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妊娠梅毒的抗梅治疗及转归

中国性科学 2009年第12期18卷 7-10页

作者：朴珉贞郑占才王家璧北京中日友好医院皮肤性病科北京100029 北京协和医院皮肤科北京100730

近年来妊娠梅毒发病率有逐年增加趋势,临床主要表现为潜伏梅毒,未经有效治疗的妊娠梅毒对胎儿有严重的影响,抗梅治疗可显著改善妊娠结局。因此婚前、孕前、孕期梅毒血清学筛查相当重要,早发现、早治疗,可以大大降低先天梅毒的发生率。

关键词：梅毒妊娠梅毒抗梅治疗

Effects of the Diameter and Alignment of Electrospun TSF Nanofibers on Neuronal Differentiation of Human Embryonic Stem Cells

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Effects of the Diameter and Alignment of Electrospun TSF Nan...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Rong Ye,Junxia Wang,Jing Qu,Huihui Wang,Xiaojing Xu,Huanxiang Zhang Medical College of Soochow University,Department of Cell Biology,Jiangsu Province Key Laboratory of Stem Cell Research,Ren Ai Road 199,Suzhou Industrial park,Suzhou 215123,China

While much effort has been devoted to the delineation of materials that are suitable for neuronal differentiation of human embryonic stem cells(hESCs),how material topographical features,especially the nanofiber diameter and alignment, influence the growth and neuronal differentiation of hESCs,however,is still *** the present study,we seeded hESCs-derived neural precursors on random or aligned tussah silk fibroin(TSF) electrospun nanofibers with diameters of 400 nm and 800 nm and found that the diameter and alignment of TSF scaffolds significantly influence the growth and differentiation of hESCs-derived neural *** results show that hESCs-derived neurons display good compatibility with TSF scaffolds:TSF nanofibers not only support the growth the hESCs,but guide the growth and migration of these cells and the neurite outgrowth of hESCs-derived neurons as ***,compared with cells on 800 nm aligned TSF fibers, hESCs on 400 nm aligned TSF show greater neuronal differentiation efficiency and hESCs-derived neurons on these fibers possess longer neurite ***,the property of the electrospun TSF nanofibers that can guide and direct hESC migration and differentiation,with a diameter of 400 nm in particular,makes these materials the promising candidates in nerve tissue engineering for therapeutic approaches to promote the regeneration of CNS after injury.

关键词： Human embryonic stem cells TSF nanofibers Neuronal differentiation Neurite outgrowth Tissue engineering

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一般人群中腹型肥胖和新发心房颤动的关系

中华高血压杂志 2017年第9期25卷 830-830页

作者：刘莉叶鹏 Baek YS Yang PS Kim TH Uhm JS park J Pak HN Lee MH Joung B

已知身高越高,体质量越大,心房颤动发生风险越高。然而,心房颤动的风险是否与腹型肥胖有关尚不清楚。Baek等纳入韩国国民健康保险计划全国样本队列中基线无心房颤动的成人501 690人,年龄（47.6±14.3）岁,女性250 664人,占50%。测定其... 详细信息

已知身高越高,体质量越大,心房颤动发生风险越高。然而,心房颤动的风险是否与腹型肥胖有关尚不清楚。Baek等纳入韩国国民健康保险计划全国样本队列中基线无心房颤动的成人501 690人,年龄（47.6±14.3）岁,女性250 664人,占50%。测定其体质量指数（body mass index,BMI）和腰围,将BMI〈18．5kg／m2定义为低体质量，18．5～〈25．0kg／m2定义为正常体质量；25．0～〈30．0kg／m2定义为超重；≥30．0kg／m2定义为肥胖；将腰围≥90（男性）和≥80cm（女性）定义为腹型肥胖。

关键词：心房颤动腹型肥胖体质量保险计划国民健康基线队列腰围样本 body

ADVANCES IN THE MODEL OF CYLINDRICAL ALKALINE CELLS

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电池工业 2002年第5期7卷 241-242页

作者： CHEH Huk-yuk 1 ,Samuel Ruben-Peter G. 2 (1.Duracell Global Business Managem ent Group,Berkshire Corporate park,Bethel,C T 06801USA,2.Departement of Chemical Engineering and Applied Chemistry Cloumbia University,New York,NY 10027USA) Duracell Global Business Management Group Berkshire Corporate ParkBethelCT 06801 USA Departement of Chemical Engineering and Applied Chemistry Cloumbia University New YorkNY 10027 USA

The advancement of a systematic inve stigation on the modeling of cylindr ical alkaline cells is *** analysis utilizes t hermodynamic and kinetic informati on to predict alkaline cell performa nce under low discharge *** modling has taken into consideration detailed information on the chemistry of electrode reactions,mass tranport of dissolved species,p hysical and chemical properties of t he electrolyte and solid phases,and in ternal geonetry of cell *** model is capable of predicting alkaline cell performance under a variety of dicharge *** model also p rovides information regarding inte rnal cell changes during *** model is the basis of a rational approach for the optimal design of cells.

关键词：圆柱型碱性电池多孔电极模型放电性能

叶酸受体阳性肿瘤靶向显像剂同型99Tcm和188Re标记的叶酸-甘氨酸-甘氨酸-半胱氨酸-谷氨酸的临床前研究

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中华核医学与分子影像杂志 2017年第7期37卷 444-444页

作者：唐军 Woo Hyoung Kim Chang Guhn Kim Myoung Hyoun Kim Dae-Weung Kim Cho Rong park Ji Yong park Yun-Sang Lee Hyewon Youn Keon Wook Kang Jae Min Jeong June-Key Chung 苏州大学附属第二医院核医学科 Department of Nuclear Medicine Seoul National University Hospital Department of Nuclear Medicine Institute of Wonkwang Medical ScienceWonkwang University School of Medicine

目的制备同型的~(（99）Tcm和~(（188）Re标记的叶酸-甘氨酸-甘氨酸-半胱氨酸-谷氨酸（叶酸-GGCE）,并通过小鼠肿瘤模型评价其用于叶酸受体（FR）靶向分子显像的可行性。方法采用固相肽合成法合成叶酸-GGCE,并用99Tcm或188Re标记。放化... 详细信息

目的制备同型的~(（99）Tcm和~(（188）Re标记的叶酸-甘氨酸-甘氨酸-半胱氨酸-谷氨酸（叶酸-GGCE）,并通过小鼠肿瘤模型评价其用于叶酸受体（FR）靶向分子显像的可行性。方法采用固相肽合成法合成叶酸-GGCE,并用99Tcm或188Re标记。放化纯测定采用放射性高效液相色谱法。99Tcm-叶酸-GGCE的生物分布研究在同时注射或不注射过量的游离叶酸的情况下完成,小鼠肿瘤模型分别为荷FR阳性的KB细胞模型和荷FR阴性的HT1080细胞模型。188Re-叶酸-GGCE的生物分布研究在荷KB细胞小鼠肿瘤模型上完成。静脉注射99Tcm-叶酸-GGCE后,采集2种小鼠肿瘤模型的系列平面图像。小鼠肿瘤模型注射99Tcm-叶酸-GGCE或188Re-叶酸-GGCE（同时注射或不注射过量的游离叶酸）后,进行系列microSPECT/CT图像采集。结果99Tcm和188Re标记的叶酸-GGCE的标记率和标记后4 h内的放化纯均>95%。荷KB细胞模型在注射99Tcm-叶酸-GGCE后1、2、4 h,其肿瘤组织的放射性摄取值分别为16.4、23.2和17.6%ID/g,如果同时注射过量的叶酸,肿瘤组织的摄取可被抑制97.4%。注射后4 h,肿瘤与血液、肝、肺、肌肉和肾的T/NT比值分别是54.3、25.2、38.3、97.8和0.3。荷KB细胞模型在注射188Re-叶酸-GGCE后2、4、8、16 h,其肿瘤组织的放射性摄取值分别为17.4、21.7、24.1和15.6%ID/g。注射后8 h,肿瘤与血液、肝、肺、肌肉和肾的T/NT比值分别是126.8、21.9、54.8、80.3和0.4。注射99Tcm或188Re标记的叶酸-GGCE后,系列平面图像和microSPECT/CT图像均见KB细胞肿瘤组织的放射性摄取较高,肿瘤显像清晰。肿瘤对显像剂的摄取在同时注射过量叶酸时可被完全抑制。结论同型99Tcm和188Re标记的叶酸-GGCE可被FR阳性肿瘤高摄取,且T/NT比值较高。2种显像剂均具有良好的靶向能力,在FR阳性肿瘤的诊断和疗效观察中有一定的应用价值。

关键词：叶酸受体肿瘤 99Tcm 188Re SPECT/CT

心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析

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中华高血压杂志 2018年第6期26卷 566-566页

作者：刘青叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA park JE Guan M Chan S Humphries KH

收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验（systolic blood pressure intervention trial,SPRINT）的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的... 详细信息

收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验（systolic blood pressure intervention trial,SPRINT）的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。

关键词：非心脏病患者舒张压低干预试验收缩压试验结果分析心血管事件心血管病患者

Erratum to： Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

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Nano Research 2017年第3期10卷 I0002-I0002页

作者： Geonwook Yoo Heekyeong park Minjung Kim Won Geun Song Seokhwan Jeong Min Hyung Kim Hyungbeen Lee Sang Woo Lee Young Ki Hong Min Goo Lee Sungho Lee Sunkook Kim School of Electronic Engineering Soongsil University Seou106978 Republic of Korea School of Advanced Materials Science & Engineering Sungkyunkwan University Suwon 16419 Republic of Korea Department of Biomedical Engineering Yonsei University Wonju 26493 Republic of Korea Korea Electronics Technology Institute Gyeonggi 13488 Republic of Korea

The second affiliation of the authors in the original version of this article was unfortunately wrongly written on the first page, instead of Multi-Functional Nano/Bio Electronics Lab., Kyung Hee University, Gyeonggi ...

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Flash Lamp Annealing Method for Improving Adhesion Strength on the Dielectric Material and Reducing Substrate Warpage

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材料科学与工程（中英文B版） 2019年第3期9卷 113-121页

作者： Jong-Young park Byeong-Jae Choi Young-Jae Kim Hideo Honma Joo-Hyong Noh Department of Materials and Surface Engineering Graduate School of EngineeringKanto Gakuin University1162-2 OgikuboOdawara 250-0042Japan Materials and Surface Engineering Research Institute Kanto Gakuin University1162-2 OgikuboOdawara 250-0042Japan Daeduck Electronics Co.Ltd. 335Somanggongwon-roSiheung-siGyeonggi-do 15106Korea

Today’s electronic devices have required higher performance properties for 5G and artificial intelligence(AI).High-performance system on chip(SOC),graphic processing unit(GPU),and central processing unit(CPU)requires advanced packages to meet demands for performance,size,and high-speed *** respond to these demands,integration approaches such as 3D IC chip stacking,package on package(PoP),2.5D interposer integration,system-in-package(SiP),and fan-out packaging technologies have emerged[6,8,11,12].Therefore,the package substrate for high-performance device will require low transmission loss and the small package *** loss materials have limitation of seed layer formation with electroless Cu ***,heat treatment has major impact on substrate warpage in order for growth of plated Cu metal and curing for epoxy mold compound(EMC)*** this paper,we believe it is possible to create a seed layer on the low-loss material by combining electroless Cu plating and flash lamp annealing(FLA)method instead of sputtering *** terms of warpage control and metal growth,the flash lamp treatment,not the conventional convection or hot plate type heat treatment,could improve electro-migration between metal line and line through improving large number of(111)slip *** addition,flash lamp not only provides alternative to conventional heat treatment process but also significantly reduces substrate *** result of this study,by using FLA method for advanced package,it is possible to provide solutions in improving adhesion strength between dielectric materials and deposited metal film,and to reduce the warpage of the substrate.

关键词： High performance device advanced package low-loss dielectric material warpage control,FLA

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基于焊缝增强接头技术的模型参数

钢结构(中英文) 2008年第5期 69-69页

作者： Sooyong park Sanghyun Choi Norris Stubbs Robert Bolton Angie H. Price Charles Sikorsky

基于整体无损伤评估方法,采用模型参数,定量评估了建设过程中焊缝增强接头技术的可行性。根据钢的屈服强度和焊缝中有效刚度的变化,改进了预测焊缝强度的表达式。通过模型参数的变化和系统识别技术,在27个焊缝区域,进行了局部刚度变化... 详细信息

基于整体无损伤评估方法,采用模型参数,定量评估了建设过程中焊缝增强接头技术的可行性。根据钢的屈服强度和焊缝中有效刚度的变化,改进了预测焊缝强度的表达式。通过模型参数的变化和系统识别技术,在27个焊缝区域,进行了局部刚度变化的无损测量试验。为了比较,传统的无损监测(NDT)方法、射线探伤以及破坏张拉试验均被用以评估无损强度预测程序的精度,从强度破坏模型和无损测量刚度变化焊接系统中所得到的预测强度与从破坏张拉试验中得到的结果也进行了比较。同时对该方法的适用范围进行了研究。

关键词：无损评估焊接模型参数强度预测