In vivo combination therapy of chloroquine and stigmasterol against Plasmodium berghei induced pathologies in mice

作     者：Auwal Adamu Muhammad A.Saliu Abdullahi A.Dantani Yaqub Nimat Hauwa T.Giaze Najib Musa Buba Hussena Morik Dorathy Ahmad M.Kandi Musa Daniel Mohammed Auwal Ibrahim Auwal Adamu;Muhammad A. Saliu;Abdullahi A. Dantani;Yaqub Nimat;Hauwa T. Giaze;Najib Musa;Buba Hussena;Morik Dorathy;Ahmad M. Kandi;Musa Daniel;Mohammed Auwal Ibrahim

作者机构：Department of BiochemistryAhmadu Bello UniversityZariaNigeria 

出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)

年 卷 期：2020年第26卷第17期

页      面：10-16页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The authorities of Ahmadu Bello University  Zaria  Nigeria areacknowledged for providing the equipment used for the study 

主　　题：Malaria Stigmasterol Chloroquine Plasmodium berghei Organ pathologies 

摘      要：Objective:To investigate the effect of combination therapy of chloroquine and stigmasterol on Plasmodium(P.)berghei malaria-induced organ ***:Totally 35 mice weighing 20-30g were placed into 7 groups of 5 mice each and distributed as uninfected administered 100 mg/kg BW stigmasterol,uninfected administered only feed and water ad libitum,infected with *** and administered 50 mg/Kg BW stigmasterol,100 mg/kg BW stigmasterol,100 mg/kg BW stigmasterol plus 5 mg/kg BW chloroquine,and 5 mg/kg BW *** last group of mice served as *** infected and not treated *** levels of parasitemia,packed cell volume,and other biochemical parameters were ***:Combination therapy of *** infection with stigmasterol and chloroquine did not significantly(P0.05)reduce parasitemia level while stigmasterol treatment alone significantly(P0.05)altered upon treatment with both doses of stigmasterol as well as the combination ***:This study concluded that the combination of stigmasterol and chloroquine could combat anemia and some organ pathologies associated with *** infection.