Dietary phytochemical consumption is inversely associated with liver alkaline phosphatase in Middle Eastern adults
作者机构：Nutrition and Food Security Research CenterShahid Sadoughi University of Medical SciencesYazdIran Department of NutritionSchool of Public HealthShahid Sadoughi University of Medical SciencesYazdIran School of Health SciencesLiverpool Hope UniversityLiverpool L169JDUnited Kingdom Nutrition and Food Security Research CenterShahid Sadoghi University of Medical SciencesYazdIran Yazd Cardiovascular Research CentreShahid Sadoughi University of Medical SciencesYazdIran School of Sports and Exercise SciencesFaculty of ScienceLiverpool John Moores UniversityIM Marsh CampusBarkhill RoadLiverpool L176AFUnited Kingdom Medical Research Council Population Health Research UnitNuffield Department of Population HealthUniversity of OxfordOxford OX37LFUnited Kingdom Department of Twin Research&Genetic EpidemiologyKing’s college LondonSouth Wing St Thomas'London SE17EHUnited Kingdom
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2022年第14卷第5期
页 面：1006-1015页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100403[医学-营养与食品卫生学] 10[医学]
主 题：Diet Phytochemical Liver Dietary phytochemical index Dietary pattern Phytochemical index Iran Middle East Nutrition
摘 要：BACKGROUND The hepatoprotective effects of phytochemicals are controversial.A dietary phytochemical index(DPI)has been suggested as an alternative method for quantifying the phytochemical content of *** To assess the DPI in relation to liver function tests among a representative sample of Iranian *** A total of 5111 participants aged 35-70 years old were included in this cross-sectional study by a multistage cluster random sampling *** intakes were collected by a validated and reliable food frequency questionnaire with 121 *** was calculated by the percent of daily energy intake taken from phytochemical-rich *** serum concentrations of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and gamma glutamyl transferase(GGT)were *** regression was used to investigate the association between DPI and levels of liver enzymes using crude and adjusted *** There was an inverse association between DPI score and serum ALP in the crude model(β=-0.05;P0.001).This association remained significant after adjustment for body mass index,age,smoking,energy intake,history of diabetes,and education(β=-0.03;P=0.01).No significant associations were found between DPI score and serum levels of AST,ALT,and *** individuals with the highest DPI scores consumed significantly higher amounts of fruits,vegetables,legumes,nuts,and cereals,yet were shown to have significantly higher serum total cholesterol and low-density lipoprotein cholesterol,as well as several other metabolic *** Higher adherence to phytochemical-rich foods was associated with lower levels of ALP,but no change in other liver *** with higher DPI scores also consumed food items associated with a healthier overall dietary pattern;however,they also presented several unexpected metabolic *** randomised trials are needed to better determine the effects of phytochemical-rich foo
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