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Biological Control of Root-Knot Nematode Meloidogyne incognita in Psoralea corylifolia Plant by Enhancing the Biocontrol Efficacy of Trichoderma harzianum Using Press Mud

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Phyton-International Journal of Experimental Botany 2022年第8期91卷 1757-1777页

作者： Yasar Nishat Mohammad Danish heba I.mohamed Hisamuddin Shaikh Abeer Elhakem Section of Plant Pathology and Nematology Department of BotanyAligarh Muslim UniversityAligarh202002India Department of Biological and geological Sciences Faculty of EducationAin Shams UniversityCairo11341Egypt Department of Biology College of Science and Humanities in Al-KharjPrince Sattam Bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia

Meloidogyne incognita is a plant pathogen causing root-knot disease and loss of crop *** present study aimed to use Trichoderma harzianum as a biocontrol agent against plant-parasitic nematodes and used press mud,which is a solid waste by-product of sugarcane,as a biocontrol agent and ***,the combined application of *** and press mud may enhance nematode control and plant *** analysis of press mud using scanning electron microscopy(SEM)integrated with an Energy Dispersive X-ray(EDX)analyzer revealed the presence of different elements such as C,O,Mg,Si,P,K,Ca,Cu and *** addition,a greenhouse study was conducted to investigate the combined effects of press mud and *** on *** reproduction and growth and the biochemical features of Psoralea *** results showed that plant length,dry biomass,leaf area,the number of seeds per plant,chlorophyll a,chl b,carotenoid content,nitrate reductase,carbonic anhydrase,and nitrogen content were significantly increased(P≤0.05)in the T2 plants(plants were treated with 100 g of press mud+50 mL *** before one week of *** inoculation),over inoculated plants(IC).Antioxidant enzyme activity of ascorbate peroxidase(APX),catalase(CAT),peroxidase(POD),and superoxide dismutase(SOD)in the foliage of *** was significantly increased when plants were treated with press mud+***.A significant reduction in the number of egg masses,nematode population,and root-knot index(RKI)was found in plants with T2 *** results suggest that the combined application of *** and press mud has the potential to control the *** infection and can be used as an environmentally safe alternative to chemical nematicides and also help in the removal of sugarcane waste that causes environmental pollution.

关键词： growth improvement antioxidant enzymes nitrate reductase carbonic anhydrase root-knot index

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Micro-fabrication of ceramics:Additive manufacturing and conventional technologies

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Journal of Advanced Ceramics 2021年第1期10卷 1-27页

作者： Hany HASSANIN Khamis ESSA Amr ELSHAER mohamed IMBABY heba H.EL-MONgY Tamer A.EL-SAYED School of Engineering Canterbury Christ Church UniversityCanterburyCT11QUUK University of Birmingham EdgbastonB152TTUK Kingston University London Penrhyn RoadKingston Upon ThamesSurreyKT12EEUK Department of Mechanical Design Faculty of EngineeringMatariaHelwan UniversityP.O.Box.11718CairoEgypt Jubail University College Mechanical EngineeringKingdom of Saudi Arabia Center for Applied Dynamics Research(CADR) School of EngineeringUniversity of AberdeenAberdeenAB243UEUK

Ceramic materials are increasingly used in micro-electro-mechanical systems(MEMS)as they offer many advantages such as high-temperature resistance,high wear resistance,low density,and favourable mechanical and chemical properties at elevated ***,with the emerging of additive manufacturing,the use of ceramics for functional and structural MEMS raises new opportunities and *** paper provides an extensive review of the manufacturing processes used for ceramic-based MEMS,including additive and conventional manufacturing *** review covers the micro-fabrication techniques of ceramics with the focus on their operating principles,main features,and processed *** that need to be addressed in applying additive technologies in MEMS include ceramic printing on wafers,post-processing at the micro-level,resolution,and quality *** paper also sheds light on the new possibilities of ceramic additive micro-fabrication and their potential applications,which indicates a promising future.

关键词： micro-electro-mechanical system(MEMS) micro-fabrication ceramics micro parts additive manufacturing

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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia guglielmo Patelli Ali mohamed Margherita Piccolella Mariarita galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Outcome of non surgical hepatic decompression procedures in Egyptian patients with Budd-Chiari

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World Journal of gastroenterology 2011年第7期17卷 906-913页

作者： Ahmed Eldorry Eman Barakat heba Abdella Sara Abdelhakam mohamed Shaker Amr Hamed Mohammad Sakr Department of Radiodi-agnosis and Interventional Radiology Faculty of Medicine AinShams University Department of Tropical Medicine Faculty of Medicine Ain Shams University

AIM: To evaluate outcome of patients with Budd-Chiari syndrome after balloon angioplasty ± stenting or transjugular intrahepatic portosystemic shunt (TIPS). METHODS: Twenty five patients with Budd-Chiari syndrome admitted to Ain Shams University Hospitals, Tropical Medicine Department were included. Twelve patients (48%) with short segment occlusion were candidates for angioplasty; with stenting in ten cases and without stenting in two. Thirteen patients (52%) had Transjugular Intrahepatic Portosystemic Shunt. Patients were followed up for 12-32 mo. RESULTS: Patency rate in patients who underwent angioplasty ± stenting was 83.3% at one year and at end of follow up. The need of revision was 41.6% with one year survival of 100%, dropped to 91.6% at end of follow up. In patients who had Transjugular Intrahepatic Portosystemic Shunt, patency rate was 92.3% at one year, dropped to 84.6% at end of follow up. The need of revision was 38.4% with one year and end of follow up survival of 100%. Patients with patent shunts showed marked improvement compared to those with occluded shunts. CONCLUSION: Morbidity and mortality following angioplasty ± stenting and TIPS are low with satisfactory outcome. Proper patient selection and management of shunt dysfunction are crucial in improvement.

关键词： Angioplasty Stenting Transjugular Intrahepatic portosystemic shunt Patency rate

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genetic Variability and Phenotypic Correlations Study among grain Quality Traits and Mineral Elements Concentrations in Colored and Non-Colored Rice (Oryza sativa L.)

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1733-1748页

作者： Adel A.Rezk mohamed M.El-Malky heba I.mohamed Hossam S.El-Beltagi Agricultural Biotechnology Department College of Agricultural and Food ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Plant Pathology Research Institute Agriculture Research CenterGiza12619Egypt Rice Research and Training Center Field Crop Research InstituteAgriculture Research Center33717Egypt Biological and geological Sciences Department Faculty of EducationAin Shams UniversityCairo11511Egypt Biochemistry Department Faculty of AgricultureCairo UniversityGiza12613Egypt

Twenty-four rice genotypes were examined to assess genetic variability,heritability,and correlations for seven-grain quality traits,eight nutritional elements,and *** revealed signiﬁcant differences for the quality traits *** every trait under study,the phenotypic coefﬁcient of variation was higher than the correspon-dence genotypic coefﬁcient of *** in a broad sense varied from 29.75%for grain length to 98.31%for the elongation *** percentage recovery had a highly signiﬁcant positive correlation with milling and head rice ***,milling percentage had a highly positive correlation with head rice *** amylose percentage,all the genotypes belonged to low amylose except the Hassawi-1 variety,which had intermediate amylose *** nutrition contents of magnesium(Mg),sodium(Na),potas-sium(K),calcium(Ca),copper(Cu),manganese(Mn),zinc(Zn),iron(Fe),or protein percentage gave different variations for 24 rice genotypes under all the nutritional *** the 24 genotypes,ten rice genotypes–HighNutrient-1,HighNutrient-2,HighNutrient-9,HighNutrient-8,HighNutrient-3,Hassawi-2,HighNutrient-7,HighNutrient-6,Hassawi-1,and HighNutrient-4–had the highest heist value for all nutritional and protein con-tents,and could be used as a donor to improving new *** was a positive and signiﬁcant correlation between magnesium Mg,K,Zn and ***,K had a positive correlation with zinc Zn,Fe,and protein *** analysis was divided into two groups:theﬁrst group included all genotypes rich in nutri-ents,while the remaining genotypes with low nutritional content were included in the second group.

关键词： Amylose cluster analysis genotypes grain quality mineral nutrition rice

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Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidine and pyrimido[1,2-α]pyrimidine derivatives

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Chinese Chemical Letters 2015年第6期26卷 690-694页

作者： mohamed S.A.El-gaby Jehan A.Micky Nadia M.Saleh Yousry A.Ammar heba S.A.mohamed Chemistry Department Faculty of ScienceAl-Azhar University at Assiut Chemistry Department Faculty of Science (Girl’s)Al-Azhar University Chemistry Department Faculty of ScienceAl-Azhar University Photochemistry Department National Research CenterEl-DokkiGizaEgypt

2-Aminocyclopenta[d]pyrimidines 3a-c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride （1：2：1 molar ratio）. Also, cyclization of 2,5-bis-（arylmethylidene）cyclopentanones 2 with guanidine hydrochloride （1：1 molar ratio） in methanol in the presence of sodium methoxide afforded cyclopenta-[d]pyrimidines 3. Compound 3c has been shown to be a useful building block for the synthesis of some novel pyrimido[ 1,2-a]pyrimidines 5, 7 and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data,

关键词： Multicomponent reaction Cyclopenta[d]pyrimidine Pyrimido[1 2-a]pyrimidine Cyclopentanone

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Molecular underpinnings of corneal angiogenesis:advances over the past decade

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 768-779页

作者： Nizar Saleh Abdelfattah mohamed Amgad Amira A.Zayed heba Hussein Nawal AbdEl-Baky Doheny Image Reading Center Doheny Eye Institute Faculty of Medicine Cairo University Department of Oncology Mayo ClinicRochester Faculty of Oral and Dental Medicine Cairo University Antibody Laboratory Protein Research DepartmentGenetic Engineering and Biotechnology Research InstituteCity for Scientific Research and Technology Applications

The cornea is maintained in an avascular state by maintaining an environment whereby anti-angiogenic factors take the upper hand over factors promoting angiogenesis. Many of the common pathologies affecting the cornea involve the disruption of such equilibrium and the shift towards new vessel formation, leading to corneal opacity and eventually-vision loss. Therefore it is of paramount importance that the molecular underpinnings of corneal neovascularization（CNV） be clearly understood, in order to develop better targeted treatments. This article is a review of the literature on the recent discoveries regarding pro-angiogenic factors of the cornea（such as vascular endothelial growth factors,fibroblast growth factor and matrix metalloproteinases）and anti-angiogenic factors of the cornea（such as endostatins and neostatins）. Further, we review the molecular underpinnings of lymphangiogenesis, a process now known to be almost separate from（yet related to） hemangiogenesis.

关键词： cornea neovascularization angiogenesis lymphangiogenesis vascular endothelial growth factor

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Vascular endothelial growth factor before and after locoregional treatment and its relation to treatment response in hepatocelluar carcinoma patients

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 1005-1009页

作者： heba Sedrak Noaman El-garem Mervat Naguib heba El-Zawahry mohamed Esmat Lila Rashed Department of Internal Medicine Faculty of Medicine Cairo University Department of Medical Oncology National Cancer Institute Cairo University Department of Medical Biochemistry Faculty of Medicine Cairo University

Objective:To evaluate vascular endothelial growth factor(VEgF)levels in hepatocellular carcinoma patients before and after transcatheter arterial chemoembolization(TACE)and percutaneous ethanol injection(PEI)and its relation to treatment ***:A total of 40 patients with unrespectable hepatocelluar carcinoma were assessed *** patients were suitable to be treated by TACE,while other 20patients were treated with *** VEgF levels were measured before and 1 month after each procedure by *** was assessed after 1 month according to Union Internationale Contre le Cancer evaluation criteria based on change in tumor size as measured by ***:There was no significant difference between TACE and PEI groups with regard to age,sex,tumor size,response to local therapy,or VEgF and alpha-fetoprotein before and after *** levels after TACE were significantly higher than before TACE[(298.1±123.6)pg/m L vs.(205.8±307.3)pg/m L;P=0.001].Also,VEgF levels were significantly higher after PEI than before PEI[(333.8±365.6)pg/m L vs.(245.3±301.8)pg/m L;P=0.000].Non-responders of both groups had significantly high VEgF levels than responder's,both before[(985.0±113.2)pg/m L vs.(117.1±75.3)pg/m L;Pg/m L vs.(171.0±94.7)pg/m L;P=0.000)].Conclusions:Both TACE and PEI were associated with an increase in serum VEgF in hepatocelluar carcinoma *** levels of VEgF before and after therapy were found in non-responders,suggesting that VEgF is a useful marker in predicting treatment response.

关键词： Hepatocelluar carcinoma Vascular endothelial growt

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Towards hepatitis C virus elimination:Egyptian experience,achievements and limitations

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World Journal of gastroenterology 2018年第38期24卷 4330-4340页

作者： Dalia Omran mohamed Alboraie Rania A Zayed mohamed-Naguib Wifi Mervat Naguib mohamed Eltabbakh mohamed Abdellah Ahmed Fouad Sherief Sahar Maklad heba Hamdy Eldemellawy Omar Khalid Saad Doaa mohamed Khamiss mohamed El Kassas Department of Endemic Medicine and Hepatology Faculty of MedicineCairo UniversityCairo 11651Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11599Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11651Egypt Department of Clinical and Chemical Pathology Faculty of MedicineCairo UniversityCairo 11651Egypt Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11599Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11566Egypt National Hepatology and Tropical Medicine Research Institute Cairo 11599Egypt Department of Internal Medicine Faculty of MedicineBeni-Suef UniversityBeni-Suef 62511Egypt Faculty of Medicine Ain Shams UniversityCairo 11566Egypt Department of Clinical and Chemical Pathology El-monera hospitalMinistry of HealthCairo 11562Egypt

Worldwide, more than one million people die each year from hepatitis C virus(HCV) related diseases, and over 300 million people are chronically infected with hepatitis B or C. Egypt used to be on the top of the countries with heavy HCV burden. Some countries are making advances in elimination of HCV, yet multiple factors preventing progress; remain for the majority. These factors include lack of global funding sources for treatment, late diagnosis, poor data, and inadequate screening. Treatment of HCV in Egypt has become one of the top national priorities since 2007. Egypt started a national treatment program intending to provide cure for Egyptian HCV-infected patients. Mass HCV treatment program had started using Pegylated interferon and ribavirin between 2007 and 2014. Yet, with the development of highly-effective direct acting antivirals(DAAs) for HCV, elimination of viral hepatitis has become a real possibility. The Egyptian National Committee for the Control of Viral Hepatitis did its best to provide Egyptian HCV patients with DAAs. Egypt adopted a strategy that represents a model of care that could help other countries with high HCV prevalence rate in their battle against HCV. This review covers the effects of HCV management in Egyptian real life settings and the outcome of different treatment protocols. Also, it deals with the current and future strategies for HCV prevention and screening as well as the challenges facing HCV elimination and the prospect of future eradication of HCV.

关键词： Hepatitis C virus Egypt Direct acting antivirals screening elimination Limitations

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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2022年第1期11卷 165-176页

作者： Amro Abdelazez heba Abdelmotaal Smith Etareri Evivie Maha Bikheet Rokayya Sami Hassan mohamed Xiangchen Meng Key Laboratory of Dairy Science Ministry of EducationCollege of Food SciencesNortheast Agricultural UniversityHarbin 150030China College of Agriculture and Forestry Linyi UniversityLinyi 276005China Department of Dairy Microbiology Animal Production Research InstituteAgriculture Research CentreDokkiGiza 12618Egypt Department ofMicrobiology SoilWaterEnvironmentand Microbiology Research InstituteAgriculture Research CentreGiza 12619Egypt Department of Food Science&Hunan Nutrition Faculty of AgricultureUniversity of BeninBenin City 300001Nigeria Department of Dairy Science Faculty of AgricultureMinia UniversityMinia 61511Egypt Department of Food Science and Nutrition College of SciencesTaif UniversityP.O.11099Taif21944Saudi Arabia Colin Ratledge Center for Microbial Lipids School of Agriculture Engineering and Food ScienceShandong University of TechnologyZibo 255049China Department of Botany and Microbiology Faculty of ScienceAl-Azhar UniversityAssiut 71524Egypt

The therapeutic effect of gamma-aminobutyric acid(gABA)on diabetes was spread as one of the alarming epidemics *** study aims to investigate the function of Lactobacillus brevis KLDS_(1.0727) and KLDS_(1.0373) strains as glutamic acid decarboxylase 65(gAD65)carriers capable of generating gABA by comparing in vitro free and freeze-dried models and gABA intervention in *** amplification of gad and in vitro i.e.,(growth rate,viability at different pH,bile tolerance,and survivability in simulated gastric juice)were *** vivo experiments were conducted in 7 groups of C57BL/6J *** group was injected with streptozotocin(Cont_(STZ),INSSTZ,LAC1_(STZ),LAC_(1MFDSTZ),LAC_(2STZ),LAC_(2MFDSTZ))daily except for the control(Cont).One group was injected with insulin(INSSTZ).The body weight and hyperglycemia in the blood were assessed weekly,post-euthanasia blood plasma parameters,insulin,and histological examination were *** indicated *** strains demonstrated a great tolerance to bile and simulated gastric juice in vitro(Pghest average glucose level(6.84±6.46)mmol/L while INS_(STZ) expressed dramatically decreed in glucose level and displayed a significant decline in the average of weekly blood glucose(−5.74±3.08)mmol/*** lowest body weight(ContSTZ)was(19.30±0.25)*** on the blood plasma analysis,*** strains improved good cholesterol properties,liver and kidney functions,where most of these parameters fall within the average the reference range and prevent the development of symptoms of type 1 diabetes in *** recommended,*** should be commonly distributed as a postbiotic gABA in pharmaceutical and nutritional applications.

关键词： Diabetes gamma-aminobutyric acid Postbiotics Lactobacillus brevis In vitro C57BL/6J mice

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