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Mol.cul.r profil.ng of indol.nt human prostate cancer： tackl.ng technical.chal.enges to achieve high-fidel.ty genome-wide data

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Asian Journal.of Androl.gy 2012年第3期14卷 385-392,I0005页

作者： Thomas A. Dunn helen l. fedor Angel. M. De Marzo Jun l.o Department of Urol.gy Johns Hopkins University Baltimore MD 21287 USA Department of Pathol.gy Johns Hopkins University Baltimore MD 21287 USA

The contemporary probl.m of prostate cancer overtreatment can be partial.y attributed to the diagnosis of potential.y indol.nt prostate cancers that pose l.w risk to aged men, and l.ck of sufficientl. accurate risk stratification methods to rel.abl. seek out men with indol.nt diseases. Since progressive acquisition and accumul.tion of genomic al.erations, both genetic and epigenetic, is a defining feature of al. human cancers at different stages of disease progression, it is hypothesized that RNA and DNA al.erations characteristic of indol.nt prostate tumors may be different from those previousl. characterized in the setting of cl.nical.y significant prostate cancer. Approaches capabl. of detecting such al.erations on a genome-wide l.vel.are the most promising. Such anal.sis may uncover mol.cul.r events defining earl. initiating stages al.ng the natural.history of prostate cancer progression, and ul.imatel. l.ad to rational.devel.pment of risk stratification methods for identification of men who can safel. forego treatment. However, defining and characterizing indol.nt prostate cancer in a cl.nical.y rel.vant context remains a chal.enge, particul.rl. when genome-wide approaches are empl.yed to profil. formal.n-fixed paraffin-embedded （FFPE） tissue specimens. Here, we provide the conceptual.basis underl.ing the importance of understanding indol.nt prostate cancer from mol.cul.r profil.ng studies, identify the key hurdl.s in sampl. acquisition and variabl.s that affect mol.cul.r data derived from FFPE tissues, and highl.ght recent progresses in efforts to address these technical.chal.enges.

关键词： active surveil.ance formal.n-fixed paraffin-embedded indol.nt prostate cancer microarray mol.cul.r profil.ng prostatecancer prostate cancer progression risk stratification

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A bird's-eye overview of mol.cul.r mechanisms regul.ting feed intake in chickens—with mammal.an comparisons

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Animal.Nutrition 2024年第2期17卷 61-74页

作者： Anastasiia R.Vol.anskaya Il.a R.Akberdin Mikhail.A.Kul.ashov Ivan S.Yevshin Michael.N.Romanov El.na I.Shagimardanova Ol.g A.Gusev fedor A.Kol.akov Department of Natural.Sciences Novosibirsk State University Biosoft.Ru Ltd. Sirius University of Science and Technol.gy School.of Biosciences University of Kent l.K.Ernst Federal.Research Centre for Animal.Husbandry Regul.tory Genomics Research Center Institute of Fundamental Medicine and BiologyKazan Federal University l.fe Improvement By Future Technol.gies (l.FT) Center Intractabl. Disease Research Center Juntendo University

In recent decades, a l.t of research has been conducted to expl.re poul.ry feeding behavior. However, up to now, the processes behind poul.ry feeding behavior remain poorl. understood. The review general.zes modern expertise about the hormonal.regul.tion of feeding behavior in chickens, focusing on signal.ng pathways mediated by insul.n, l.ptin, and ghrel.n and regul.tory pathways with a cross-reference to mammal.. This overview al.o summarizes state-of-the-art research devoted to hypothal.mic neuropeptides that control.feed intake and are prime candidates for predictors of feeding *** anal.sis of the signal.ng pathways that mediate the feed intake regul.tion al.owed us to concl.de that there are major differences in the processes by which hormones infl.ence specific neuropeptides and their contrasting rol.s in feed intake control.between two vertebrate cl.des.

关键词： Chicken Feed intake Hypothal.mus Neuropeptide Signal.ng pathway Hormone

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Continuity of care by a primary midwife(casel.ad midwifery):a cost anal.sis using resul.s from the COSMOS randomised control.ed trial

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Gynecol.gy and Obstetrics Cl.nical.Medicine 2024年第2期4卷 94-101页

作者： Emil. J Cal.ander Hannah Jackson helen l.Mcl.chl.n Mary-Ann Davey Del.a A Forster University of Technol.gy Sydney SydneyNew South WalesAustralia The Royal.Women's Hospital MelbourneVictoriaAustralia Facul.y of Heal.h University of Technology SydneyBroadwayNew South WalesAustralia Judith l.ml.y Centre La Trobe UniversityMelbourneVictoriaAustralia School.of Nursing and Midwifery a Trobe UniversityMelbourneVictoriaAustralia Department of Obstetrics and Gynaecol.gy Monash UniversityClaytonVictoriaAustralia

Introduction Casel.ad midwifery(continuity of midwifery carer)offers benefits incl.ding l.wer caesarean section rates,l.wer risks of preterm birth and stil.irth,and improved maternal.satisfaction of *** these advantages,concerns about additional.costs hinder widespread *** study examinesthecost of casel.ad midwifery compared with standard maternity care from the perspective of both publ.c hospital. and publ.c *** A cost anal.sis was conducted using data from a randomised control.ed trial.of 2314 l.w-risk pregnant women in Mel.ourne,*** randomised to casel.ad care received antenatal.intrapartum and postpartum care from a primary midwife,with some care provided by a‘back-up'*** in standard care received midwifery-l.d care with varying l.vel. of continuity,junior obstetric care or community-based medical.*** cost anal.sis compared differences in mean costs of heal.h resources to publ.c hospital. and to publ.c ***,a budget impact anal.sis estimated total.costs to the heal.h system between 2023 and *** For publ.c hospital.,there was no significant difference in overal. costs between women receiving casel.ad midwifery(n=1146)versus standard care(n=1151)($SA12363(SD:$A4967)vs$A12323(SD:$A7404);p=0.85).Conversel.,publ.c funders incurred l.wer expenditures for women receiving casel.ad midwifery($A20330(SD:$A8312))versus standard care($A21637(SD:$A11818);pl.sis estimated savings of sA625mil.ion to the heal.h system over the next 5 years with expanded access to casel.admidwifery *** Casel.admidwifery in l.w-risk women is cost-neutral.to publ.c hospital. and cost-saving to publ.c *** abstract Continuity of midwifery for l.w-risk women reduces costs to publ.c funders,with no additional.costs to hospital..

关键词： random continuity Continuity

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SARS-CoV-2 variants are associated with different cl.nical.courses in chil.ren with MIS-C

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Worl. Journal.of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emel.a Bainto helen Harvey Adriana H.Tremoul.t Jane C.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in chil.ren has been associated with mul.isystem infl.mmatory syndrome in chil.ren(MIS-C).SARS‑CoV-2 has undergone different *** publ.cations exist about specific variants and their correl.tion with the severity of *** This was a singl.-center,retrospective study incl.ding al. patients admitted with MIS-C at Rady Chil.ren’s Hospital.San Diego between May 2020 and March *** epidemiol.gic data,incl.ding viral.genomic information,were obtained from publ.c ***,cl.nical.presentation,l.boratory val.es,and outcomes were obtained from el.ctronic medical.*** The anal.sis incl.ded 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave incl.ded cl.des 20A to *** the second wave,there were variants from cl.des 20A to C,20G,21C(Epsil.n),20I(Al.ha),and 20J(Gamma).The third wave had Del.a strains(cl.des 21A,21I,and 21J),and the fourth had Omicron variants(cl.des 21K,21l.and 22C).MIS-C presented with simil.r symptoms and l.boratory findings across al. *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical.circul.tory support,and onl. two required invasive ventil.tory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe cl.nical.*** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Compl.cations COVID-19 MIS-C SARS-CoV-2 variants

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Derived, stil. l.ving cockroach genus Caribl.ttoides （Bl.ttida： Bl.ttel.idae） from the Eocene sediments of Green River in Col.rado, USA

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Insect Science 2012年第2期19卷 143-152页

作者： Peter Vrsansky l.ubomir Vidl.cka fedor Ciampor Jr Finnegan Marsh Geol.gical.Institute SlovakAcademy of Sciences BraUslava Slovakia Pal.ontol.gical.Institute Russian Academy of Sciences Moscow Russia Institute of Zool.gy Slovak Academy of Sciences Department of Biol.gy Faculty of Education Comenius University Bratislava Slovakia Department of Pal.obiol.gy National Museum of Natural History Smithsonian Institution Washington DC USA

Caribl.ttoides l.bandeirai sp.n. from the Eocene sediments of Green River in Col.rado, USA bear onl. two pl.siomorphies, but al.o several.significant autapomorphies within the advanced and highl. derived l.ving cockroach genus. Thus, Caribl.ttoides with extant occurrence in the Caribbean and South America was historical.y common in the Nearctic, and represents important evidence for the occurrence of derived l.ving genera of cockroaches -50 Ma ago. General.y, the vast majority of l.ving genera were absent during the Pal.eocene, thus the diversification of most l.ving cockroach l.neages near the Pal.eocene/Eocene boundary must have been extremel. rapid. Femal.s of l.ving C. suave, the type species, have identical.（sophisticated） col.ration ofpronotum, but the most rel.ted l.ving taxa are C. piraiensis and *** from Brazil.（supported by phyl.genetical.anal.sis）.

关键词： Bl.ttida -- Bl.ttaria = Bl.ttodea Caribl.ttoides Eocene fossil.insects,Green River Tertiary cockroaches

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Chromosomal.disorders and mal. infertil.ty

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Asian Journal.of Androl.gy 2012年第1期14卷 32-39,175页

作者： Gary l.Harton helen G Tempest Reprogenetics Livingston NJ 07039 USA Department of Human and Mol.cul.r Genetics Herbert Wertheim College of Medicine Florida International University Miami FL 33132 USA

Infertil.ty in humans is surprisingl. common occurring in approximatel. 15% of the popul.tion wishing to start a famil.. Despite this, the mol.cul.r and genetic factors underl.ing the cause of infertil.ty remain l.rgel. undiscovered. Neverthel.ss, more and more genetic factors associated with infertil.ty are being identified. This review wil. focus on our current understanding of the chromosomal.basis of mal. infertil.ty specifical.y： chromosomal.aneupl.idy, structural.and numerical.karyotype abnormal.ties and Y chromosomal.microdel.tions. Chromosomal.aneupl.idy is the l.ading cause of pregnancy l.ss and devel.pmental.disabil.ties in humans. Aneupl.idy is predominantl. maternal.in origin, but concerns have been raised regarding the safety of intracytopl.smic sperm injection as infertil. men have significantl. higher l.vel. of sperm aneupl.idy compared to their fertil. counterparts. Mal.s with numerical.or structural.karyotype abnormal.ties are al.o at an increased risk of producing aneupl.id sperm. Our current understanding of how sperm aneupl.idy transl.tes to embryo aneupl.idy wil. be reviewed, as wel. as the appl.cation of preimpl.ntation genetic diagnosis （PGD） in such cases. Cl.nical.recommendations where possibl. wil. be made, as wel. as discussion of the use of emerging array technol.gy in PGD and its potential.appl.cations in mal. infertil.ty.

关键词： chromosomal.aneupl.idy chromosomal.transl.cation intracytopl.smic sperm injection in vitro fertil.zation mal. infertil.ty non-disjunction preimpl.ntation genetic diagnosis Y-chromosome microdel.tion

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TRPC3 is required for the survival. pl.ripotency and neural.differentiation of mouse embryonic stem cel.s(mESCs)

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Science China(l.fe Sciences) 2018年第3期61卷 253-265页

作者： helen Baixia Hao Sarah E. Webb Jianbo Yue Marc Moreau Catherine l.cl.rc Andrew l. Mil.er Division of l.fe Science and State Key l.boratory of Mol.cul.r Neuroscience HKUST Clear Water Bay Hong Kong China Department of Biomedical.Sciences City University of Hong Kong Hong Kong China Centre de Biol.gie du Dével.ppement (CBD) Centre de Biologie Intégrative (CBI) Université de Toulouse CNRS UPS Toulouse F-31062 France

Transient receptor potential.canonical.subfamil. member 3(TRPC3) is known to be important for neural.devel.pment and the formation of neuronal.networks. Here, we investigated the rol. of TRPC3 in undifferentiated mouse embryonic stem cel.s(mESCs) and during the differentiation of mESCs into neurons. CRISPR/Cas9-mediated knockout(KO) of TRPC3 induced apoptosis and the disruption of mitochondrial.membrane potential.both in undifferentiated mESCs and in those undergoing neural.differentiation. In addition, TRPC3 KO impaired the pl.ripotency of mESCs. TRPC3 KO al.o dramatical.y repressed the neural.differentiation of mESCs by inhibiting the expression of markers for neural.progenitors, neurons, astrocytes and *** together, our new data demonstrate an important function of TRPC3 with regards to the survival. pl.ripotency and neural.differentiation of mESCs.

关键词： transient receptor potential.canonical.subfamil. member 3 (TRPC3) mouse embryonic stem cel.s (mESCs) neurondifferentiation CRISPR/Cas9 pl.ripotency apoptosis mitochondrial.membrane potential

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景观—社会学视角下的北京高密度城区儿童游戏专属和发现空间

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风景园林 2024年第2期31卷 19-31页

作者： [英]海伦·伍利汤湃谢菲尔德大学风景园林系英国皇家风景园林协会 GUIC国际研究组中国研究组同济大学建筑与城市规划学院 GUIC国际研究组

【目的】在任何地方进行游戏是儿童的天性。以北京中心城区高密度城市环境为例,深入探究儿童如何创造性地使用城市户外公共空间。【方法】从景观—社会学视角,通过半构建访谈、照片访谈和行为观察等方法收集儿童户外活动空间数据。【结... 详细信息

【目的】在任何地方进行游戏是儿童的天性。以北京中心城区高密度城市环境为例,深入探究儿童如何创造性地使用城市户外公共空间。【方法】从景观—社会学视角,通过半构建访谈、照片访谈和行为观察等方法收集儿童户外活动空间数据。【结果】将儿童使用的多样户外空间分为专属空间和发现空间,以及介于两者之间的灵活空间3种类别。深入探究不同类别的活动空间的特点发现,配置有固定游戏设备的儿童专属游乐场所提供的游戏机会单一,无法满足全龄儿童进行多样户外游戏的需求,但专属空间为儿童提供了最为正式且相对安全的游戏环境;儿童广泛使用的灵活空间,如广场和可进入的绿地,其开放性为更为广泛的年龄群体提供了可供奔跑、跳跃和骑车等高强度活动的机会,但营造公平且友好的共享公共环境是灵活空间面临的挑战;发现空间的设计初衷并非为儿童使用,因此儿童在使用这类空间的过程中普遍存在潜在安全隐患。【结论】针对高密度城市环境中有限的公共空间提出了更加包容且儿童友好的营造方式以及优化设计建议,期望为提升高密度城市公共空间服务效能、实现城市可持续发展提供一定科学参考。

关键词：高密度城区儿童友好可供性发现空间户外空间

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Gl.ucoma surgery and induced astigmatism:a systematic review

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Eye and Vision 2017年第1期4卷 159-163页

作者： helen H.l.Chan Yu Xiang G.Kong Royal.Victorian Eye and Ear Hospital 32 Gisborne StEast MelbourneVIC 3002Australia

Background:The refractive outcomes of gl.ucoma surgeries,particul.rl. their effect on astigmatism,are incompl.tel. *** body:Trabecul.ctomy is associated with a considerabl. amount of with-the-rul. astigmatic change in the immediate postoperative *** is fol.owed by a gradual.against-the-rul. *** changes are al.ered with the use of mitomycin C(MMC).Non-penetrating surgery such as deep scl.rectomy is al.o associated with a simil.r or smal.er degree of induced *** invasive gl.ucoma surgery appears to be astigmatical.y *** is no cl.ar evidence regarding refractive outcomes of gl.ucoma drainage device ***:Induced astigmatism may account for a reduction in unaided visual.acuity in the earl. postoperative period fol.owing a successful.*** changes appear to stabil.se at 3 months,and it woul. be prudent to defer the prescription of new gl.sses until.this *** sequential.cataract surgery is to be performed,toric intraocul.r l.nses can be a useful.option for astigmatic correction.

关键词： Fil.ration surgery Trabecul.ctomy Astigmatism Refractive outcome

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Stress response sil.ncing by an E3 l.gase mutated in neurodegeneration

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四川生理科学杂志 2024年第1期46卷 21-21页

作者： Diane l.Haakonsen Department of Mol.cul.r and Cel. Biol.gy University of California at Berkeley Berkeley CA USA Howard Hughes Medical.Institute University of California at Berkeley Berkeley CA USA Cal.fornia Institute for Quantitative Biosciences (QB3) University of California at Berkeley Berkeley CA USA Institute for Stem Cel. Biol.gy and Regenerative Medicine Stanford University School of Medicine Stanford CA USA Department of Pathol.gy Stanford University School of Medicine Stanford CA USA

Stress response pathways detect and al.eviate adverse conditions to safeguard cel. and tissue homeostasis,yet their prol.nged activation induces apoptosis and disrupts organismal.*** stress responses are turned off at the right time and pl.ce remains poorl. *** we report a ubiquitin-dependent mechanism that sil.nces the cel.ul.r response to mitochondrial.protein import stress.

关键词： homeostasis sil.nce turned

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