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CD44 and CD221 directed magnetic cubosomes for the targeted delivery of helenalin to rhabdomyosarcoma cells

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Nano Research 2023年第2期16卷 2915-2926页

作者： Hakmin Mun Yuriy Chaban Tanveer A.Tabish Nanasaheb Thorat Nathan Cowieson CDavid Owen helen E.Townley Nuffield Department of Women’s and Reproductive health University of OxfordOxford OX39DUUK Electron Bio-Imaging Centre Diamond Light SourceDidcot OX110DEUK Radcliffe Department of Medicine University of OxfordOxford OX37BNUK B21 Diamond Light SourceDidcot OX110DEUK Department of Engineering Science University of OxfordOxford OX13PJUK

Confining chemotherapy to tumour sites by means of active targeting nanoparticles(NPs)may increase the treatment effectuality while reducing potential side *** are one of the next-generation drug delivery nanocarriers by virtue of their biocompatibility and bioadhesion,sizeable payload encapsulation and high ***,an active tumour targeting system towards rhabdomyosarcoma(RMS)cells was *** were loaded with helenalin(a secondary metabolite from Arnica plants),which we have previously shown to induce apoptosis in RMS *** functionalization of the cubosomes was accomplished to enable binding to membrane receptors and translocation under a magnetic *** cells overexpress CD44 and CD221 on their membrane surface and,therefore,hyaluronic acid(HA,a ligand for CD44)and antibodies(Abs)against CD221 were coupled to cubosomes via electrostatic attraction and the thiol-Michael reaction,*** of the cubic phase NPs was achieved by embedding superparamagnetic iron oxide NPs(SPIONPs)into the cubic ***-function and multi-function cubosomes had Im3m cubic phase structures with well-organized lattice *** with 2%HA or anti-CD221 half Abs and/or 1%SPIONPs showed significantly higher uptake into RMS cells compared to unfunctionalized ***44 and CD221 directed magnetic(triple-function)cubosomes were capable of internalizing into RMS cells in an energy-independent ***-laden triple functionalized cubosomes showed limited impact on the viability of control fibroblast cells,while they induced a high degree cytotoxicity against RMS *** tumour cell death was observed in both two-dimensional(2D)culture and three-dimensional(3D)tumour spheroids.

关键词： cubosome active targeting rhabdomyosarcoma helenalin nanoparticle functionalization

Magnetoelectric and converse magnetoelectric responses in Tb_xDy_(1-x)Fe_(2-y) alloy & Pb(Mg_(1/3)Nb_(2/3))_(1-x)Ti_xO_3 crystal laminated composites

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Chinese Science Bulletin 2008年第14期53卷 2129-2134页

作者： JIA YanMin LUO HaoSu OR Siu Wing WAng YaoJin CHAN helen L W State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 201800 China Department of Applied Physics The Hong Kong Polytechnic University Hong Kong China

Measured results of magnetoelectric (ME) and converse magnetoelectric (CME) effects of TbxDy1-xFe2-y/ Pb(Mg1/3Nb2/3)(1-x)TixO3/TbxDy1-xFe2-y (TD/PMNT/TD) and PMNT/TD/PMNT laminated composites are pre- sented. ME effect was determined by measuring laminate voltage output under a Helmholtz-gener- ated AC field biased by a DC field (0―1 kOe) (1 Oe = 79.58 A/m). The CME effect was measured by re- cording the voltage induced in a solenoid encompassing the ME sample while exposed to a DC bias field and PMNT layer driven by a 10 V AC source. The ME and CME responses in the two laminated structure are linear. The highest values of ME coefficients in TD/PMNT/TD and PMNT/TD/PMNT com- posites are 384 mV/Oe and 158 mV/Oe, respectively, while the highest values of CME coefficients in the two composites are 118 mG/V and 162 mG/V (1 G=10-4 T), respectively.

关键词：磁电效应压电性复合材料合金晶体结构

Histone deacetylase inhibitors as a novel therapeutic approach for pheochromocytomas and paragangliomas

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Oncology Research 2022年第5期30卷 211-219页

作者： ASPASIA MANTA SPYRIDON KAZANAS STEFANOS KARAMAROUDIS helen GOGAS DIMITRIOS C.ZIOGAS Endocrine Unit Second Department of Internal Medicine Propaedeutic&Research InstituteMedical SchoolNational and Kapodistrian University of AthensAttikon University HospitalAthens12461Greece First Department of Internal Medicine Medical SchoolNational and Kapodistrian University of AthensLaikon General HospitalAthens11527Greece Department of Obstetrics&Gynecology General Hospital of Elefsina ThriassioElefsina19600Greece

Epigenetic mechanisms,such as DNA methylation and histone modiﬁcations(e.g.,acetylation and deacetylation),are strongly implicated in the carcinogenesis of various *** transcription,the expression and functionality of coding gene products are altered following the histone acetylation and *** processes are regulated by histone acetyltransferases(HATs)and histone deacetylases(HDACs),*** inhibitors(HDACis)have been developed as promising therapeutic agents,to limit exposure to traditional and toxic chemotherapies and offer more alternatives for some speciﬁc malignant diseases with limited ***,these agents affect many intracellular pathways,including cell cycle arrest,apoptosis and differentiation,and their mechanism of action mainly depends on the type of ***,ﬁve HDACis have been approved for the treatment of several hematological malignancies(e.g.,T-cell lymphoma subtypes and multiple myeloma);while,many of them are tested for further therapeutic indications in solid tumors(e.g.,colorectal,thyroid,breast,lung and pancreatic cancer).Herein,we review the literature and gather all available evidence,from in vitro and in vivo data to clinical trial results,that recognizes the antitumor activity of HDACis on pheochromocytomas and paragangliomas;and supports their clinical implementation in the treatment of these rare neuroendocrine tumors at metastatic setting.

关键词： HDACis HDAC inhibitors Neuroendocrine tumors Epigenetics Histone deacetylation Cancer

Restrictions of the Islamic Financial System and Counterpart Financial Support for Xinjiang

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Journal of Systems Science and Information 2021年第2期9卷 105-130页

作者： helen Hui HUAng Hui WAng Zexin WEI Jiawei XIA Shimming ZHAng Faculty of Business Administration University of ReginaReginaSKS4S 0A2Canada School of Economics and Management Beijing Information Science and Technology UniversityBeijing 100192China School of Finance Renmin University of ChinaBeijing 100872China

This paper builds a theoretical framework of two-period general equilibrium model to explore whether 1) the restrictions of the Islamic financial system(RIFS) limit economic development in Xinjiang and 2) counterpart financial support for Xinjiang(CFSX) promotes economic development and social stability. First, we introduce above mentioned restrictions caused by Islamic beliefs into a general equilibrium model and modify Islamic agents' budget constraints to define the benchmark *** the benchmark equilibrium with the perfect equilibrium, in which these restrictions are removed, we discover the RIFS paradox that RIFS undermine the social welfare and income of ***, the financial support is introduced into the pattern of benchmark equilibrium as an exogenous variable to model its impact and hence we define the CFSX equilibrium. A series of policy analyses implies that the CFSX strategy improves living standards and social welfare in Xinjiang.

关键词： islamic religious beliefs general equilibrium benchmark equilibrium perfect equilibrium economic development

A Strategy for Multi-objective Optimization under Uncertainty in Chemical Process Design

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Chinese Journal of Chemical Engineering 2008年第1期16卷 39-42页

作者：孙力 helen H.Lou Department of Chemical Engineering Dalian University of Technology Dalian 116023 China Department of Chemical Engineering Lamar University Beaumont Texas 77710 USA

In many circumstances, chemical process design can be formulated as a multi-objective optimization （MOO） problem. Examples include bi-objective optimization problems, where the economic objective is maximized and environmental impact is minimized simultaneously. Moreover, the random behavior in the process,property, market fluctuation, errors in model prediction and so on would affect the performance of a process. Therefore, it is essential to develop a MOO methodology under uncertainty. In this article, the authors propose a generic and systematic optimization methodology for chemical process design under uncertainty. It aims at identifying the optimal design from a number of candidates. The utility of this methodology is demonstrated by a case study based on the design of a condensate treatment unit in an ammonia plant.

关键词： multi-objective optimization uncertainty chemical process design

The Beginnings of Wisdom: Challenges in Engineering Education

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Engineering 2016年第1期2卷 45-47页

作者： helen Atkinson Department of Engineering University of Leicester the Education and Skills Committee (formerly the Standing Committee on Education and Training) for the Royal Academy of Engineering

What does it take to form an artist？ And what forms a great musician？ What more does it take to educate an engineer of in- ternational standard, who can bring their expertise to bear on the global grand challenges but, what is more, be effective in bringing solutions into being？ How do we help our young people to grow, not only in their technical knowledge, but also in their judgment, in wisdom？

关键词：工程教育智慧国际标准技术知识艺术家音乐家工程师年轻人

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World Tourism Day

小朋友 2016年第17期 22-23页

作者： helen

Adiponectin signalling in bone homeostasis,with age and in disease

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Bone Research 2021年第1期9卷 15-25页

作者： Jonathan W.Lewis James R.Edwards Amy J.Naylor helen M.McGettrick Rheumatology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

Research on the Relationship Between Garlic and Young GarlicShoot Based on Big Data

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Computers, Materials & Continua 2019年第2期58卷 363-378页

作者： Feng Guo Pingzeng Liu Wanming Ren Ning Cao Chao Zhang Fujiang Wen helen Min Zhou College of information science and engineering Shandong Agricultural UniversityTai’an271000China Shandong Provincial Department of Agriculture Information Center Jinan250013China College of Information Engineering Qingdao Binhai UniversityQingdaoChina School of Engineering Manukau Institute of TechnologyAucklandNew Zealand

In view of the problems such as frequent fluctuation of garlic price, lack ofefficient forecasting means and difficulty in realizing the steady development of garlicindustry, combined with the current situation of garlic industry and the collected datainformation. Taking Big Data platform of garlic industry chain as the core, using themethods of correlation analysis, smoothness test, co-integration test, and Grangercausality test, this paper analyzes the correlation, dynamic, and causality between garlicprice and young garlic shoot price. According to the current situation of garlic industry,the garlic industry service based on Big Data is put forward. It is concluded that there is apositive correlation between garlic price and young garlic shoot price, and there is a longtermstable dynamic equilibrium relationship between young garlic shoot price and garlicprice fluctuation, and young garlic shoot price can affect garlic price. Finally, it isproposed to strengthen the infrastructure construction of garlic Big Data, increase thetechnological innovation and application of garlic Big Data technology, and promote thesafety and security ability of the whole industry to promote the development of garlicindustry.

关键词： Big Data big data in agriculture granger causality test big data platform