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Dietary phytochemical consumption is inversely associated with liver alkaline phosphatase in Middle Eastern adults

World Journal of Hepatology 2022年第5期14卷 1006-1015页

作者： Zahra Darabi Richard James Webb hassan mozaffari-khosravi Masoud Mirzaei Ian Glynn Davies Sayyed Saeid Khayyatzadeh Mohsen Mazidi Nutrition and Food Security Research Center Shahid Sadoughi University of Medical SciencesYazdIran Department of Nutrition School of Public HealthShahid Sadoughi University of Medical SciencesYazdIran School of Health Sciences Liverpool Hope UniversityLiverpool L169JDUnited Kingdom Nutrition and Food Security Research Center Shahid Sadoghi University of Medical SciencesYazdIran Yazd Cardiovascular Research Centre Shahid Sadoughi University of Medical SciencesYazdIran School of Sports and Exercise Sciences Faculty of ScienceLiverpool John Moores UniversityIM Marsh CampusBarkhill RoadLiverpool L176AFUnited Kingdom Medical Research Council Population Health Research Unit Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUnited Kingdom Department of Twin Research&Genetic Epidemiology King’s college LondonSouth Wing St Thomas'London SE17EHUnited Kingdom

BACKGROUND The hepatoprotective effects of phytochemicals are controversial.A dietary phytochemical index(DPI)has been suggested as an alternative method for quantifying the phytochemical content of *** To assess the DPI in relation to liver function tests among a representative sample of Iranian *** A total of 5111 participants aged 35-70 years old were included in this cross-sectional study by a multistage cluster random sampling *** intakes were collected by a validated and reliable food frequency questionnaire with 121 *** was calculated by the percent of daily energy intake taken from phytochemical-rich *** serum concentrations of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and gamma glutamyl transferase(GGT)were *** regression was used to investigate the association between DPI and levels of liver enzymes using crude and adjusted *** There was an inverse association between DPI score and serum ALP in the crude model(β=-0.05;P<0.001).This association remained significant after adjustment for body mass index,age,smoking,energy intake,history of diabetes,and education(β=-0.03;P=0.01).No significant associations were found between DPI score and serum levels of AST,ALT,and *** individuals with the highest DPI scores consumed significantly higher amounts of fruits,vegetables,legumes,nuts,and cereals,yet were shown to have significantly higher serum total cholesterol and low-density lipoprotein cholesterol,as well as several other metabolic *** Higher adherence to phytochemical-rich foods was associated with lower levels of ALP,but no change in other liver *** with higher DPI scores also consumed food items associated with a healthier overall dietary pattern;however,they also presented several unexpected metabolic *** randomised trials are needed to better determine the effects of phytochemical-rich foo

关键词： Diet Phytochemical Liver Dietary phytochemical index Dietary pattern Phytochemical index Iran Middle East Nutrition

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Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes： a randomized, double-blind clinical trial

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Journal of Integrative Medicine 2017年第2期15卷 124-134页

作者： Nazli Samadi hassan mozaffari-khosravi Masoud Rahmanian Mohsen Askarishahi Department of Nutrition School of Public Health Shahid Sadoughi University of Medical Sciences Yazd Iran Yazd Diabetic Research Center Shahid Sadoughi University of Medical Sciences Yazd Iran Department of Internal Medicine Faculty of Medicine Shahid Sadoughi University of Medical Sciences Yazd Iran Department of Biostatistics and Epidemiology Faculty of Health Shahid Sadoughi University of Medica Sciences Yazd. Iran

BACKGROUND： Propolis, a natural resinous substance made by bees from material extracted from plants, flowers and bee＇s wax, has shown great therapeutic effects and been widely used in food and drug industries. Recently, some researchers have studied the effect of this substance in the treatment of diabetes. OBJECTIVE： The purpose of this trial was to determine the effect of bee propolis on glycemic contro serum lipid profile and insulin resistance indices in patients with type 2 diabetes （T2D）. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This randomized clinical trial involved 66 patients with T2D, which were randomly divided into two groups of intervention （IG） and placebo （PG）. IG received 300 mg three times a day for a total of 900 mg/d of propolis pills, while PG received similar pills, lacking propolis, on the same schedule for 12 weeks. MAIN OUTCOME MEASURES： Fasting blood glucose （FBG）, hemoglobin Alc （HbAlc）, total cholestero （TC）, low-density lipoprotein （LDL）, high-density lipoprotein （HDL）, triglyceride （TG）, serum insulin and insulin resistance indices were the main outcome measures. RESULTS： The mean change in FBG between the IG （（17.76 ±27.72） mg/dL decrease） and the PG （（6.48 ± 42.77） mg/dL increase） was significantly different （P = 0.01）. Change in mean HbAlc had a similar pattern to FBG. The mean change in TC between the IG （（5.16± 43.80） mg/dL increase） and the PG （（28.9 ± 27.4） mg/dL increase） was also significantly different （P = 0.01）, showing the protective role of propolis against the increase in TC. The change in mean LDL was similar to mean TC. There was no significant difference in other lipids or insulin resistance indices between the two groups. CONCLUSION： Based on this study, the daily intake of 900 mg of bee propolis supplement for 12 weeks results in improvement of glycemic and some serum lipid levels in patients with *** REGISTRATION： This study is registered on the website of Iranian Ministry of Health （***）with p

关键词： propolis diabetes mellitus, type 2 blood glucose insulin resistance

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Analysis of cohesive particles mixing behavior in a twin-paddle blender:DEM and machine learning applications

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Particuology 2024年第7期90卷 350-363页

作者： Behrooz Jadidi Mohammadreza Ebrahimi Farhad Ein-mozaffari Ali Lohi Department of Chemical Engineering Toronto Metropolitan University350 Victoria StreetToronto M5B 2K3Canada

This research paper presents a comprehensive discrete element method(DEM)examination of the mixing behaviors exhibited by cohesive particles within a twin-paddle blender.A comparative analysis between the simulation and experimental results revealed a relative error of 3.47%,demonstrating a strong agreement between the results from the experimental tests and the DEM *** main focus centers on systematically exploring how operational parameters,such as impeller rotational speed,blender's fill level,and particle mass ratio,influence the *** investigation also illustrates the significant influence of the mixing time on the mixing *** gain a deeper understanding of the DEM simulation findings,an analytical tool called multivariate polynomial regression in machine learning is *** method uncovers significant connections between the DEM results and the operational parameters,providing a more comprehensive insight into their *** multivariate polynomial regression model exhibited robust predictive performance,with a mean absolute percentage error of less than 3%for both the training and validation sets,indicating a slight deviation from actual *** model's precision was confirmed by low mean absolute error values of 0.0144(80%of the dataset in the training set)and 0.0183(20%of the dataset in the validation set).The study offers valuable insights into granular mixing behaviors,with implications for enhancing the efficiency and predictability of the mixing processes in various industrial applications.

关键词： Machine learning Granular mixing Discrete element method Mixing kinetics and mechanism Cohesive particles

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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor khosravi Farzad Dastaviz Mehdi Sheikh Arabi Ayyoob khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor khosravi Ayyoob khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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An Online Fake Review Detection Approach Using Famous Machine Learning Algorithms

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Computers, Materials & Continua 2024年第2期78卷 2767-2786页

作者： Asma hassan Alshehri Department of Computer Sciences College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl KharjSaudi Arabia

Online review platforms are becoming increasingly popular,encouraging dishonest merchants and service providers to deceive customers by creating fake reviews for their goods or *** Sybil accounts,bot farms,and real account purchases,immoral actors demonize rivals and advertise their *** academic and industry efforts have been aimed at detecting fake/fraudulent product or service evaluations for *** primary hurdle to identifying fraudulent reviews is the lack of a reliable means to distinguish fraudulent reviews from real *** paper adopts a semi-supervised machine learning method to detect fake reviews on any website,among other *** reviews are classified using a semi-supervised approach(PU-learning)since there is a shortage of labeled data,and they are ***,classification is performed using the machine learning techniques Support Vector Machine(SVM)and Nave *** performance of the suggested system has been compared with standard works,and experimental findings are assessed using several assessment metrics.

关键词： Security fake review semi-supervised learning ML algorithms review detection

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Advancing sandstone reservoir compressibility prediction:A correlation-driven methodology

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Petroleum Research 2024年第2期9卷 273-279页

作者： Tarek Ganat Meftah Hrairi Amr Badawy Vahid khosravi Mohammed Abdalla Department of Petroleum Chemical Engineering Sultan Qaboos UniversityP.O.Box 50Al-Khod123MuscatOman Department of Mechanical and Aerospace Engineering International Islamic University MalaysiaP.O.Box 1050728Kuala LumpurMalaysia Reservoir Engineering Section Petronas Carigali SDN BHDP.O.Box 10500088Kuala LumpurMalaysia Department of Chemical and Petroleum Engineering Faculty of EngineeringTechnologyand Built EnvironmentUCSI University56000Kuala LumpurMalaysia Chemical&Petroleum Engineering United Arab Emirates UniversityP.O.Box No.15551Al AinUAE

This study presents a correlation-based approach for predicting the compressibility of sandstone reservoir *** study proposes a matrix of new empirical equations that significantly improve the precision of measuring the pore volume compressibility,with the most optimal fit of results based on a cubic polynomial *** accuracy of the calculations was validated through comparison with actual data using root mean square method,and the suggested correlations significantly enhance the precise prediction of rock compressibility in sandstone *** this study,the source of data collection is consolidated and unconsolidated sandstone from East Asia offshore ***,variations in compressibility with net overburden pressure over the course of the field's lifespan have been *** results demonstrate the application of regression analysis in establishing a network of linkages between independent and dependent *** proposed correlations for consolidated and unconsolidated sandstones offer a remarkable improvement in the accurate calculation of rock compressibility compared to traditional laboratory procedures,with an average error of 2.5%compared to 5-10%for laboratory *** approach of this study offers a cost-effective and time-efficient alternative to remarkedly enhance the overall performance of sandstone reservoirs in the oil and gas industry.

关键词： Compressibility Consolidated and unconsolidated sandstone Rock properties Rock mechanics

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An Electrical Impedance Imaging System Towards Edge Intelligence for Non-Destructive Testing of Concrete

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Tsinghua Science and Technology 2024年第3期29卷 883-896页

作者： Abolfazl Roshanpanah Mahdi Abbasi Hani Attar Ayman Amer Mohammad R.khosravi Ahmed A.Solyman Department of Electrical Engineering Islamic Azad UniversityScience and Research BranceTehran ***Iran Department of Computer Engineering Bu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Department of Computer Engineering Persian Gulf UniversityBushehr ***Iran Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNişantaşıUniversityIstanbul 34398Turkey

In the construction industry,to prevent accidents,non-destructive tests are necessary and *** impedance tomography is a new technology in non-invasive imaging in which the image of the inner part of conductive bodies is reconstructed by the arrays of external electrodes that are connected on the periphery of the *** equipment is cheap,fast,and edge *** this imaging method,the image of electrical conductivity distribution(or its opposite;electrical impedance)of the internal parts of the target object is *** image reconstruction process is performed by injecting a precise electric current to the peripheral boundaries of the object,measuring the peripheral voltages induced from it and processing the collected *** an electrical impedance tomography system,the voltages measured in the peripheral boundaries have a non-linear equation with the electrical conductivity *** paper presents a cheap Electrical Impedance Tomography(EIT)instrument for detecting impurities in the concrete.A voltage-controlled current source,a micro-controller,a set of multiplexers,a set of electrodes,and a personal computer constitute the structure of the *** conducted tests on concrete with impurities show that the designed EIT system can reveal impurities with a good accuracy in a reasonable time.

关键词： non-destructive testing system concrete electrical impedance tomography

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Heating-Cooling Monitoring and Power Consumption Forecasting Using LSTM for Energy-Efficient Smart Management of Buildings: A Computational Intelligence Solution for Smart Homes

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Tsinghua Science and Technology 2024年第1期29卷 143-157页

作者： Omid Akbarzadeh Sahand Hamzehei Hani Attar Ayman Amer Nazanin Fasihihour Mohammad R.khosravi Ahmed A.Solyman Department of Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262799China Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNisantası UniversityIstanbul 25370The Republic of Turkiye

Energy management in smart homes is one of the most critical problems for the Quality of Life(QoL)and preserving energy *** of the relevant issues in this subject is environmental contamination,which threatens the world's *** computing-enabled Artificial Intelligence(Al)algorithms can provide impactful solutions to this *** research proposes using one of the Recurrent Neural Network(RNN)algorithms known as Long Short-Term Memory(LSTM)to comprehend how it is feasible to perform the cloud/fog/edge-enabled prediction of the building's *** parameters of power electricity,power heating,power cooling,and total power in an office/home in cold-climate cities are considered as our features in the *** on the collected data,we evaluate the LSTM approach for forecasting parameters for the next year to predict energy consumption and online monitoring of the model's performance under various *** implementing the Al predictive algorithm,several existing tools are *** results have been generated through simulations,and we find them promisingforfutureapplications.

关键词： design-builder Besos smart cities smart building neural network Long Short-Term Memory(LSTM)

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Distributed Hybrid Model Predictive Secondary Control of DC Microgrids with Random Communication Disorders

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 925-935页

作者： Meysam Yaribeygi Zeinab Karami Qobad Shafiee hassan Bevrani the Department of Electrical Engineering K.N.Toosi University of TechnologyTehranIranand he is now with the Sportradar CompanyTrondheimNorway the Department of Engineering Cybernetics(ITK) Norwegian University of Science and Technology(NTNU)TrondheimNorway the Smart/Micro Grids Research Center Department of Electrical EngineeringUniversity of KurdistanSanandajIran

A reliable and robust communication network is essential to exchange information between distributed generators(DGs)and accurately calculate their control actions in microgrids(MGs).However,the integration of the communication network and MGs poses challenges related to the flexibility,availability,and reliability of the ***,random communication disorders such as time delays and packet loss can negatively impact the system ***,it is essential to design a suitable secondary controller(SC)with a fast dynamic response to restore voltage and appropriate powersharing,while ensuring that the effects of random communication disorders are *** this regard,an optimal distributed hybrid model predictive secondary control method is presented in this *** simulations are carried out in a mixed simulation environment based on MATLAB and OMNET++,by considering IEEE 802.11(Wi Fi)using the recently developed Internet networking(INET)*** the implemented application layer,the recovery Unit is responsible for reducing the impact of random communication *** effectiveness and performance of the proposed method in comparison with a conventional model predictive control are verified by simulation results.

关键词： Microgrid model predictive control random communication disorder secondary control

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