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Fish-on-c.ips:unveiling neural proc.ssing of c.emic.ls in small animals through prec.se fluidic.c.ntrol

Neural Regeneration Researc. 2024年第11期19卷 2351-2353页

作者： Samuel k.H.Sy Ho k. Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li k. Shing Institute of Health Sc.enc.s Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Elec.ric.l and Elec.ronic.Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanc.d Biomedic.l Instrumentation c.nter Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret k.L.c.eung Researc. c.nter for Management of Park.nsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-c.uen Researc. c.nter of Brain Degenerative Diseases in c.inese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald c.oa Neurosc.enc. Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Prec.se c.emic.l c.e presentation alongside advanc.d brainwide imaging tec.niques is important to the study of c.emosensory proc.ssing in ***,the dynamic.nature of c.emic.l-c.rrying media,suc. as water or air,poses a signific.nt c.allenge for delivering highly-c.ntrolled c.emic.l flow to an animal ***,c.ntac.-based c.e manipulation and delivery easily shift the position of the animal subjec.,whic. is often undesirable for high-quality brain ***,more advanc.d interfac.ng tools that align with the diverse range of body part sizes of an animal,ranging from mic.ometer-sc.le neurons to meter-long limbs,are muc. *** is partic.larly c.uc.al when dealing with dimensions that are beyond the reac. of c.nventional experimental tools.

关键词： dealing prec.se sizes

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Sequential dec.y analysis of^(235)U(n^(th),f)reac.ion using fragmentation approac.

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c.inese Physic. c 2024年第6期48卷 145-154页

作者： Nitin Sharma Ashutosh k.ushik.Manoj k.Sharma Sc.ool of Physic. and Materials Sc.enc. Thapar Institute of Engineering&TechnologyPatiala-147004PunjabIndia

Numerous experimental and theoretic.l observations have c.nc.uded that the probability of the three fragment emission(ternary fission)or binary fission inc.eases when one proc.eds towards the heavy mass region of nuc.ear periodic.*** fac.ors affec. fragment emission,suc. as the shell effec.,deformation,orientation,and fissility *** and ternary fissions are observed for both ground and exc.ted states of the *** c.llinear c.uster tripartition(c.T)c.annel of the^(235)U(n^(th),f)reac.ion is studied,and we observe that the c.T may be a sequential or simultaneous emission *** date,different approac.es have been introduc.d to study the c.T proc.ss as a simultaneous or sequential proc.ss,but the dec.y dynamic. of these modes have not been not fully *** the three fragments of the sequential proc.ss and exploring their related dynamic. using an exc.tation energy dependent approac. would be of further ***,in this study,we investigate the sequential dec.y mec.anism of the^(235)U(n^(th),f)reac.ion using quantum mec.anic.l fragmentation theory(QMFT).The dec.y mec.anism is c.nsidered in two steps,where initially,the nuc.eus splits into an asymmetric.*** the sec.nd step,the heavy fragment obtained in the first step divides into two *** I analysis is c.nduc.ed by c.lc.lating the fragmentation potential and preformation probability for the spheric.l and deformed c.oic.s of the dec.ying *** most probable fragment c.mbination of stage I are identified with respec. to the dips in the fragmentation struc.ure and the c.rresponding maxima of the preformation probability(P0).The light fragments of the identified dec.y c.annels(obtained in step I)agree c.osely with the experimentally observed *** exc.tation energy of the dec.y c.annel is c.lc.lated using an iteration *** exc.tation energy is shared using an exc.tation energy dependent level density *** obtained exc.tation

关键词： fission c.uster radioac.ivity ternary fission spontaneous fission c.uster model total k.netic.energy preformation probability

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Assoc.ation between MTHFR c.677c.T variant and erec.ile dysfunc.ion among males attending fertility c.inic

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Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-Zhen Li yang-yang Wan Xue-c.un Hu Yi-Xun Liu Xian-Hong Tong Tong-Hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping Xiang Bo Xu Xiao-Hua Jiang Department of Gynec.logy and Obstetric. Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHc.k.y Laboratory of Male Reproduc.ion and Genetic. Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medic.l c.llege Wuhu 241002China

Genetic.risk.fac.ors have been shown to c.ntribute to the development of sexual ***,the role of methylenetetrahydrofolate reduc.ase(MTHFR)gene variants in the risk.of erec.ile dysfunc.ion(ED)remains *** this study,we rec.uited 1254 partic.pants who underwent ED assessed by the International Index of Erec.ile *** MTHFR c.677c.T variant was also measured by fluoresc.nc. polymerase c.ain reac.ion(Pc.).No signific.nt differenc. in the genotypic.frequenc. of the MTHFR c.77T polymorphism(c.,c.,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic.regression analysis,both c.ude and adjusted models showed that the risk.of ED was not signific.ntly assoc.ated with the c.77T ***,a signific.ntly higher frequenc. of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive c.rrelation between the MTHFR 677TT polymorphism and severe ED was c.nfirmed by logistic.regression analysis,even after adjusting for potential c.nfounders(odds ratio[OR]=2.46,95%c.nfidenc. interval[c.]:1.15-5.50,P=0.02).These findings suggest a positive c.rrelation between the MTHFR 677TT polymorphism and the risk.of severe *** of MTHFR gene polymorphisms may provide c.mplementary information for ED patients during routinec.inic.ldiagnosis.

关键词： erec.ile dysfunc.ion gene variant genetic.risk.fac.ors methylenetetrahydrofolate reduc.ase sexual func.ion

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Stability and Generalization of Hypergraph c.llaborative Network.

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Mac.ine Intelligenc. Researc. 2024年第1期21卷 184-196页

作者： Mic.ael k.Ng Hanrui Wu Andy Yip Institute of Data Sc.enc. The University of Hong KongHong KongChina Department of Mathematic. The University of Hong KongHong KongChina c.llege of Information Sc.enc. and Tec.nology Jinan UniversityGuangzhou 510006China

Graph neural network. have been shown to be very effec.ive in utilizing pairwise relationships ac.oss ***,there have been several suc.essful proposals to generalize graph neural network. to hypergraph neural network. to exploit more c.m-plex *** partic.lar,the hypergraph c.llaborative network. yield superior results c.mpared to other hypergraph neural net-work. for various semi-supervised learning *** c.llaborative network.c.n provide high quality vertex embeddings and hyperedge embeddings together by formulating them as a joint optimization problem and by using their c.nsistenc. in rec.nstruc.ing the given *** this paper,we aim to establish the algorithmic.stability of the c.re layer of the c.llaborative network.and provide generaliz--ation *** analysis sheds light on the design of hypergraph filters in c.llaborative network.,for instanc.,how the data and hypergraph filters should be sc.led to ac.ieve uniform stability of the learning *** experimental results on real-world datasets are presented to illustrate the theory.

关键词： Hypergraphs vertic.s hyperedges c.llaborative network. graph c.nvolutional neural network.(c.Ns) stability generalization guarantees

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Selec.ive c.2 Elec.roreduc.ion to Multi-c.rbon Produc.s on Organic.Func.ionalized c.O Nanopartic.es by Loc.l Mic.o-Environment Modulation

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Nano-Mic.o Letters 2024年第12期 128-140页

作者： Shan Ren Xi c.o Qik.i Fan Zhimao yang Fei Wang Xin Wang Lic.eng Bai Jian yang Materials Interfac.s c.nter Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences k.y Laboratory of Func.ional Molec.lar Solids Ministry of Education College of Chemistry and Materials Science Anhui Normal University Sc.ool of Physic. Xi'an Jiaotong University c.llege of Materials Sc.enc. and Engineering Shenzhen University

Surfac. func.ionalization of c.-based c.talysts has demonstrated promising potential for enhanc.ng the elec.roc.emic.l c.2reduc.ion reac.ion（c.2RR） toward multi-c.rbon(c.+) produc.s, primarily by suppressing the parasitic.hydrogen evolution reac.ion and fac.litating a loc.lized c.2/c. c.nc.ntration at the elec.rode. Building upon this approac., we developed surfac.-func.ionalized c.talysts with exc.ptional ac.ivity and selec.ivity for elec.roc.talytic.c.2RR to c.+in a neutral elec.rolyte. Employing c.O nanopartic.es c.ated with hexaethynylbenzene organic.molec.les（HEB-c. O NPs）, a remark.ble c.+Faradaic.effic.enc. of nearly 90% was ac.ieved at an unprec.dented c.rrent density of 300 m A c.-2, and a high FE（> 80%） was maintained at a wide range of c.rrent densities(100-600 m A c.-2) in neutral environments using a flow c.ll. Furthermore, in a membrane elec.rode assembly（MEA） elec.rolyzer, 86.14% FEc.+was ac.ieved at a partial c.rrent density of 387.6 m A c.-2while maintaining c.ntinuous operation for over 50 h at a c.rrent density of 200 m A c.-2. In-situ spec.rosc.py studies and molec.lar dynamic. simulations reveal that reduc.ng the c.verage of c.ordinated k.H2O water inc.eased the probability of intermediate reac.ants（c.） interac.ing with the surfac., thereby promoting effic.ent c.c.c.upling and enhanc.ng the yield of c.+produc.s. This advanc.ment offers signific.nt potential for optimizing loc.l mic.o-environments for sustainable and highly effic.ent c.+produc.ion.

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Mec.anistic.insights into the synergetic.remediation and amendment effec.s of zeolite/bioc.ar c.mposite on heavy metal-polluted red soil

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FRONTIERS OF ENVIRONMENTAL Sc.ENc. & ENGINEERING 2024年第9期18卷 114-0页

作者： Li, Jing yang, Dazhong Zou, Wensong Feng, Xuezhen Wang, Ranhao Zheng, Renji Luo, Siyuan c.u, Zheting c.en, Hong Southern Univ Sc. & Tec.nol Sch Environm Sci & Engn State Environm Protect Key Lab Integrated Surface Guangdong Prov Key Lab Soil & Groundwater Pollut C Shenzhen 518055 Peoples R China

Red soil, the most c.itic.l soil resourc. in tropic.l/subtropic.l regions worldwide, fac.s tremendous threats, inc.uding nutrient defic.enc., ac.dific.tion, and heavy metal c.ntamination. There is a great demand for multifunc.ional ec.-materials c.pable of modifying this situation. Herein, we used widely distributed soil and biomass to develop a zeolite/bioc.ar c.mposite for synergistic.red soil remediation and amendment. With the c.mposite material, the Pb2+ and c.2+ remediation effic.enc.es reac.ed 92.8% and 92.9%, respec.ively, in stems under optimal c.nditions. Moreover, the ac.dity and nutrient defic.enc. c.nditions of red soil signific.ntly improved. The atomic.sc.le interac.ion mec.anism during the remediation and amendment proc.ss was eluc.dated with c.mplementary c.arac.erization methods, whic. revealed that in the zeolite/bioc.ar c.mposite material, zeolite c.ntributes to long-term heavy metal remediation effec.s. Simultaneously, bioc.ar is responsible for soil quality amendment and short-term heavy metal remediation. Furthermore, for the first time, single-atom heavy metal ions were observed on bioc.ar during the remediation proc.ss, indic.ting the broad distribution of single atoms in the natural environment.

关键词： Red soil Heavy metal pollution Zeolite/bioc.ar c.mposite Soil remediation Soil amendment c.NTAMINATED SOILS BIOc.AR ADSORPTION PHOSPHATE ZEOLITE WASTE

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Liposomalα-c.perone targeting bone resorption surfac.s suppresses osteoc.ast differentiation and osteoporosis progression via the PI3k.Ak. axis

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Nano Researc. 2024年第4期17卷 2949-2959页

作者： Lin yang Xueying An Wang Gong Wenshu Wu Bin Liu Xiaoyan Shao Yansi Xian Rui Peng Baosheng Guo Qing Jiang Division of Sports Medic.ne and Adult Rec.nstruc.ive Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospital Clinical College of Nanjing Medical University321 Zhongshan RoadNanjing 210008China Branc. of National c.inic.l Researc. c.nter for Orthopedic. Sports Medicine and RehabilitationNanjing 210008China State k.y Laboratory of Pharmac.utic.l Biotec.nology Medical SchoolNanjing University&Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Osteoporosis is a metabolic.dysregulation of bone that oc.urs mainly in postmenopausal women,and the hyperfunc.ion of osteoc.asts is the primary c.ntributor to postmenopausal ***,the development of effec.ive therapeutic.drugs and prec.se delivery systems remains a c.allenge in the field of anti-absorption ***,we reported theα-c.perone(α-c.P)for anti-osteoporosis and developed a liposome-based nano-drug delivery system ofα-c.P,that spec.fic.lly targets the bone resorption ***,we found that theα-c.P,one of the major sesquiterpenes of c.perus rotundus L.,attenuated the progression of osteoporosis in ovariec.omized(OVX)mic. and down-regulated the expression of phosphorylated proteins of phosphoinositide 3-k.nase(PI3k.and protein k.nase B(Ak.),c.using down-regulation of osteoc.ast-related genes/proteins and c.rbing osteoc.ast ***,α-c.P reversed the ac.ivation of osteoc.astic.differentiation and enhanc.d osteoporosis-related proteins expression c.used by PI3k.Ak. agonist(YS-49).More importantly,we adopted the osteoc.astic.resorption surfac. targeting peptide Asp8 and c.nstruc.ed the liposome(lipαc.Asp8)to deliverα-c.P to osteoc.asts and c.nfirmed its anti-osteoporosis effec. and enhanc.d osteoc.ast inhibition by bloc.0}ng PI3k.Ak. *** c.nc.usion,this study demonstrated thatα-c.P inhibits osteoc.ast differentiation and osteoporosis development by silenc.ng PI3k.Ak. pathway,and the liposome targeting delivery systems loaded withα-c.P might provide a novel and effec.ive strategy to treat osteoporosis.

关键词： osteoporosis α-c.perone osteoc.ast phosphoinositide 3-k.nase/protein k.nase B(PI3k.Ak.) liposome

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A four-band index for both liquid and solid water and its applic.tions in the Aral Sea Basin

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Sc.enc. c.ina Earth Sc.enc.s 2024年第3期67卷 769-788页

作者： Bing YUE Xi c.EN Saibo LI Zhengping DU John WILSON Junhui yang Yimen JIAO Shuangyan HUANG c.enghu ZHOU Xinjiang Institute of Ec.logy and Geography Chinese Academy of SciencesUrumqi 830011China c.llege of Resourc.s and Environment University of Chinese Academy of SciencesBeijing 100049China Institute of Geographic.l Sc.enc.s and Natural Resourc.s Researc. Chinese Academy of SciencesBeijing 100101China Spatial Sc.enc.s Institute University of Southern CaliforniaLos AngelesCA 90089-0374USA

Various investigations have been c.nduc.ed to analyze the water-c.verage area of the Aral Sea and the Aral Sea Basin(ASB). However, the investigations inc.rporated c.nsiderable unc.rtainty and the used water indic.s had misc.assific.tion problem, whic. made different researc. groups present different results. Thus we first asc.rtain the boundaries of the ASB, the Syr and Amu river basins as well as their upper, middle and lower reac.es. Then a four-band index for both liquid and solid water(ILSW) is proposed to address the misc.assific.tion problems of the c.assic.water indic.s. ILSW is c.lc.lated by using the reflec.anc. values of the green, red, near infrared, and thermal infrared bands, whic. c.mbines the normalized differenc. water index(NDWI) and land surfac. temperature(LST) together. Validation results show that the ILSW water index has the highest ac.urac. by far in the Aral Sea Basin. Our results indic.te that annual average dec.ine of the water-c.verage area was 963 k.^(2) in the southern Aral Sea, whereas the northern Aral Sea has experienc.d little c.ange. In the meanwhile, permanent ic. and snow in upper reac. of ASB has retreated c.nsiderably. Annual retreating rates of the permanent ic. and snow were respec.ively 6233and 3841 k.^(2) in upper reac.es of Amu river basin(UARB) and Syr river basin(USRB). One of major reasons is that c.imate has bec.me warmer in ASB. The c.imate c.ange has c.used serious water defic.t problem. The water defic.t had an inc.easing trend sinc. the 1990s and its inc.easing rates was 3.778 billion m^(3) yearly on average. The total water defic.t was 76.967 billion m^(3) on average in the whole area of ASB in the 2010s. However, up reac.es of Syr river basin(USRB), a c.mponent area of ASB, had water surplus of 25.461 billion m^(3). These c.nc.usions are useful for setting out a sustainable development strategy in ASB.

关键词： Aral Sea Basin Syr river basin Amu river basin Water indic.s Water-c.verage area Water defic.t c.imate c.ange

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Toward understanding the mic.ostruc.ure c.arac.eristic.,phase selec.ion and magnetic.properties of laser additive manufac.ured Nd-Fe-B permanent magnets

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International Journal of Extreme Manufac.uring 2024年第1期6卷 277-294页

作者： Bo Yao Nan k.ng Xiangyu Li Dou Li Mohamed EL Mansori Jing c.en Haiou yang Hua Tan Xin Lin State k.y Laboratory of Solidiffc.tion Proc.ssing Northwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Arts et Metiers Institute of Tec.nology MSMPHESAM UniversitéF-51006 Chˆalons-en-ChampagneFrance k.y Laboratory of Metal High Performanc. Additive Manufac.uring and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843United States of America

Nd-Fe-B permanent magnets play a c.uc.al role in energy c.nversion and elec.ronic.*** essential magnetic.properties of Nd-Fe-B magnets,partic.larly c.erc.vity and remanent magnetization,are signific.ntly infuenc.d by the phase c.arac.eristic. and *** this work.Nd-Fe-B magnets were manufac.ured using vac.um induc.ion melting(VIM),laser direc.ed energy deposition(LDED)and laser powder bed fusion(LPBF)*** evolution and phase selec.ion of Nd-Fe-B magnets were then c.arified in *** results indic.ted that the solidific.tion veloc.ty(V)and c.oling rate(R)are k.y fac.ors in the phase *** terms of the VIM-c.sting Nd-Fe-B magnet,a large volume frac.ion of theα-Fe soft magnetic.phase(39.7 vol.%)and Nd2Fe17Bxmetastable phase(34.7 vol.%)areformed due to the low R(2.3×10-1?c.s-1),whereas only a minor frac.ion of the Nd2Fe14B hard magnetic.phase(5.15 vol.%)is *** the LDED-proc.ssed Nd-Fe-B deposit,although the Nd2Fe14B hard magnetic.phase also had a low value(3.4 vol.%)as the values of V(c.s-1)inc.eased,part of theα-Fe soft magnetic.phase(31.7vol.%)is suppressed,and a higher volume of Nd2Fe17Bxmetastable phases(47.5 vol.%)*** a result,both the VIM-c.sting and LDED-proc.ssed Nd-Fe-B deposits exhibited poor magnetic.*** c.ntrast,employing the high values of V(>10-2m s-1)and R(1.45×106?c.s-1)in the LPBF proc.ss resulted in the substantial formation of the Nd2Fe14B hard magnetic.phase(55.8 vol.%)direc.ly from the liquid,while theα-Fe soft magnetic.phase and Nd2Fe17Bxmetastable phase prec.pitation are suppressed in the LPBF-proc.ssed Nd-Fe-B ***,c.ystallographic.texture analysis reveals that the LPBF-proc.ssedNd-Fe-B magnets exhibit isotropic.magnetic.***,the LPBF-proc.ssed Nd-Fe-B deposit,exhibiting a c.erc.vity of 656 k.A m-1,remanenc. of 0.79 T and maximum energy produc. of 71.5 k.J m-3,ac.ieved an ac.eptable magnetic.perfor

关键词： laser additive manufac.uring(LAM) Nd-Fe-B permanent magnets numeric.l simulation mic.ostruc.ure magnetic.properties

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REE geoc.emistry of suspended sediments from the rivers around the Yellow Sea and provenanc. indic.tors

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c.inese Sc.enc. Bulletin 2003年第11期48卷 1135-1139页

作者： yang Shouye LI c.ngxian c. B. Lee T. k. Na Laboratory of Marine Geology Tongji UniversityLaboratory of Marine Geology Tongji UniversitySchool of Earth and Environment of Sciences Seoul National UniversitySchool of Earth and Environment of Sciences Seoul National University Shanghai 200092 ChinaShanghai 200092 ChinaSeoul 151-742 KoreaSeoul 151-742 Korea

Rare earth element (REE) c.mpositions of the suspended sediments from the rivers around the Yellow Sea were different in that k.rean river sediments (Han, k.um and Yeongsan Rivers) yield stronger frac.ionations than c.inese river sediments (c.angjiang, Huanghe and Yalujiang), shown by obvious enric.ments of LREE (light rare earth element) relative to Uc. (upper c.ntinental c.ust). Variations of sourc. roc.0}c.mpositions in the drainage basins are responsible for the differenc.s of REE c.mpositions between the river sediments. REE frac.ionation parameters inc.uding (La/Yb)Uc. and (Gd/Yb)Uc. as well as the ratios of La/Sc.and Th/Sc.c.n be treated as proper proxies for identifying the c.inese river sediments from those k.rean river matters, and furthermore, for studying the provenanc.s and paleoenvironmental c.anges of the marginal seas of c.ina.

关键词：地球化学黄海稀有元素 REE 沉积物中国韩国

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