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Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogen.c.specific tran.c.iption factor

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Food Science and Human Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-Geun Lee H.H.A.c.K.Jayawardhana Fengqi Yang D.P.nagahawaththa n.M.Liyanage Kyung-Mo Song Yun-Sang choi Seung-Hong Lee You-Jin Jeon Min.c.eol Kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAc)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogen.c.and lipogen.c.proteins in 3T3-L1 ***,oral supplementation with STAc significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAc and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

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Alpha7 n.c.tin.c.receptors as potential theranostic targets for experimental stroke

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neural Regeneration Research 2024年第5期19卷 939-940页

作者： Maider Garbizu Laura Aguado Abraham Martín Achucarro Basque center for neuroscience LeioaSpain cIc biomaGUnE Basque Research and Technology AllianceSan SebastianSpain Ikerbasque Basque Foundation for Science BilbaoSpain

Inflammatory reflex and cholinergic anti-inflammatory pathway:Innate immune system triggers a local inflammatory response following an injury or a pathogen ***,this inflammatory response is limited by rapid,localized,and adaptive anti-inflammatory responses which are crucial for maintaining ***,the loss of these responses converts a limited and protective inflammatory response into an excessive and harmful ***-inflammatory responses are integrated into the central nervous system,since the central nervous system accumulates information about harmful events,activates defenses,and builds memory for *** the same time,it has been demonstrated that hypothalamic neuronal signaling can be altered by inflammation in peripheral ***,immune cells release neuropeptides and neurotransmitters such as acetylcholine(Ach),the main neurotransmitter of the parasympathetic autonomic nervous system,evidencing the commun.c.tion between the immune and nervous systems(Tracey,2002).

关键词： protective invasion Alpha

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Mid-term survival of the Optimys short stem: A prospective case series of 500 patients

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World Journal of Orthopedics 2024年第3期15卷 257-265页

作者： Bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker Esther R c Janssen Inger n Sierevelt Gino M M J Kerkhoffs Daniël Haverkamp Department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther R c Janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery and Sports Medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BAcKGROUnD In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in.c.mparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechan.c. and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in different *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(Mathys Ltd,Bettlach,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(PROMs).Kaplan-Meier analysis was used to calculate the 5-year survival ***-minus-log transformation was performed to calculate the 95%confidence interval(95%cI).Mixed model analyses were performed to assess the course of the PROMs during the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in PROMs during both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile range:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%cI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%cI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival Revision PROMs

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comparison of Perovskite Systems Based on AFeO_(3)(A=ce,La,Y)in.c._(2) Hydrogenation to cO

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Transactions of Tianjin University 2024年第4期30卷 337-358页

作者： Anna n.Matveyeva Shamil O.Omarov Laboratory of Materials and Processes for Hydrogen Energy Ioff e Institute194021 St.PetersburgRussia

cO_(2) is the most cost-eff ective and abundant carbon resource,while the reverse water-gas reaction(rWGS)is one of the most eff ective methods of cO_(2) *** work presents a comparative study of rWGS activity for perovskite systems based on AFeO_(3)(where A=ce,La,Y).These systems were synthesized by solution.c.mbustion synthesis(ScS)with diff erent ratios of fuel(glycine)and oxidizer(φ),diff erent amounts of nH 4 nO_(3),and the addition of alumina or silica as *** techniques,including X-ray diff raction analysis,thermogravimetric analysis,Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy,energy-dispersive X-ray spectroscopy,n 2-physisorption,H_(2) temper-ature-programmed reduction,temperature-programmed desorption of H_(2) and cO_(2),Raman spectroscopy,and in situ FTIR,were used to relate the physicochemical properties with the catalytic performance of the obtained *** specifi c perovskite-containing system(either bulk or supported)has its own optimalφand nH_(4) nO_(3) amount to achieve the highest yield and dispersion of the perovskite *** all synthesized systems,bulk ScS-derived La-Fe-O systems showed the highest resistance to reducing environments and the easiest hydrogen desorption,outperforming La-Fe-O produced by solgel combustion(SGc).cO_(2) conversion into cO at 600°c for bulk ferrite systems,depending on the A-cation type and preparation method,follows the order La(SGc)cecS).The diff erences in properties between La-Fe-O obtained by the ScS and SGc methods can be attributed to diff erent ratios of oxygen and lanthanum vacancy contributions,hydroxyl coverage,morphology,and free iron oxide *** situ FTIR data revealed that cO_(2) hydrogenation occurs through formates generated under reaction.c.nditions on the bulk system based on La-Fe-O,obtained by the ScS method.γ-Al_(2)O_(3) improves the dispersion of ceFeO_(3) and LaFeO_(3) phases,the specifi c surface area,and the quant

关键词： Perovskites LaFeO_(3) ceFeO_(3) YFeO_(3) Solution.c.mbustion synthesis cO_(2) hydrogenation Reverse water–gas reaction(rWGS)

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Key Technologies and Prospects for Electric Vehicles Within Emerging Power Systems: Insights from Five Aspects

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cSEE Journal of Power and Energy Systems 2024年第2期10卷 439-447页

作者： Yalun Li Minggao Ouyang c.c.chan Xueliang Sun Yonghua Song Wei cai Yilin Xie Yuqiong Mao Department of Electrical Engineering and School of Vehicle and MobilityTsinghua UniversityBeijing 100084China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China Department of Electrical and Electron.c.Engineering The University of Hong KongHong Kong 999077China Department of Mechan.c.l and Materials Engineering University of Western OntarioLondonON N6A 3K7Canada State Key Laboratory of Internet of Things for Smart city University of MacaoTaipaMacao 999078China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China School of Electrical and Electron.c.Engineering Harbin University of Science and TechnologyHarbin 150080China

The energy revolution requires coordination in energy consumption, supply, storage and institutional *** energy generation technologies, along with their associated costs, are already fully equipped for large-scale ***, energy storage remains a bottlen.c., and solutions areneeded through the use of electric vehicles, which traditionallyplay the role of energy consumption in power systems. Toclarify the key technologies and institutions that support EVsas terminals for energy use, storage, and feedback, the cSEEJPES forum assembled renowned experts and scholars in relevantfields to deliver keynote reports and engage in discussions ontopics such as vehicle–grid integration technology, advancedsolid-state battery technology, high-performance electric motortechnology, and institutional innovation in the industry *** experts also provided prospects for energy storage andutilization technologies capable of decarbonizing new powersystems.

关键词： Electric vehicles engineering philosophy highpower density motor new power system solid state batteries vehicle grid integration.

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“如果”句功能的类型学考察

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汉语学习 2024年第2期 22-32页

作者：吴炳章姜彩璨许冰中国海洋大学外国语学院山东青岛266100

“如果”句的语义结构和用法复杂多样,但学界对该结构的功能类型分析过于笼统。文章通过语料库梳理书面语中“如果”句的结构特点和语篇关系,对其进行了功能分类。从功能视角看,“如果”句在知识域、语言域和人际域中分别发挥前提限定... 详细信息

“如果”句的语义结构和用法复杂多样,但学界对该结构的功能类型分析过于笼统。文章通过语料库梳理书面语中“如果”句的结构特点和语篇关系,对其进行了功能分类。从功能视角看,“如果”句在知识域、语言域和人际域中分别发挥前提限定、语篇建构和会话修辞等功能。根据从句和主句的意义关系,“如果”句可以分为蕴含条件句和非蕴含条件句。各类“如果”句的功能各有句法语义特征。从各类“如果”句的用法分布看,“如果”句的主要功能是表达推理关系,其次是语篇关系,再次是话语修辞。

关键词： “如果”句假设条件句间接条件句

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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra c.Mota J.Bauer H.Ferreira Rui L.Reis n.neves S.camarero-Espinosa M.B.Baker L.Moroni Department of complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal IcVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PcL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PcL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PcL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogen.c.differentiation of human mesenchymal stromal cells(hMScs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on.c.ll differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density click chemistry Human

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A novel framework to intercept GPS-denied,bomb-carrying,nonmilitary,kamikaze drones:Towards protecting critical infrastructures

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Defence Technology（防务技术） 2024年第10期40卷 225-241页

作者： Athanasios n.Skraparlis Klimis S.ntalianis n.c.las Tsapatsoulis University of West Attica 28 Agiou Spyridonos str.Athens 12241Greece cyprus University of Technology Limassol 3036Cyprus

Protection of urban.c.itical infrastructures(cIs)from GPS-denied,bomb-carrying kamikaze drones(G-BKDs)is very *** approaches based on drone jamming,spoofing,commun.c.tion interruption and hijacking cannot be applied in the case under examination,since G-B-KDs are *** the other hand,drone capturing schemes and electromagnetic pulse(EMP)weapons seem to be ***,again,existing approaches present various limitations,while most of them do not examine the case of *** paper,focuses on the aforementioned under-researched field,where the G-B-KD is confronted by two defensive *** first neutralizes and captures the kamikaze drone,while the second captures the *** defensive drones are equipped with a net-gun and an innovative algorithm,which,among others,estimates the locations of interception,using a real-world trajectory ***,one of the defensive drones is also equipped with an EMP weapon to damage the electron.c. equipment of the kamikaze drone and reduce the capturing time and the overall *** simulated experiments and comparisons to state-of-art methods,reveal the advantages and limitations of the proposed *** specifically,compared to state-of-art,the proposed approach improves:(a)time to neutralize the target by at least 6.89%,(b)maximum number of missions by at least 1.27%and(c)total cost by at least 5.15%.

关键词： critical infrastructure Kamikaze drone GPS-Denied Bomb-carrying Trajectory estimation

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The Ti-TAn plasmid toolbox for TurboID-based proximity labeling assays in n.c.tiana benthamiana

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Journal of Integrative Plant Biology 2024年第2期66卷 166-168页

作者： Huang Tan Yu Zhou Erik Dinius Rosa Lozano-Durán Department of Plant Biochemistry Center for Plant MolecularBiology(ZMBP)Eberhard Karls UniversityTubingenD‐72076Germany

Protein-protein interactions and the formation of protein.c.mplexes play a central role in the regulation of virtually all aspects of *** identification and characterization of interactions between proteins is the bas... 详细信息

关键词： proximity complexes enable

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Exploring the shadow of a rotating charged ModMax black hole

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commun.c.tions in Theoretical Physics 2024年第2期76卷 89-101页

作者： Khurshid Karshiboev Farruh Atamurotov Ahmadjon Abdujabbarov Ali Övgün Anvar Reyimberganov Institute of Theoretical Physics National University of UzbekistanTashkent 100174Uzbekistan new Uzbekistan University Movarounnahr Street 1Tashkent 100000Uzbekistan central Asian University Milliy Bog'Street 264Tashkent 111221Uzbekistan University of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan Tashkent State Techn.c.l University Tashkent 100095Uzbekistan Ulugh Beg Astronomical Institute Astronomy Street 33Tashkent 100052Uzbekistan Institute of Fundamental and Applied Research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkey Urgench State University Urgench 220100Uzbekistan

The research presented in this paper discusses the impact that the parameters of charge(Q)and screening factor(γ)have on properties of the horizon and silhouette of rotating charged Mod Max black holes which were reviewed in[***.J.c(2022)82:1155]recently,building upon previous findings in the ***,the study explores the behavior of null geodesics,which can help us better understand the apparent shape of the black hole’s silhouette,as well as the distortion parameter and approximate radii of the silhouette that are influenced by the aforementioned parameters,and there are some values of parameter Q which corresponds to data from the Event Horizon Telescope(EHT).notably,we explore the distortion parameter and approximate radii of the silhouette,revealing that while an increase inγleads to a growth in silhouette radius(Rs),it simultaneously reduces the distortion rate(δs).conversely,heightened Q charge results in a reduction of Rsaccompanied by an increase inδ***,the paper analyzes the effects of the black hole’s parameters on the effective potential and energy emission:the peak value of the energy emission rate experiences a decrease as the screening factor(γ)increases,while it increases with higher values of the charge parameter(Q).

关键词： black hole ModMax gravity rotating black hole black hole shadow

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