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Observation of a single protein by ultrafast X-ray diffraction

Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer he.ry n.chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.n.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PnSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to the.ry,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

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销售培训必读 3版

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丛书名：课里播企业培训课程.营销实务学习方案

2001年

作者：（美）Elwood n.chapman 信春霞译

中美合金:本书介绍销售的基本知识，内容包括：态度与销售的成功、怎样销售、重新出发三大部分。

ISBN: (纸本)7810495739

中美合金:本书介绍销售的基本知识，内容包括：态度与销售的成功、怎样销售、重新出发三大部分。

关键词：销售学科:方法

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职业生涯发现方案

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丛书名：课里播企业培训课程.职业生涯学习方案

2002年

作者：（美）Elwood n.chapman 韩经纶曾辉译

中美合金:本书是一本帮助人们发现职业生涯的指导手册，书中揭示了对职业生涯搜寻起决定作用的因素，并依此制定出一套易于操作的完全行动方案。

ISBN: (纸本)731001796X

中美合金:本书是一本帮助人们发现职业生涯的指导手册，书中揭示了对职业生涯搜寻起决定作用的因素，并依此制定出一套易于操作的完全行动方案。

关键词：职业选择

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赢得工作

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丛书名：课里播企业培训课程.职业生涯学习方案

2002年

作者：（美）Elwood n.chapman 韩经纶王玎译

中美合金:本书旨在于帮助读者确立一套适合自身特点和需要的求职战略和战术。作者从态度、电话技巧、简历准备、面试准备、提升技能和创造自己的工作等12个方面分析了求职过程中的一些关键性问题。

ISBN: (纸本)7310018001

关键词：职业选择

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万千瓦级燃煤磁流体/蒸汽联合循环中试电站系统分析

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东南大学学报（自然科学版） 1992年第3期22卷 54-61页

作者：蔡宁生徐益谦沙次文 Jamcs n.chapman 热能工程研究所中国科学院电工研究所美国田纳西大学空间研究所

本文对万千瓦级燃煤磁流体/蒸汽联合循环中试电站进行了系统分析,给出了对北京第三热电厂的一台12MW_e,两台12MW。并置或一台50MW_e汽轮发电机组采取磁流体发电改建的系统性能.另对其中2×12MW。机组磁流体发电改建方案进行了参数分析,... 详细信息

本文对万千瓦级燃煤磁流体/蒸汽联合循环中试电站进行了系统分析,给出了对北京第三热电厂的一台12MW_e,两台12MW。并置或一台50MW_e汽轮发电机组采取磁流体发电改建的系统性能.另对其中2×12MW。机组磁流体发电改建方案进行了参数分析,由此得出最佳系统设计参数.

关键词：燃煤磁流体联合循环发电

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Dose-efficient scanning Compton X-ray microscopy

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Light(Science & Applications) 2023年第6期12卷 1141-1152页

作者： Tang Li JLukas Dresselhaus nikolay Ivanov Mauro Prasciolu Holger Fleckenstein Oleksandr Yefanov Wenhui Zhang David Pennicard Ann-Christin Dippel Olof Gutowski Pablo Villanueva-Perez he.ry n.chapman Saša Bajt The Hamburg Centre for Ultrafast Imaging 22761 HamburgGermany Center for Free-Electron Laser Science CFEL Deutsches ElektronenSynchrotron DESY22607 HamburgGermany Deutsches Elektronen Synchrotron DESY 22607 HamburgGermany Synchrotron Radiation Research and nanoLund Lund University22100 LundSweden Department of Physics Universität Hamburg22761 HamburgGermany

The highest resolution of images of soft matter and biological materials is ultimately limited by modification of the structure,induced by the necessarily high energy of short-wavelength *** the inelastically scattered X-rays at a photon energy of 60 keV(0.02 nm wavelength)offers greater signal per energy transferred to the sample than coherent-scattering techniques such as phase-contrast microscopy and projection *** present images of dried,unstained,and unfixed biological objects obtained by scanning Compton X-ray microscopy,at a resolution of about 70 *** microscope was realised using novel wedged multilayer Laue lenses that were fabricated to sub-ångström precision,a new wavefront measurement scheme for hard X rays,and efficient pixel-array *** doses required to form these images were as little as 0.02%of the tolerable dose and 0.05%of that needed for phase-contrast imaging at similar resolution using 17 keV photon *** images obtained provide a quantitative map of the projected mass density in the sample,as confirmed by imaging a silicon *** on these results,we find that it should be possible to obtain radiation damage-free images of biological samples at a resolution below 10 nm.

关键词： wedge dried scattered

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BIM for the Underground-An enabler of trenchless construction

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Underground Space 2020年第4期5卷 354-361页

作者： David chapman Stylianos Providakis Christopher Rogers Department of Civil Engineering University of BirminghamBirmingham B152TTUK

The subsurface space in urban areas is an important ***,the information available on this environment is relatively poor compared to above ground *** paper proposes a Building Information Model(BIM)for underground applications as means to address this information *** creation and progressive update of BIM for a constructed artefact ensures that data on the structures is available and can be used throughout its lifetime.A BIM for underground applications integrates data on surface structures,such as buildings,and subsurface infrastructures,such as pipes,along with details of the surrounding ground,the associated soil and rock properties and groundwater regime into a single *** approach is demonstrated by applying it to trenchless construction operations,including a microtunnelling project for a new *** data from this extended BIM concept can be interactively used with analysis packages to conduct risk assessments for new construction *** also shows how BIM for the Underground can be used throughout the planning,construction and post-construction stages of a project,and,importantly,how this information can be available for future projects.

关键词： Trenchless BIM Underground Pipe jacking Microtunnelling Horizontal directional drilling

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Erratum to “A gyroscope-based system for intraoperative measurement of tibia coronal plane alignment in total knee arthroplasty” [Med nov Technol Dev, 13, 2022, 100112]

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Medicine in novel Technology and Devices 2024年第1期21卷 120-120页

作者： Michael A.Kokko ryan M.chapman Martin W.Roche Douglas W.Van Citters Thayer School of Engineering at Dartmouth College 14 Engineering DriveHanoverNH03755USA Department of Kinesiology College of Health SciencesUniversity of Rhode Island25 W.Independence WayKingstonRI02881USA Orthopedic Research Institute Holy Cross Hospital 4725 N Federal Hwy.FtLauderdaleFL33308USA

The publisher would like to include the Ethical approval and informed consent statement for this *** study did not involve human subjects or animal research,and was therefore not subject to institutional ethics approval and did not require informed *** single cadaveric specimen used in ex vivo evaluation was obtained from Science Care(https://***/)and was handled in accordance with applicable Science Care policy.

关键词： approval statement alignment

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A universal strategy for the creation of machine learning-based atomistic force fields

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npj Computational Materials 2017年第1期3卷 146-153页

作者： Tran Doan Huan Rohit Batra James chapman Sridevi Krishnan Lihua Chen Rampi Ramprasad Department of Materials Science&Engineering and Institute of Materials Science University of Connecticut97 North Eagleville Rd.Unit 3136StorrsCT 06269-3136USA

Emerging machine learning(ML)-based approaches provide powerful and novel tools to study a variety of physical and chemical *** this contribution,we outline a universal strategy to create ML-based atomistic force fields,which can be used to perform high-fidelity molecular dynamics *** scheme involves(1)preparing a big reference dataset of atomic environments and forces with sufficiently low noise,e.g.,using density functional the.ry or higher-level methods,(2)utilizing a generalizable class of structural fingerprints for representing atomic environments,(3)optimally selecting diverse and nonredundant training datasets from the reference data,and(4)proposing various learning approaches to predict atomic forces directly(and rapidly)from atomic *** the atomistic forces,accurate potential energies can then be obtained by appropriate integration along a reaction coordinate or along a molecular dynamics *** on this strategy,we have created model ML force fields for six elemental bulk solids,including Al,Cu,Ti,W,Si,and C,and show that all of them can reach chemical *** proposed procedure is general and universal,in that it can potentially be used to generate ML force fields for any material using the same unified workflow with little human ***,the force fields can be systematically improved by adding new training data progressively to represent atomic environments not encountered previously.

关键词： utilizing preparing selecting

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沿海城市的城市韧性:胡志明市和东南亚其他新兴城市的挑战和机遇

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城市规划学刊 2018年第1期 125-126页

作者： DUY P n.chapman L TIGHT M

洪涝已经成为当前很多城市日益频繁的灾害事件,并不时占据新闻头条。根据不完全统计,1908-2009年间,洪水造成了全球539811人死亡并影响了超过28亿人的生活。极端气候灾难可能造成长期损失,而小型洪水也可能对城市活动带来显著影响。应... 详细信息

洪涝已经成为当前很多城市日益频繁的灾害事件,并不时占据新闻头条。根据不完全统计,1908-2009年间,洪水造成了全球539811人死亡并影响了超过28亿人的生活。极端气候灾难可能造成长期损失,而小型洪水也可能对城市活动带来显著影响。应对减缓洪水的标准化措施是建设包括海堤、河堤、水坝和堤岸系统在内的防洪设施,但防洪标准通常受限于某一重现期的设计洪水位(如抵御百年一遇的洪水)。防洪设施的设计与建设显

关键词：沿海城市胡志明市东南亚

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