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Environmental impact improvements due to introducing automation into underground copper mines

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International Journal of Mining Science and Technology 2021年第6期31卷 1159-1167页

作者： Kyle Moreau Corey Laamanen Ron Bose helen Shang John Ashley Scott School of Engineering Laurentian UniversitySudburyON P3E 2C6Canada XPS–Glencore Greater SudburyON P0M 1S0Canada

A life-cycle assessment(LCA) model was developed to comparatively analyze the use of manual and automated mining equipment in underground copper mine *** and key variables that were determined to contribute to the environmental impact of operations were identified for six mine sites in a range of geographical locations around the *** model successfully calculated carbon dioxide(CO_(2) eq.) emissions to within 4.9% of the reported annual emissions from the site's respective *** implementation of automation was found to decrease global warming potential by a range of 11.4%-18.0% or 3.9-17.9 kg CO_(2) eq./t *** model was also used to estimate the average reductions across several impact potentials including,acidification(11.9%-17.8%),eutrophication(7.6%-13.7%),and human toxicity(16.0%-20.0%).World-wide the mining industry is moving toward introducing significantly more automation to enhance productivity and *** novel work demonstrates an important third dimension that can support this move,reduced environmental impact.

关键词： Automation Underground copper mines Environmental improvements Life cycle assessment Modelling

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Cancer immunotherapy

Chinese Journal of Cancer 2014年第9期33卷 413-415页

作者： Li Yan helen X.Chen US Chinese Anti-Cancer Association Therapy Evaluation Program (CTEP) National Cancer Institute (NCI)

Unprecedented progress has seen made in the last decade in the fi eld of cancer *** recent approval of nivolumab(Opdivo),the fi rst anti-programmed cell death-1(PD-1)antibody,for metastatic melanoma in Japan,marked a ... 详细信息

关键词：免疫治疗肿瘤细胞毒性T淋巴细胞程序性细胞死亡 CTLA-4 免疫疗法黑色素瘤转移性

Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring

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Asian Journal of Andrology 2013年第2期15卷 261-268,I0009页

作者： Richard Ivell Kee Heng helen Nicholson Ravinder Anand-Ivell School of Molecular and Biomedical Science University of Adelaide Adelaide 5005 Australia FBN Leibniz Institute of Farm Animal Biology Dummerstorf 18196 Germany Centre for Reproduction and Genomics Otago School of Medical Sciences University of Otago Dunedin 9054 New Zealand School of Pharmacy and Medical Sciences University of South Australia Adelaide 5000 Australia

Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can influence the later adult-type Leydig cell phenotype. In this study, Sprague-Dawley rats were exposed to dibutyl phthalate （DBP; from gestational day （GD） 14.5 to postnatal day （PND） 6） or diethylstilbestrol （DES; from GD14o5 to GD16.5） during a short gestationalllactational window, and male offspring subsequently analysed for various postnatal testicular parameters. All offspring remained in good health throughout the study. Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory. Part of this effect appeared to be due to a treatment-specific impact on Leydig cell proliferation during puberty for both xenobiotics. Taken together, these results support the notion that maternal exposure to certain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly through an effect on the Leydig stem cell population.

关键词： diethylstilbestrol (DES) INSL3 Leydig cells dibutyl phthalate (DBP) puberty testis

Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects

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Acta Pharmacologica Sinica 2006年第3期27卷 259-272页

作者： Irena MANOV helen MOTANIS Idan FRUMIN Theodore C IANCU Pediatric Research and Electron Microscopy Unit.Ruth and Baruch Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifa Israel

With the increasing incidence of drug-induced liver disease,attempts are beingmade to better understand the mechanisms behind these frequently life-endan-gering *** and anti-inflammatory drugs are a major group ex-hibiting *** review research relating to these reactions,focusingon ultrastructural findings,which may contribute to the comprehension and pos-sible avoidance of drug-induced liver *** also present some originalobservations on clinical material and cultured cells exposed to acetaminophenalone or in combination with the antioxidant N-acetylcysteine or the P-glycopro-tein inhibitor verapamil.

关键词： non-steroidal anti-inflammatory agents drug toxicity liver aspirin acetaminophen cultured cells electron microscopy apoptosis P-glycoprotein acetylcysteine

Automated Image Analysis of Mud and Mudrock Microstructure and Characteristics of Hemipelagic Sediments: IODP Expedition 339

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Journal of Earth Science 2019年第2期30卷 407-421页

作者： Shereef A.Bankole Jim Buckman Dorrik Stow helen Lever Institute of Petroleum Engineering Heriot-Watt University Department of Chemical and Geological Sciences Al-Hikmah University

The microstructural analysis of muds and mudrocks requires very high-resolution measurement. Recent advances in electron microscopy have contributed significantly to the improved characterisation of mudrock microstructures and their consequent petrophysical properties. However, imaging through electron microscopy is limited to small areas of coverage such that upscaling of these properties is a great challenge. In this paper, we develop a new methodology for multiple large-area imaging using scanning electron microscopy through automated acquisition and stitching from polished thin-sections and ion-milled samples. The process is fast, efficient and minimises user-input and bias. It can provide reliable, quantifiable data on sediment grain size, grain orientation, pore size and porosity. Limitations include the time involved for individual runs and manual segmentation, the large amount of computer memory required, and instrument resolution at the nano-scale. This method is applied to selected samples of Quaternary muddy sediments from the Iberian margin at IODP Site 1385. The section comprises finegrained(very fine clayey silts), mixed-composition, biogenic-terrigenous hemipelagites, with a pronounced but non-regular colour cyclicity. There is a multi-tiered and diverse trace fossil assemblage of the deep-water Zoophycos ichnofacies. The sediment microstructures show small-scale heterogeneity in all properties, and an overall random fabric with secondary preferred grain-alignment. These results on the fabric differ, in part, from previous studies of hemipelagic muds. Further work is underway on their comparison with other deep-water sediment facies.

关键词： mudrocks microstructure microporosity grain-orientation hemipelagites trace fossils

Discussing why population growth is still ignored or denied

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Chinese Journal of Population,Resources and Environment 2016年第2期16卷 133-143页

作者： helen Kopnina Haydn Washington Institute Cultural Anthropology and Development Sociology Leiden University international Business Management Studies The Hague University of Applied Science Interdisciplinary Environmental Studies University of New South Wales

Due to a number of factors outlined in this article,the issue of population growth is excluded from the sustainability *** this article,we explore some of the ethical presumptions that underlie the issues linking population growth and *** argue that action to address population creates social and economic segregation,and portray overpopulation concerns as being "anti-poor," "anti-developing country," or even "antihuman." Yet,de-linking demographic factors from sustainability concerns ignores significant global realities and trends,such as the ecological limits of the Earth,the welfare and long-term livelihood of the most vulnerable groups,future prospects of humanity,as well as the ecosystems that support society.

关键词： Population growth overpopulation sustainability

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依前列醇多样的信号选择(英文)

Acta Pharmacologica Sinica 2003年第7期24卷 3-8+102页

作者： helen WISE China Department of Pharmacology Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR New Territories Shatin

The fate of a cell following stimulation by the prostanoid prostacyclin is cell specific, depending not only on the ability of prostacyclin to activate the cell surface prostacyclin(IP) receptor and regulate its coupling to various G proteins, but also on its ability to act intracellularly via the nuclear peroxisome proliferator-activated receptor family(PPAR). This review will highlight the different signalling options available to prostacyclin, and discuss the consequences for cell responses.

关键词：依前列醇 IP受体过氧化物酶体增殖因子活化受体受体转换

The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

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Science China(Life Sciences) 2014年第4期57卷 366-371页

作者： CLARK Charlotte EJ LIU Yaobo COOPER helen M Queensland Brain Institute The University of QueenslandBrisbane Institute of Neuroscience Soochow University

In the developing embryo,nascent axons navigate towards their specific targets to establish the intricate network of axonal connections linking neurons within the mature nervous *** navigational systems comprising repulsive and attractive guidance cues form chemotactic gradients along the pathway of the exploring growth ***-bound receptors detect these gradients and determine the trajectory of the migrating growth *** contrast to their benevolent role in the developing nervous system,repulsive guidance receptors are detrimental to the axon’s ability to regenerate after injury in the *** this review we explore the essential and beneficial role played by the chemorepulsive Wnt receptor,Ryk/Derailed in axon navigation in the embryonic nervous system(the Yin function).Specifically,we focus on the role of Wnt5a/Rykmediated guidance in the establishment of two major axon tracts in the mammalian central nervous system,the corticospinal tract and the corpus *** studies have also identified Ryk as a major suppressor of axonal regeneration after spinal cord ***,we also discuss this opposing aspect of Ryk function in axonal regeneration where its activity is a major impediment to axon regrowth(the Yang function).

关键词： Ryk Derailed Wnt Wnt signalling axon guidance axonal regeneration spinal cord injury

The role of the Mid-Cimmerian Unconformity on the quality of the underlying Skagerrak sandstone reservoir in the Kittiwake Field,central North Sea

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Energy Geoscience 2021年第4期2卷 254-273页

作者： Abdulati Araibi Dorrik Stow helen Lever Zeinab Smillie Department of Earth Science Elmergib UniversityAlkhomsLibya Institute of Geo-Energy Engineering School of EnergyGeoscienceInfrastructure and SocietyEdinburghUK

The central aim of this paper is to address the role of unconformities in affecting reservoir *** they facilitate diagenesis that leads to either enhanced or reduced porosity through dissolution or cementation?Or,do they have little effect?We have investigated the Late Triassic Skagerrak sandstone reservoir underlying the Mid-Cimmerian Unconformity in the Kittiwake Field,central North *** is strong evidence for the development of secondary porosity through the dissolution of unstable silicate minerals,primarily *** includes the presence of oversized pores,partial dissolution of framework grains,and complete dissolution of grains leaving remnant grain margins and partially filled *** dissolution as a late-stage event is demonstrated by the complete lack of compaction effects on the secondary pores and diagenetic products despite present burial depths in excess of 3000 *** observations,coupled with an absence of systematic trends linked to the unconformity surface in respects of reservoir porosity,feldspar amount and dissolution,and kaolinization,lead to the conclusion that there has been no effect of the Mid-Cimmerian Unconformity on reservoir quality in the Kittiwake *** is no evidence for leaching or cementation linked to meteoric water influx either shortly after deposition or following the uplift and exposure,which led to development of the Mid-Cimmerian ***,we propose that the late-stage dissolution of feldspar and generation of secondary porosity are most likely related to the influx of organic acids and carbon dioxide generated either from thermogenic maturation of the source rock or from biodegradation of oil within the reservoir near the oil-water contact(OWC)transition zone.

关键词： North sea Kittiwake field Unconformity Skagerrak sandstone