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世界核心医学期刊文摘(眼科学分册) 2006年第3期 37-38页

作者： Popovic P Jarc-Vidm.r m.hawlina m. 王大江 University Eye Clinic Medical Center Ljubljana Zaloska 29a 1000 Ljubljana Slovenia

Background: Fundus autofluorescence (AF) in som. patients with retinitis pigm.ntosa is characterized by a parafoveal ring of increased AF which surrounds the centre as hypofluorescent changes appear at the periphery. The aim.of this study was to evaluate the AF patterns in relation to retinal function m.asured by ele ctroretinography and visual fields. m.thods: Thirty-two patients with RP were included in the study. AF im.ging of the m.cular area was perform.d with the scanning laser ophthalm.scope. Patients were divided in two groups according to their fundus AF patterns. All patients from.group 1 had a ring of increased AF of different size but no atrophic areas inside vascular arcades. Patients with a ring of increased AF and round atrophic changes at different eccentricities from.their fovea were selected in group 2. Visual fields were tested with kinetic, autom.ted perim.try and m.croperim.try; the radius of the hyperfluorescent ring and the sm.llest distance of hypofluorescent areas from.the fovea were com.ared to visual fields, PERG P50 and N95 and m.ERG P1 am.litudes of the inner three rings. Results: A linear relationship was found in group 1 between the radius of the ring of increased AF and both the autom.ted (r=0.82) and kinetic perim.try (r=0.80). The radius of the AF ring correlated highlywith the PERG P50 (r=0.72) and N95 (r=0.74) am.litudes. In all patients, m.ERG responses were reduced at all retinal locations, m.re pronounced at periphery. There was a good correlation between the ring of increased AF and the P1 am.litude of ring 2 of m.ERG (r=0.62). Pati ents from.group 2 had significantly reduced or non-recordable PERGs and m.ERGs. The eccentricities of hypofluorescent changes did not correlate with any type of perim.try. Conclusions: Our results show that in stages of retinitis pigm.ntosa, before atrophic lesions spread inside the vascular arcades, the pattern of fundus autofluorescence correlates well with functional tests such as perim.try and

关键词：视网膜视网膜色素变性眼底自发荧光患者功能

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用微视野和自身荧光检查Best卵黄样营养不良患者的中心视功能

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 49-50页

作者： Jarc-Vidm.r m. Popovic P. hawlina m. 喻平平 University Eye Clinic Medical Centre Ljubljana Zaloka 29a 1000 Ljubljana Slovenia

Purpose: To evaluate retinal sensitivity and fixation patterns in patients with Best's dystrophy by m.croperim.try (m.) and to correlate the results with static perim.try and retinal m.rphology seen by autofluorescence (AF). m.thods: Central 10°visual fields in 11 patients with Best's dystrophy (VA: 0.5±0.38)were recorded by the Octopus m. TOP program.and by m. (m.1, Nidek Technologies). AF was recorded by HRA (Heidelberg Engineering). Results: High correlation (R=0.75, -0.76,-0. 48)was found between static perim.try (m.,m. and CLV indices) and *** on m. and AF results, three groups of patients were form.d. Patients in the first two groups fixated inside the central nonuniform.hypo-and hyperfluorescent AF ring area, next to relative (Group 1) or absolute scotom. (Group 2). Inner parts of the retina close to the fovea were m.st affected, whereas regions closer to the periphery of the 10°visual field showed near norm.l function. As the disease progressed, there was an evident shift of fixation to preferential retinal locus (PRL) in eight eyes with visual acuity 0.2 or less (Group 3). Fixation shift was superior in four eyes, tem.oral in two eyes, and nasal in two eyes. Conclusion: m. enabled a highly sensitive topographic m.nitoring of retinal function, showing central or pericentral fixation in the early stages, until loss of central function, in eyes with VA 0.2 or less, caused evident shift of fixation to PRL. PRL was never situated inside the central uniform.hypofluorescent area,but corresponded with the hyperfluorescent ring seen with AF im.ging.

关键词：营养不良 Best 患者卵黄

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