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Chinese Journal of Electronics 2024年第5期33卷 1181-1187页

作者： nan he Lei WANG Yi TONG College of Electronic and Optical Engineering College of Flexible Electronics (Future Technology) and College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications Gusu Laboratory of Materials

Three-atoms-type V2C MXene, an emerging class of transition metal carbides, has attracted tremendous attention in the fabrication of advanced memristive devices due to its excellent electrochemical properties. However,the inserted effects and corresponding physical mechanisms of inserting V2C on traditional TiO2-based memristors have not been clearly explored. In this work, exhaustive electrical characterizations of the V2C/TiO2-based devices exhibit enhanced performance（e.g., improved switching stability and lower operating voltages） compared to the TiO2-based counterparts. In addition, the advantaged influences of the inserted V2C have also been studied by means of first-principles calculations, confirming that V2C MXene enables controllable internal ionic process and facilitated formation mechanism of the Ag conductive filaments. This work demonstrates a way to combine experimental and theoretical investigations to reveal the positive effects of introducing V2C MXene on memristor, which is beneficial for fabricating performance-enhanced memristors.

关键词： Performance evaluation Fabrication Memristors Process control Metals Switches Stability analysis Memristor V2C MXene First-principles calculation Switching stability Formation mechanism

Ionization Engineering of Hydrogels Enables Highly Efficient Salt‑Impeded Solar Evaporation and Night‑Time Electricity Harvesting

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nano-Micro Letters 2024年第1期16卷 131-146页

作者： nan he Haonan Wang Haotian Zhang Bo Jiang Dawei Tang Lin Li School of Energy and Power Engineering Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of EducationDalian University of TechnologyDalian 116024People’s Republic of China

Interfacial solar evaporation holds immense potential for brine desalination with low carbon footprints and high energy ***,as a tunable material platform from the molecular level to the macroscopic scale,have been considered the most promising candidate for solar ***,the simultaneous achievement of high evaporation efficiency and satisfactory tolerance to salt ions in brine remains a challenging scientific bottleneck,restricting the widespread ***,we report ionization engineering,which endows polymer chains of hydrogels with electronegativity for impeding salt ions and activating water molecules,fundamentally overcoming the hydrogel salt-impeded challenge and dramatically expediting water evaporating in *** sodium dodecyl benzene sulfonate-modified carbon black is chosen as the solar *** hydrogel reaches a ground-breaking evaporation rate of 2.9 kg m−2 h−1 in 20 wt%brine with 95.6%efficiency under one sun irradiation,surpassing most of the reported *** notably,such a hydrogel-based evaporator enables extracting clean water from oversaturated salt solutions and maintains durability under different high-strength deformation or a 15-day continuous ***,on the basis of the cation selectivity induced by the electronegativity,we first propose an all-day system that evaporates during the day and generates salinity-gradient electricity using waste-evaporated brine at night,anticipating pioneer a new opportunity for all-day resource-generating systems in fields of freshwater and electricity.

关键词： Solar evaporation Hydrogel evaporators Salt impeding Ionization engineering Cyclic vapor-electricity generation

Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： GAO Chen-yan QIN Gao-feng ZheNG Ming-cui TIAN Mei-jing he Yan-nan WANG Peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(Phe expressions of SYP and PSD95 in the BG were higher than those in the MG(Phe BG was higher than that in the MG(Phe intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(Phe MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(Phe levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

Identification of an Aux/IAA regulator for flesh firmness using combined GWAS and bulked segregant RNA-Seq analysis in watermelon

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Horticultural Plant Journal 2024年第5期10卷 1198-1213页

作者： Muhammad Anees Hongju Zhu Muhammad Jawad Umer Chengsheng Gong Pingli Yuan Xuqiang Lu nan he Mohamed Omar Kaseb Dongdong Yang Yong Zhao Wenge Liu henan Joint International Research Laboratory of South Asian Fruits and Cucurbits Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China henan Key Laboratory of Fruit and Cucurbit Biology Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural Science(ICRCAAS)AnyangHenan 455000China National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China

Watermelon is a highly cultivated fruit crop renowned for its quality properties of fruit *** various quality factors,fruit flesh firmness is a crucial quality parameter influencing the fruit texture,shelf life and its commercial *** auxin/indole-3-acetic acid(Aux/IAA)plays a significant role in fruit development and ripening of non-climacteric ***,the regulatory mechanism of Aux/IAA in controlling fruit flesh firmness and ripening in watermelon remains *** this study,we employed an integrative approach combining genome-wide association study(GWAS)and bulked segregant RNA-Seq analysis(BSR-Seq)to identify an overlapping candidate region between 12776310 and 12968331 bp on chromosome 6,underlying an auxin-responsive gene(Aux/IAA)associated with flesh firmness in *** analysis,followed by real-time quantitative reverse transcription PCR(qRT-PCR),confirmed that the expression of Aux/IAA was consistently higher in fruits with high flesh *** sequence alignment revealed a single base mutation in the coding region of Aux/***,the concomitant Kompetitive/Competitive allele-specific PCR(KASP)genotyping data sets for F2 population and germplasm accessions identified Aux/IAA as a strong candidate gene associated with flesh ***/IAA was enriched in the plant hormone signal transduction pathway,involving cell enlargement and leading to low flesh *** determined the higher accumulation of abscisic acid(ABA)in fruits with low flesh firmness than hard ***,overexpression of Aux/IAA induced higher flesh firmness with an increased number of fruit flesh cells while reducing ABA content and flesh cell ***,the allelic variation in Aux/IAA for soft flesh firmness was found to exist in Citrullus mucosospermus and gradually fixed into Citrullus lanatus during domestication,indicating that soft flesh firmness was a domesticated *** findings significantly enhanced our unders

关键词： Watermelon Flesh firmness GWAS BSR-Seq KASP marker analysis Transient overexpression

Personalized treatment of perihilar cholangiocarcinoma based on tumor genetic and molecular characteristics

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2769-2773页

作者： he-nan Tang Ming-Wei Wang Xue-Song Liu Yan Jiao Department of Outpatient The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Ministry of health Key Laboratory of Radiobiology School of Public Health of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Gastrointestinal Surgery Changchun Central HospitalChangchun 130000Jilin ProvinceChina Department of hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

This editorial discusses the article written by Tchilikidi et al that was published in the latest edition of the World Journal of Gastrointestinal *** and molecular profiling of perihilar cholangiocarcinoma(pCCA)has identified a number of key abnormalities that drive tumor growth and spread,including pyruvate kinase M2,proline rich 11,and transcription factor 7,*** has specific genetic and molecular features that can be used to develop personalized treatment *** treatment approaches offer new opportunities for effectively targeting the underlying drivers of tumor growth and *** findings based on tumor genetic and molecular characteristics highlight the importance of developing personalized treatment strategies.

关键词： Perihilar cholangiocarcinoma Molecular characteristics Tumor genetic Personalized Treatment

Clostridium difficile infection following colon subtotal resection in a patient with gallstones: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3048-3056页

作者： Feng Ke Zhen-Hua Dong Fan Bu Cheng-nan Li Qi-Tong he Zhi-Cheng Liu Ji Lu Kai Yu Da-Guang Wang he-nan Xu Chang-Tao Ye Department of General Surgery Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina Department of Gastrointestinal Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Plastic and Aesthetic Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Encephalopathy Rehabilitation Chaoyi HospitalYanbian Korean Autonomous PrefectureYanji 133000Jilin ProvinceChina Department of Urology The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

BACKGROUND Clostridium difficile(***)infection(CDI)is a rare clinical disease caused by changes in the intestinal microenvironment,which has a variety of causes and a poor prognosis,and for which there is no standardized clinical *** SUMMARY A patient experienced recurrent difficulty in bowel movements over the past ***,symptoms worsened within the last ten days,leading to a clinic visit due to *** patient was subsequently referred to our ***,the patient was diagnosed with obstructed colon accom-panied by *** antibiotics were administered both before and after surgery to prevent *** the fourth day post-surgery,symptoms of CDI *** cultures confirmed the presence of *** *** involved a combination of vancomycin and linezolid,resulting in the patient's successful recovery upon ***,the patient failed to adhere to the prescribed medication after discharge and was discovered deceased during a follow-up two months *** CDI is the leading cause of nosocomial post-operative care,with limited clinical cases and poor patient prognosis,and comprehensive clinical treatment guidelines are still *** infection can be triggered by a variety of factors,including intestinal hypoxia,inappropriate antibiotic use,and bile acid circulation *** patients with chronic bowel disease and related etiologies,prompt preoperative attention to possible CDI and preoperative bowel preparation is *** and prolonged medication should be maintained in the treatment of CDI to prevent recurrence of the disease.

关键词： Cholecystolithiasis Clostridium difficile Bile acid circulation Intestinal microenvironment Case report

伴中枢神经系统症状的单基因遗传性肾小球疾病的研究进展

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中国当代儿科杂志 2024年第6期26卷 652-658页

作者：王英(综述) 何庆南(审校) 中南大学湘雅二医院儿科湖南长沙410007 中南大学湘雅三医院儿科湖南长沙410013

至今为止,已报道约500种单基因遗传性肾脏病,其中50多个基因与单基因孤立性或综合征性肾病综合征的发病相关,这些基因大多在肾小球足细胞中表达。神经系统症状为综合征性肾病综合征常见的肾外表现,各种研究发现足细胞和神经元在形态和... 详细信息

至今为止,已报道约500种单基因遗传性肾脏病,其中50多个基因与单基因孤立性或综合征性肾病综合征的发病相关,这些基因大多在肾小球足细胞中表达。神经系统症状为综合征性肾病综合征常见的肾外表现,各种研究发现足细胞和神经元在形态和功能方面存在联系。该综述总结了同时出现肾小球和中枢神经系统病变的单基因遗传病的遗传学进展及临床特点,有助于提高临床医生对该类疾病的了解,认识基因诊断技术对共病筛查的重要性,降低漏诊、误诊率。

关键词：肾小球疾病中枢神经系统单基因遗传病

人工肌肉驱动的仿生腿结构系统设计与仿真研究

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机械工程与自动化 2024年第1期 22-23,26页

作者：何楠沈阳科技学院辽宁沈阳110168

基于三维辅助设计软件Pro/E进行了仿生腿模型结构设计和建模研究;介绍了仿生腿的主要关节结构——髋、膝、踝三个关节的结构设计及其驱动设计过程,论述了以人工肌肉作为仿生腿膝关节驱动方式的可行性,并基于Pro/E软件的Mechanism模块完... 详细信息

基于三维辅助设计软件Pro/E进行了仿生腿模型结构设计和建模研究;介绍了仿生腿的主要关节结构——髋、膝、踝三个关节的结构设计及其驱动设计过程,论述了以人工肌肉作为仿生腿膝关节驱动方式的可行性,并基于Pro/E软件的Mechanism模块完成了机构仿真实验,验证了设计的准确性。

关键词：仿生腿结构系统设计人工肌肉仿真实验

基于岩溶发育地区岩土工程勘察及场地稳定性评价

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科技资讯 2024年第8期22卷 146-148页

作者：何难贵州省煤田地质局一五九队贵州六盘水553500

在岩溶地区进行岩土工程勘察时为准确获得岩土体物理力学参数,为解决因岩土工程勘察技术不当而导致勘察数据失真的问题。通过对岩溶发育地区进行仔细分析研究,在进行岩土工程勘察前制订与勘察现场相符合的勘察设计方案。根据设计方案进... 详细信息

在岩溶地区进行岩土工程勘察时为准确获得岩土体物理力学参数,为解决因岩土工程勘察技术不当而导致勘察数据失真的问题。通过对岩溶发育地区进行仔细分析研究,在进行岩土工程勘察前制订与勘察现场相符合的勘察设计方案。根据设计方案进行勘察,当出现新的地质问题时及时调整方案,最大限度地发挥岩土工程勘察技术手段的优越性,最终提供完整且准确的勘察数据。勘察完毕后,对岩溶场地进行稳定性评价,提供可靠的地基承载力和地基持力层,提供地基基础初步建议。

关键词：岩溶地区勘察手段稳定性评价工程勘察

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智能仿生腿结构设计与运动学建模研究

顺德职业技术学院学报 2024年第1期22卷 53-57页

作者：何楠沈阳科技学院辽宁沈阳110168

智能仿生腿作为下肢残缺者辅助行走的工具,用以补偿下肢截肢者残肢侧运动功能,其本体结构设计包括髋、膝、踝三个位置的结构设计。文章利用三维辅助设计软件PRO/E进行仿生腿结构设计建模研究,介绍了仿生腿的主要关节结构-髋、膝、踝三... 详细信息

智能仿生腿作为下肢残缺者辅助行走的工具,用以补偿下肢截肢者残肢侧运动功能,其本体结构设计包括髋、膝、踝三个位置的结构设计。文章利用三维辅助设计软件PRO/E进行仿生腿结构设计建模研究,介绍了仿生腿的主要关节结构-髋、膝、踝三个关节的结构设计及其驱动设计过程,将人工肌肉作为仿生腿膝关节驱动方式,提高了膝关节的拟人性。通过拉格朗日方法对仿生腿的支撑相和摆动相建立运动学模型,推导并计算仿生腿运动学及动力学方程。最后,基于Matlab和Adams软件联合仿真功能进行了模型动力学仿真研究,结果证明所建立的模型可以实现假肢拟人步态。

关键词：智能仿生腿结构设计运动学建模