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Computational cytometer based on magnetically modulated coherent imaging and deep learning

Light(Science & Applications) 2019年第1期8卷 385-399页

作者： Yibo Zhang Mengxing Ouyang Aniruddha Ray Tairan Liu Janay Kong Bijie Bai Donghyuk Kim Alexander Guziak Yi Luo Alborz Feizi Katherine Tsai Zhuoran Duan Xuewei Liu Danny Kim Chloe Cheung Sener Yalcin hatice Ceylan Koydemir Omai B.Garner Dino Di Carlo Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Department of Physics and Astronomy University of ToledoToledoOH 43606USA Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Yale School of Medicine New HavenCT 06510USA Department of Biochemistry University of CaliforniaLos AngelesCA 90095USA Department of Pathology and Laboratory Medicine University of CaliforniaLos AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive Cancer Center University of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Detecting rare cells within blood has numerous applications in disease *** rare cell detection techniques are typically hindered by their high cost and low ***,we present a computational cytometer based on magnetically modulated lensless speckle imaging,which introduces oscillatory motion to the magneticbead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three dimensions(3D).In addition to using cell-specific antibodies to magnetically label target cells,detection specificity is further enhanced through a deep-learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network(P3D CNN),which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic *** demonstrate the performance of this technique,we built a high-throughput,compact and cost-effective prototype for detecting MCF7 cancer cells spiked in whole blood *** serial dilution experiments,we quantified the limit of detection(LoD)as 10 cells per millilitre of whole blood,which could be further improved through multiplexing parallel imaging channels within the same *** compact,cost-effective and high-throughput computational cytometer can potentially be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

关键词： rare magnetic speckle

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丙泊酚注射对苯妥英钠用药下行开颅术患儿肝胰功能及酸碱平衡的影响

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麻醉与镇痛 2012年第3期8卷 62-67页

作者： hatice Ture, MD Arzu Mercan, MD , Ozge Koner, MD Bora Aykac, MD Ugur Tare, MD 王琦(译) 李文志(校) Departments of Anesthesioloty and Reanimation Departments of tNeurosurgery Yeditepe University School of Medicine Istanbul Turkey 不详

背景在此项研究中，我们评估了应用苯妥英钠预防癫痫的患儿行开颅手术中输注丙泊酚对其肝、胰酶和酸碱平衡的影响。方法在这项前瞻性的临床研究中，我们测定了30例4—12岁患儿的血清谷草转氨酶（AST）、谷丙转氨酶（ALT）、γ-谷氨酰转... 详细信息

背景在此项研究中，我们评估了应用苯妥英钠预防癫痫的患儿行开颅手术中输注丙泊酚对其肝、胰酶和酸碱平衡的影响。方法在这项前瞻性的临床研究中，我们测定了30例4—12岁患儿的血清谷草转氨酶（AST）、谷丙转氨酶（ALT）、γ-谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）、胰淀粉酶、胰脂肪酶及三酰甘油水平。患儿接受丙泊酚麻醉并应用苯妥英钠预防癫痫。以前已用苯妥英钠的患儿则继续用药。未曾用药者口服苯妥英钠5mg·kg^-1·d^-1。经医院批准于术前1天，术后第1、3、5、7天测定患儿血清中AST、ALT、GGT、ALP、胆红素、胰淀粉酶、胰脂肪酶、三酰甘油水平。分别于气管插管后、术中2小时和术中4小时、拔管以及拔管后1、2、6、12小时采集动脉血气样本。结果术后血清AST、ALT、GGT、ALP、胰淀粉酶、胰脂肪酶、三酰甘油水平显著高于术前基础值，且于术后第1天达峰值，并在1周内恢复正常。拔管后碱剩余与基础值相比显著降低，但仍在正常范围内，并于术后6小时恢复到基础值水平。患儿并未表现出肝炎或胰腺炎的临床症状或体征。胆红素水平正常。患儿在术后4—6个月内未发生肝胰相关的并发症。结论尽管开颅术患儿肝、胰酶在术后轻微上升，但丙泊酚全麻维持未对其酸碱平衡或肝、胰酶产生临床意义的显著影响。

关键词：口服苯妥英钠酸碱平衡开颅术患儿肝炎用药血清谷草转氨酶胰功能

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Multiple progressive focal nodular hyperplasia lesions of liver in a patient with hemosiderosis

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World Journal of Radiology 2010年第10期2卷 405-409页

作者： Arda Kayhan Nanda Venu hatice Lakadamyall Donald Jensen Aytekin Oto Department of Radiology Namlk Kemal University Department of Gastroenterology University of Chicago Department of Radiology Baskent University Department of Radiology University of Chicago

Focal nodular hyperplasia(FNH) is the second most common benign lesion of the *** is a solitary lesion and usually does not *** present the magnetic resonance imaging findings of multiple progressive FNH lesions in a patient with hemosiderosis using GadoliniumEOB-DTPA(Eovist) as a hepatobiliary contrast *** possible mechanisms underlying the occurrence and progression of FNH lesions and the potential value of Eovist in characterizing the lesions were discussed.

关键词： Focal nodular hyperplasia Hemosiderosis Magnetic resonance imaging Gadolinium-EOB-DTPA

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The relation between differential leukocyte count, neutrophil to lymphocyte ratio and the presence and severity of coronary artery disease

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Open Journal of Internal Medicine（内科学期刊） 2012年第3期

作者： hatice Selcuk Lale Dinc Mehmet Timur Selcuk Orhan Maden Ahmet Temizhan

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Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer

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World Journal of Radiology 2011年第10期3卷 241-245页

作者： Arda Kayhan Cheng Yang Fatma Nur Soylu hatice Lakadamyal Ila Sethi Gregory Karczmar Walter Stadler Aytekin Oto Department of Radiology University of ChicagoChicagoIL 60637United States Department of Medicine University of ChicagoChicagoIL 60637United States Cancer Research Center University of ChicagoChicagoIL 60637United States

AIM:To evaluate the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) findings of bone metastasis in prostate cancer ***:Sixteen men with a diagnosis of metastatic prostate cancer to bones were examined with DCE-MRI at 1.5 *** mean contrast agent concentration vs time curves for bone metastasis and normal bone were calculated and K trans and ve values were estimated and ***:An early significant enhancement (wash-out:n=6,plateau:n=8 and persistent:n=2) was detected in all bone metastases (n=16).Bone metastasis from prostate cancer showed significant enhancementand high K trans and ve values compared to normal bone which does not enhance in the elderly *** mean K trans was 0.101/mmiinn and 0.0051/mmiinn (P < 0.001),the mean ve was 0.141 and 0.0038 (P < 0.001),for bone metastases and normal bone,respectively.

关键词： Prostate Cancer Bone Metastasis Dynamic contrast-enhanced MR imaging

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A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study

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Health 2013年第7期5卷 30-40页

作者： Yesim Gokce Kutsal Nurten Eskiyurt Jale Irdesel Vesile Sepici hatice Ugurlu Yesim Kirazli Fusun Ardic Mirko Korsic Tonko Vlak Mane Grlickov Snezana Markovic Temelkova Miroslav Lazarov Nada Pilipovic Vera Popovic Aleksandar Dimic Branka Kovacev Dorina Ruci Argjend Tafaj Elma Kucukalic-Selimovic Dijana Avdic Hajrija Seleskovic Snjezana Pejicic Bulent Butun Gulseren Akyuz Lale Cerrahoglu Omer Faruk Sendur Peyman Yalcin Sema Oncel Merih Saridogan Tunay Sarpel Mehmet Tosun Kazim Senel Savas Gursoy Ferhan Canturk Huseyin Demir Blazenka Miskic Dalibor Krpan Franjo Skreb Simeon Grazio Zeljka Crncevic-Orlic Fatih Ozdener Hakan Oncel Clinic for Orthopaedic Surgery Clinical Centre Vodnjansk Skopje Macedonia Clinic of Endocrinology Diabetes and Metabolic Disorders Skopje Macedonia Clinic of Rheumatology Clinical Centre Skopje Macedonia Clinical Center of Vojvodina Novi Sad Serbia Clinical Center Banja Luka Bosnia and Herzegovina Clinical Hospital Centre Split Croatia Department of PMR Cerrahpasa School of Medicine Istanbul University Istanbul Turkey Department of PMR Clinical Hospital Center Rijeka Rijeka Croatia Department of PMR Dr. Josip Bencevic General Hospital Slavonski Brod Croatia Department of PMR Istanbul School of Medicine Istanbul University Istanbul Turkey Department of PMR Polyclinic for Internal Medicine Zagreb Croatia Department of PMR School of Medicine Adnan Menderes University Aydin Turkey Department of PMR School of Medicine Akdeniz University Ankara Turkey Department of PMR School of Medicine Ankara University Ankara Turkey Department of PMR School of Medicine Ataturk University Erzurum Turkey Department of PMR School of Medicine Celal Bayar University Manisa Turkey Department of PMR School of Medicine Cukurova University Adana Turkey Department of PMR School of Medicine Dokuz Eylul University Izmir Turkey Department of PMR School of Medicine Ege University Izmir Turkey Department of PMR School of Medicine Erciyes University Kayseri Turkey Department of PMR School of Medicine Gazi University Ankara Turkey Department of PMR School of Medicine Gaziantep University Gaziantep Turkey Department of PMR School of Medicine Hacettepe University Ankara Turkey Department of PMR School of Medicine Karadeniz Technical University Trabzon Turkey Department of PMR School of Medicine Marmara University Istanbul Turkey Department of PMR School of Medicine Ondokuz Mayis University Samsun Turkey Department of PMR School of Medicine Pamukkale University Denizli Turkey Department of PMR School of Medicine Selcuk University Konya Turkey Department

A candidate identification questionnaire (CIQ) was tested to determine its predictive value for patient-reported satisfaction in patients switched from once-weekly or once-daily treatment with a bisphosphonate to once-monthly dosing. This was a prospective, open-label, multicenter international study in patients with postmenopausal osteoporosis who had been receiving once-daily or once-weekly alendronate or risendronate for at least 3 months. Patients completed a CIQ, then commenced 150 mg monthly ibandronate for 6 months. Patients completed the Osteoporosis Patient Satisfaction Questionnaire (OPSAT-QTM) at baseline for 6 months. Scores were converted to composite satisfaction scores (CSS, scale 0-100). Totally 677 patients completed a CIQ, 645 were enrolled in the treatment phase and comprised the intent-to-treat (ITT) population, and 630 completed the study. In the ITT population, 68.1% patients answered “yes” to one or more CIQ questions. OPSAT-Q scores increased for the convenience, quality of life and overall satisfaction domains (p scores for the side effects domains were significant (p < 0.001) in the CIQ “yes” group, but not for the degree of bother (decrease in mean of 0.1 points, p = 0.50) or duration (no change, p = 0.84) of non-gastrointestinal side effects. Of 638 patients who completed the preference questionnaire, 93.0% of patients preferred the once-monthly dosing schedule and 563 patients (90.7%) found it more convenient. The most common adverse events were dyspepsia (1.9%), nausea (1.1%), and upper abdominal pain (0.9%). Patients are likely to prefer treatment with monthly ibandronate to a weekly or monthly bisphosphonate irrespective of their stated preference before switching treatment.

关键词： Bisphosphonate Compliance Ibandronate Postmenopausal Osteoporosis

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Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution

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Plant Communications 2023年第3期4卷 80-98页

作者： Salih Kafkas Xiaokai Ma Xingtan Zhang Hayat Topc¸u Rafael Navajas-Pérez Ching Man Wai Haibao Tang Xuming Xu Mortaza Khodaeiaminjan Murat Güney Aibibula Paizila Harun Karcı Xiaodan Zhang Jing Lin Han Lin Roberto de la Herrán Carmelo Ruiz Rejón Jerson Alexander García-Zea Francisca Robles Coral del Val Muñoz Agnes Hotz-Wagenblatt Xiangjia Jack Min HakanÖzkan Elmira Ziya Motalebipour hatice Gozel Nergiz C¸oban Nesibe Ebru Kafkas Andrej Kilian HuaXing Huang Xuanrui Lv Kunpeng Liu Qilin Hu Ewelina Jacygrad William Palmer Richard Michelmore Ray Ming Department of Horticulture Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Center for Genomics and Biotechnology Haixia Institute of Science and TechnologySchool of Future TechnologyFujian Agriculture and Forestry UniversityFuzhouChina Key Laboratory of Orchid Conservation and Utilization of National Forestry and Grassland Administration Fujian Agriculture and Forestry UniversityFuzhouChina Departamento de Genética Facultad de CienciasCampus de Fuentenueva s/n18071 GranadaSpain Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and EcologyXiamen UniversityXiamen 361102China Department of Computer Science University of GranadaGranadaSpain Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI Institute) 18014 GranadaSpain German Cancer Research Center Omics IT and Data Management Core FacilityHeidelbergGermany Department of Biological Sciences Youngstown State UniversityYoungstownOH 44555USA Department of Field Crops Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Pistachio Research Institute SxahinbeyGaziantep 27060Turkey Diversity Arrays Technology University of CanberraCanberraACTAustralia Genome Center University of California Davis451 Health Sciences DriveDavisCA 95616USA

Pistachio is a nut crop domesticated in the Fertile Crescent and a dioecious species with ZW sex *** sequenced the genomes of Pistacia vera cultivar(cv.)Siirt,the female parent,and *** ***,the male *** chromosome-level reference genomes of pistachio were generated,and Z and W chromosomes were *** ZW chromosomes originated from an autosome following the first inversion,which occurred approximately 8.18 *** inversion events in the W chromosome led to the formation of a 12.7-Mb(22.8%of the W chromosome)non-recombining *** W-specific sequences contain several genes of interest that may have played a pivotal role in sex determination and contributed to the initiation and evolution of a ZW sex chromosome system in *** W-specific genes,including defA,defA-like,DYT1,two PTEN1,and two tandem duplications of six VPS13A paralogs,are strong candidates for sex determination or *** history analysis of resequenced genomes suggest that cultivated pistachio underwent severe domestication bottlenecks approximately 7640 years ago,dating the domestication event close to the archeological record of pistachio domestication in *** identified 390,211,and 290 potential selective sweeps in 3 cultivar subgroups that underlie agronomic traits such as nut development and quality,grafting success,flowering time shift,and drought *** findings have improved our understanding of the genomic basis of sex determination/differentiation and horticulturally important traits and will accelerate the improvement of pistachio cultivars and rootstocks.

关键词： Pistacia vera pistachio sequencing reference genome sex chromosome domestication

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自然教育:户外学习提升学生地图识读能力、解决问题的反思性思维能力

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中国校外教育 2023年第3期 111-128页

作者：伊莱夫·阿拉达格阿拉丁·阿里坎哈蒂杰·奥泽诺格鲁() 方琮(译) 王萍(译) 陈均瑶(译) 胡奇(译) 毛峰(译) 不详华东理工大学中国儿童中心上海对外经贸大学国际商务外语学院

地图识读能力、解决问题的反思性思维能力,二者之间有何关系,自然教育对二者有何影响,以此为研究目标,根据探索性序列混合研究设计,以36名七年级学生为研究样本,使用地图识读量表、解决问题的反思性思维能力量表,并设计半结构式访谈表... 详细信息

地图识读能力、解决问题的反思性思维能力,二者之间有何关系,自然教育对二者有何影响,以此为研究目标,根据探索性序列混合研究设计,以36名七年级学生为研究样本,使用地图识读量表、解决问题的反思性思维能力量表,并设计半结构式访谈表、活动手册、学生工作表收集数据。定量研究结果显示,自然教育之下,学生的地图识读能力、解决问题的反思性思维能力都有了明显提高,并且两种能力之间存在很强的相关性。对参与学生进行的访谈也证实了以上研究发现。基于以上发现,研究人员建议教师投入更多时间进行自然教育,并在课程中普及自然教育。

关键词：户外学习空间思维解决问题社会研究科学

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聚丁二酸丁二醇酯--一种新兴的纺织聚酯?

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国际纺织导报 2018年第12期46卷 6-8页

作者： B.Weise J. Golz S. Wenning H. Demirel A. Friedmann T. Turki G. Wortberg G. Seide 乔士亚(译) 于俊荣(校) 亚琛工业大学纺织技术研究所德国马斯特里赫特大学亚琛-马斯特里赫特生物材料研究所荷兰不详

鉴于石油储量的逐渐减少,以及制造商和消费者环保意识的日益增强,由可再生资源制成的聚合物材料被认为是下一代纺织品的理想材料。然而,生物基聚合物的成本目前是商品聚合物(如聚酰胺和聚烯烃)的两倍以上。由聚酰胺和常规聚酯[如聚对苯... 详细信息

鉴于石油储量的逐渐减少,以及制造商和消费者环保意识的日益增强,由可再生资源制成的聚合物材料被认为是下一代纺织品的理想材料。然而,生物基聚合物的成本目前是商品聚合物(如聚酰胺和聚烯烃)的两倍以上。由聚酰胺和常规聚酯[如聚对苯二甲酸乙二醇酯(PET)]制成的纺织品,其全球产量分别为1 500万t和5 500万t(2015年),在当今纺织工业中占据主导地位。2015年,欧洲市场已将10万t可生物降解聚合物用于商业用途,其中包装应用占主导地位。

关键词：聚丁二酸丁二醇酯纺织品生物基聚合物

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