotion and Prevention Quality of Life