用微视野和自身荧光检查Best卵黄样营养不良患者的中心视功能

作     者：Jarc-Vidmar M. Popovic P. Hawlina M. 喻平平 

作者机构：University Eye Clinic Medical Centre Ljubljana Zaloka 29a 1000 Ljubljana Slovenia 

出 版 物：《世界核心医学期刊文摘(眼科学分册)》 (Digest of the World Core Medical Journals)

年 卷 期：2006年第12期

页      面：49-50页

学科分类：1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

主　　题：营养不良 Best 患者 卵黄 

摘      要：Purpose: To evaluate retinal sensitivity and fixation patterns in patients with Best s dystrophy by microperimetry (MP) and to correlate the results with static perimetry and retinal morphology seen by autofluorescence (AF). Methods: Central 10°visual fields in 11 patients with Best s dystrophy (VA: 0.5±0.38)were recorded by the Octopus M2 TOP program and by MP (MP1, Nidek Technologies). AF was recorded by HRA (Heidelberg Engineering). Results: High correlation (R=0.75, -0.76,-0. 48)was found between static perimetry (MS,MD and CLV indices) and *** on MP and AF results, three groups of patients were formed. Patients in the first two groups fixated inside the central nonuniform hypo-and hyperfluorescent AF ring area, next to relative (Group 1) or absolute scotoma (Group 2). Inner parts of the retina close to the fovea were most affected, whereas regions closer to the periphery of the 10°visual field showed near normal function. As the disease progressed, there was an evident shift of fixation to preferential retinal locus (PRL) in eight eyes with visual acuity 0.2 or less (Group 3). Fixation shift was superior in four eyes, temporal in two eyes, and nasal in two eyes. Conclusion: MP enabled a highly sensitive topographic monitoring of retinal function, showing central or pericentral fixation in the early stages, until loss of central function, in eyes with VA 0.2 or less, caused evident shift of fixation to PRL. PRL was never situated inside the central uniform hypofluorescent area,but corresponded with the hyperfluorescent ring seen with AF imaging.