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Dostarlimab in the treatment of mismatch repair deficient recurrent or advanced endometrial cancer

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Cancer Pathogenesis and Therapy 2024年第3期2卷 135-141页

作者： Siddhant Shukla harsh patel Shuzhen Chen Rainie Sun Liuya Wei Zhe-Sheng Chen Institute for Biotechnology St.John's UniversityNew YorkNew York 11439United States Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's UniversityNew YorkNew York 11439United States School of Pharmacy Weifang Medical UniversityWeifangShandong 261053China Stuyvesant High School New YorkNew York 10282United States

Dostarlimab,a programmed death receptor-1(PD-1)-blocking IgG4 humanized monoclonal antibody,gained accelerated approval from the US Food and Drug Administration(FDA)in April 2021,and received a full approval in February *** was approved for treating adult patients with mismatch repair deficient(dMMR)recurrent or advanced endometrial cancer(EC)that progressed during or after prior treatment who have no other suitable treatment ***,we review the structure-based mechanism of action of dostarlimab and the results of a clinical study(GARNET;NCT02715284)to comprehensively clarify the efficacy and toxicity of the *** efficacy and safety of dostarlimab as monotherapy was assessed in a non-randomized,multicenter,open-label,multi-cohort trial that included 209 patients with dMMR recurrent or advanced solid tumors after receiving systemic *** received 500 mg of dostarlimab intravenously every three weeks until they were given four ***,patients received 1000 mg dostarlimab intravenously every six weeks until disease progression or unacceptable *** overall response rate,as determined by shrinkage in tumor size,was 41.6%(95%confidence interval[CI];34.9,48.6),with 34.7 months as the median response *** conclusion,dostarlimab is an immunotherapy-based drug that has shown promising results in adult patients with recurrent or advanced dMMR ***,its efficacy in other cancer subtypes,the development of resistance to monotherapy,and efficacy and safety in combination with other immunotherapeutic drugs have not yet been studied.

关键词： Dostarlimab PD-1 Immunotherapy Endometrial cancer Check-point inhibitor

Advanced imaging and artificial intelligence for Barrett's esophagus:What we should and soon will do

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World Journal of Gastroenterology 2022年第11期28卷 1113-1122页

作者： Marco Spadaccini Edoardo Vespa Viveksandeep Thoguluva Chandrasekar Madhav Desai harsh K patel Roberta Maselli Alessandro Fugazza Silvia Carrara Andrea Anderloni Gianluca Franchellucci Alessandro De Marco Cesare Hassan Pradeep Bhandari Prateek Sharma Alessandro Repici Department of Endoscopy Humanitas Research HospitalIRCCSRozzano 20089Italy Department of Biomedical Sciences Humanitas UniversityRozzano 20089Italy Department of Gastroenterology and Hepatology Mayo ClinicPhoenixAZ 85054United States Department of Gastroenterology and Hepatology Kansas City VA Medical CenterKansas CityMO 66045United States Department of Internal Medicine Ochsner Clinic FoundationNew OrleansLA 70124United States Endoscopy Unit Nuovo Regina Margherita HospitalRoma 00153Italy Department of Gastroenterology Portsmouth Hospitals University NHS TrustPortsmouth PO63LYUnited Kingdom School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO63LYUnited Kingdom

Barrett’s esophagus(BE)is a well-established risk factor for esophageal *** is recommended that patients have regular endoscopic surveillance,with the ultimate goal of detecting early-stage neoplastic lesions before they can progress to invasive *** of both dysplasia or early adenocarcinoma permits curative endoscopic treatments,and with this aim,thorough endoscopic assessment is crucial and improves *** burden of missed neoplasia in BE is still far from being negligible,likely due to inappropriate endoscopic *** the last two decades,advanced imaging techniques,moving from traditional dye-spray chromoendoscopy to more practical virtual chromoendoscopy technologies,have been introduced with the aim to enhance neoplasia detection in *** witnessed in other fields,artificial intelligence(AI)has revolutionized the field of diagnostic endoscopy and is set to cover a pivotal role in BE as *** aim of this commentary is to comprehensively summarize present evidence,recent research advances,and future perspectives regarding advanced imaging technology and AI in BE;the combination of computer-aided diagnosis to a widespread adoption of advanced imaging technologies is eagerly *** will also provide a useful step-by-step approach for performing high-quality endoscopy in BE,in order to increase the diagnostic yield of endoscopy in clinical practice.

关键词： Barrett’s esophagus Endoscopy Artificial intelligence Surveillance Advanced imaging Neoplasia

Artificial intelligence technologies for the detection of colorectal lesions: The future is now

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World Journal of Gastroenterology 2020年第37期26卷 5606-5616页

作者： Simona Attardo Viveksandeep Thoguluva Chandrasekar Marco Spadaccini Roberta Maselli harsh K patel Madhav Desai Antonio Capogreco Matteo Badalamenti Piera Alessia Galtieri Gaia Pellegatta Alessandro Fugazza Silvia Carrara Andrea Anderloni Pietro Occhipinti Cesare Hassan Prateek Sharma Alessandro Repici Department of Endoscopy and Digestive Disease AOU Maggiore della CaritàNovara 28100Italy Department of Gastroenterology and Hepatology Kansas City VA Medical CenterKansas CityMO 66045United States Department of Endoscopy Humanitas Research HospitalRozzano 20089Italy Department of Biomedical Sciences Humanitas UniversityRozzano 20089Italy Department of Internal Medicine Ochsner Clinic FoundationNew OrleansLA 70124United States Endoscopy Unit Nuovo Regina Margherita HospitalRoma 00153Italy

Several studies have shown a significant adenoma miss rate up to 35%during screening colonoscopy,especially in patients with diminutive *** use of artificial intelligence(AI)in colonoscopy has been gaining popularity by helping endoscopists in polyp detection,with the aim to increase their adenoma detection rate(ADR)and polyp detection rate(PDR)in order to reduce the incidence of interval *** efficacy of deep convolutional neural network(DCNN)-based AI system for polyp detection has been trained and tested in ex vivo settings such as colonoscopy still images or *** trials have evaluated the real-time efficacy of DCNN-based systems showing promising results in term of improved ADR and *** this review we reported data from the preliminary ex vivo experiences and summarized the results of the initial randomized controlled trials.

关键词： Endoscopy Colonoscopy Screening Surveillance Technology Quality Artificial intelligence

Aerobic vs anaerobic exercise training effects on the cardiovascular system

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World Journal of Cardiology 2017年第2期9卷 134-138页

作者： harsh patel Hassan Alkhawam Raef Madanieh Niel Shah Constantine E Kosmas Timothy J Vittorio Department of Internal Medicine State University of New York at Brooklyn-School of Medicine Department of Medicine Icahn School of Medicine at Mount Sinai(Elmhurst) St.Francis Hospital-the Heart Center^® Center for Advanced Cardiac Therapeutics Icahn School of Medicine Mount Sinai Hospital Center

Physical exercise is one of the most effective methods to help prevent cardiovascular(CV) disease and to promote CV health. Aerobic and anaerobic exercises are two types of exercise that differ based on the intensity, interval and types of muscle fibers incorporated. In this article, we aim to further elaborate on these two categories of physical exercise and to help decipher which provides the most effective means of promoting CV health.

关键词： Cardiovascular Exercise Training Aerobic Anaerobic

探索互联汽车之重新定义互联汽车中的高速数据

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中国电子商情 2019年第10期 27-29页

作者： Ali Javed harsh patel 莫仕公司

在汽车行业-以及驾驶体验方面,我们正处于一场巨大的变革之中。汽车的连接性能变得前所未有的重要。技术的进步正在使车辆上几乎每一方面都在发生变化-当物体距离过近时,传感器对我们发出提醒,可以实现自动制动来避免碰撞,甚至可以在转... 详细信息

在汽车行业-以及驾驶体验方面,我们正处于一场巨大的变革之中。汽车的连接性能变得前所未有的重要。技术的进步正在使车辆上几乎每一方面都在发生变化-当物体距离过近时,传感器对我们发出提醒,可以实现自动制动来避免碰撞,甚至可以在转弯时使车大灯转动,同时,信息娱乐系统可以为驾驶者提供流媒体形式的新闻及其他广播内容,让乘客观看影片,而GPS则在交通中引导我们,使我们更迅速、更安全的抵达目的地。

关键词：汽车行业定义驾驶体验广播内容媒体形式娱乐系统传感器驾驶者

Novel succinoylated carboxymethyl guar gum nanocarriers of glimepiride for controlling type-2 diabetes

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Medicine in Novel Technology and Devices 2024年第2期22卷 133-139页

作者： harsh Yadav Biswajit Maji Sabyasachi Maiti Department of Pharmacy Indira Gandhi National Tribal UniversityAmarkantakMadhya PradeshIndia Department of Chemistry Indira Gandhi National Tribal UniversityAmarkantakMadhya PradeshIndia

In this study,guar gum(GG)was chemically modified to its carboxymethyl derivative,which was then esterified with octenyl succinic anhydride(OSA)using a nucleophilic catalyst 4-dimethylaminopyridine(DMAP)to render the derivative amphiphilic *** carboxymethyl guar gum(CMGG)and succinoylated CMGG was characterized using Fourier transform infrared spectroscopy(FTIR)*** amphiphilic CMGG synthesized using DMAP/OSA ratio of 0.5:1(CMGGOSA-I),was found to be *** amphiphilic guar gum self-assembled in water to form nanocarriers with mean diameter of 430 nm and zeta potential of19.0 *** electron microscope(TEM)image showed spherical nature of the developed CMGGOSA-I nano*** presence of amphiphilic CMGG,the aqueous solubility of glimepiride was enhanced by about *** nanocarriers released glimepiride in simulated gastrointestinal fluids for a period of more than 24 h,following Higuchi's ***-Peppas modeling of the drug release data revealed that a combination of swelling and diffusion mechanism was operative in the event of drug *** streptozotocin-induced diabetic rat model,the nanocarriers outperformed pure drug suspensions in terms of anti-diabetic activity,which lasted up to 24 ***;the newly synthesized amphiphilic CMGG nanocarriers demonstrated controlled drug release properties and showed promise for controlling type-2 diabetes.

关键词： Guar gum Glimepiride Octenyl succinic anhydride Anti-diabetic efficacy

A Brassica carinata pan-genome platform for Brassica crop improvement

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Plant Communications 2024年第1期5卷 20-23页

作者： Yan Niu Qingqing Liu Zhesi He Rosy Raman Hao Wang Xinxin Long Han Qin harsh Raman Isobel A.P.Parkin Ian Bancroft Jun Zou National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanChina Department of Biology University of YorkHeslingtonYork YO105DDUK NSW Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNSW 2650Australia Agriculture and Agri-Food Canada Saskatoon Research and Development CentreSaskatoonSKCanada

Dear Editor,Brassica carinata(Bc Bc Cc Cc),an important agricultural crop cultivated for the edible oil,leafy vegetable,high-value protein stockfeed,and biofuel markets,contains favorable genetic variation that can be exploited to develop climate-resilient and wateruse-efficient Brassica crops(Seepaul et al.,2021).Although several quantitative trait loci(QTLs)for flowering time,seed quality traits,and pod shatter resistance(PSR)have been identified based on high-density genetic linkage maps(Zou et al.,2014;Raman et al.,2017;Zhang et al.,2017),this information alone is insufficient for practical genetic improvement and breeding applications.

关键词： breeding crops cultivated

Impact of phytoconstituents on oral health practices:a post COVID-19 observation

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Food Science and Human Wellness 2024年第5期13卷 2386-2400页

作者： harsh Kumar Reena Singh Daljeet Singh Dhanjal Chirag Chopra Natália Cruz-Martins Gheyath K.Nasrallah Amin F.Majdalawieh Sivakumar Manickam Shahida Anusha Siddiqui Dinesh Kumar Indu Sharma Varun Sharma School of Bioengineering&Food Technology Shoolini University of Biotechnology and Management SciencesSolan 173229India School of Bioengineering and Biosciences Lovely Professional UniversityPunjab 144402India Faculty of Medicine University of PortoPorto 4200-319Portugal Institute for Research and Innovation in Health(i3S) University of PortoPorto 4200-135Portugal Institute of Research and Advanced Training in Health Sciences and Technologies(CESPU) RuaCentral de GandraGandra 4585-116Portugal TOXRUN-Toxicology Research Unit University Institute of Health SciencesCESPUCRLGandra 4585-116Portugal Biomedical Research Center Qatar UniversityDoha 2713Qatar Department of Biomedical Science College of Health SciencesQatar UniversityDoha 2713Qatar Department of Biology Chemistryand Environmental SciencesCollege of Arts and SciencesAmerican University of SharjahSharjah 26666United Arab Emirates Petroleum and Chemical Engineering Faculty of EngineeringUniversiti Teknologi BruneiBandar Seri Begawan BE1410Brunei Campus Straubing for Biotechnology and Sustainability Technical University of MunichStraubing 94315Germany Genetic Heritage Group New York UniversityAbu Dhabi 129188United Arab Emirates Bioinformatics Division NMC Genetics India Pvt.Ltd.Gurugram 122001India

Appropriate oral hygiene significantly reduces the possibility of oral ***,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral ***,herbal compounds have gained interest in maintaining oral *** of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and *** amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral *** COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb *** cavity is among the gateways for virus entry into *** is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the *** enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial *** review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.

关键词： COVID-19 SARS-CoV-2 Oral Hygiene Microbiota Phytochemicals

Battery health management-a perspective of design,optimization,manufacturing,fault detection,and recycling

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Energy Storage and Saving 2024年第3期3卷 190-208页

作者： Pavel M.Roy harsh H.Sawant Pratik P.Shelar Prashil U.Sarode S.H.Gawande Industrial Tribology Laboratory Department of Mechanical EngineeringM.E.S.College of EngineeringSavitribai Phule Pune UniversityPune411007India

This paper explores the key aspects of battery technology,focusing on lithium-ion,lead-acid,and nickel metal hydride(NiMH)*** delves into manufacturing processes and highlighting their significance in optimizing battery *** addition,the study investigates battery fault detection,emphasizing the importance of early diagnosis using artificial intellignece(AI)and machine learning(ML)*** paper also addresses battery recycling techniques,discussing methods such as pyrometallurgy,hydrometallurgy,mechanical separation,and electrodialysis,considering their environmental *** comprehensive analysis sheds light on the evolution of battery technology and its role in sustainable energy systems.

关键词： Battery health Manufacturing Fault detection Recycling