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MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development

Insect Science 2023年第5期30卷 1431-1444页

作者： Do-Hwan Lim Min-Seok Choi Ji Won jeon Young Sik Lee School of Systems Biomedical Science Soongsil UniversitySeoulRepublic of Korea College of Life Sciences and Biotechnology Korea UniversitySeoulRepublic of Korea Institute of Animal Molecular Biotechnology Korea UniversitySeoulRepublic of Korea

The Notch signaling pathway plays a central role in the development of various ***,dysregulation of microRNAs(miRNAs),which are crucial regulators of gene expression,can disrupt signaling pathways at all stages of *** Notch signaling is involved in wing development in Drosophila,the mechanism underlying miRNA-based regulation of the Notch signaling pathway is ***,we report that loss of Drosophila miR-252 increases the size of adult wings,whereas the overexpression of miR-252 in specific compartments of larval wing discs leads to patterning defects in the adult *** miR-252 overexpression-induced wing phenotypes were caused by aberrant Notch signaling with intracellular accumulation of the full-length Notch receptor during development,which could be due to defects in intracellular Notch trafficking associated with its recycling to the plasma membrane and autophagy-mediated ***,we identified Rab6 as a direct target of miR-252-5p;Rab6 encodes a small Ras-like GTPase that regulates endosomal trafficking *** with this finding,RNAi-mediated downregulation of Rab6 led to similar defects in both wing patterning and Notch ***,co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression,further supporting that Rab6 is a biologically relevant target of miR-252-5p in the context of wing ***,our data indicate that the miR-252-5p-Rab6 regulatory axis is involved in Drosophila wing development by controlling the Notch signaling pathway.

关键词： Drosophila miR-252-5p Notch signaling Rab6 wing development

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Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2281-2285页

作者： Chae Hyun Song Seung Jun Lee Ha Ra jeon Department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do 10444South Korea Department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do ASI/KR/KS009/GoyangSouth Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)is a neurotoxic encephalopathic state with clinical symptoms such as headache,altered consciousness,visual disturbances,and *** edema occurs predominantly in the posterior occipital and parietal lobes of the *** is caused by various diseases,and its mechanism remains ***,it can be easily diagnosed based on characteristic lesions on magnetic resonance *** SUMMARY A 51-year-old woman with unremarkable past medical history presented with progressively worsening back pain since 2 *** examinations revealed paralumbar muscle tenderness,a large lesion on the right breast and several masslike lesions on both *** blood pressure(BP)was elevated(150/90 mmHg),and did not respond to antihypertensive *** the seventh day of hospitalization,she exhibited a confused mental status and generalized tonicclonic *** magnetic resonance imaging,bilateral cortical and subcortical edema of the occipital lobes,suggestive of PRES,was *** serum calcium was 15.8 mg/*** two days of treatment with nicardipine,elcatonin,and zolendronic acid,her BP was 130/91 mmHg and serum calcium was 10.1 mg/*** patient regained consciousness and her mental status ***-positron emission tomography revealed right breast cancer with extensive *** Although rare,hypercalcemia can lead to PRES by causing uncontrolled *** diagnosis can help prevent severe mental disturbances and even death.

关键词： Posterior reversible encephalopathy syndrome Breast cancer Hypercalcemia Hypertension Case report

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Missing Value Imputation Model Based on Adversarial Autoencoder Using Spatiotemporal Feature Extraction

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Intelligent Automation & Soft Computing 2023年第8期37卷 1925-1940页

作者： Dong-Hoon Shin Seo-El Lee Byeong-Uk jeon Kyungyong Chung Department of Computer Science Kyonggi UniversitySuwon-siGyeonggi-do16227Korea Department of Public Safety Bigdata Kyonggi UniversitySuwon-siGyeonggi-do16227Korea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon-siGyeonggi-do16227Korea

Recently,the importance of data analysis has increased significantly due to the rapid data *** particular,vehicle communication data,considered a significant challenge in Intelligent Transportation Systems(ITS),has spatiotemporal characteristics and many missing *** missing values in data lead to the decreased predictive performance of *** missing value imputation models ignore the topology of transportation net-works due to the structural connection of road networks,although physical distances are close in spatiotemporal image ***,the learning process of missing value imputation models requires complete data,but there are limitations in securing complete vehicle communication *** study proposes a missing value imputation model based on adversarial autoencoder using spatiotemporal feature extraction to address these *** proposed method replaces missing values by reflecting spatiotemporal characteristics of transportation data using temporal convolution and spatial *** results show that the proposed model has the lowest error rate of 5.92%,demonstrating excellent predictive *** this,it is possible to solve the data sparsity problem and improve traffic safety by showing superior predictive performance.

关键词： Missing value adversarial autoencoder spatiotemporal feature extraction

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Superior laryngeal nerve block for treatment of throat pain and cough following laryngeal herpes zoster:A case report

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World Journal of Clinical Cases 2023年第18期11卷 4433-4437页

作者： Jinyoung Oh Youngje Park jeongkyu Choi Younghoon jeon Department of Anesthesiology and Pain Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Anesthesiology and Pain Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Anesthesiology and Pain Medicine School of DentistryKyungpook National UniversityDaegu 41944South Korea

BACKGROUND Herpes zoster is caused by reactivation of latent varicella-zoster virus infection within the sensory nerve ganglion of the spinal or cranial *** herpes zoster is rare and involves superior laryngeal nerve,which leads to several complications such as throat pain,and *** SUMMARY Patient concerns:A 52-year old woman presented with a 70 d history of throat pain and a 67 d history of non-productive *** days after onset of pain,she was diagnosed with laryngeal herpes *** nasolaryngoscopy revealed multiple white ulcerated lesions on the left hemi epiglottis and the left supraglottic *** was prescribed with 750 mg famciclovir a day for 7 d,and 150 mg pregabalin,100 mg tramadol and 10 mg nortriptyline a day for 67 ***,despite of these medications,she complained of pain and persistent ***,superior laryngeal nerve block under ultrasound guidance was *** days after the intervention,the throat pain and cough *** patient remained symptom-free at 3 mo *** A superior laryngeal nerve block can be an effective option for treatment of pain and cough following laryngeal herpes zoster.

关键词： Cough Herpes zoster Larynx Neuralgia Pain Superior laryngeal nerve Case report

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-Ra jeon Muhammad Irfan Seung Eun Lee jeong Hoon Lee Man Hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all P<0.01).Conclusion:Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

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Pressure changes in tapered and cylindrical shaped cuff after extension of head and neck:A randomized controlled trial

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World Journal of Clinical Cases 2022年第31期10卷 11419-11426页

作者： Gukjin Seol Juhwa Jin Jinyoung Oh Sung-Hye Byun Younghoon jeon Department of Oral and Maxillofacial Surgery School of DentistryKyungpook National UniversityDaegu 41944South Korea Department of Anesthesiology and Pain Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Anesthesiology and Pain Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Anesthesiology and Pain Medicine School of DentistryKyungpook National UniversityDaegu 41944South Korea

BACKGROUND The proper cuff pressure of endotracheal tube(ET)plays an important role in sealing the airway and preventing airway complications during mechanical *** ET cuff shape affects the cuff pressure after positional *** To investigate cuff pressure between tapered and cylindrical cuff after extension of head and neck during nasal endotracheal *** In a randomized clinical trial,52 patients were randomized to one of two groups:cylindrical cuff or Tapered *** pressure with 22 cmH_(2)O was applied to patients in the neutral *** extension of head and neck,the cuff pressure was evaluated again and readjusted to 22 cmH_(2)*** addition,the extent of cephalad migration of ET tip was assessed and postoperative airway complications such as sore throat,and hoarseness were *** The cuff pressure was higher in the tapered cuff(28.7±1.0 cmH_(2)O)than in the cylindrical cuff(25.5±0.8 cmH_(2)O)after head and neck extension(P<0.001).The extent of cephalad migration of tube tip was greater in TaperGuard ET(18.4±2.2 mm)than in conventional ET(15.1±1.2 mm)(P<0.001).The incidence of postoperative airway complications was comparable between two *** After head and neck extension,the cuff pressure and the extent of cephalad migration of ET was greater in tapered cuff than in cylindrical cuff during nasal intubation,respectively.

关键词： Cuff pressure Cylindrical cuff Endotracheal tube Nasal intubation Tapered cuff

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移动监测技术在大气环境研究中的应用

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环境工程技术学报 2024年第3期14卷 826-835页

作者：朱明玉初红涛高元官李刚全权浩蔡爀基赵刚张浩杨小阳齐齐哈尔大学化学与化学工程学院中国环境科学研究院大气环境研究所韩国国立环境科学院

移动监测是把用于环境监测的设备安装在移动载体(汽车、自行车、无人机和船等)上,开展环境质量监测的技术。移动监测技术以其灵活、机动、及时等优势,近年来被广泛应用于大气环境监测中,但针对移动监测技术在大气环境研究中的应用场景... 详细信息

移动监测是把用于环境监测的设备安装在移动载体(汽车、自行车、无人机和船等)上,开展环境质量监测的技术。移动监测技术以其灵活、机动、及时等优势,近年来被广泛应用于大气环境监测中,但针对移动监测技术在大气环境研究中的应用场景及其存在的优缺点等缺少系统性研究。通过文献调研的方式对国内外移动监测技术在大气环境研究中的应用进行综述,重点讨论了监测设备及其搭载平台。将移动监测设备划分为传感器和大型设备2类,其中传感器以体积小、成本低等优势被大量应用在无人机、汽车等平台中。大型设备则包括监测仪和分析仪,但由于受到体积和成本的限制多被应用在飞机和船等面积较大的平台中。根据大气环境移动监测设备搭载的平台将其划分为车载移动监测、机载移动监测和船载移动监测三大类,其中车载移动监测主要用于环境质量监测、溯源分析和热点监测、汽车尾气排放监测及空气污染暴露监测等,机载移动监测主要用于环境空气质量监测、溯源分析和热点监测及大气污染物传输监测,船载移动监测主要用于海表大气组分、溯源分析和船舶尾气排放等研究。最后讨论了移动监测平台现有应用中存在的问题(例如覆盖率、续航、数据质量等),并对未来研究进行了展望。

关键词：气溶胶空气质量监测移动平台传感器研究进展

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Knot impingement after arthroscopic rotator cuff repair mimicking infection:A case report

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World Journal of Clinical Cases 2022年第15期10卷 5097-5102页

作者： Du-Han Kim Jong-Hyuk jeon Byung-Chan Choi Chul-Hyun Cho Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND Knot impingement as a complication after arthroscopic rotator cuff repair(ARCR)has been suggested as a cause of persistent pain with limited *** report on a case involving a patient who developed knot impingement after ARCR who complained of acute onset of pain with limited motion,which was confused with *** SUMMARY A 55-year-old female who complained of severe pain with limited motion of the right shoulder visited our emergency *** range of motion could not be evaluated due to the patient’s severe *** patient had undergone ARCR using a suture-bridge technique at a local clinic four months ago for treatment of a small supraspinatus tear of the right *** erosive change of the undersurface of the acromion was observed on plain radiographs of the right shoulder,and a moderate amount of bursal fluid and synovial thickening with enhancement was observed by magnetic resonance *** of an analysis of the aspirated fluid showed that the WBC count was 3960 with 90% *** arthroscopic view showed healing of the repaired supraspinatus tendon and loose suture threads and knots with severe subacromial bursitis were *** of inflammatory tissues of the glenohumeral joint and subacromial space was performed for the removal of all suture *** patient’s symptoms subsided immediately after the surgical *** Although the incidence of knot impingement is rare,the possibility of knot impingement after ARCR should be a consideration.

关键词： Rotator cuff Knot impingement Shoulder Infection Arthroscopy Case report

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Repeated ventricular bigeminy by trigeminocardiac reflex despite atropine administration during superficial upper lip surgery: A case report

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World Journal of Clinical Cases 2022年第32期10卷 11967-11973页

作者： Su-Yeon Cho Bo-Hyun Jang Hye-Jin jeon Dong-Joon Kim Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea

BACKGROUND The trigeminocardiac reflex(TCR)is usually caused by an increased parasympathetic tone when pressure or traction is applied to the surrounding tissue of the trigeminal ***,the inexperienced anesthesiologists may have challenges on the management of TCR *** SUMMARY This is the case of an 18-year-old woman diagnosed with hemangioma of the upper *** the operation,about 1 h after surgery started,a constant 1:1 premature ventricular complex was detected,and blood pressure was decreased when approaching the deeper part with more strong traction for exposure of the *** the management of arrhythmias,such as lidocaine and atropine,was injected,arrhythmia induced by surgical stimulation could not be eliminated *** the traction repeated,bradycardia was also repeated,despite injecting additional ***,the anesthesiologist and the surgeon decided to perform the operation only to the extent that the vascular tissue was selectively removed only at the site without the *** With TCR,anesthesiologists should perform appropriate *** addition to proper drug administration,surgeons should be consulted to cope with stopping the surgery and setting the scope of the surgery even if the site is superficial.

关键词： Trigeminocardiac reflex Bigeminy Arrhythmia Hypotension Atropine Case report

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Multi-layer composite autoencoders for semi-supervised change detection in heterogeneous remote sensing images

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Science China(Information Sciences) 2023年第4期66卷 124-125页

作者： Jiao SHI Tiancheng WU Hanwen YU A.K.QIN Gwanggil jeon Yu LEI School of Electronics and Information Northwestern Polytechnical University School of Resources and Environment University of Electronic Science and Technology of China Department of Computer Science and Software Engineering Swinburne University of Technology Department of Embedded Systems Engineering Incheon National University

With the increasing complexity of application scenarios, the fusion of different remote sensing data types has gradually become a trend, which can greatly improve the utilization of massive remote sensing *** the problem of change detection for heterogeneous remote images can be much more complicated than the traditional change detection for homologous remote sensing images,

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