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第九届全国实验血液学会议

作者：杜新 Hitendra S.Chand hector DavidInzunza Steven Brodie Walter Kisiel 深圳市第二人民医院 Department of Pathology and Internal Medicine University of New Mexico Health Sciences Center Albuquerque New Mexico 87106 U.S.A.

目的探讨组织因子途径抑制物-2(Tissue Factor Pathway Inhibitor-2,TFPI-2)在体内抑制肿瘤生长和转移的作用。方法1.质粒构建TFPI-2 cDNA克隆至真核细胞载体pcDNA3。2.细胞转染已构建质粒(实验组)及载体(对照组)分别转染人纤维母细胞...

目的探讨组织因子途径抑制物-2(Tissue Factor Pathway Inhibitor-2,TFPI-2)在体内抑制肿瘤生长和转移的作用。方法1.质粒构建TFPI-2 cDNA克隆至真核细胞载体pcDNA3。2.细胞转染已构建质粒(实验组)及载体(对照组)分别转染人纤维母细胞瘤细胞株HT-1080。3.动物模型将5×10转染的HT1080细胞皮下接种至Blab/c SCID雄性裸鼠。每组12只。每周观察肿瘤大小,连续5周。至5周末收集肿块和肺脏供实验用。4.组织化学与免疫组织化学染色观察肿瘤生长和肺内转移以及

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Cellular & Molecular Immunology 2021年第4期18卷 1005-1015页

作者： Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina lnstitute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Liver Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SARChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Life Science Hong Kong University of Science and TechnologyHong Kong SARChina Department of Surgery The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong Kong SARChina Department of Clinical Oncology The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Cancer InstituteShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SARChina Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Cancer Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer *** a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely ***,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive *** an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)*** of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,***,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic ***,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation *** summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic *** findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.

关键词： Cell cycle related kinase liver metastasis liver immune microenvironment myeloid-derived suppressor cell natural killer T cell

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Hypertension effects on p73 expression in the rat circumventricular organs and cerebrospinal fluid

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World Journal of Neuroscience 2012年第2期2卷 68-73页

作者： Emilia M.Carmona-Calero Ibrahim González-Marrero Manuela Castaneyra-Martin Juan M.Gonzalez-Toledo Leandro Castaneyra-Ruiz hector de Paz-Carmona Agustín Castaneyra-Ruiz Lidia Ruiz-Mayor Agustín Castaneyra-Perdomo Departamento de Anatomía Facultad de MedicinaUniversidad de La LagunaTenerifeIslas CanariasSpain Departamento de Biotecnología Instituto de Investigacion y Ciencias de Puerto del RosarioFuerteventuraIslas CanariasSpain

It has been reported that spontaneously hypertensive rats (SHR) show ventricular dilation, changes in CSF proteins and variations in the circumventricular organs (CVO) such as: the subcommissural organ (SCO), the subfornical organ (SFO) and the area postrema (AP) which are located in the walls of the third and fourth ventricles. On the other hand, p73 proteins are present in cells of the central nervous system (CNS) such as circumventricular structures and the neuroepithelium which are altered in ventricular dilation. The purpose of the present work is to study the TAp73 isoform expression in the circumventricular organs (CVO) and their variations in ventricular dilatation and arterial hypertension. Brains and cerebrospinal fluid (CSF) from control Wistar-Kyoto rats (WKY) and SHR were used. The paraffin sections containing the CVO were immunohistochemically proc-essed with anti-TAp73 and by western blot, p73 bands in the CSF and circumventricular organ extract were also identified. The western blot study showed bands marked with p73 in the CSF and CVO, the p73 band expression was bigger in the SHR than in the WKY rats. We also found stronger markings in the SFO, SCO and AP of the hypertensive rats than in the WKY rats. It could be concluded that hypertension in the SHR produces altera-tions in the relationship between the p73 protein, circumventricular structures and CSF.

关键词： Circumventricular Organs p73 CSF Hypertensive Rats

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The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine

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Genes & Diseases 2019年第3期6卷 201-223页

作者： Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago MedicineChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Rosalind Franklin University Chicago Medical SchoolNorth ChicagoIL 60064USA SIR Program Illinois Math and Science Academy(IMSA)AuroraIL 60506USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL60208USA The Department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL60616USA

Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological *** roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ *** of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP *** it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other *** effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of ***,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and *** review aims to summarize our current understanding of BMP9 across biology and the body.

关键词： Adipogenesis Bone morphogenetic proteins(BMPs) BMP9/GDF2 Mesenchymal stem cells(MSCs) Metabolism Osteogenesis Regenerative medicine Tumorigenesis

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先天性长QT综合征的新进展

先天性长QT综合征的新进展

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全国疑难急诊心电图学和心律失常诊疗新进展专题会议（2013）

作者：胡丹阮磊张存泰白融 hector M.Barajas-Martinez Charles Antzelevitch Masonic Medical Research Laboratory UticaNYUSA13501 华中科技大学同济医学院附属同济医院心内科(老年科)

先天性长QT综合征(LQTS)是发病率在1/2 500左右的恶性遗传性心脏疾病。LQTS的典型心脏表现包括可导致心脏骤停和心脏猝死的晕厥发作,以及包括QT间期延长和T波异常在内的心电图异常。90年代中期,LQTS的治病基因被首次发现,至今已有13型... 详细信息

先天性长QT综合征(LQTS)是发病率在1/2 500左右的恶性遗传性心脏疾病。LQTS的典型心脏表现包括可导致心脏骤停和心脏猝死的晕厥发作,以及包括QT间期延长和T波异常在内的心电图异常。90年代中期,LQTS的治病基因被首次发现,至今已有13型被确认。致病基因主要是离子通道和转运相关蛋白。对于具有典型特征的患者,医生并无诊断困难。对于模棱两可的病例,需要参照特殊诊断标准,比如心电图,病史和家族史等等。此外,基因扫描正日益成为诊断过程的一部分。除非有明确的禁忌证,治疗上还是要首选β受体阻滞剂。若在接受足量β受体阻滞剂期间,还有1次以上的晕厥,需立即采取左侧交感神经切除术,并根据病人特征(年龄、性别、临床病史、24 h Holter在内的心电图特征、基因表型等)考虑安装埋藏式心脏转复除颤器。病人接受适当治疗后,一般预后较好。但是LQTS8(Timothy综合征)病人,携带KCNQ1突变的Jervel Lange-Nielsen综合征患者,以及伴有2:1房室传导阻滞,病窦综合征或Brugada综合征的LQT3病患的预后极其不容乐观。

关键词：心脏猝死长QT综合征综述基因表型危险分层治疗

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先天性长QT综合征的新进展

先天性长QT综合征的新进展

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全国心律失常的现代诊疗新进展专题会议

作者：胡丹阮磊张存泰白融 hector M.Barajas.Martinez Charles Antzelevitch Masonic Medical Research Laboratory 华中科技大学同济医学院附属同济医院心内科(老年科)

先天性长QT综合征（LQTS）是发病率在1/2 500左右的恶性遗传性心脏疾病。LQTS的典型心脏表现包括可导致心脏骤停和心脏猝死的晕厥发作,以及包括QT间期延长和T波异常在内的心电图异常。90年代中期,LQTS的治病基因被首次发现,至今已有13... 详细信息

先天性长QT综合征（LQTS）是发病率在1/2 500左右的恶性遗传性心脏疾病。LQTS的典型心脏表现包括可导致心脏骤停和心脏猝死的晕厥发作,以及包括QT间期延长和T波异常在内的心电图异常。90年代中期,LQTS的治病基因被首次发现,至今已有13型被确认。致病基因主要是离子通道和转运相关蛋白。对于具有典型特征的患者,医生并无诊断困难。对于模棱两可的病例,需要参照特殊诊断标准,比如心电图,病史和家族史等等。此外,基因扫描正日益成为诊断过程的一部分。除非有明确的禁忌证,治疗上还是要首选β受体阻滞剂。若在接受足量β受体阻滞剂期间,还有1次以上的晕厥,需立即采取左侧交感神经切除术,并根据病人特征（年龄、性别、临床病史、24 h Holter在内的心电图特征、基因表型等）考虑安装埋藏式心脏转复除颤器。病人接受适当治疗后,一般预后较好。但是LQTS8（Timothy综合征）病人,携带KCNQ1突变的Jervel Lange-Nielsen综合征患者,以及伴有2:1房室传导阻滞,病窦综合征或Brugada综合征的LQT3病患的预后极其不容乐观。

关键词：心脏猝死长QT综合征综述基因表型危险分层治疗

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曼氏血吸虫感染鼠肝脏虫卵肉芽肿反应及胶原含量定量测定

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中国寄生虫病防治杂志 2000年第1期13卷 58-59页

作者：王勇 hectorJHernandez MiguelJStadecker 安徽省血吸虫病防治研究所安徽芜湖241000 美国Tufts大学医学院病理系

应用形态计量学方法和化学染色法 ,分别对 6个品系小鼠定量感染曼氏血吸虫后 7.5 wk的肝脏石蜡切片中虫卵肉芽肿面积和肝脏胶原纤维含量进行了定量观察。结果表明 ,感染鼠肝脏虫卵肉芽肿面积在不同种系小鼠间显示出一定差别 ,肝脏胶原... 详细信息

应用形态计量学方法和化学染色法 ,分别对 6个品系小鼠定量感染曼氏血吸虫后 7.5 wk的肝脏石蜡切片中虫卵肉芽肿面积和肝脏胶原纤维含量进行了定量观察。结果表明 ,感染鼠肝脏虫卵肉芽肿面积在不同种系小鼠间显示出一定差别 ,肝脏胶原含量较对照组均有明显增加。经相关分析 ,不同种系感染鼠肝脏虫卵肉芽肿面积与肝脏胶原含量间不存在相关关系。鉴于虫卵肉芽肿形成与肝纤维化过程在时相上的差别。

关键词：虫卵肉芽肿胶原含量形态计量血吸虫病

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幻想交响曲 Op.14

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丛书名：奥伊伦堡 CD+总谱

2006年

作者：埃克托·柏辽兹（hector Berlioz）作曲尼古拉斯·腾佩利（Nicholas Temperley）编订

并列题名：Symphonie fantastique

ISBN: (纸本)7540437979

并列题名：Symphonie fantastique

关键词：交响曲法国近代总谱

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Nitric oxide production is associated to increased lipoperoxidation and active caspase-3 in demyelinated brain regions of the taiep rat

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Advances in Bioscience and Biotechnology 2012年第6期3卷 695-704页

作者： Guadalupe Soto-Rodríguez Daniel Martínez-Fong Rosa Arroyo Patricia Aguilar-Alonso hector Rubio José Ramón Eguibar Araceli Ugarte Maricela Torres-Soto Juan Antonio González-Barrios Jorge Cebada Eduardo Brambila Bertha Alicia Leon-Chavez Departamento de Fisiología Biofísica y Neurociencias Cinvestav Apdo. Postal 14-740 México D.F. 07000 México División de Medicina Genómica del Hospital regional 1o de Octubre ISSSTE Avenida Instituto Politécnico Nacional 1669 México D. F. 07760 México Escuela de Biología BUAP Puebla Pue. Mexico Facultad de Ciencias Químicas BUAP 14 sur y Av. Edif. 138 San Claudio 72570 Puebla Pue. México Facultad de Medicina Universidad Autónoma de Yucatán Mexico Instituto de Fisiología BUAP 14 sur 6301 Puebla Pue. México

We previously showed that the increase in nitric oxide (NO) levels and NO synthase (NOS) expression correlate with the progression of reactive astrocytosis and demyelination in the brains of 6-month-old taiep rats. Increased levels of NO can result in high concentration of peroxynitrite and thus cause tissue damage, which consists of lipoperoxidation of the cytoplasmic membrane, such as the myelin, and of apoptotic and necrotic cell-death. On this basis, we studied whether the increased NO production is associated with lipoperoxidation and cell death in the cerebellum and brainstem over the age (1, 3, 6, and 8 months) of taiep rats. The results were compared with those obtained in matched Sprague-Dawley (SD) rats. We measured the levels of nitrites (NO production), malonyldialdehyde, and 4-hydroxyalkenal (lipoperoxidation) in brain tissue homogenates. The three NOS isoforms and cleaved caspase-3 were evaluated by using ELISA and immunostaining techniques. Our results showed that NO production and lipoperoxidation increased in the cerebellum and brainstem as the age of the taiep rats increased compared to SD rats. The overexpression of nNOS and iNOS were in the Purkinje cells, magnocellular neurons, and in oligodendrocytes, whereas the glial cells showed strong cleaved-caspase-3 immunoreactivity. In summary our results suggest that NO plays a role in the demyelination and cell death in the taiep rat.

关键词： Hypomyelination Nitrite Malonyldialdehyde Apoptosis Necrosis

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Biological and Chemical Control in Rot Root in Avocado by Phytophthora cinnamomi Rands

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Journal of Agricultural Science and Technology(A) 2012年第7期2卷 882-887页

作者： Ma. Blanca Nieves Lara-Chavez Teresita del Carmen Avila-Val Jestus Alejandro Guerrero-Tejeda Francisco Said Barriga-Gonzalez Eulalio Venegas-Gonzalez Salvador Aguirre-Paleo Margarita Vargas-Sandoval hector Guillen Andrade Satul Rodriguez-Lopez Universidad Michoacana de San Nicolas de Hidalgo Facultad de Agrobiologla "Presidente Juarez" Uruapan Michoacan C.P.60190 Mexico

＂Avocado sadness＂ caused by the Oomycete Phytophthora cinnamomi Rands, is one of the main diseases affecting this fruit crop in Michoacan, M6xico, without having an efficient control strategy for that. In this research three Trichoderma isolates and Ridomil Gold 4E fungicide were tested in avocado trees infected with this pathogen using the growing and coloring vegetative flow growing. Results were analyzed with an experimental design completely random with four treatments and repetitions. Different responses were presented form avocado trees to each treatment. Trichoderma erinaceum Bissett, Kubicek ＆ Szackacs treatment was the best controlling disease in trees with grade II and III damage. Trichoderma aggressivum Samuels ＆ W. Gams controlled better in trees with grade III damage. At last, Trichoderma arundinaceum Zafari, Graef. and Samuels were the best controlling trees with the highest grade damage. Fungicide Ridomil Gold 4E controlled the disease in trees with the lowest grade damage （I and II）, their medias were similar to witness.

关键词： Biological and chemical control Trichoderma aggressivum T. erinaceum T. arundinaceum Ridomil Gold 4E.

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