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World Journal of Gastroenterology 2021年第48期27卷 8357-8369页

作者： Dong-Hoe koo Min-hee Ryu Mi-Yeon Lee Mee-Sun Moon Yoon-koo Kang Division of Hematology/Oncology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Biostatistics Department of R&D ManagementKangbuk Samsung HospitalSeoul 03181South Korea

BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic *** To develop a new model,MRGC patients who received fluoropyrimidines/platinum doublet chemotherapy between 2008 and 2015 were *** A total of 1883 patients was divided into a training set(n=937)and an independent validation set(n=946).RESULTS Multivariate analysis showed that the following six factors were associated with poor overall survival(OS)in the training set:Eastern Cooperative Oncology Group performance score≥2 and bone metastasis(2 points each),peritoneal metastasis,high alkaline phosphatase level,low albumin level,and high neutrophil-lymphocyte ratio(1 point each).A prognostic model was developed by stratifying patients into good(0-1 point),moderate(2-3 points),and poor(≥4 points)risk *** the validation set,the median OS of the three risk groups was 15.8,10.1,and 5.7 mo,respectively,and those differences were significant(P<0.001).CONCLUSION We identified six factors readily measured in clinical practice that are predictive of poor prognosis in patients with *** new model is simpler than the old and more easily predicts OS.

关键词： Stomach neoplasms Chemotherapy Prognosis Validation Gastric cancer

High-Throughput Pb Recycling for Perovskite Solar Cells Using Biomimetic Whitlockite

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Energy & Environmental Materials 2023年第3期6卷 170-176页

作者： jung Sug Hong hee jung Kim Chang Hwun Sohn Oh Yeong Gong Jin Hyuk Choi Kang hee Cho Gill Sang Han Ki Tae Nam Hyun Suk jung Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Korea

Pb contamination in aquatic environments causes severe pollution;therefore,harmless absorbents are *** this study,we report a novel synthesis of whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12)),which is the second most abundant biomineral in human bone,and its application as a high-performing Pb^(2+)***(HAP)and WH are prepared via a simple precipitation *** Pb2+absorption performance and mechanism of the synthesized biominerals are investigated in aqueous solutions at neutral *** results demonstrate that WH exhibits an excellent Pb2+absorption capacity of 2339 mg g^(−1),which is 1.68 times higher than the recorded value for ***,the absorbed Pb^(2+) ions are recycled into high-purity PbI_(2).This is employed as a precursor for the fabrication of perovskite solar cells(PSCs),resulting in a conversion efficiency of 19.00%comparable to that of commercial PbI2 powder(99.99%purity).Our approach provides an efficient way to remove Pb^(2+)ions from water and reuse them in the recycling of PSCs.

关键词： Pb absorption Pb recycling perovskite solar cells water purification whitlockite

Attaching single carbon nanotube on tip's apex using dielectrophoresis of DC-pulse voltage

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中国有色金属学会会刊：英文版 2009年第B09期19卷 280-283页

作者： hee-Jin JEONG Yoong-Ho jung Deug-Woo LEE Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Pusan National University Department of Nanosystem and Nanoprocess Engineering Pusan National University

Single carbon nanotubes (CNTs) are candidates for a number of electronics and sensing applications, provided that single CNTs can be separated from a bundle of CNTs in suspension. Dielectrophoresis has recently been demonstrated as one route for the extraction of desired CNTs. However, previous methods using dielectrophoresis have found it difficult to extract single nanotubes from bundles of CNTs in solution. Here, we show that this restriction can be overcome by using pulsed DC voltage of an electric field, instead of regular AC and DC voltages.

关键词：碳纳米管直流脉冲脉冲电压介电顶点消息电子号码 CNTs

Development and characterization of novel polymorphic microsatellite markers for the Korean freshwater snail Semisulcospira coreana and cross-species amplification using next-generation sequencing

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Journal of Oceanology and Limnology 2020年第2期38卷 503-508页

作者： Yeon jung PARK Mi Nan LEE Eun-Mi KIM jung Youn PARK Jae koo NOH Tae-Jin CHOI jung-Ha KANG Biotechnology Research Division National Institute of Fisheries ScienceBusan 46083Republic of Korea Department of Microbiology Pukyoung National UniversityBusan 48513Republic of Korea

Korean freshwater snails of the genus Semisulcospira are widely distributed across East *** has been a very popular nutritional food in Korea,and is an ecologically important water quality indicator because it lives only in clean ***,no microsatellite markers have been generated to study the population genetic diversity of this *** the present study,we developed and characterized 18 novel microsatellite loci from Semisulcospira coreana genomic *** microsatellites were isolated using 454 GS-FLX titanium sequencing and 18 markers were used for genotyping in *** addition,we also tested the cross-species transferability of the microsatellite markers in four additional Semisulcospira *** identified 18 polymorphic loci and the number of alleles per loci,and their polymorphism information content values ranged from 2 to 17 and 0.203 to 0.902,*** observed and expected heterozygosities of the loci ranged from 0.063 to 0.924 and 0.226 to 0.924,*** to the analysis of the cross-species transferability of these markers,four species,***,***,***,and ***,showed a very high transferability(80%–85%).These results show that this set of nuclear markers could be useful for population genetics studies of this species and closely related species.

关键词： Semisulcospira next-generation sequencing(NGS) microsatellite markers cross-species transferability

Korean red ginseng decreases 1-methyl-4-phenylpyridinium-induced mitophagy in SH-SY5Y cells

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Journal of Integrative Medicine 2021年第6期19卷 537-544页

作者： Hyongjun Jeon hee-Young Kim Chang-Hwan Bae Yukyung Lee Sungtae koo Seungtae Kim Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Korean Medicine Research Center for Healthy Aging Pusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea

Objective:Mitophagy is known to contribute towards progression of Parkinson’s *** red ginseng(KRG)is a widely used medicinal herb in East Asia,and recent studies have reported that KRG prevents 1-methyl-4-phenylpyridinium ion(MPP^(+))-induced cell *** study was undertaken to investigate whether KRG suppresses MPP^(+)-induced apoptosis and ***:SH-SY5 Y cells were incubated with KRG for 24 h,and subsequently exposed to MPP^(+).The MPP^(+)-induced cell death was confirmed with the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay,and the terminal deoxynucleotidyl transferase-mediated d UTP nick end-labeling *** in the structure and function of mitochondria were confirmed using mitotracker,Mito SOX red mitochondrial superoxide indicator,parkin,and phosphatase and tensin homolog deleted on chromosome ten-induced putative kinase 1(PINK1)immunofluorescent *** blotting was performed to evaluate the expression of apoptosis-related factors in whole cells,including Bax,Bcl-2 and cleaved caspase-3,and mitophagy-related factors in the mitochondrial fraction,including cytochrome c,parkin,PINK1,translocase of the outer membrane 20(TOM20),p62 and Beclin ***:MPP^(+)induced cell death by cytochrome c release and caspase-3 activation;however,this effect was suppressed by KRG’s regulation of the expressions of Bcl-2 and ***,MPP^(+)exposure increased the mitochondrial expressions of parkin,PINK1,Beclin 1 and p62,and decreased TOM20,cytochrome c and Bcl-2 *** MPP^(+)-induced changes in the mitochondrial fraction were attenuated by treatment with ***:KRG effectively prevents MPP^(+)-induced SH-SY5 Y cell death by regulating cytochrome c release from mitochondria and PINK1/parkin-mediated mitophagy,through regulation of the Bcl-2 family.

关键词： Parkinson’s disease Apoptosis Mitophagy 1-Methyl-4-phenylpyridinium Korean red ginseng

Controlled oxidation of Ni for stress-free hole transport layer of large-scale perovskite solar cells

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Nano Research 2019年第12期12卷 3089-3094页

作者： Seongha Lee hee-Suk Roh Gill Sang Han jung-Kun Lee Department of Mechanical Engineering and Materials Science University of PittsburghPennsylvania 15261USA School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

The effect of the residual thermal stress of NiO films on the performance of an inverted type perovskite solar cell was *** this study,NiO films were grown on fluorine dopedtin oxide(FTO)substrates of different surface roughness by thermally oxidizing Ni film and weretested as a hole transport layer for large-scale perovskite solar *** and simulation results show that it is very important tosuppress the appearance of the residual stress at the NiO-FTO in terface during the oxidation of the Ni film for effective hole extracti *** Ni oxidation on the flat FTO film produced in-plane compressive stress in the NiO film due to the Ni film volume *** led to theformation of defects including small *** residual stress and defects in creased leakage curre nt through the NiO film,preve ntingholes from being selectively collected at the NiO-perovskite ***,when Ni was deposited and oxidized on the rough surface,the residual stress of the NiO film was negligible and its inhere nt high resistance was ***-free NiO film is an excelle nt holetransport layer that stops the photogenerated electrons of the perovskite layer from moving to *** improvements in the structural andelectrical qualities of the NiO film by engirteering the residual stress reduce the carrier recombination and increase the power conversi onefficiency of the perovskite solar cells to 16.37%.

关键词： nickel oxidation surface roughness residual stress perovskite solar cells large scale processing

Patient safety culture and handoff evaluation of nurses in small and medium-sized hospitals

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International Journal of Nursing Sciences 2021年第1期8卷 58-64,I0004页

作者： jung hee Kim jung Lim Lee Eun Man Kim Department of Nursing Science Shinsung UniversityChungnamSouth Korea Department of Nursing Daejeon UniversityDaejeonSouth Korea Department of Nursing Science Sun Moon UniversityChungnamSouth Korea

Objectives:This study was conducted to investigate the current status of handoffs,perception of patient safety culture,and degrees of handoff evaluation in small and medium-sized hospitals and identified factors that make a difference in handoff ***:This is a descriptive study.425 nurses who work at small and medium-sized hospitals in South Korea were included in our *** completed a set of self-reporting questionnaires that evaluated demographic data,handoff-related characteristics,perception of patient safety culture,and handoff ***:Results showed that the overall score of awareness of a patient safety culture was 3.65±0.45,the level was *** score of handoff evaluation was 5.24±*** nurses experienced errors in handoff and most nurses had no guidelines and checklist in the *** evaluation differed significantly according to the level of education,work patterns,duration of hospital employment,handoff method,degree of satisfaction with the current handoff method,errors occurring at the time of handoff,handoff guidelines,and appropriateness of handoff education time(P<0.05).Conclusion:For handoff improvement,guidelines and standards should be *** is necessary to develop a structured handoff education *** formal handoff education should be implemented to spread knowledge uniformly.

关键词： Evaluation studies Handoff Hospital nursing staff Patient safety

Topology optimization of reactive material structures for penetrative projectiles

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Defence Technology（防务技术） 2022年第7期18卷 1205-1218页

作者： Shinyu Kim Saekyeol Kim Taekyun Kim Sangin Choi Tae hee Lee jung Su Park Sang-Hyun jung Department of Automotive Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul04763Republic of Korea The 4th R&D Institute Agency for Defense Development35Yuseong P.O.BoxDaejeon34186Republic of Korea

Recently,reactive materials have been developed for penetrative projectiles to improve impact resistance and energy ***,the design of a reactive material structure,involving shape and size,is challenging because of difficulties such as high non-linearity of impact resistance,manufacturing limitations of reactive materials and high expenses of penetration *** this study,a design optimization methodology for the reactive material structure is developed based on the finite element analysis.A finite element model for penetration analysis is introduced to save the expenses of the *** resistance is assessed through the analysis,and result is calibrated by comparing with experimental *** on the model,topology optimization is introduced to determine shape of the *** design variables and constraints of the optimization are proposed considering the manufacturing limitations,and the optimal shape that can be manufactured by cold spraying is *** on the optimal shape,size optimization is introduced to determine the geometric dimensions of the *** a result,optimal design of the reactive material structure and steel case of the penetrative projectile,which maximizes the impact resistance,is *** the design process proposed in this study,reactive material structures can be designed considering not only mechanical performances but also manufacturing limitations,with reasonable time and cost.

关键词： Reactive material Penetrative projectile Topology optimization Manufacturing constraint Cold gas dynamic spray Additive manufacturing

SMARCA4-deficient undifferentiated thoracic tumor:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2521-2527页

作者： hee jung Kwon Min Hye Jang Department of Pathology Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND SMARCA4-deficient undifferentiated tumors(SMARCA4-DUTs)present with diverse clinical manifestations and progress to metastasis and even cause death within a few *** novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking ***-guishing it from other malignancies is *** SUMMARY A 62-year-old man presented with chest pain for 7 *** patient had no respiratory symptoms and normal pulmonary function test *** patient had been a smoker for 8 years and quit smoking 2 years *** computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple *** samples were obtained using open frozen biopsy,after several unsuccessful *** tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent *** differential diagnosis included high-grade lymphoma,germ cell tumor,NUT carcinoma,undifferentiated carcinoma,and *** tumor cells were large,arranged in sheets,and did not exhibit glandular or squamous *** foci of necrosis were *** was no evidence of epithelial differentiation on immunohistochemical *** SMARCA4 stain showed complete loss of expression of SMARCA4,which is *** In the present case,thoracic SMARCA4-DUT was diagnosed based on clinical features,absence of epithelial differentiation,and negative SMARCA4 expression.

关键词： SMARCA4 BRG1 Deficient Undifferentiated tumor Thoracic Case report

Fournier’s gangrene after insertion of thermo-expandable prostatic stent for benign prostatic hyperplasia:A case report

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世界临床病例杂志 2023年第27期11卷 6498-6504页

作者： hee Chang jung Yeong Uk Kim Department of Urology Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Thermo-expandable urethral stent(Memokath 028)implantation is an alternative treatment for older patients with lower urinary tract symptoms and benign prostatic *** prostatic urethral stent implantation,minor complications such as urinary tract infection,irritative symptoms,gross hematuria,and urethral pain have been observed;however,there are no reports of life-threatening ***,we report a critical case of Fournier’s gangrene that occurred 7 years after prostatic *** SUMMARY An 81-years-old man with benign prostatic hyperplasia(volume,126 ccs;as measured by transrectal ultrasound)had undergone insertion of a thermoexpandable urethral stent(Memokath 028)as he was unfit for surgery under general ***,the patient had undergone a suprapubic cystostomy for recurrent acute urinary retention 4 years after the insertion of prostatic stent(Memokath 028).We had planned to remove the Memokath 028;however,the patient was lost to *** patient presented to the emergency department 3 years after the suprapubic cystostomy with necrotic changes from the right scrotum to the right inguinal *** digital rectal examination,tenderness and heat of prostate was ***,the black skin color change with foulsmelling from right scrotum to right inguinal area was *** computed tomography finding,subcutaneous emphysema was identified to same *** was diagnosed with Fournier’s gangrene based on the physical examination and computed tomography *** emergency room,Fournier’s gangrene severity index value is seven ***,he underwent emergent extended surgical debridement and removal of the Memokath ***-spectrum intravenous antibiotics were administered and additional necrotic tissue debridement was ***,the patient died 14 days after surgery due to multiorgan *** If Memokath 028 for benign prostatic hyperplasia is not working in older patients,its rapid

关键词： Urethral stents Minimally invasive surgery Complication Fournier’s gangrene Benign prostatic hyperplasia Case report