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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Antioxidant and lipoxygenase inhibitory properties of a novel flavonoid from Pistacia chinensis Bunge and its molecular docking analysis

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Traditional Medicine Research 2025年第2期10卷 30-36页

作者： Abdur Rauf Zuneera Akram Naveed Muhammad Najla AlMasoud Taghrid Saad Alomar Saima Naz Abdul Wadood Chandni hayat Marcello Iriti Department of Chemistry University of SwabiAmbar 23561Pakistan Department of Pharmacology Faculty of Pharmaceutical SciencesBaqai Medical UniversityKarachi 74600Pakistan Department of Pharmacy Abdul Wali Khan University MardanMardan 23200Pakistan Department of Chemistry College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Biotechnology BKUC-Bacha Khan University CharsaddaCharsadda 24620Pakistan Department of Biochemistry Abdul Wali Khan University MardanMardan 23200Pakistan Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20129Italy National Interuniversity Consortium of Materials Science and Technology(INSTM) Firenze 50121Italy

Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and *** study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia ***:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were *** docking studies were conducted using a molecular operating ***:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µ*** antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%*** docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/***:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.

关键词： Pistacia chinensis Bunge antioxidant DPPH assay antilipoxygenase docking analysis

Resistance Spot Weldability of Dissimilar Materials: BH180-AISI304L Steels and BH180-IF7123 Steels

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Journal of Materials Science & Technology 2011年第11期27卷 1047-1058页

作者： Fatih hayat Metallurgy & Materials Engineering Department Engineering Faculty Karabuk University

In this study, resistance spot weldability of 180 grade bake hardening steel （BH180）, 7123 grade interstitial free steel （IF7123） and 304 grade austenitic stainless steel （AISI304L） with each other was investigated. In the joining process, electrode pressure and weld current were kept constant and six different weld time were chosen. Microstructure, microhardness, tensile-shear properties and fracture types of resistance spot welded joints were examined. In order to characterize the metallurgical structure of the welded joint, the microstructural profile was developed, and the relationship between mechanical properties and microstructure was determined. The change of weld time, nugget diameter, the HAZ （heat affected zone） width and the electrode immersion depth were also investigated. Welded joints were examined by SEM （scanning electron microscopy） images of fracture surface. As a result of the experiment, it was determined that with increasing weld time, tensile shear load bearing capacity （TLBC） increased with weld time up to 25 cycle and two types of tearing occurred. It was also determined that while the failure occurred from IF side at the BHIS0＋IF7123 joint, it occurred from the BH180 side at the BHIS0＋AISI304L joint.

关键词： Resistance spot welding Bake hardening steel Interstitial free steel Stainless steel

EXACT SOLUTIONS OF A DIPOLAR FLUID FLOW

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Acta Mechanica Sinica 2003年第4期19卷 308-314页

作者： T.hayat DepartmentofMathematics Quaid-i-AzamUniversityIslamabad44000Pakistan

Exact solutions for three canonical flow problems of a dipolar fluid are obtained: (i) The flow of a dipolar fluid due to a suddenly accelerated plate, (ii) The flow generated by periodic oscillation of a plate, (iii) The flow due to plate oscillation in the presence of a transverse magnetic field. The solutions of some interesting flows caused by an arbitrary velocity of the plate and of certain special oscillations are also obtained.

关键词： unsteady flows dipolar fluid periodic oscillations MHD flow

Anticarcinogenic and antioxidant activity of diindolylmethane derivatives

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Acta Pharmacologica Sinica 2004年第5期25卷 124-129页

作者： Sakina hayat BENABADJI Department of Medicinal Chemistry Medical Center of Fudan University

AIM: To investigate the synthesis methods and the bioactivity of diindolylmethane (DIM) derivatives. METHODS:1) A 3D-Quantitative Structure-Active Relationships (QSAR) Comparative Molecular Field Analysis (CoMFA) studyof 14 DIM derivatives was investigated to predict their anticarcinogenic activity. 2) Based on CoMFA model, aseries of new derivatives of DIM were designed and synthesized. 3) Their free radical scavenging and antioxidantpotentials were tested using in-vitro DPPH radical scavenging and b-carotene antioxidant models. 4) Theanticarcinogenic activities of some compounds were tested by using microculture tetrazolium assay (MTT) andsulforhodamine B (SRB) proteochromosomic assays. RESULTS: 1) The CoMFA model derived from DIM ana-logues proved a good predictive ability with q2 value of 0.827. 2) New designed compounds 3c and 4c exhibited3-fold more potent radical scavenging activity than reference substance Vitamin E in DPPH model expressed by IC50values. 3) The primary antitumor screening essay showed that some DIM derivatives designed exhibited theinhibitory activities to some tumor cell growth at relatively high concentration, and DIM was the most effectiveamong them. CONCLUSION: DIMs 3D-QSAR model is reliable. According to it, eleven DIM derivatives weresynthesized, and two derivatives of them possess potent radical scavenging activities and some showed the inhibi-tory activities in primary anticancer assay in vitro.

关键词： indole-3-carbinol diindolylmethane CoMFA analysis antioxidants free radical scavengers 1,1-DPPH carotenoids antitumor drug screening assay

MHD UNSTEADY FLOWS DUE TO NON—COAXIAL ROTATIONS OF A DISK AND A FLUID AT INFINITY

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Acta Mechanica Sinica 2003年第3期19卷 235-240页

作者： T.hayat IslamicInternationalEngineeringCollegec/oHeadOfficeIIMC OldSupremeCourtBuilding274PeshawarroadTheMallRawalpindiCanntPakistan

Exact analytical solution for flows of an electrically conducting fluid over an infinite oscillatory disk in the presence of a uniform transverse magnetic field is constructed. Both the disk and the fluid are in a state of non-coaxial rotation. Such a flow model has a great significance not only due to its own theoretical interest, but also due to applications to geophysics and engineering. The resulting initial value problem has been solved analytically by applying the Laplace transform technique and the explicit expressions for the velocity for steady and unsteady cases have been established. The analysis of the obtained results shows that the flow field is appreciably influenced by the applied magnetic field, the frequency and rotation parameters.

关键词： general periodic oscillation non-coaxial rotation magnetohydrodynamic flow Laplace transform

Comparing Properties of Adhesive Bonding,Resistance Spot Welding,and Adhesive Weld Bonding of Coated and Uncoated DP 600 Steel

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Journal of Iron and Steel Research International 2011年第9期18卷 70-78页

作者： Fatih hayat Metallurgy and Materials Engineering Department Engineering FacultyKarabuk University Baliklarkayasi

Zinc coated dual phase 600 steel （DP 600 grade） was investigated, utilisation of which has gradually increased with each passing day in the automotive industry. The adhesive bonding （AB）, resistance spot welding （RSW）, and adhesive weld bonding （AWB） ioints of the zinc coated DP 600 steel were investigated. Additionally, the zinc coating was removed using HCL acid in order to investigate the effect of the coating. The microstructure, tensile shear strengths, and fracture properties of adhesive bonding （AB）, resistance spot welding （RSW）, and adhesive weld bonding （AWB） joints of the coated and uncoated DP 600 steel were compared. In addition, a mechani cal-electrical-thermal coupled model in a finite element analysis environment was utilised. The thermal profile phe nomenon was calculated by simulating this process. The results of the tensile shear test indicated that the tensile load bearing capacity （TLBC） values of the coated specimens among the three welding methods were higher than those of the uncoated specimens. Additionally, the tensile strength of the AWB joints of the coated and uncoated specimens was higher than that of the AB and RSW joints. It was determined that the fracture behaviours and the deformation caused were different for the three welding methods.

关键词： advanced high strength steel DP600 adhesive weld bonding microstructure deformation fracture

Induced magnetic field stagnation point flow of nanofluid past convectively heated stretching sheet with Buoyancy effects

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Chinese Physics B 2016年第11期25卷 360-368页

作者： Tanzila hayat S Nadeem Department of Mathematics Quaid-I-Azam University

This paper presents the buoyancy effects on the magneto-hydrodynamics stagnation point flow of an incompressible,viscous,and electrically conducting nanofluid over a vertically stretching *** impacts of an induced magnetic field and viscous dissipation are taken into *** assisting and opposing flows are *** overseeing nonlinear partial differential equations with the associated boundary conditions are reduced to an arrangement of coupled nonlinear ordinary differential equations utilizing similarity transformations and are then illuminated analytically by using the optimal homotopy investigation strategy（OHAM）.Graphs are introduced and examined for different parameters of the velocity,temperature,and concentration ***,numerical estimations of the skin friction,local Nusselt number,and local Sherwood number are explored using numerical values.

关键词： stretching electrically incompressible viscous dissipation ordinary conducting sheet hydrodynamics arrangement

Overexpression of rice OsLOL2 gene confers disease resistance in tobacco to Pseudomonas syringae pv. tabaci

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Progress in Natural Science:Materials International 2008年第7期18卷 807-812页

作者： Khizar hayat Bhatti Beijing 100101 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China State Key Laboratory of Plant Genomics Institute of Microbiology Chinese Academy of Sciences

LSD1-related proteins of Arabidopsis with LSD1-like zinc finger domains regulate disease resistance and programmed cell death (PCD). We cloned a rice OsLOL2 gene, orthologous to LSD1 of Arabidopsis and expressed it in a tobacco plant. Transgenic tobacco lines displayed enhanced disease resistance to a virulent bacterium Pseudomonas syringae pv. tabaci (Pst). RT-PCR analysis showed that overexpression of OsLOL2 in transgenic tobacco lines resulted in upregulation of two pathogenesis-related (PR) protein genes, PR2 and PR5. Our results suggest that overexpression of OsLOL2 in transgenic tobacco enhances the resistance through the induction of PR pro- teins and hypersensitive response-like reaction.

关键词： OsLOL2 Zinc finger protein/domain Hypersensitive response (HR) Pseudomonas syringae pv. tabaci Disease resistance