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In vivo combination therapy of chloroquine and stigmasterol against Plasmodium berghei induced pathologies in mice

Journal of Hainan Medical University 2020年第17期26卷 10-16页

作者： Auwal Adamu Muhammad A.Saliu Abdullahi A.Dantani Yaqub Nimat hauwa t.giaze Najib Musa Buba Hussena Morik Dorathy Ahmad M.Kandi Musa Daniel Mohammed Auwal Ibrahim Department of Biochemistry Ahmadu Bello UniversityZariaNigeria

Objective:to investigate the effect of combination therapy of chloroquine and stigmasterol on Plasmodium(P.)berghei malaria-induced organ ***:totally 35 mice weighing 20-30g were placed into 7 groups of 5 mice each and distributed as uninfected administered 100 mg/kg BW stigmasterol,uninfected administered only feed and water ad libitum,infected with *** and administered 50 mg/Kg BW stigmasterol,100 mg/kg BW stigmasterol,100 mg/kg BW stigmasterol plus 5 mg/kg BW chloroquine,and 5 mg/kg BW *** last group of mice served as *** infected and not treated *** levels of parasitemia,packed cell volume,and other biochemical parameters were ***:Combination therapy of *** infection with stigmasterol and chloroquine did not significantly(P>0.05)reduce parasitemia level while stigmasterol treatment alone significantly(Pthe parasitemia ***,the *** induced anemia was decreased significantly(Ptreatment with a combination of chloroquine and stigmasterol as well as with stigmasterol ***,the combination of chloroquine and stigmasterol significantly(Pthe activities of serum alanine aminotransferase,aspartate aminotransferase,urea and level of spleen total proteins in *** infected mice in comparison with the untreated *** of *** infected mice with stigmasterol alone and in combination with chloroquine significantly(Pthe level of serum creatinine while serum and spleen malondialdehyde levels were significantly(Ptathione in spleen and kidney were insignificantly(P>0.05)altered upon treatment with both doses of stigmasterol as well as the combination ***:this study concluded that the combination of stigmasterol and chloroquine could combat anemia and some organ pathologies associated with *** infection.

关键词： Malaria Stigmasterol Chloroquine Plasmodium berghei Organ pathologies

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