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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-Muñoz heidi R.fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Re-evaluating the importance of carbohydrates as regenerative biomaterials

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Regenerative Biomaterials 2019年第1期6卷 1-12页

作者： heidi f.Oldenkamp Julia E.Vela Ramirez Nicholas A.Peppas Institute for Biomaterials Drug Deliveryand Regenerative Medicine McKetta Department of Chemical Engineering Department of Biomedical Engineering Department of Pediatrics Dell Medical School Department of Surgery and Perioperative Care Dell Medical School Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA

Introduction Carbohydrates are the most abundant natural biomaterials in the *** interacting with cells of a variety of levels,they take part in essential functions of organisms including cellular communication,inflammation,infection development and *** carbohydrate–cell interactions occur on a variety of levels through glycoconjugates such as glycolipids,glycosaminoglycans(GAGs),glycoproteins and proteoglycans[1–4].The roles of carbohydrates in biological systems pose them as some of the most sought-after *** use of these multifaceted molecules provides the opportunity to tailor desired responses depending on the target application[1–5].

关键词： carbohydrate regenerative biomaterials polysaccharide tissue engineering

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Commercial wound dressings for the treatment of exuding wounds:an in-depth physico-chemical comparative study

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Burns & Trauma 2022年第1期10卷 465-478页

作者： Manon Minsart Sandra Van Vlierberghe Peter Dubruel arn Mignon Polymer Chemistry&Biomaterials Research Group Centre of Macromolecular ChemistryDepartment of Organic and Macromolecular ChemistryGhent UniversityKrijgslaan 281Building S4-bis9000 GhentBelgium Smart Polymeric Biomaterials Research Group Biomaterials and Tissue Engineering(SIEM)@Campus Group T LeuvenAndreas Vesaliusstraat 133000 LeuvenBelgium

Background:Nowadays,a wide range of wound dressings is already commercially *** selection of the dressing is of paramount importance as inappropriate wound management and dressing selection can delay the wound healing *** only can this be distressing for the patient,but it can also contribute to complications such as maceration and subsequent *** researchers are targeting the design of dressings with superior properties over existing commercial ***,reported results in the state-of-the-art are rarely benchmarked against commercial *** aim of this study was to determine several characteristics of a large variety of the most frequently used commercial wound dressings,providing an overview for both practitioners and ***:for this comparative study,11 frequently used commercial wound dressings were selected,representing the different *** morphology was studied using scanning electron *** dressings were characterized in terms of swelling capacity(water,phosphate buffered saline and simulated wound fluid),moisture vapour transmission rate(MVTR)and moisture uptake capacity(via dynamic vapour sorption)as well as mechanical properties using tensile testing and ***:The selected dressings showed distinctive morphological differences(fibrous,porous and/or gel)which was reflected in the different ***,the swelling capacities ranged between 1.5 and 23.2 g/g(water),2.1 and 17.6 g/g(phosphate buffered saline)or 2.9 and 20.8 g/g(simulated wound fluid).The swelling capacity of the dressings in water increased even further upon freeze-drying,due to the formation of *** MVTR values varied between 40 and 930 g/m^(2)/24 *** maximal moisture uptake capacity varied between 5.8%and 105.7%at 95%relative *** commercial dressings exhibited a superior mechanical strength,due to either being hydrophobic or ***:The present work not only offers i

关键词： Wound dressings Burns Exuding wounds Wound healing Exudate management Physico-chemical

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Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1077-1097页

作者： Lindokuhle Cindy Nene heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfontein 2028South Africa

Cancer remains one of the diseases with the highest incidence and mortality *** treatment modalities have demonstrated threatening drawbacks including invasiveness,noncontrollability,and development of resistance for some,including chemotherapy,radiation,and ***-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment modality which offers a non-invasive and controllable therapeutic *** combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer *** use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and *** review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.

关键词： Sonodynamic therapy Photodynamic therapy Combinatorial therapy Phthalocyanines Sensitizer Cancer

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Ecohydrological processes and ecosystem services in the Anthropocene: a review

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Ecological Processes 2017年第1期6卷 364-372页

作者： Ge Sun Dennis Hallema heidi Asbjornsen Eastern forest Environmental Threat Assessment Center Southern Research StationU.S.Department of Agriculture Forest Service920 Main Campus Dr.Suite 300RaleighNC 27606USA Oak Ridge Institute for Science and Education U.S.Department of EnergyOak RidgeTN 37830USA Institute for the Study of Earth Oceansand SpaceUniversity of New HampshireDurhamNHUSA

The framework for ecosystem services has been increasingly used in integrated watershed ecosystem management practices that involve scientists,engineers,managers,and policy *** objective of this review is to explore the intimate connections between ecohydrological processes and water-related ecosystem services in human-dominated ecosystems in the *** synthesize current literature to illustrate the importance of understanding the ecohydrological processes for accurately quantifying ecosystem services under different environmental and socioeconomic settings and *** synthesis focuses on managed ecosystems that are dominated by humans and explores how ecological processes affect the tradeoffs and synergies of multiple ecosystem *** identify research gaps in studying ecological processes mainly including energy,carbon,water,and nutrient balances to better assess and quantify ecosystem services that are critical for sustaining natural resources for future *** better assess ecosystem services,future ecohydrological studies need to better account for the scaling effects of natural and anthropogenic stressors exerted on evapotranspiration and other water supply and demand *** studies should focus on the bidirectional interactions between hydrological functions and services and human actions to solve real world problems such as water shortages,ecological degradation,and climate change adaptation.

关键词： watershed services ecosystem

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Spatial context in the calculation of gas emissions for underground coal mines

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International Journal of Mining Science and Technology 2017年第5期27卷 787-794页

作者： Patrick Booth heidi Brown Jan Nemcik Ren Ting School of Civil Mining and Environmental EngineeringSchool of Earth and Environmental SciencesUniversity of WollongongWollongong 2500Australia

The prediction of gas emissions arising from underground coal mining has been the subject of extensive research for several decades, however calculation techniques remain empirically based and are hence limited to the origin of calculation in both application and resolution. Quantification and management of risk associated with sudden gas release during mining(outbursts) and accumulation of noxious or combustible gases within the mining environment is reliant on such predictions, and unexplained variation correctly requires conservative management practices in response to risk. Over 2500 gas core samples from two southern Sydney basin mines producing metallurgical coal from the Bulli seam have been analysed in various geospatial context including relationships to hydrological features and geological structures. The results suggest variability and limitations associated with the present traditional approaches to gas emission prediction and design of gas management practices may be addressed using predictions derived from improved spatial datasets, and analysis techniques incorporating fundamental physical and energy related principles.

关键词： Gas emission prediction Spatial analysis Underground coal mining Risk management Greenhouse gas Climate

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The Shifting Landscape of Latent Print Testimony:An American Perspective

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Journal of forensic Science and Medicine 2017年第2期3卷 72-81页

作者： heidi Eldridge RTI International Research Triangle ParkNCUSA School of Criminal Justice University of LausanneLausanneSwitzeriand

friction ridge comparison testimony in the United States has long been characterized by speaking in absolutes:fingerprints are unique,the Analysis,Comparison,Evaluation,and Verification methodology has a zero-error rate,and the testimony presented by the expert should be regarded as an incontrovertible *** the National Research Council released their watershed report in 2009,questioning and criticizing these clear overstatements of the strength of the evidence,many commentators and professional organizations recommended that the friction ridge community rethink the way their evidence was presented in reports and in ***,change has been slow to *** some agencies have begun a shift in the way they present their findings,many others still testify the same way they always *** paper presents the historical context of where American friction ridge testimony has been,lays out the arguments for why it needs to change,describes some recent efforts to improve,and highlights some likely directions for the future of friction ridge reporting and testimony in the United States.

关键词： friction ridge latent prints testimony

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Accuracy of abdominal ultrasound for the diagnosis of small bowel obstruction in the emergency department

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World Journal of Emergency Medicine 2018年第4期9卷 267-271页

作者： Sarah E. frasure Amy f. Hildrcth Raghu Seethala heidi H. Kimberly George Washington University Hospital Washington DC 20037 USA NavalMedical Center San Diego San Diego CA 92134 USA Department of Emergency Medicine Brigham and Women 's Hospital Boston MA 02115 USA

BACKGROUND： Emergency physicians frequently encounter patients with acute small bowel obstructions （SBO）. Although computed tomography （CT） imaging is the current gold standard in the assessment of patients with suspected SBO in the emergency department, a few studies have examined the use of ultrasound as an alternative imaging technique. METHODS： We evaluated the accuracy of ultrasound performed in the ED by a variety of providers （physicians with various levels of training, physician assistants） compared to CT imaging in 47 patients with suspected SBOs. RESULTS： Our data demonstrated a sensitivity of 93.8% and a specificity of 93.3% when compared to abdominal CT, and a sensitivity of 94.3% and specificity of 95.2% using a composite endpoint of abdominal CT and discharge diagnosis. CONCLUSION： Ultrasound can play an important role in the identification of small bowe obstructions in ED patients.

关键词： Abdominal ultrasound Small bowel obstruction Emergency department

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Hepatitis C virus:Is it time to say goodbye yet? Perspectives and challenges for the next decade

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World Journal of Hepatology 2015年第5期7卷 725-737页

作者： heidi Barth Laboratoire de Virologie Hopitaux Universitaires de Strasbourg67000 StrasbourgFrance

The majority of individuals exposed to hepatitis C virus(HCV) establish a persistent infection,which is a leading cause of chronic liver disease,cirrhosis and hepatocellular *** progress has been made during the past twenty-five years in understanding the HCV life cycle and immune responses against HCV *** evidence indicates that host genetic factors can significantly influence the outcome of HCV infection and the response to interferon alpha-based antiviral *** arrival of highly effective and convenient treatment regimens for patients chronically infected with HCV has improved prospects for the eradication of HCV *** trials are evaluating the best anti-viral drug combination,treatment doses and *** new treatments are better-tolerated and have shown success rates of more than 95%.However,the recent breakthrough in HCV treatment raises new questions and challenges,including the identification of HCVinfected patients and to link them to appropriate health care,the high pricing of HCV drugs,the emergence of drug resistance or naturally occurring polymorphism in HCV sequences which can compromise HCV treatment ***,we still do not have a vaccine against *** this concise review,we will highlight the progress made in understanding HCV infection and *** will focus on the most significant unsolved problems and the key future challenges in the management of HCV infection.

关键词： Pathogenesis Host genetics Direct-actingantivirals Drug resistance Vaccine Hepatitis C virus

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