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Barrett's esophagus:Prevalence and risk factors in patients with chronic GERD in Upper Egypt

World Journal of Gastroenterology 2009年第28期15卷 3511-3515页

作者： Yasser m Fouad madiha m makhlouf heba m tawfik Hussein El Amin Wael Abdel Ghany Hisham R El-khayat Department of Tropical medicine and Gastroenterology Minya University Department of Pathology Minya University Department of Internal medicine Gastroenterology Unit Assuit University Department of Gastroenterology Theodore Bilharz Research Institute

AIm： To determine the prevalence and possible risk factors of Barrett＇s esophagus （BE） in patients with chronic gastroesophageal reflux disease （GERD） in EI minya and Assuit, Upper Egypt. mETHODS： One thousand consecutive patients with chronic GERD symptoms were included in the study over 2 years. They were subjected to history taking including a questionnaire for GERD symptoms, clinical examination and upper digestive tract endoscopy. Endoscopic signs suggestive of columnar-lined esophagus （CLE） were defined as mucosal tongues or an upward shift of the squamocolumnar junction. BF was diagnosed by pathological examination when specialized intestinal metaplasia was detected histologically in suspected CLE. pH was monitored in 40 patients. RESULTS： BE was present in 7.3% of patients with chronic GERD symptoms, with a mean age of 48.3 ± 8.2 years, which was significantly higher than patients with GERD without BE （37.4 ± 13.6 years）. Adenocarcinoma was detected in eight cases （0.8%）, six of them in BE patients. There was no significant difference between patients with BE and GERD regarding sex, smoking, alcohol consumption or symptoms of GERD. Patients with BE had significantly longer esophageal acid exposure time in the supine position, measured by pH monitoring. CONCLUSION： The prevalence of BE in patients with GERD who were referred for endoscopy was 7.3%. BE seems to be associated with older age and more in patients with nocturnal gastroesophageal reflux.

关键词： Barrett's esophagus Gastrointestinal Endoscopy Gastroesophageal reflux Risk factors

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Fractional diffusion-advection equation with resetting:An analytical approach

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Journal of Ocean Engineering and Science 2024年第3期9卷 216-221页

作者： Ashraf m.tawfik m.A.Abdou Theoretical Physics Research Group Physics DepartmentFaculty of ScienceMansoura UniversityMansoura 35516Egypt Physics Department College of ScienceUniversity of BishaPO Box 344Bisha 61922Kingdom of Saudi Arabia

In this article,the fractional diffusion-advection equation with resetting is introduced to promote the theory of anomalous *** fractional equation describes a particle’s non-diffusive motion performing a random walk and is reset to its initial *** analytical method is proposed to obtain the solution of the fractional equation with resetting via Fourier and Laplace *** study the influence of the fractional-order and resetting rate on the probability distributions,and the mean square displacements are analyzed for different cases of anomalous regimes.

关键词： Fractional calculus Anomalous diffusion Stochastic resetting

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Genetic Variability and Phenotypic Correlations Study among Grain Quality Traits and mineral Elements Concentrations in Colored and Non-Colored Rice (Oryza sativa L.)

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1733-1748页

作者： Adel A.Rezk mohamed m.El-malky heba I.mohamed Hossam S.El-Beltagi Agricultural Biotechnology Department College of Agricultural and Food ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Plant Pathology Research Institute Agriculture Research CenterGiza12619Egypt Rice Research and Training Center Field Crop Research InstituteAgriculture Research Center33717Egypt Biological and Geological Sciences Department Faculty of EducationAin Shams UniversityCairo11511Egypt Biochemistry Department Faculty of AgricultureCairo UniversityGiza12613Egypt

Twenty-four rice genotypes were examined to assess genetic variability,heritability,and correlations for seven-grain quality traits,eight nutritional elements,and *** revealed signiﬁcant differences for the quality traits *** every trait under study,the phenotypic coefﬁcient of variation was higher than the correspon-dence genotypic coefﬁcient of *** in a broad sense varied from 29.75%for grain length to 98.31%for the elongation *** percentage recovery had a highly signiﬁcant positive correlation with milling and head rice ***,milling percentage had a highly positive correlation with head rice *** amylose percentage,all the genotypes belonged to low amylose except the Hassawi-1 variety,which had intermediate amylose *** nutrition contents of magnesium(mg),sodium(Na),potas-sium(K),calcium(Ca),copper(Cu),manganese(mn),zinc(Zn),iron(Fe),or protein percentage gave different variations for 24 rice genotypes under all the nutritional *** the 24 genotypes,ten rice genotypes–HighNutrient-1,HighNutrient-2,HighNutrient-9,HighNutrient-8,HighNutrient-3,Hassawi-2,HighNutrient-7,HighNutrient-6,Hassawi-1,and HighNutrient-4–had the highest heist value for all nutritional and protein con-tents,and could be used as a donor to improving new *** was a positive and signiﬁcant correlation between magnesium mg,K,Zn and ***,K had a positive correlation with zinc Zn,Fe,and protein *** analysis was divided into two groups:theﬁrst group included all genotypes rich in nutri-ents,while the remaining genotypes with low nutritional content were included in the second group.

关键词： Amylose cluster analysis genotypes grain quality mineral nutrition rice

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Optimization of Cooperative Relayingmolecular Communications for Nanomedical Applications

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Computer modeling in Engineering & Sciences 2024年第2期138卷 1259-1275页

作者： Eman S.Attia Ashraf A.m.Khalaf Fathi E.Abd El-Samie Saied m.Abd El-atty Konstantinos A.Lizos Osama Alfarraj heba m.El-Hoseny Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61111Egypt Department of Electronics and Electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computer science The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Recently,nano-systems based on molecular communications via diffusion(mCvD)have been implemented in a variety of nanomedical applications,most notably in targeted drug delivery system(TDDS)***,because the mCvD is unreliable and there exists molecular noise and inter symbol interference(ISI),cooperative nano-relays can acquire the reliability for drug delivery to targeted diseased cells,especially if the separation distance between the nano transmitter and nano receiver is *** this work,we propose an approach for optimizing the performance of the nano system using cooperative molecular communications with a nano relay scheme,while accounting for blood flow effects in terms of drift *** fractions of the molecular drug that should be allocated to the nano transmitter and nano relay positioning are computed using a collaborative optimization problem solved by themodified Central Force Optimization(mCFO)*** the previous work,the probability of bit error is expressed in a closed-form *** is used as an objective function to determine the optimal velocity of the drug molecules and the detection threshold at the nano *** simulation results show that the probability of bit error can be dramatically reduced by optimizing the drift velocity,detection threshold,location of the nano-relay in the proposed nano system,and molecular drug budget.

关键词： Nanomedical system molecular communication cooperative relay optimization

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赛德西港用于船舶减排的陆上可再生能源供电评估

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 506-524页

作者： merna makram Ameen m.Bassam Adel A.tawfik Waleed Yehia Naval Architecture and marine Eng.Dept. Faculty of EngineeringPort Said UniversityPort Fuad 42526Egypt

Air pollution from shipping is becoming a critical issue,particularly in dense hub port *** proposed solution to minimize ship-based emissions at ports is the implementation of an Onshore Power Supply(OPS)*** allows ships to shut off their auxiliary engines and instead connect to the port *** there have been numerous studies conducted on ports in Europe and the United States,little research has been done on Egyptian ***,this paper aims to investigate the feasibility of implementing OPS at Port Said West Port in Egypt,aligning with Egypt Vision 2030’s goals for addressing climate *** research primarily focuses on analyzing data collected from calling ships to generate socio-economic and cost-effectiveness analyses of *** further enhance the environmental benefits of OPS,the paper proposes the use of solar energy as the OPS electricity *** findings of the study revealed that by relying on the national grid,emissions can be reduced by 28%.moreover,it is predicted that this reduction could reach 100%if electricity generation is solely based on solar ***,the economic analysis demonstrates promising profitability,with a payback period of approximately two years.

关键词： Onshore power supply Port sustainability Shipping emissions inventory Solar energy Photovoltaic systems

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Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in Saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： Saleh Fahad Alqifari Aya K Esmail Dalal m Alarifi Ghalya Y Alsuliman maram m Alhati may R mutlaq mohammed Aldhaeefi Shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf S Wasel heba R Hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes mellitus(Dm)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe *** Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient *** To assess the adherence of patients with Dm to the CDC/ACIP immunization recommendations in Saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in Saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,*** patients with Dm in Saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and *** such as vaccine recommendations provided by family physicians or specialists,site of care,income level,Dm-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with Dm,the most reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with *** In S

关键词： Diabetes mellitus Vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization Retrospective study

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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz martina Strnadová Akhil Velluva heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(mC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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Prevelance of Bovine Cysticercosis in Egypt and the Cysticidal Effect of Two Extracts Obtained from Balanites aegyptiaca and moringa oleifera on mice model Affected with T. saginata Cysticerci

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Open Journal of Animal Sciences 2024年第2期14卷 39-55页

作者： Omnia m. Kandil Noha m. F. Hassan Doaa Sedky Hatem A. Shalaby heba m. Ashry Nadia m. T. Abu El Ezz Sahar m. Kandeel mohamed S. Abdelfattah L. Ying Ebtesam m. Al-Olayan Parasitology and Animal Diseases Department Veterinary Research Institute National Research Centre Dokki Cairo Egypt Chemistry of Natural Compounds Department Pharmaceutical and Drugs Industries Research Institute National Research Centre Dokki Cairo Egypt Chemistry Department Faculty of Science Helwan University Cairo Egypt State Key Laboratory of Plateau Ecology and Agriculture Qinghai University Xining China College of Agriculture and Animal Husbandry Qinghai University Xining China Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The aim of the present study was to determine the prevalence of bovine cysticercosis in both cattle and buffloas, in Egypt and to assess the cysticidal efficacy of Balanites aegyptiaca fruits (B. aegyptiaca) and moringa oleifera seeds (m. oleifera) extracts in experimentally infected mice. The study detected the level of tumor necrosis factor (TNF-α) to monitor the immune and inflammatory responses of experimentally infected mice. Through meat inspection, a total number of 2125 male bovine, 2 to 5 years old, (1125 cattle and 1000 buffloes) were examined under the authority of Albsatine and Alwaraq official abattoirs in Cairo Governorate, Egypt covering the period extended from march 2022 to April 2023. The overall prevalence of the disease among bovine was 7.8% (6.31% of cattle and 9.5% of buffloes). Besides, B. aegyptiaca and m. oleifera extracts showed cysticidal activity in experimentally infected mice. A decrease in the numbers of cysticerci was found in all treated mice groups, and up to 88% reduction was achieved in the B. aegyptiaca-treated group;higher than that was recorded in both m. oleifera (72.23%) and albendazole-treated ones (80.56%). Postmortem findings proved that m. oleifera and B. aegyptiaca reduced cysticerci numbers comparable to a commercial anthelmintic. The study showed a significant decrease (P 0.001) in TNF-α levels after treatment with Balanites and moringa extracts, compared with the untreated control and the albendazole-treated groups.

关键词： Prevalence Balanites aegyptiaca moringa oleifera mice T. saginata Cysticerci

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New trends in pharmacological treatment of acute kidney injury

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Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 285-297页

作者： heba m.I.Abdallah Department of Pharmacology Medical Research DivisionNational Research CentreGiza 12622Egypt

Acute kidney injury,previously known as acute renal failure(AKI),is defined as an abrupt decrease in kidney function that occurs within hours or *** new nomenclature opens a new door for possibility of treatment of developing renal injury before progression to unresolved renal *** arises due to diverse etiologic factors that rely mainly on three categories namely,prerenal,intrinsic renal,and post-renal factors with different clinical pictures,and confers a spectrum of injury ranging from mild to severe and sometimes leads to end-stage renal *** of pathogenesis and other factors generate barriers to developing effective treatments despite a large number of experimental and clinical *** this review,recent advances in the potential of the currently used drugs for renoprotection,novel pharmacological targets,and prospective therapeutics for AKI are *** information in this review was extracted from electronic resources(Pub med,Google Scholar,Wiley,Science Direct,Springer),and English scientific books by using keywords including kidney,injury,recent therapy,and pharmacological *** articles were carefully checked for their relevance to the current *** targets of cellular repair or regenerative processes involved in AKI such as autophagy,ferroptosis inhibition,and p53 antagonism seem to be effective in disease *** may help researchers and clinicians to understand how to target the interrelated molecular and cellular mechanisms underlying the pathogenesis of AKI.

关键词： Acute kidney injury Recent therapy Promising pharmacological targets

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Oscillation Criteria of Second Order Half Linear Delay Dynamic Equations on Time Scales

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Acta mathematicae Applicatae Sinica 2017年第1期33卷 83-92页

作者： H.A. AGWO A.m.m. KHODIER heba A. HASSAN Department of mathematics Faculty of Education Ain Shams University 11757 beside Tabary school RoxyCairo Egypt

In this paper, we establish some new oscillation criteria for a non autonomous second order delay dynamic equation （r（t）g（x△（t）））△＋p（t）f（x（τ（t）））=0 on a time scale T. Oscillation behavior of this equation is not studied before. Our results not only apply on differential equations when T=R, difference equations when T=N but can be applied on different types of time scales such as when T=N for q〉1 and also improve most previous results. Finally, we give some examples to illustrate our main results.

关键词： time scales oscillation second order delay dynamic equations generalized Riccati technique generalized exponential function

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