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Intraarticular calcaneal fractures Operative management

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中华创伤骨科杂志 2004年第8期 68-72页

作者： Tim Pohlemann,David Ring,hartmut R. AO Publishing Stettbachstrasse 10 CH-8600 Dǚbendorf Switzerland AO Publishing Stettbachstrasse 10 CH-8600 Dǚbendorf Switzerland AO Publishing Stettbachstrasse 10 CH-8600 Dǚbendorf Switzerland

Evidence is lacking from these trials concerning the optimal procedure for treatment of displaced intraarticular calcaneal fractures. Clinical trials comparing different treatment ,especially as they relate to potenti... 详细信息

关键词： Fracture Intraarticular fractures Calcaneal fractures

Single-operator cholangioscopy for biliary complications in liver transplant recipients

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World Journal of Gastroenterology 2017年第22期23卷 4064-4071页

作者： Anna Hüsing-Kabar Hauke Sebastian Heinzow hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar Department of Transplant Medicine University Hospital Muenster Department of Medicine D Division of General Internal MedicineNephrology and RheumatologyUniversity Hospital Muenster Department of Medicine A Hematology and OncologyUniversity Hospital Muenster

To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography (ERCP) for management of biliary complications after liver transplantation (LT).METHODSTwenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December 2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy system (SpyGlass DS™) was performed during the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility ***-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14 (53.8%) patients, non-anastomotic strictures in seven (26.9%), biliary cast in three (11.5%), and stones in six (23.1%). A benefit of cholangioscopy was seen in 12 (46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive (43.2%), 12 (32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic ***-operator c

关键词： Cholangioscopy Endoscopic retrograde cholangiopancreatography Liver transplantation Biliary complications Biliary strictures

采用对比基因杂交技术建立嗅神经母细胞瘤基因畸变模型

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中华肿瘤杂志 2005年第1期27卷 16-21页

作者：游学俊 Iver Petersen hartmut Arps Wolfgang Draf Ulrike Bockmhl 华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科武汉430030 德国柏林洪堡大学附属夏瑞特医院病理研究所德国富尔达市Fulda医院病理研究所德国富尔达市Fulda医院耳鼻咽喉头颈及颌面整形外科

目的　建立嗅神经母细胞瘤 (ENB)的基因畸变模型并分析其特征。方法　采用对比基因杂交 (CGH)技术对 12例原发、3例复发、7例转移ENB标本进行基因检测 ,用特殊软件系统对所采集照片的荧光信号进行量化分析 ,确定肿瘤DNA与正常对照DNA之... 详细信息

目的　建立嗅神经母细胞瘤 (ENB)的基因畸变模型并分析其特征。方法　采用对比基因杂交 (CGH)技术对 12例原发、3例复发、7例转移ENB标本进行基因检测 ,用特殊软件系统对所采集照片的荧光信号进行量化分析 ,确定肿瘤DNA与正常对照DNA之间的基因差别。结果　ENB常见DNA丢失主要见于 1p、2q、3p/q、4p/q、5p/q、6q、8p/q、9p、10p/q、11p、12q、13q、18q和 2 1q ,DNA过度表达见于 1p、7q、9q、11q、14q、16p/q、17p/q、19p/q、2 0p/q和 2 2p/q。ENB的 1p2 1 p31DNA丢失与该类肿瘤患者预后差有明显相关性。死于ENB的患者均具有以下共性 :1p2 1 p31DNA丢失、临床分期为C或D期、分化程度低 (Ⅲ或Ⅳ级 )。对 4例发生转移、复发的患者 ,将检测结果与其原发病灶基因畸变情况进行对比分析表明 ,转移、复发病灶与其原发病灶间具有高度的克隆一致性。结论　采用CGH能建立ENB的典型基因畸变模型 ,该模型有助于解释此肿瘤的生物学特性并对其预后进行评估 ,并与神经母细胞瘤、小细胞肺癌以及头颈部鳞癌进行鉴别。

关键词：嗅神经母细胞瘤瘤基因复发 CGH 原发病灶患者转移结论对比共性

Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice

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Liver Research 2021年第2期5卷 79-87页

作者： Hua Sun Hong-Min Ni Jennifer M.McCracken Jephte Y Akakpo Sam Fulte Tara McKeen hartmut Jaeschke Hua Wang Wen-Xing Ding Department of Pharmacology Toxicology and TherapeuticsThe University of Kansas Medical CenterKansas CityKSUSA Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina

Background:Acetaminophen(APAP)overdose can cause liver injury and liver failure,which is one of the most common causes of drug-induced liver injury in the United *** activation of autophagy by inhibiting mechanistic target of rapamycin(mTOR)protects against APAP-induced liver injury likely via autophagic removal of APAP-adducts and damaged *** the present study,we aimed to investigate the role of genetic ablation of mTOR pathways in mouse liver in APAP-induced liver injury and liver repair/***:Albumin-Cre(Alb-Cre)mice,mTOR^(f/f) and Raptor^(f/f) mice(C57BL/6J background)were crossbred to produce liver-specific mTOR knockout(L-mTOR KO,Alb Cret/-,mTOR^(f/f))and liver-specific Raptor KO(L-Raptor,Alb Cret/-,Raptor^(f/f))***-Cre littermates were used as wild-type(WT)*** mice were treated with APAP for various time points for up to 48 *** injury,cell proliferation,autophagy and mTOR activation were ***:We found that genetic deletion of neither Raptor,an important adaptor protein in mTOR complex 1,nor mTOR,in the mouse liver significantly protected against APAP-induced liver injury despite increased hepatic autophagic *** deletion of Raptor or mTOR in mouse livers did not affect APAP metabolism and APAP-induced c-Jun N-terminal kinase(JNK)activation,but slightly improved mouse survival likely due to increased hepatocyte ***:Our results indicate that genetic ablation of mTOR in mouse livers does not protect against APAP-induced liver injury but may slightly improve liver regeneration and mouse survival after APAP overdose.

关键词： Acetaminophen(APAP) Autophagy Hepatotoxicity Liver injury Liver regeneration Mechanistic target of rapamycin(mTOR) Regulatory associated protein of mTOR complex(Raptor)

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我们的第一次五千米赛跑

中学生英语 2020年第15期 12-15页

作者： Lisa M.bartelt 杨舟不详

团结就是力量……在有团队合作的时候,美好的事情就可以实现。——马提·斯特帕尼克.我警告过我丈夫,我嘴里忍不住快要说出什么疯狂的东西了。“我觉得我们要跑一次五千米赛跑。”

关键词：团结就是力量团队合作赛跑帕尼克

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防水鞋面革和防水变色革的水性涂饰

中国皮革 2009年第15期38卷 4-6,10页

作者： hartmut Huber 刘鹏杰(译) 科莱恩产品有限责任公司德国不详

详细介绍了防水鞋面革和防水变色革的涂饰方法,包括坯革的准备、粘合层、底涂、顶涂过程中产品的选择和过程参数的确定,以及涂饰过程中的注意事项。

关键词：防水革鞋面革变色革涂饰

Lipids in liver transplant recipients

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World Journal of Gastroenterology 2016年第12期22卷 3315-3324页

作者： anna hüsing iyad kabar hartmut h schmidt department of transplant medicine university hospital münster48149 münsterGermany

Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. Due to recent improvements in survival of liver transplant recipients, the prevention of cardiovascular events has become more important, especially as approximately 64% of liver transplant recipients present with an increased risk of cardiovascular events. Management of dyslipidemia and of other modifiable cardiovascular risk factors, such as hypertension, diabetes and smoking, has therefore become essential in these patients. Treatment of hyperlipidemia after liver transplantation consists of life style modification, modifying the dose or type of immunosuppressive agents and use of lipid lowering agents. At the start of administration of lipid lowering medications, it is important to monitor drugdrug interactions, especially between lipid lowering agents and immunosuppressive drugs. Furthermore, as combinations of various lipid lowering drugs can lead to severe side effects, such as myopathies and rhabdomyolysis, these combinations should therefore be avoided. To our knowledge, there are no current guidelines targeting the management of lipid metabolism disorders in liver transplant recipients. This paper therefore recommends an approach of managing lipid abnormalities occurring after liver transplantation.

关键词： Liver transplantation Dyslipidemia Lipid management Immunosuppression m TOR-inhibition Treatment

The Tree Structure for Time-of-flight Dataset Representation

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The Tree Structure for Time-of-flight Dataset Representation

Automaton Model with Variable Cell Size for the Simulation of Pedestrian Flow

The Ninth International Conference on Information and Management Sciences

作者： Matthias Plaue Gnter Brwolff hartmut Schwandt Institut fr Mathematik Technische Universitt BerlinGermanya

＜正＞In the current paper,we present a tree-like structure for the object representation in time-of-flight（TOF） datasets which enables an efficient computation of the object contour *** generated contour lines can be further processed in object detection and recognition for the TOF *** illustrate this idea in the application of a monitoring system using the TOF ranging *** addition,we also present a fast algorithm of visualizing the object contour lines as unstructured（that ***）pixels.

关键词： tree time-of-flight contour line object detection/recognition

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Automaton Model with Variable Cell Size for the Simulation o...