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Journal of Innovative Optical Health Sciences 2021年第6期4卷 81-89页

作者： Sang hee Jo yoonhee Kim yoon Bum Lee Sung Suk Oh Jong-ryul Choi School of Biomedical Engineering Daegu Catholic University(DCU)Gyeongsan 38430Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) Daegu 41061Republic of Korea Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) Daegu 41061Republic of Korea

Recently,research has been conducted to assist in the processing and analysis of histopathological images using machine learning *** this study,we established machine learning-based algorithms to detect photothrombotic lesions in histological images of photothrombosis-induced rabbit *** machine learning-based algorithms for binary classification were applied,and the accu-racies were compared to classify normal tissues and photothrombotic *** lesion classification model consisting of a 3-layered neural network with a rectified linear unit(ReLU)activation function,Xavier initialization,and Adam optimization using datasets with a unit size of 128×128 pixels yielded the highest accuracy(0.975).In the validation using the tested histological images,it was confirmed that the model could identify regions where brain damage occurred due to photochemical ischemic *** the development of machine learning-based photothrombotic lesion classi-fication models and performance comparisons,we confirmed that machine learning algorithms have the potential to be utilized in histopathology and various medical diagnostic techniques.

关键词： Machine learning histopathological images photothrombotic lesion rabbit brain binary classification logistic regression multi-layer neural networks

Immune checkpoint inhibitors in ovarian cancer:where do we go from here?

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Cancer Drug Resistance 2023年第2期6卷 358-377页

作者： Won-hee yoon Anna DeFazio Lawrence Kasherman Department of Medical Oncology Blacktown Cancer and Haematology CentreBlacktown HospitalBlacktown 2148Australia Department of Medical Oncology Crown Princess Mary Cancer CentreWestmead HospitalWestmead 2145Australia Centre for Cancer Research The Westmead Institute for Medical ResearchWestmead 2145Australia Faculty of Medicine and Health The University of SydneyCamperdown 2050Australia Department of Gynecological Oncology Westmead HospitalWestmead 2145Australia The Daffodil Centre The University of Sydneya joint venture with Cancer Council New South WalesSydney 2011Australia Department of Medical Oncology Illawarra Cancer Care CentreWollongong 2500Australia

Epithelial ovarian cancer(EOC)is the most lethal gynaecological malignancy,and despite advancements in therapeutics,most women unfortunately still succumb to their ***,in particular immune checkpoint inhibitors(ICI),have been therapeutically transformative in many tumour types,including gynaecological malignancies such as cervical and endometrial ***,these therapeutic successes have not been mirrored in ovarian cancer clinical *** review provides an overview of the ovarian tumour microenvironment(TME),particularly factors associated with survival,and explores current research into immunotherapeutic strategies in EOC,with an exploratory focus on novel therapeutics in navigating drug resistance.

关键词： Ovarian cancer immunotherapy tumour microenvironment drug development

Epidural blood patch for spontaneous intracranial hypotension with subdural hematoma: A case report and review of literature

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World Journal of Clinical Cases 2022年第1期10卷 388-396页

作者： Se hee Choi Youn young Lee Won-Joong Kim Anesthesiology and Pain Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea Anesthesiology and Pain Medicine School of MedicineEwha Womans UniversitySeoul 07985South Korea

BACKGROUND Cerebrospinal fluid(CSF)leakage at C1/2 in spontaneous intracranial hypotension(SIH)is *** hematoma(SDH),a serious complication of SIH,may lead to neurological *** report presents a case of SDH after spontaneous C1/2 CSF leakage,which was treated with a targeted epidural blood patch(EBP).CASE SUMMARY A 60-year-old man with no history of trauma was admitted to our hospital with orthostatic headache,nausea,and *** computed tomography imaging revealed bilateral,subacute to chronic *** magnetic resonance imaging(MRI)findings were SDH with dural enhancement in the bilateral cerebral convexity and posterior fossa and mild sagging,suggesting *** the patient underwent burr hole trephination,the patient’s orthostatic headache was *** myelography led to a suspicion of CSF leakage at C1/***,we performed a targeted cervical EBP using an epidural catheter under fluoroscopic *** 5 d after EBP,a follow-up MR myelography revealed a decrease in the interval size of the CSF *** his symptoms improved,the patient still complained of headaches;therefore,we repeated the targeted cervical EBP 6 d after the initial ***,his headache had almost disappeared on the 8th day after the repeated *** Targeted EBP is an effective treatment for SDH in patients with SIH due to CSF leakage at C1/2.

关键词： Cerebrospinal fluid Chronic subdural hematoma Epidural blood patch Myelography Spontaneous intracranial hypotension Case report

Properties of multilayer gallium and aluminum doped ZnO(GZO/AZO) transparent thin films deposited by pulsed laser deposition process

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 96-99页

作者： Jin-Hyun SHIN Dong-Kyun SHIN hee-young LEE Jai-Yeoul LEE Department of Materials Engineering Yeungnam University

Multilayer gallium and aluminum doped ZnO （GZO/AZO） films were fabricated by alternative deposition of Ga-doped zinc oxide（GZO） and Al-doped zinc oxide（AZO） thin film by using pulsed laser deposition（PLD） process. The electrical and optical properties of these GZO/AZO thin films were investigated and compared with those of GZO and AZO thin films. The GZO/AZO （1：1） thin film deposited at 400 ~C shows the electrical resistivity of 4.18 x 10 4 ~.cm, an electron concentration of 7.5 x 1020/cm3, and carrier mobility of 25.4 cm2/（V.s）. The optical transmittances of GZO/AZO thin films are over 85%. The optical band gap energy of GZO/AZO thin films linearly decreases with increasing the AI ratio.

关键词： multilayer thin films Ga-doped zinc oxide Al-doped zinc oxide pulsed laser deposition

Numerical Visualization of Air Intake Induced by Free Surface Vortex

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Journal of Thermal Science 2017年第6期26卷 540-544页

作者： young Kyu Park Mohan Kumar Dey yoon Hwan Choi Yeon Won Lee Research Institute of Industrial Science & Technology Pukyong National University Busan Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Korea Department of Mechanical Design Engineering Pukyong National University Busan Korea

Free surface vortex control is vital in a pump sump system because the air absorbed by free surface vortex induc- es noise, vibration, and cavitation corrosion on the pumping system. In this study, the change of free surface vor- tex and air absorption in a pump intake has been investigated by the Volume of Fraction （VOF） method with steady multiphase flow model in order to represent the behavior of the free surface vortex exactly. The homoge- neous free surface model is used to apply interactions of air and water. The results show that air intake by the free surface vortex motion can be visualized using the iso-surface of air volume fraction. The vortices make an air column from the free surface to the pump intake. Also, it was found that the flee surface vortex can be controlled by installing curtain walls.

关键词： free surface vortex numerical visualization curtain wall air intake

Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise

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Journal of Sport and Health Science 2017年第2期6卷 225-230页

作者： hee-Tae Roh Su-Youn Cho Wi-young So Department of Physical Education Dong-A University Busan 604-714 Republic of Korea School of Taekwondo College of Creative Human ResourcesYoungsan UniversityYangsan-si 626-790Republic of Korea Sports and Health Care Major College of Humanities and ArtsKorea National University of TransportationChungju-si 380-702Republic of Korea

Purpose: The purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status,neurotrophic factor expression, and blood-brain barrier(BBB) ***: Twenty-four healthy, untrained men(12 non-obese(mean 14.9% body fat) and 12 obese subjects(mean 29.8% body fat)) performed20 min of continuous submaximal aerobic exercise at 85% maximal oxygen consumption. Blood sampling was performed to examine the oxidant-antioxidant status(reactive oxygen species(ROS) and superoxide dismutase(SOD)), neurotrophic factors(brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF)), and BBB disruption(S100β and neuron-specific enolase) before and after acute ***: The obese group showed significantly higher pre-exercise serum ROS levels and significantly lower pre-exercise serum SOD levels than the non-obese group(p < 0.05). Serum ROS, SOD, BDNF, NGF, and S100β levels were significantly increased post-exercise compared with pre-exercise levels in both the non-obese and the obese groups(p < 0.05). The obese group showed significantly higher serum ROS, BDNF, NGF,and S100β levels post-exercise compared to the non-obese group(p < 0.05).Conclusion: Our study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption,and it is assumed that oxidative stress was the main cause of this BBB disruption.

关键词： Antioxidant enzyme Blood-brain barrier Exercise Neurotrophic factor Obesity Oxidative stress

Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 621-630页

作者： Ju-hee Oh Joo Hyun Lee young-Joo Lee Division of Biopharmaceutics College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea Department of Life and Nanopharmaceutical Sciences College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea

Quercetin is a biologically active flavonoid that has been used as a popular health *** is reported that quercetin may cause flavonoid-drug interaction mediated by P-glycoprotein,the most predominant efflux *** this study,we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2(MRP2),another major efflux ***2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in *** evaluate the induction effect of quercetin on Mrp2 in vivo,Mrp2 mRNA expression in rat liver,kidney,and small intestinal tissues was determined after the oral administration of quercetin(50,100,or 250 mg/kg)for seven ***2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of ***,the effect of quercetin on absorption of docetaxel,a P-glycoprotein and CYP3A4 substrate,was also *** inhibited the function of MRP2 at 10μM and induced the mRNA expression of MRP2 at 50μM in ***,at 100 mg/kg,quercetin markedly increased Mrp2 expression in the small intestine of ***,there was no significant change in phenolsulfonphthalein pharmacokinetics due to single-(50,100,or 250 mg/kg)or multiple-dose(50,100,or 250 mg/kg for seven days)quercetin *** contrast,a significant interaction caused by quercetin(100 mg/kg)was observed in the absorption of *** results suggested that although quercetin modulates the function and expression of MRP2 in vitro,it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.

关键词： Quercetin P-glycoprotein Multidrug resistance-associated protein 2 Pharmacokinetics Flavonoid-drug interaction

Loose-fit graphitic encapsulation of silicon nanowire for one-dimensional Si anode design

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Journal of Materials Science & Technology 2017年第10期33卷 1120-1127页

作者： Seh-yoon Lim Sudong Chae Su-Ho Jung Yuhwan Hyeon Wonseok Jang Won-Sub yoon Jae-young Choi Dongmok Whang School of Advanced Materials Science and Engineering SKKU Advanced Institute of Nanotechnology Sungkyunkwan University Suwon 440-746 South Korea Department of Energy Sdence Sungkyunkwan University Suwon 440-746 South Korea

Silicon nanowires（SiNWs） encapsulated with graphene-like carbon sheath（GS） having a void space in between（SiNW@V@GS） are demonstrated for the improved electrochemical performance of Si anode in lithium ion battery. The Si NW@V@GS structure was synthesized by a scalable fabrication method including four successive reactions： metal-catalyzed CVD growth of Si NWs, controlled thermal oxidation, and deposition of the graphitic layer, to form Si NW@SiO2@GS and additional chemical etching of sacrificial SiO2 layer between Si NWs and carbon sheath. During the synthetic process, the thickness of the void spacing was controlled by adjusting the oxidation-dependent process. The well-controlled void space and crystalline graphitic carbon sheath of the SiNW@V@GS structure enable good reversible capacity of1444 m Ahg^（-1） and cycling stability of 85% over 150 cycles.

关键词： Lithium ion battery Silicon nanowire Graphene Void spacing Anode

Design of 1 kbit antifuse one time programmable memory IP using dual program voltage

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Journal of Central South University 2011年第1期18卷 125-132页

作者：金丽妍 JANG Ji-Hye KIM Du-Hwi KIM young-hee Department of Electronic Engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

A 1 kbit antifuse one time programmable(OTP) memory IP,which is one of the non-volatile memory IPs,was designed and used for power management integrated circuits(ICs).A conventional antifuse OTP cell using a single positive program voltage(VPP) has a problem when applying a higher voltage than the breakdown voltage of the thin gate oxides and at the same time,securing the reliability of medium voltage(VM) devices that are thick gate transistors.A new antifuse OTP cell using a dual program voltage was proposed to prevent the possibility for failures in a qualification test or the yield *** the newly proposed cell,a stable sensing is secured from the post-program resistances of several ten thousand ohms or below due to the voltage higher than the hard breakdown voltage applied to the terminals of the *** layout size of the designed 1 kbit antifuse OTP memory IP with Dongbu HiTek's 0.18 μm Bipolar-CMOS-DMOS(BCD) process is 567.9 μm×205.135 μm and the post-program resistance of an antifuse is predicted to be several ten thousand ohms.

关键词： one time programmable memory IP antifuse hard breakdown dual program voltage post-program resistance

Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

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World Journal of Gastroenterology 2018年第34期24卷 3849-3860页

作者： Jae yoon Jeong young Seo Cho Joo Hyun Sohn Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine Department of Radiology Hanyang University Guri Hospital Hanyang University College of Medicine

Liver biopsy is the gold standard for evaluating the degree of liver fibrosis in patients with chronic liver disease. However, due to the many limitations of liver biopsy, there has been much interest in the use of noninvasive techniques for this purpose. Among these techniques real-time two-dimensional shear wave elastography(2D-SWE) has the advantage of measuring tissue elasticity with the guidance of B-mode images. Recently, many studies have been conducted on the application of 2D-SWE in patients with various liver diseases, and their validity has been confirmed. Here, we briefly discuss the role of 2D-SWE in patients with chronic liver diseases, particularly aspects of the examination techniques and clinical applications.

关键词： Shear wave elastography Liver disease Liver fibrosis Portal hypertension Hepatocelluar carcinoma