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Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer

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World Journal of Clinical Oncology 2024年第11期15卷 1412-1427页

作者： Hui Li he-qing huang Zhi-Guang huang Rong-Quan he Ye-Ying Fang Rui Song Jia-Yuan Luo Da-Tong Zeng Kai Qin Dan-Ming Wei Gang Chen Department of Colorectal and Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Colorectal cancer(CRC)causes many deaths *** binding cytoplasmic RNA interacting protein(SYNCRIP)is an RNA-binding protein that plays an important role in multiple cancers by epigenetically targeting some *** study will examine the expression,potential effect,biological function and clinical value of SYNCRIP in *** To examine the expression,potential effect,biological function and clinical value METHODS The expression of SYNCRIP was examined by immunohistochemistry arrays and high-throughput *** effect of SYNCRIP gene in CRC cell growth was evaluated by CRISPR-Cas9 *** target genes of SYNCRIP were calculated using various algorithms,and the molecular mechanism of SYNCRIP in CRC was explored by mutation analysis and pathway *** clinical value of SYNCRIP in prognosis and radiotherapy was revealed via evidence-based medicine *** The protein and mRNA levels of SYNCRIP were both highly expressed in CRC samples compared to nontumorous tissue based on 330 immunohistochemistry arrays and 3640 CRC *** grew more slowly in eleven CRC cell lines after knocking out the SYNCRIP *** could epigenetically target genes to promote the occurrence and development of CRC by boosting the cell cycle and affecting the tumor *** addition,CRC patients with high SYNCRIP expression are more sensitive to *** SYNCRIP is upregulated in CRC,and highly expressed SYNCRIP can accelerate CRC cell division by exerting its epigenetic regulatory *** addition,SYNCRIP is expected to become a potential biomarker to predict the effect of radiotherapy.

关键词： Synaptotagmin binding cytoplasmic RNA interacting protein Colorectal cancer Radiotherapy Cell mitosis Immune microenvironment

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STUDIES ON CARBOHYDRATES *** STEREOSELECTIVE SYNTheSIS OF 1-O-α-ACYL-D-MANNOPYRANOSE FROM The CORRESPONDING MANNOSYL TRIMETHYLSILYL ETheR

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Chinese Chemical Letters 1995年第4期6卷 275-278页

作者： he qing huang Zhong Jun LI Meng Shen CAI School of Pharmaceutical Sciences Beijing Medical UniversityBeijing 100083

In the presence of ***2, 1-O-trimethylsilyi-2,3,4,6-tetra-O-benzyl-α-D-mannopyranose (1)reacted stereoselectively with a series of carboxylic acids to give the corresponding α-mannosyl carboxylates in good yields. T... 详细信息

关键词： t?

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Gender of large river deltas and parasitizing rivers

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International Journal of Sediment Research 2012年第1期27卷 18-36页

作者： Zhao-yin WANG Guo-an YU he qing huang Rui-yu WANG State Key Laboratory of Hydro-Science and Engineering Tsinghua University University of Illinois at Champain and Urbana Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Chairman of the Advisory Council of UNESCO International Research and Training Center on Erosion and Sedimentation

Deltas are the most dynamic part of large rivers and the characteristics of deltas reflect the basic nature of morphodynamics,ecology and anthropogenic *** authors investigated many deltas of large rivers,including the Yellow,Yangtze,Pearl,Rhine,Nile,Mississippi,Luanhe and Ebro *** were collected and sediment,water,benthic invertebrates and fish were sampled. Statistical analysis showed that deltas can be classified into male deltas and female *** deltas of the Yellow,Mississippi,Luanhe,Ural and Ebro rivers are male *** deltas extend into the ocean,each with only one or two channels,forming a *** development process is accompanied with periodic nodal or random *** deltas develop if the sediment load/water ratio is high and the tidal range is *** deltas of the Yangtze,Rhein-Meuse-Scheldt,Pearl and Irrawaddy rivers are *** deltas consist of complex channel networks and numerous bars and *** deltas develop if the load/water ratio is not high and tidal current is relatively *** deltas provide stable and multiple habitats for various ***,the biodiversity of female deltas and the taxa richness of benthic invertebrates and fish are much higher than that of male *** activities reduced sediment load and change the delta gender from male to *** rivers have high levees in their lower reaches and *** rivers originate from the levees of a male river and flow parallel with the river into the ***, persistence,length and stability of these rivers depend on the male river to which they are attached. Therefore,these rivers are named parasitizing *** general,parasitizing rivers have no tributaries and almost no drainage *** runoff of these rivers comes from the rainfall on the surrounding area,and therefore,the flow discharge exhibits very sharp peaks during *** Yellow and Luanhe rivers have many parasitizing rivers.

关键词： Classification of deltas Male and female rivers Morphology River patterns Parasitizing river Yellow River

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Bed load transport under different streambed conditions-a field experimental study in a mountain stream

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International Journal of Sediment Research 2012年第4期27卷 426-438页

作者： Guo-an YU Zhao-yin WANG he qing huang Huai-xiang LIU Brendon BLUE Kang ZHANG Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences State Key Laboratory of Hydroscience and Engineering Tsinghua University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Nanjing Hydraulic Research Institute School of Environment The University of Auckland Pearl River Hydraulic Research Institute

Bed load transport in mountain streams is closely linked to streambed *** structures are arrangements of boulders and cobbles deposited during extreme floods,in a stable configuration exhibiting high dissipation of *** experiments were carried out in a mountain stream in Yunnan,southwestern China,studying bed load movement on three typical streambeds,i.e.,with well developed,partially developed,and no *** underwater observation and video-capturing system was designed to observe and measure the movement of bed load *** initiation mode, trajectory,velocity,and acceleration of bed load particles under the three conditions were observed and *** showed that the bed load movement was highly associated with streambed *** well-developed structures,bed load particles moved intermittently through saltation and the bed load transport rate was very *** partially-developed structures most bed load particles moved through saltation but a portion of sediment moved in sliding and *** the case with no streambed structure(plane bed) contact load motion(sliding and rolling) gradually became ***,laminated load motion occurred and became the main component of bed load transport when the flow discharge and incoming sediment load were very *** load motion was a special form of bed load motion with an extremely high *** load transport and streambed structure both acted to dissipate flow energy and were mutually *** rates of bed load transport occurred in the streams with no or poor bed structures,and low bed load transport was associated with well developed *** bed load transport rate was inversely correlated to the degree of streambed development.

关键词： Bed load transport Streambed structure Mountain stream Underwater observation and Video capturing system

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A gel polymer electrolyte based on IL@NH_(2)-MIL-53(Al)for high-performance all-solid-state lithium metal batteries

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Chinese Journal of Chemical Engineering 2024年第5期69卷 47-55页

作者： Sijia Wang Ye Liu Liang he Yu Sun qing huang Shoudong Xu Xiangyun Qiu Tao Wei School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China Power&Energy Storage System Research Center College of Mechanical and Electrical EngineeringQingdao UniversityQingdao 266071China

Solid polymer composite electrolytes possess the benefits of superior compatibility with electrodes and good thermal characteristics for more secure energy storage ***,a new gel polymer electrolyte(GPE)containing NH_(2)-MIL-53(Al),[PP_(13)][TFSI],LiTFSI,and PVDF-HFP was prepared using a simple method of solution *** effects of encapsulating different ratios of ionic liquid([PP_(13)][TFSI])into the micropores of functionalized metal-organic frameworks(NH_(2)-MIL-53(Al))on the electrochemical properties were ***,SEM,nitrogen adsorption-desorption isotherms,and electrochemical measurements were *** GPE demonstrates a superior ionic conductivity of 8.08×10^(-4)S·cm^(-1)at 60℃and can sustain a discharge specific capacity of 156.6 mA·h·g^(-1)at 0.2 C for over 100 *** work might offer a potential approach to alleviate the solid-solid contact with the solid-state electrolyte and electrodes and broaden a new window for the creation of all-solid-state batteries.

关键词： Metal-organic frameworks(MOFs) All solid-state lithium batteries(ASSLBs) Ionic liquid NH_(2)-MIL-53(Al) Solid-state electrolytes(SSEs)

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A theory for three-dimensional response of micropolar plates

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1403-1414页

作者： Dianwu huang Linghui he College of Civil Engineering and Architectural Jiaxing UniversityJiaxing 314001Zhejiang ProvinceChina Department of Modern Mechanics and State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar *** ad hoc assumptions regarding through-thickness assumptions of the field variables are made,and the governing equations are two-dimensional,with the displacements and microrotations of the mid-plane as the *** the deformation of the mid-plane is solved,a three-dimensional micropolar elastic field within the plate is generated,which is exact up to the second order except in the boundary region close to the plate *** an illustrative example,the bending of a clamped infinitely long plate caused by a uniformly distributed transverse force is analyzed and discussed in detail.

关键词： micropolar plate transfer-matrix asymptotic expansion three-dimensional response

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Distributed Nash Equilibrium Seeking on Compact Action Sets over Jointly Strongly Connected Switching Networks

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Journal of Systems Science & Complexity 2024年第1期37卷 63-81页

作者： he Xiongnan huang Jie Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China.

This paper studies the distributed Nash equilibrium seeking(DNES)problem for games whose action sets are compact and whose network graph is switching satisfying the jointly strongly connected *** keep the actions of all players in their action sets all the time,one has to resort to the projected gradient-based *** the assumption that the unique Nash equilibrium is the unique equilibrium of the pseudogradient system,an algorithm is proposed that is able to exponentially find the Nash ***,the authors also consider the distributed Nash equilibrium seeking problem for games whose actions are governed by high-order integrator dynamics and belong to some compact *** examples are used to illustrate the proposed approach.

关键词： Compact action sets jointly strongly connected switching graphs Nash equilibrium seeking projected gradient-based algorithm.

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Accurate Shortwave Radiation Simulation with a Two-Layer Aerosol Model in Xinjiang Region

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Journal of Meteorological Research 2024年第1期38卷 69-87页

作者： Guan huang Yonghang CheN Qiong LIU Pengtao WANG Qianshan he qing he Shuai LI Weiling SHAO Ting FAN School of Tourism&Research Institute of Human Geography Xi’an International Studies UniversityXi’an 710128 Center for Silk Road and Eurasian Civilization Studies Xi’an International Studies UniversityXi’an 710128 College of Environmental Science and Engineering Donghua UniversityShanghai 201620 Shanghai Meteorological Service Shanghai 200030 Shanghai Key Laboratory of Meteorology and health Shanghai 200030 Taklimakan Desert Meteorology Field Experiment Station of China Meteorological Administration Institute of Desert MeteorologyUrumqi 830002 Xinjiang Climate Centre Xinjiang Meteorological ServiceUrumqi 830002

To harness the rich solar energy resources in Xinjiang Region of Northwest China,this study tries to address the issue of lack of downward surface shortwave radiation(DSSR)observations and the need to improve the accuracy of satellite retrieval and numerical simulation of DSSR under varied sky and meteorological conditions.(1)A two-layer aerosol model specific to Xinjiang was developed to capture the vertical distributions of aerosols based on multiple data sources including lidar,GPS sounding,ground meteorological observations,and profiles from the ECMWF reanalysis version 5(ERA5)*** results show that the ERA5/PBLH(planetary boundary layer height)and ERA5/ALH(aerosol layer height)could be used to establish the two-layer aerosol model and characterize the vertical distribution of aerosols in Xinjiang Region.(2)Using the Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART)model,a localized inverse model of clear-sky DSSR was *** parameter adjustment and using the optimal combination of input parameters for DSSR simulation together with the two-layer aerosol model,the model-simulated DSSR(DSSRSBD)under clear-sky conditions improved significantly compared to the initial results,with all fitting indices greatly improved.(3)In addition,the study demonstrated that the impact of the two-layer aerosol model on DSSR was more pronounced under dust conditions than clear-sky conditions.(4)Using the localized clear-sky DSSR inversion model and its required parameters,simulations were also conducted to capture the spatiotemporal distribution of DSSR under clear-sky conditions in Xinjiang from 2017 to *** annual average DSSR_(SBD)under clear-sky conditions in Xinjiang during 2017–2019 was 606.78 W m^(-2),while DSSR from CERES(DSSR_(CER))under the same conditions was generally higher(703.95 W m^(-2)).(5)It is found that satellite remote sensing products experienced data loss in high-altitude snow areas,where numerical simulation technology could ser

关键词： downward surface shortwave radiation(DSSR) aerosol vertical distribution Clouds and the Earth’s Radiant Energy System(CERES) Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART) Xinjiang

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Higher-dimensional integrable deformations of the classical Boussinesq-Burgers system

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Communications in Theoretical Physics 2024年第6期76卷 1-12页

作者： Xiaoyu Cheng qing huang School of Mathematics Northwest UniversityXi'an 710127China

In this paper,the(1+1)-dimensional classical Boussinesq-Burgers(CBB)system is extended to a(4+1)-dimensional CBB system by using its conservation laws and the deformation *** Lax integrability,symmetry integrability and a large number of reduced systems of the new higher-dimensional system are ***,for illustration,an exact solution of a(1+1)-dimensional reduced system is constructed from the viewpoint of Lie symmetry analysis and the power series method.

关键词： classical Boussinesq-Burgers system higher-dimensional system deformation algorithm Lax pair conservation law

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Phase regulated suppression and enhancement switches of four-wave mixing and fluorescence

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Frontiers of physics 2014年第2期9卷 153-156页

作者： Zhi-Guo Wang Peng Ying Pei-Ying Li Hua-Yan Lan he-qing huang Hao Tian Jian-Ping Song Yan-Peng Zhang Key Laboratory for Physical Electronics and Devices of the Ministry of Education Shaanxi Key Lab of Information Photonic Technique Xi'an Jiaotong University Xi'an 710049 China

We experimentally study the phase regulated switch between elcctromagnctically induced trans- parency and electromagmetically induced absorption in probe transmission signal and the conver- sion between enhancement and suppression in four-wave mixing and fluorescence signals for the first time. By changing the relative phase, electromagnetically induced transparency can be eonverted into electromagnetically induced absorption. In this process, the conversion from suppression to enhancement is also obtained in four-wave mixing and fluorescence signals. This research can be applied in non-linear optical device like optical switch and optical wavelength convertor.

关键词： four-wave mixing fluorescence phase regulation enhancement and suppression

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