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Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

World Journal of Gastroenterology 2020年第9期26卷 918-932页

作者： Chieko Tashita Masato Hoshi Akihiro Hirata Kentaro Nakamoto Tatsuya Ando Takayuki hattori Yasuko Yamamoto Hiroyuki Tezuka Hiroyuki Tomita Akira Hara Kuniaki Saito Department of Disease Control and Prevention Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Department of Biochemical and Analytical Science Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Division of Animal Experiment Life Science Research CenterGifu UniversityGifu 501-1193Japan Department of Cellular Function Analysis Research Promotion and Support HeadquartersFujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Faculty of Medical Technology Gifu University of Medical ScienceGifu 501-3892Japan Department of Tumor Pathology Gifu University Graduate School of MedicineGifu 501-1193Japan

BACKGROUND Inflammatory bowel disease,such as Crohn’s disease and ulcerative colitis,is characterized by chronic intestinal inflammation leading to intestinal mucosal *** bowel disease causes dysregulation of mucosal T cell responses,especially the responses of CD4+T ***,we demonstrated that indoleamine-2,3-dioxygenase plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate(TNBS)-induced *** indoleamine-2,3-dioxygenase exerts immunosuppressive effects by altering the local concentration of tryptophan(Trp)and immunomodulatory Trp metabolites,the specific changes in immune regulation during colitis caused by Trp metabolites and its related enzymes remain *** To investigate role of kynurenine 3-monooxygenase(KMO)in TNBS-induced colitis and involvement of Trp metabolites in maintenance of intestinal *** Colitis was induced in eight-week-old male KMO+/+or KMO−/−mice of C57BL/6N background using *** days later,the colon was used for hematoxylin-eosin staining for histological grading,immunohistochemical or immunofluorescence staining for KMO,cytokines,and immune *** and anti-inflammatory cytokines were measured using quantitative RT-PCR,and kynurenine(Kyn)pathway metabolites were measured by high-performance liquid *** cell proportions of colonic lamina propria and mesenteric lymph nodes were analyzed by flow *** KMO expression levels in the colonic mononuclear phagocytes,including dendritic cells and macrophages increased upon TNBS ***,KMO deficiency reduced TNBS-induced colitis,resulting in an increased frequency of Foxp3+regulatory T cells and increased mRNA and protein levels of antiinflammatory cytokines,including transforming growth factor-βand *** Absence of KMO reduced TNBS-induced colitis via generation of Foxp3+regulatory T cells by producing ***,Kyn may play a therapeutic role in colon protection

关键词： Kynurenine 3-monooxygenase Kynurenine Regulatory T cell Inflammatory bowie diseases

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Bacteremia or pseudobacteremia?Review of pseudomonas fluorescens infections

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World Journal of Emergency Medicine 2017年第2期8卷 151-154页

作者： Takeshi Nishimura Kenji hattori Akihiko Inoue Taiji Ishii Tctsuya Yumoto Kohei Tsukahara Astunori Nakao Satoshi Ishihara Shinichi Nakayama Hyogo Emergency Medical Center 1-3-1 Wakinohamakaigando-riChuo-kuKobeHyogo 651-0073Japan Department of Emergency and Critical Care Medicine Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences2-5-1 ShikatachoKitakuOkayama CityOkayama700-8558Japan

INTRODUCTION *** is an aerobic,Gram-negative bacillus related to Pseudomonas *** other species of Pseudomonas,the organism is widespread in nature and is found in water,moist soil,and *** to its low virulence,*** is an infrequent cause of infections except for catheter-related bloodstream infections in cancer *** August 1,2003 to May 31,2016,Hyogo Emergency Medical Center and the Kobe Red Cross Hospital treated three cases of bloodstream infection

关键词： Bacteremia pseudobacteremia pseudomonas fluorescens infections

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吉林东部汪清新生代玄武岩中地幔包体的矿物化学：对该地区岩石圈地幔形成过程的启示

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地学前缘 2013年第5期20卷 75-86页

作者：宋樾王建刘金霖谢志鹏 Keiko H. hattori 吉林大学地球科学学院吉林长春130061 Department of Earth Sciences University of Ottawa Ottawa Ontario K1N 6N5 Canada

在对吉林汪清新生代玄武岩中橄榄岩包体进行全岩主、微量元素分析的基础上，重点分析了矿物的主、微量元素含量，讨论了华北克拉通东北缘与兴蒙造山带结合部位陆下岩石圈地幔所经历的部分熔融作用和地幔交代作用。橄榄石的Fo、单斜辉石... 详细信息

在对吉林汪清新生代玄武岩中橄榄岩包体进行全岩主、微量元素分析的基础上，重点分析了矿物的主、微量元素含量，讨论了华北克拉通东北缘与兴蒙造山带结合部位陆下岩石圈地幔所经历的部分熔融作用和地幔交代作用。橄榄石的Fo、单斜辉石以及尖晶石的Mg#和Cr#均表明该地区陆下岩石圈地幔相对饱满。对地幔橄榄岩透辉石微量元素模拟计算证实，汪清陆下岩石圈地幔经历了1％～3％的部分熔融作用，并遭受后期硅酸盐熔体交代作用。这些地幔特征与中国东部其他地区新生代主体岩石固相似。研究结果证明，吉林汪清中、新生代以来岩石圈性质的转变是在汇聚板块构造体制下通过“拆沉作用”实现的。

关键词：地幔橄榄岩矿物化学拆沉软流圈底辟汪清吉林东部

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Phenytoin-Induced Elevation of the Intracellular Calcium Concentration by Stimulation of Calcium-Sensing Receptors in Gingival Fibroblasts

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Pharmacology & Pharmacy 2013年第2期4卷 261-265页

作者： Toshimi hattori Keisuke Nakano Toshiyuki Kawakami Department of Dental Pharmacology Matsumoto Dental University Shiojiri Japan Hard Tissue Pathology Unit Institute of Oral Science Matsumoto Dental University Shiojiri Japan.

Background:The mechanism concerning gingival overgrowth as a side effect of phenytoin, a therapeutic drug for epilepsy has been still unclear. As one of mechanisms, by measuring the intracellular calcium concentration ([Ca2+]i) of the gingival fibroblasts, it has been advocated that there is relationship between gingival overgrowth and phenytoin-induced alterations in the [Ca2+]i in gingival fibroblasts. To confirm that phenytoin elevates the [Ca2+]i, and if so, to find out its mode of action. Methods: The [Ca2+]i was measured with the Ca2+-sensitive fluorescent dye fura-2/AM. Cells were soaked in a flexiperm chamber and perfused by a saline. Drugs at appropriate concentrations were added to the perfusate. Results: Phenytoin concentration-dependently elevated the [Ca2+]i. NPS2390, a calcium-sensing receptor (CaSR) blocker, significantly suppressed the phenytoin-induced [Ca2+]i elevation. U73122, a phospholipase C (PLC) inhibitor, inihibited the phenytoin-induced [Ca2+]i elevation. TMB-8, a blocker of inositol triphophate (IP3) receptors in ER, significantly depressed the phenytoin-induced [Ca2+]i elevation. m-3M3FBS, a PLC activator, enhanced the phenytoin-induced [Ca2+]i elevation. From the findings obtained, it is discussed as follows: The Ca2+-free saline and NPS2390, a CaSR antagonist, inhibited the phenytoin-induced [Ca2+]i rise;These results indicate that CaSRs exist in gingival fibroblasts and that CaSRs are involved in the phenytoin-induced [Ca2+]i rise;U73122 and TMB-8 depressed the phenytoin-induced [Ca2+]i elevation and furthermore, m-3M3FBS enhanced the phenytoin-induced [Ca2+]i elevation, showing that the Ca2+ release from the ER is involved in the phenytoin-induced [Ca2+]i elevation. Conclusion: We have concluded that phenytoin elevates the [Ca2+]i by activating CaSRs and enhancing the Ca2+ release from the Ca2+ stores in gingival fibroblasts.

关键词： Phenytoin Calcium-Sensing Receptor Endoplasmic Reticulum Gingival Fibroblast Gingival Overgrowth

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Melatonin Enhances Object Recognition Memory through Melatonin MT1 and MT2 Receptor-Mediated and Non-Receptor-Mediated Mechanisms in Male Mice

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Journal of Behavioral and Brain Science 2022年第12期12卷 640-657页

作者： Masahiro Sano Hikaru Iwashita Atsuhiko hattori Atsuhiko Chiba Department of Materials and Life Sciences Faculty of Science and Technology Sophia University Tokyo Japan Department of Biology College of Liberal Arts and Sciences Tokyo Medical and Dental University Chiba Japan

Melatonin (MEL) has been reported to have acute enhancing effects on some aspects of cognition. Recently, we revealed that N1-acetyl-5-methoxyquinuramine (AMK), a brain metabolite of MEL, is much more potent than MEL in converting short-term memory (STM) to long-term memory (LTM) with a single administration immediately after the acquisition trial of the novel object recognition (NOR) task. These data suggest that the memory-enhancing effects of MEL may be mediated by mechanisms independent of the activation of MEL MT1 and MT2 receptors. In the present study, we examined the contribution of MT1 and MT2 receptor-mediated and non-receptor-mediated mechanisms to the acute memory-enhancing effects of MEL using NOR task. Mice were administered with either MEL, AMK, or a highly selective MT1/MT2 receptor agonist ramelteon (RAM) immediately after the acquisition trial and the effects of varying doses of these drugs on both STM and LTM performance were compared. We found that both AMK and RAM were more potent than MEL in both facilitating STM and promoting LTM formation. We also found that pretreatment with luzindole, a MT1/MT2 receptor antagonist, markedly suppressed only the effects of RAM. These results suggest that acutely administered MEL enhances NOR memory through both MT1 and MT2 receptor-mediated and non-receptor-mediated mechanisms.

关键词： Melatonin N1-Acetyl-5-Methoxykynuramine Ramelteon Novel Object Recognition Memory Melatonin Receptors

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Evaluation of Cisplatin-Loaded Polymeric Micelles and Hybrid Nanoparticles Containing Poly(Ethylene Oxide)-Block-Poly(Methacrylic Acid) on Tumor Delivery

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Pharmacology & Pharmacy 2016年第1期7卷 1-8页

作者： Andang Miatmoko Kumi Kawano Etsuo Yonemochi Yoshiyuki hattori Department of Drug Delivery Research Hoshi University Shinagawa Japan Department of Physical Chemistry Hoshi University Shinagawa Japan

Particulate carriers such as polymeric micelles (PMs) and liposomes have been investigated to increase drug accumulation in tumors and reduce distribution to healthy tissues. In this study, we prepared PM and hybrid nanoparticles (HNPs) with poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-b-PMAA) for loading cisplatin, and evaluated cisplatin release, cytotoxicity, and biodistribution in mice. PM composed of PEO-b-PMAA and HNPs composed of egg phosphatidylcholine (EPC)/PEO-b-PMAA at molar ratios of 50/2.8 (HNP-P5) and 50/50 (HNP-P50), respectively, were prepared by a nanoprecipitation method. The sizes of PM, HNP-P5, and HNP-P50 after inclusion of cisplatin were approximately 200, 100, and 55 nm, respectively, and their entrapment efficiencies were approximately 44% - 66%. In the drug-release study, HNP-P5 and HNP-P50 showed reduced release of cisplatin compared with PM. Regarding the cytotoxic assay, HNP-P5 exhibited lower cytotoxicity for mouse Lewis lung carcinoma (LLC) and mouse colon carcinoma Colon 26 cells than PM and HNP-P50. In terms of biodistribution, PM could significantly improve blood circulation and tumor accumulation after intravenous injection into Colon 26 tumor-bearing mice compared with free cisplatin, but HNP-P5 and HNP-P50 did not. EPC in HNPs might be destabilized in the circulation, although it could reduce release of cisplatin in in vitro experiments. This study suggested that polymeric micelles composed of PEO-b-PMAA are a better carrier for cisplatin than hybrid nanoparticles composed of PEO-b-PMAA and EPC.

关键词： Polymeric Micelles Hybrid Nanoparticles Cisplatin PEO-b-PMAA

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HSC加速器的初步大功率加速实验

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原子能科学技术 2015年第B10期49卷 569-572页

作者：卢亮 Toshiyuki hattori 赵环昱何源孙良亭赵红卫中国科学院近代物理研究所甘肃兰州730000 日本放射线医学综合研究所

混合单腔(HSC)型直线加速器是将一段4杆型射频四极(RFQ)加速结构和一段交叉指(IH)型漂移管(DT)加速结构混合到一个IH型腔里,利用IH型腔体具有的低功耗加速梯度高的优点,使得整个IH型混合腔的加速功率效率较其他加速结构腔体的更高。本... 详细信息

混合单腔(HSC)型直线加速器是将一段4杆型射频四极(RFQ)加速结构和一段交叉指(IH)型漂移管(DT)加速结构混合到一个IH型腔里,利用IH型腔体具有的低功耗加速梯度高的优点,使得整个IH型混合腔的加速功率效率较其他加速结构腔体的更高。本文进行了低功率测试和初步大功率C6+加速实验。结果显示低功率测试结果与计算结果吻合较好,初步的大功率测试结果表明HSC加速器能满足下一步的高功率实验。

关键词： RFQ IH结构漂移管混合型重离子注入器

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OBSERVATION ON THE EFFECTS OF CHINESE MEDICINE ZHENXUANYIN FOR IMPROVING CEREBRAL BLOOD FLOW IN RATS WITH CEREBRAL ISCHEMIA

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Journal of Traditional Chinese Medicine 1997年第4期17卷 299-303页

作者：王静怡 Yasuhiro Magata Naoya hattori Yoshiharu Yonekura Nagara Tamaki Fumiko Tanaka Junji Konishi Seok Rye Choi Shigeru Matsuzaki Department of Nuclear Medicine Faculty of Medicine Kyoto University Japan Chemistry Department of Radio Medicine Faculty of Pharmacy Kyoto University Japan Department of Neurological Internal Medicine Faculty of Medicine Kyoto University Japan Mailing Address of Jingyi Wang: Department of Neurological Internal Medicine Hospital of Traditional Chinese Medicine Xi'an 710001 China

Zhenxuanyin (镇眩饮) is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes’ complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03g kg, 0.3g kg, Ig kg, or 3g/ kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3g/ kg can increase cerebral blood flow (CBF) to the normal level.

关键词：镇眩饮

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Design of Intersample Response in a Hard Disk Control System

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Journal of Mechanics Engineering and Automation 2012年第7期2卷 405-410页

作者： Takao Sato Yoshiki hattori Nozomu Araki Yasuo Konishi Graduate School of Engineering University of Hyogo Himeji 671-2201 Japan

The present paper discusses a design method for the head position in a Hard Disk Drive （HDD） control system. In the HDD control system, the sampling interval of the head position is constrained because of the hardware specifications, but the hold interval of the control input is not constrained. In the present study, a multirate control system is designed, in which the sampling and the hold intervals are not equal. A multirate control law, which stabilizes a closed-loop system, is extended using newly introduced parameters such that the sample response of the plant output is maintained. Furthermore, intersample ripples in the steady state are eliminated using the new design parameters, which can be selected independently of the sample response. As a result, the intersample response can be improved independently of the sample response. The proposed method is applied to a benchmark problem of an HDD system, and its effectiveness is demonstrated.

关键词： Multirate control system single-rate control system hard disk drive state-space representation intersample response sample response pole assignment.

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OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation

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Journal of Integrative Plant Biology 2018年第2期60卷 130-143页

作者： Peng Huang Hideki Yoshida Kenji Yano Shunsuke Kinoshita Kyosuke Kawai Eriko Koketsu Masako hattori Sayaka Takehara Ji Huang Ko Hirano Reynante Lacsamana Ordonio Makoto Matsuoka Miyako Ueguchi-Tanaka Bioscience and Biotechnology Center Nagoya University Nagoya 464-8601 Japan State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo 113-8657 Japan Plant Breeding and Biotechnology Division Philippine Rice Research Institute Maligaya Science City of Munoz 3119 The Philippines

Previously, we found 123 transcription factors（TFs） as candidate regulators of secondary cell wall（SCW）formation in rice by using phylogenetic and co-expression network analyses. Among them, we examined in this work the role of OsIDD_2, a zinc finger and indeterminate domain（IDD） family TF. Its overexpressors showed dwarfism, fragile leaves, and decreased lignin content, which are typical phenotypes of plants defective in SCW formation, whereas its knockout plants showed slightly increased lignin *** RNA-seq and quantitative reverse transcription polymerase chain reaction analyses confirmed that some lignin biosynthetic genes were downregulated in the OsIDD_2-overexpressing plants, and revealed the same case for other genes involved in cellulose synthesis and sucrose metabolism. The transient expression assay using rice protoplasts revealed that OsIDD_2 negatively regulates the transcription of genes involved in lignin biosynthesis, cinnamyl alcohol dehydrogenase 2 and 3（CAD_2 and 3）, and sucrose metabolism, sucrose synthase 5（SUS_5）, whereas an Alpha Screen assay, which can detect the interaction between TFs and their target DNA sequences, directly confirmed the interaction between OsIDD_2 and the target sequences located in the promoter regions of CAD_2 and CAD_3. Based on these observations, we conclude that OsIDD_2 is negatively involved in SCW formation and other biological events by downregulating its target genes.

关键词： IDD Figure OsIDD2 a zinc finger and INDETERMINATE DOMAIN protein SCW

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