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Primary central nervous system lymphoma presenting as a single choroidal lesion mimicking metastasis:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1291-1295页

作者： hee Ryeong Jang kyu-Hyoung lim kyungyul Lee Department of Internal Medicine Kangwon National University HospitalKangwon National University School of MedicineChuncheon 24289South Korea Department of Pathology Kangwon National University HospitalKangwon National University School of MedicineChuncheon 24289South Korea

BACKGROUND Primary choroidal lymphoma is usually an indolent B-cell lymphoma and rarely progresses to extraocular ***,we report a case of primary choroidal lymphoma diagnosed as diffuse large B-cell lymphoma(DLBL),which progressed to the brain parenchyma after 4 *** SUMMARY A 78-year-old man presented with diminution of vision in his right eye.A choroidal lesion suspected of metastatic lesion was observed in the right eye by ophthalmologic *** discover the primary tumor,imaging investigations were performed but no malignant lesion was *** 4 mo,the patient returned to the clinic presenting with neurological *** magnetic resonance imaging revealed an abnormal contrast-enhancing mass in the left cerebellum.A stereotactic biopsy was performed,and DLBL was *** patient received the high dose methotrexate-based chemotherapy and he achieved complete *** Primary choroidal lymphoma is usually known to have a benign clinical course without systemic *** present a rare case of primary choroidal lymphoma diagnosed as DLBL that progressed to the brain parenchyma within months.

关键词： Primary choroidal lymphoma Diffuse large B-cell lymphoma Primary central nervous system lymphoma Case report

Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer

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World Journal of Clinical Cases 2022年第28期10卷 10066-10076页

作者： hee Ryeong Jang Hui-Young Lee Seo-Young Song kyu-Hyoung lim Department of Internal Medicine Kangwon National University HospitalKangwon National University School of MedicineChuncheon-siGangwon-do 24289South Korea

BACKGROUND The 5-fluorouracil-based chemotherapy combined with oxaliplatin or irinotecan is usually used in colorectal cancer(CRC).The addition of a targeted agent(TA) to this combination chemotherapy is currently the standard treatment for metastatic ***,the efficacy and safety of combination chemotherapy for metastatic CRC in patients aged above 80 years has yet to be *** To assess the clinical outcomes and feasibility of combination chemotherapy using a TA in extremely elderly patients with *** Eligibility criteria were:(1) Age above 80 years;(2) Metastatic colorectal cancer;(3) Palliative chemotherapy na?ve;(4) Eastern Cooperative Oncology Group performance status 0-1;and(5) Adequate organ *** received at least one dose of combination chemotherapy with or without *** was evaluated every 8 *** Of 30 patients,the median age of 15 patients treated with TA was 83.0 years and that of those without TA was 81.3 *** median progression-free survival(PFS) and overall survival(OS) in patients treated with TA were 7.4 mo and 15.4 mo,respectively,compared with 4.4 mo and 15.6 mo,respectively,in patients treated without *** was no significant difference in PFS(P:0.193) and OS(P:0.748) between patients treated with and without *** grade 3/4 hematologic toxicities were anemia(16.7%) and neutropenia(10.0%).After disease progression,the median OS of patients who were treated with and without salvage chemotherapy were 23.5 mo and 7.0 mo,respectively,suggesting significant difference in OS(P = 0.001).CONCLUSION Combination chemotherapy with TA for metastatic CRC may be considered feasible in patients aged above 80 years,when with careful *** chemotherapy can help improve OS in some selected of these elderly patients.

关键词： Combination chemotherapy Targeted agent Colorectal cancer Salvage chemotherapy Elderly patient

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab

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Oncology research 2025年第1期33卷 57-65页

作者： Ryul Kim Joo kyung Park Minsuk Kwon Minae An Jung Yong Hong Joon Oh Park Sung hee lim Seung Tae Kim Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Department of Hematology-Oncology Ajou University School of Medicine Suwon-si Gyeonggi-do Korea. Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea.

Background:Immune checkpoint inhibitors (ICIs) are effective in a subset of patients with metastatic solid tumors. However, the patients who would benefit most from ICIs in biliary tract cancer (BTC) are still controversial.Materials and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line therapy.Results:All patients had microsatellite stable (MSS) type tumors. Three of the 32 patients achieved partial response (PR), with an objective response rate (ORR) of 9.4% (95% confidence interval [CI], 2.0-25.2) and nine showed stable disease (SD), exhibiting a disease control rate (DCR) of 37.5% (95% CI, 21.1-56.3). For the 31 patients who had access to PD-1 ligand 1 (PD-L1) combined positive score (CPS) testing (cut-off value ≥1%), the ORR was not different between those who had PD-L1-positive (PD-L1+; 1/11, 9.1%) and PDL1-(2/20, 10.0%) tumors ( = 1.000). The tumor mutational burden (TMB) of PD-L1+ BTC was comparable to that of PD-L1-BTC ( = 0.630). TMB and any exonic somatic mutations were also not predictive of pembrolizumab response. Molecular analysis of blood and tumor samples demonstrated a relatively high natural killer (NK) cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor response. Moreover, the tumors of these patients presented high enrichment scores for NK cells, antitumor cytokines, and Th1 signatures, and a low enrichment score for cancer-associated fibroblasts.Conclusions:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Biliary tract cancer Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing

Model development to estimate site index values for six major tree species in North Korea

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Journal of Forestry Research 2023年第2期34卷 387-400页

作者： Sohee Park A-Ram Yang Eun-hee Kim Joongbin lim Division of Global Forestry Department of Future Forest StrategyNational Institute of Forest ScienceSeoul 02455Republic of Korea Forest ICT Research Center National Institute of Forest ScienceSeoul 02455Republic of Korea

Due to considerable deforestation in North Korea,there is a need to plan forest restoration programs based on scientific forest *** this study,a methodology was developed for estimating the site index values of six major tree species and the forest productivity *** site index values of these tree species were derived in South Korea using the Chapman-Richards *** values were used with data from the 6th National Forest Inventory,which included 20 types of edaphic,topographic,and climatic factors,and random forest analysis—a widely used machine learning technique for spatial prediction—to develop a new model for estimating the site index values of these species across South *** prediction accuracy of this model was evaluated using the root mean square *** results show that the prediction accuracy was high,with a root mean square error of~***,the importance of the variables related to climate and geography was generally *** proposed site index estimation model for six tree species was applied across North Korea,and its effectiveness tested by comparing the estimated values with those reported in literature from North *** differences between the model outputs and recorded data in the northern alpine regions were presumably due to the lack of data for high-altitude regions in South *** model is based on the determination of the suitability of tree species in restoration ***,it can contribute to the evaluation of forest productivity in North Korea and may help plan efficient forest restoration programs.

关键词： Environmental factors Forest productivity Machine learning North Korea Random forest Site index

Importance of proper ventilator support and pulmonary rehabilitation in obese patients with heart failure:Two case reports

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World Journal of Clinical Cases 2023年第13期11卷 3029-3037页

作者： Eun-hee lim Sung-hee Park Yu Hui Won Physical Medicine and Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Physical Medicine and Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Research Institute of Clinical Medicine of Jeonbuk National University Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND The optimal treatment for heart failure(HF)is a combination of appropriate *** the disease using only medical therapy is difficult in patients with HF,severe hypercapnia,and *** patients should first receive ventilator support followed by pulmonary rehabilitation(PR).CASE SUMMARY We report two cases in which arterial blood gas(ABG)improved and PR was possible with appropriate ventilator *** patients with extreme obesity complaining of worsening dyspnea–a 47-year-old woman and a 36-year-old man both diagnosed with HF–were hospitalized because of severe hypercapnia and *** proper medical treatment,hypercapnia and desaturation resolved in neither case,and both patients were transferred to the rehabilitation department for *** the time of the first consultation,the patients were bedridden because of *** demand was successfully reduced once noninvasive ventilation was *** the patients’dyspnea gradually improved to the point where they could be weaned off the ventilator during the daytime,they started engaging in functional training and aerobic *** 4 mo of followup,both patients were able to perform activities of daily living and maintain their lower body weight and normalized ABG *** Symptoms of patients with obesity and HF may improve once ABG levels are normalized through ventilator support and implementation of PR.

关键词： Noninvasive ventilation Heart failure Obesity Rehabilitation Dyspnea Case report

Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2447-2450页

作者： Hye Seong Bo kyu Choi Young-hee Han Jun Hyoung Kim Jeong-An Gim Sooyeon lim Ji Yun Noh hee Jin Cheong Woo Joo Kim Joon Young Song Department of Internal Medicine Korea University College of MedicineSeoulRepublic of Korea Asia Pacific Influenza Institute Korea University College of MedicineSeoulRepublic of Korea Vaccine Innovation Center Korea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Department of Food and Nutrition Chungbuk National UniversityCheongjuRepublic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongjuRepublic of Korea Medical Science Research Center Korea University College of MedicineSeoulRepublic of Korea

Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global *** vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics.

关键词： vaccines respiratory acute

Spatial phase-shifting interferometry with compensation of geometric errors based on genetic algorithm(Invited Paper)

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Chinese Optics Letters 2009年第12期7卷 1113-1116页

作者： Joonku Hahn Hwi Kim Yongjun lim Eun-hee Kim Byoungho Lee School of Electrical Engineering Seoul National University

We propose a novel spatial phase-shifting interferometry that exploits a genetic algorithm to compensate for geometric errors. Spatial phase-shifting interferometry is more suitable for measuring objects with properties that change rapidly in time than the temporal phase-shifting interferometry. However, it is more susceptible to the geometric errors since the positions at which interferograms are collected are different. In this letter, we propose a spatial phase-shifting interferometry with separate paths for object and reference waves. Also, the object wave estimate is parameterized in terms of geometric errors, and the error is compensated by using a genetic algorithm.

关键词： Spatial phase-shifting interferometry with compensation of geometric errors based on genetic algorithm

Varicella-zoster virus meningitis after spinal anesthesia:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9127-9131页

作者： Ye-Won Lee Byunghoon Yoo Yun hee lim Department of Anesthesiology and Pain Medicine College of MedicineInje UniversitySanggye Paik HospitalSeoul 01757South Korea

BACKGROUND Headache is a common complication of regional *** treatment of post spinal anesthesia headache varies depending on the *** meningitis is rare,it can cause significant harm to the *** dural puncture headache and septic meningitis are the most commonly suspected causes of post spinal anesthesia headache;however,other causes should also be *** SUMMARY A 69-year-old woman was scheduled for varicose vein stripping surgery under spinal *** procedure was performed aseptically,and surgery was completed without any *** 4 d,the patient visited the emergency room with complaints of headache,nausea,and *** examination revealed that the patient was *** the history of spinal anesthesia,post dural puncture headache and septic meningitis was initially suspected,and the patient was treated with empirical ***,varicella-zoster virus PCR test result was positive,and all other test results were *** patient was diagnosed with meningitis caused by varicella-zoster virus and was treated with acyclovir for 5 *** headache improved,and the patient was discharged without any *** Viral meningitis due to virus reactivation may cause headache after regional ***,clinicians should consider multiple etiologies of headache.

关键词： Aseptic meningitis Headache Regional anesthesia Spinal anesthesia Varicella zoster virus infection Case report

Comprehensive molecular analysis to predict the efficacy ofchemotherapy containing bevacizumab in patients with metastaticcolorectal cancer

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Oncology Research 2023年第6期31卷 855-866页

作者： SUNG hee lim hee JIN CHO KYOUNG-MEE KIM HO YEONG lim WON KI KANG JEEYUN LEE YOUNG SUK PARK hee CHEOL KIM SEUNG TAE KIM Division of Hematology/Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea Precision Medicine Research Institute Samsung Medical CenterGangnam-guSeoul06351Korea Department of Biomedical Convergence Science and Technology Kyungpook National UniversityDaegu41566Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea

Background:Although bevacizumab is an important treatment for metastatic colorectal cancer(CRC),not allpatients with CRC benefit from it;in unselected patient populations,only modest survival benefits have been ***:We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identifybiomarkers for a response to bevacizumab-containing *** molecular analysis comprised whole-exomesequencing,ribonucleic acid sequencing,and a methylation array on patient ***:Genomic and molecularcharacterization was successfully conducted in 103 *** of 103 CRC samples were hypermutated,and none ofthe non-hypermutant tumors were microsatellite *** those 103 patients,89 had adenocarcinoma(ADC),15 were diagnosed with mucinous ADC,and six had signet-ring cell carcinoma(SRCC).Consensus molecular subtype(CMS)2 was unique to *** the four SRCCs,two were CMS1,one was CMS4,and the other was *** status was a significantly enriched factor in responders to bevacizumab *** growth factorreceptor(FGFR)1/2 signaling was upregulated in non-responders,whereas cell cycle,transfer ribonucleic acidprocessing,nucleotide excision repair,and oxidative phosphorylation pathways were enriched in ***,IGF1 was differentially expressed in non-responders(log2 fold change=−1.43,p=4.11×10^(−5),falsediscovery rate=0.098),and FLT1 was highly methylated in non-responders(p=7.55×10^(−3)).When the molecularpathways were reanalyzed separately according to the backbone chemotherapy(FOLFOX ***),thesignificance of the molecular pathways varied according to the backbone ***:This studysought a subset of CRC patients with a distinct clinical response to chemotherapy containing *** need to be validated in a large group of homogenous patient cohort and examined according to the differentchemotherapy backbones to create personalized therapeutic oppor

关键词： Bevacizumab Whole-exome sequencing Ribonucleic acid sequencing Methylation array Colorectal cancer