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The impact of foot reflexology on fatigue and sleep quality in school-aged children undergoing hemodialysis

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Journal of Integrative Nursing 2024年第2期6卷 76-82页

作者： Amal hashem mohamed Mostafa SHABAN Huda Hamdy MOHAMMED Randa mohamed ABOBAKER Salman Hamdan ALSAQRI Rania Abd-Elnaby Mohammed ALLAM Faculty of Nursing Minia UniversityMinyaEgypt College of Nursing Jouf UniversitySakakaSaudi Arabia Faculty of Nursing Cairo UniversityGizaEgypt Northern College of Nursing ARARSaudi Arabia College of Nursing University of HailHailSaudi Arabia

Objective:This study aimed to evaluate the effects of foot reflexology on fatigue and sleep quality in school-aged children receiving ***:A quasi-experimental pretest-posttest design was *** children of ages 6-12 undergoing in-center hemodialysis were *** Pittsburgh Sleep Quality Index(PSQI)and Inventory of Fatigue Symptom(IFS)scales were administered at *** then received 30 min of foot reflexology massage before hemodialysis sessions 3 days per week for 12 *** administration of the sleep and fatigue scales occurred after the intervention ***:Reflexology massage led to significant improvements in sleep quality components,including duration(0%-30%normal sleepers),efficiency(0%-50%>85%),latency(50%-0%>60 min),disturbances,and daytime *** mean PSQI score decreased from 18.2 to 9.7(P<0.05).Fatigue severity substantially decreased,with the mean IFS score improving from 105.7 to 64.1(P<0.05).Conclusion:Foot reflexology is an effective nursing intervention for reducing fatigue and improving sleep quality in children on hemodialysis,warranting integration into routine care.

关键词： Fatigue hemodialysis massage pediatric reflexology sleep

Stress combination:When two negatives may become antagonistic,synergistic or additive for plants?

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Pedosphere 2023年第2期33卷 287-300页

作者： Hera NADEEM Amir KHAN Rishil GUPTA mohamed hashem Saad ALAMRI Mansoor Ahmad SIDDIQUI Faheem AHMAD Department of Botany Aligarh Muslim UniversityAligarh 202002(India) Department of Biology College of ScienceKing Khalid UniversityAbha 61413(Saudi Arabia) Botany and Microbiology Department Faculty of ScienceAssiut UniversityAssiut 71516(Egypt)

Plants in their natural environment are constantly subjected to various abiotic and biotic stressors and,therefore,have developed several defense mechanisms to maintain *** responses are intricate and require various physiological,biochemical,and cellular changes in *** reaction mechanisms in plants subjected to drought,salinity,or heat stress alone have been explained in numerous ***,the field conditions are significantly different from the controlled laboratory *** the field,crops or plants are simultaneously exposed to two or more abiotic and/or biotic stress conditions,such as a combination of salinity and heat,drought and cold,or any of the abiotic stresses combined with pathogen *** have shown that plants’reactions to combinations of more than two stress factors are distinct and cannot be explicitly deduced from their responses to different stresses when applied ***,additional research is needed to understand the complete mechanism of plant responses to stress by analyzing data between single stress and multiple stress *** review aims to provide an overview of current research on plant responses to a combination of various stress conditions and their influence on the metabolic,transcriptional,and physiological characteristics of plants.

关键词： abiotic stress abscisic acid biotic stress defence mechanism multifactorial stress reactive oxygen species stress response

Cellulose Nanocrystal from Washingtonia Fibre and Its Characterization

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Journal of Renewable Materials 2022年第6期10卷 1459-1470页

作者： Mohammad Jawaid Lau Kia Kian Hassan Fouad Ramzi Khiari Othman Y.Alothman mohamed hashem Laboratory of Biocomposite Technology Institute of Tropical Forestry and Forest Products(INTROP)Universiti Putra MalaysiaSelangorMalaysia Applied Medical Science Department Community CollegeKing Saud UniversityRiyadhSaudi Arabia CNRS University of Grenoble AlpesGrenobleFrance Department of Textile Higher Institute of Technological Studies of Ksar HellalKsar HellalTunisia University of Monastir Laboratory of Environmental Chemistry and Cleaner Process(LCE2P-LR21ES04)MonastirTunisia Chemical Engineering Department College of EngineeringKing Saud UniversityRiyadhSaudi Arabia Dental Health Department College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia

Cellulose nanocrystal(CNC)is a biomaterial derived from plant lignocellulosic components,widely applied in various industrial ***,with the growth of awareness in developing green nanomaterial,the explored Washingtonia fibre could be alternative biomass for obtaining CNC *** the present work,different acid concentrations of 5%,15%,and 25%hydrochloric solutions were employed to produce CNCs from Washingtonia *** the chemical treatments,the yield of the CNC product was successfully retained at 21.6%-25.1%.Individually separated and needle-shaped CNC particles could be observed under the microscopic viewing with the increased acid *** elemental analysis,a relatively pure cellulose compartment was produced for all CNC *** zeta potential values between-10 to-16 mV proved that each nanoparticle sample possessed dispersion ability within an aqueous ***,the degree of crystallinity and the thermal behavior of CNCs were enhanced with the increased acidic ***,the isolated CNCs(with 15%)from Washingtonia fibre lead a CNC with the highest aspect ratio(30).This parameter is so important that these structures show empowering points of view as nanomaterials for reinforced polymer composites,and it could be a reliable nano-filler for the composite fabrication process in the future.

关键词： Cellulose nanocrystal washingtonia fibre structure degree of crystallinity thermal behavior

Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-hashem Salah O.Bashir Amal F.Dawood Moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni mohamed D.Morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic Medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the Morris Water Maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

Biosynthesis of raw starch degradingβ-cyclodextrin glycosyltransferase by immobilized cells of Bacillus licheniformis using potato wastewater

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BIOCELL 2021年第6期45卷 1661-1672页

作者： YASSER S.MOSTAFA SAAD A.ALAMRI SULIMAN A.ALRUMMAN TAREK H.TAHA mohamed hashem MAHMOUD MOUSTAFA LAMIAA I.FAHMY Department of Biology College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Prince Sultan Bin Abdulaziz Center for Environmental and Tourism Research and Studies King Khalid UniversityAbha9004Saudi Arabia Environmental Biotechnology Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research&Technological ApplicationsNew Borg El-Arab City21934Egypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiut71515Egypt Department of Botany and Microbiology Faculty of ScienceSouth Valley UniversityQena83523Egypt Department of Microbiology and Immunology Faculty of PharmacyOctober University for Modern Science and ArtGiza12451Egypta

The study was sought to enhance the synthesis of thermal stableβ-cyclodextrin glycosyltransferase(β-CGTase)using potato wastewater as a low-cost medium and assess the degree to which it is efficient for industrial production ofβ-cyclodextrin(β-CD)from raw potato *** bacteria producingβ-CGTase was isolated from Saudi Arabia and the promising strain was identified as Bacillus licheniformis using phylogenetic analysis of the 16S rRNA ***-encapsulated cultures exhibited twice-fold ofβ-CGTase production more than free *** electron microscopy(SEM)of polymeric capsules indicated the potential for a longer shelf-life,which promotes the restoration of activity in bacterial cells across semi-continuous fermentation ofβ-CGTase production for 252 *** optimal conditions forβ-CGTase synthesis using potato wastewater medium were at 36 h,pH of 8.0,and 50°C with 0.4%potato starch and 0.6%yeast extract as carbon and nitrogen sources,*** purified enzyme showed a specific activity of 63.90 U/mg with a molecular weight of∼84.6 kDa as determined by SDS-PAGE *** high enzyme activity was observed up to 60°C,and complete stability was achieved at 75°*** levels of activity and stability were shown at pH 8.0,and the pH range from 7.0–10.0,*** enzyme has an appreciable affinity for raw potato starch with a Km of 5.7×10−6 M and a Vmax of 87.71μmoL/mL/min.β-CD production was effective against 25 U/g of raw potato *** outcomes demonstrated its feasibility to develop a fermentation process by integrating the cost-effective production ofβ-CGTase having distinctive properties forβ-CD production with ecofriendly utilization of potato wastewater.

关键词： Potato wastewater Bacillus licheniformis β-CGTase 16S rDNA gene Semi-continuous fermentation β-cyclodextrin

Development of Longer-Lasting Insect Repellence Cellulosic Based Curtain Fabrics

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Materials Sciences and Applications 2011年第3期2卷 200-208页

作者： Shahba Afaf Farag Halawa Osama Ragaei mohamed hashem mohamed 不详

Long lasting insect repellent curtain fabrics were developed and characterized. Different types of fabrics which are generally used in manufacture of curtain fabrics were functionalized with monochlorotriazenyl β-cyclodextrin (MCT-β-CD) then treated with different concentration from permethrin to impart the fabric insect repellent properties. These fabrics were 100% cotton, cotton/viscose, cotton/linen, polyester/cotton, polyester/linen and polyester/viscose blend fabrics. The treated curtain fabrics were evaluated for insect repellent retention capacity against mosquitoes. The repellent efficacy comprises the determination of percent mosquitoes repelled, knockdown and killed (mortality) resulting from exposed mosquitoes to the treated fabric. Results obtained shows that, the insect repellent retention capacity of curtain fabrics functionalized with R-β-CD then treated with permethrin depends on the amount of β-CD moieties on the curtain fabrics, type of fabric and permethrin concentration. Higher action is obtained when the fabric was functionalized with 100 g/L, MCT-β-CD in alkaline medium followed by treatment with 15 g/L permethrin. The results show also that, curtain fabric made of cotton/linen shows highest mosquitoes repellent retention capacity and highest resistance against washing compared with 100% cotton or cotton/viscose or polyester based curtain fabrics. The insect repellent treatment of curtain fabrics did not adversely affect the tensile strength or drapability index of curtain

关键词： Cotton Curtain Fabrics β-Cyclodextrin Linen Insect Repellent Fabric Polyester Viscose

Characterization of aerodynamic performance of wind-lens turbine using high-fidelity CFD simulations

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Frontiers in Energy 2022年第4期16卷 661-682页

作者： Islam hashem Aida A.HAFIZ mohamed H.mohamed Mechanical Power Engineering Department Faculty of Engineering-MatariaHelwan UniversityCairo 11718Egypt State Key Laboratory of Hydroscience and Engineering Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Mechanical Engineering Department College of Engineering and Islamic ArchitectureUmm Al-Qura UniversityMakkah5555Saudi Arabia

Wind-lens turbines(WLTs)exhibit the prospect of a higher output power and more suitability for urban areas in comparison to bare wind *** wind-lens typically comprises a diffuser shroud coupled with a flange appended to the exit periphery of the ***-lenses can boost the velocity of the incoming wind through the turbine rotor owing to the creation of a lowpressure zone downstream the flanged *** this paper,the aerodynamic performance of the wind-lens is computationally assessed using high-fidelity transient CFD simulations for shrouds with different profiles,aiming to assess the effect of change of some design parameters such as length,area ratio and flange height of the diffuser shroud on the power *** power coefficient(Cp)is calculated by solving the URANS equations with the aid of the SST k–ω***,comparisons with experimental data for validation are accomplished to prove that the proposed methodology could be able to precisely predict the aerodynamic behavior of the windlens *** results affirm that wind-lens with cycloidal profile yield an augmentation of about 58%increase in power coefficient compared to bare wind turbine of the same rotor *** is also emphasized that diffusers(cycloid type)of small length could achieve a twice increase in power coefficient while maintaining large flange heights.

关键词： shroud diffuser-augmented wind turbine(DAWT) Betz limit aerodynamics computational fluid dynamics(CFD)

Diagnosis,treatment protocols,and outcomes of liver transplant recipients infected with COVID-19

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World Journal of Clinical Cases 2023年第10期11卷 2140-2159页

作者： Mai hashem mohamed El-Kassas Tropical Medicine and Gastroenterology Assiut University HospitalAssiut 71515Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Several cases of fatal pneumonia during November 2019 were linked initially to severe acute respiratory syndrome coronavirus 2,which the World Health Organization later designated as coronavirus disease 2019(COVID-19).The World Health Organization declared COVID-19 as a pandemic on March 11,*** the general population,COVID-19 severity can range from asymptomatic/mild symptoms to seriously *** mortality rate could be as high as 49%.The Centers for Disease Control and Prevention have acknowledged that people with specific underlying medical conditions,among those who need immunosuppression after solid organ transplantation(SOT),are at an increased risk of developing severe illness from *** transplantation is the second most prevalent SOT *** to their immunosuppressed state,liver transplant(LT)recipients are more susceptible to serious ***,comorbidities and prolonged immunosuppression among SOT recipients enhance the likelihood of severe *** is crucial to comprehend the clinical picture,immunosuppressive management,prognosis,and prophylaxis of COVID-19 infection because it may pose a danger to transplant *** review described the clinical and laboratory findings of COVID-19 in LT recipients and the risk factors for severe disease in this population *** the following sections,we discussed current COVID-19 therapy choices,reviewed standard practice in modifying immunosuppressant regimens,and outlined the safety and efficacy of currently licensed drugs for inpatient and outpatient ***,we explored the clinical outcomes of COVID-19 in LT recipients and mentioned the efficacy and safety of vaccination use.

关键词： COVID-19 Liver transplantation Recipient Protocols Outcomes

Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged mohamed Maher Abou-hashem Dina mohamed Abo-elmatty Noha Mostafa Mesbah Ahmed mohamed Abd EL-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HELA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HELA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HELA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HELA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HELA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis