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New therapeutic opportunities for Hepatitis C based on small RNA

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World Journal of Gastroenterology 2007年第33期13卷 4431-4436页

作者： Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus harry la janssen Luc JW van der laan Departments of Gastroenterology & Hepatology and Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Cell Biology Erasmus MC- University Medical Centre Rotterdam The Netherlands Department of Gastroenterology & Hepatology Erasmus MC-University Medical Centre Rotterdam The Netherlands

Hepatitis C virus （HCV） infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, antisense oligonucleotides （ASO）, or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA （miR-222） in viral replication and discuss its potential for HCV molecular therapy.

关键词： Hepatitis C virus therapy miR-122 RNAi Antisense oligonucleotides Viral vectors

聚乙二醇干扰素α-2b单药或聚乙二醇干扰素α-2b联合拉米夫定治疗HBeAg阳性慢性乙型肝炎的多中心、随机、双盲、对照试验

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传染病信息 2005年第Z1期18卷 44-47页

作者： harry la janssen Erasmus MC-University Medical Centre Rotterdam

　　与干扰素非应答者相比,应答的慢性乙型肝炎(乙肝)患者发生肝硬化、肝衰竭及肝细胞癌的可能性明显下降[1,2].然而,大部分慢性乙肝患者不能获得应答.在已经获得批准治疗慢性乙肝的药物中,最常用的是干扰素和核苷类似物,如拉米夫定或... 详细信息

　　与干扰素非应答者相比,应答的慢性乙型肝炎(乙肝)患者发生肝硬化、肝衰竭及肝细胞癌的可能性明显下降[1,2].然而,大部分慢性乙肝患者不能获得应答.在已经获得批准治疗慢性乙肝的药物中,最常用的是干扰素和核苷类似物,如拉米夫定或阿德福韦.……

关键词：拉米夫定 HBeAg 慢性乙型肝炎聚乙二醇干扰素α 干扰素抗病毒药阳性单药对照试验双盲

Bean yellow disorder virus： Parameters of transmission by Bemisia tabaci and host plant range

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Insect Science 2011年第1期18卷 50-56页

作者： German Martin Isabel Maria Cuadrado Dirk janssen Instituto Andaluz de Investigacion y Formacion Agraria y Pesquera Centro La Mojonera Almeria Spain

Bean yellow disorder virus （BnYDV） was recently identified as the first crinivirus （family Closteroviridae） that infects members of the family Leguminosae. It was first observed during the autumn of 2003, causing heavy losses in French bean （Phaseolus vulgaris L.） grown commercially in Spain. The virus is transmitted by the sweetpotato whitefly, Bemisia tabaci （Hemiptera： Aleyrodidae） Q-biotype, and disease symptoms resemble nutritional disorders consisting of interveinal mottling and yellowing in leaves, combined with stiffness or brittleness, and are typically produced on the middle to lower parts of the plant. Transmission experiments showed that 50% and 100% of B. tabaci adults acquired the virus after a feeding period of 3 and 7 h, respectively. Viruliferous whiteflies infected 66% and 100% ofP. vulgaris plants after a feeding period of 12 and 24 h, respectively. The transmission efficiency of single whiteflies was 37% and persistence of BnYDV in the vector lasted up to 2 weeks with a half-life of 9 days. BnYDV was transmitted to P. vulgaris, Pisum sativum L., Lens culinaris Medik., and Vicia faba L., but not to Vigna unguiculata L., Glycine max （L.） Merr., Cicer arietum L., and to crop species belonging to families of the Solanaceae and Cucurbitaceae. No virus was detected in field samples collected from 30 different species from Boraginaceae, Asteraceae, Geraniaceae, lamiaceae, Leguminosae, Malvaceae, Scrophulariaceae, Thymelaeaceae and Verbenaceae. The restricted host range and efficient management of crops regarding whitefly infestation may be key elements in the control of BnYDV.

关键词： bean Closteroviridae Crinivirus disease vector whiteflies

Parentage analysis in Gabonese colonies of soil-feeding termites belonging to the Cubitermes sp. affinis subarquatus complex of species （Termitidae＂ Termitinae）

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Insect Science 2010年第2期17卷 84-90页

作者： Virginie Roy Lise Dupont Myriam harry Unite Mixte de Recherche 7618 Bioemco Universite Paris 12-Val de Mame 61 avenue du Gen6ral de Gaulle 94010 Creteil cedex laboratoire Evolution Genomes et Speciation UPRg034 Centre National de la Recherche Scientifique 91198 Gif sur YvetteFrance

Cubitermes spp. are widely distributed soil-feeding termite species in sub- Saharan Africa which play a fundamental role in soil structure and fertility. A complex of at least four cryptic species （i.e., Cubitermes sp. affunis subarquatus complex of species） has been recently described using molecular markers. In order to investigate the breeding system of these species, five microsatellite markers were used to carry out parentage and re- latedness analyses in 15 Gabonese colonies. Monogamy was confirmed as the predominant reproductive organization in Cubitermes spp. （76% of the colonies）. Within 30% of these monogamous colonies, a high relatedness between reproductives was shown, suggesting that mating between related individuals occurs. However, Cubitermes colonies can deviate from monogamy. Indeed, parental contributions by at least two related reproductives of the same sex were revealed in four colonies and polyandry was demonstrated in two of them. Infiltration of reproductives in the colony is the most plausible explanation for such cases of polygamy in Cubitermes spp.

关键词： breeding system Cubitermes spp. microsatellite markers monogamy soil- feeding termites

Petrographic and geochemical characterization of seep carbonate from Alaminos Canyon,Gulf of Mexico

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Chinese Science Bulletin 2008年第11期53卷 1716-1724页

作者： FENG Dong CHEN DuoFu QI Liang harry H. ROBERTS Key laboratory of Marginal Sea Geology Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou510640 China Graduate University of Chinese Academy of Sciences Beijing 100049 China State Key lab of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Coastal Studies Institute Louisiana State University Baton Rouge LA 70803 USA

Seep carbonates were collected from the Alaminos Canyon lease area, Gulf of Mexico. The carbonates are present as slabs and blocks. Bivalve shell and foraminifer are the dominant bioclasts in carbonate. Pores are common and usually filled with acicular aragonite crystals. XRD investigation shows that aragonite is the dominate mineral (98%). Peloids, clotted microfabirc and botryoidal aragonite are de-veloped in carbonate and suggest a genesis linked with bacterial degradation of the hydrocarbons. The δ13C value of bioclasts in carbonate is from-4.9‰ to-0.6‰, indicating that the carbon source is mainly from sea water as well as the small portion incorporation of the seep hydrocarbon. The microcrystalline and sparite aragonite shows the δ13C value from-31.3‰ to-23.4‰, suggesting that their carbon is derived mainly from microbial degradation of crude oil. 14C analyses give the radiocarbon age of about 10 ka. Rare earth elements (REE) analyses of the 5% HNO3-treated solution of the carbonates show that the total REE content of the carbonates is low, that is from 0.752 to 12.725 μg·g-1. The shale-normalized REE patterns show significantly negative Ce anomalies. This suggests that cold seep carbonate is most likely formed in a relatively aerobic environment.

关键词：墨西哥黑金刚石岩相学地球化学特征

Mercury levels in human population from a mining district in Western Colombia

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Journal of Environmental Sciences 2018年第6期30卷 83-90页

作者： harry Gutiérrez-Mosquera S.B.Sujitha M.P.Jonathan S.K.Sarkar Fairy Medina-Mosquera Helcias Ayala-Mosquera Gladis Morales-Mira laura Arreola-Mendoza Facultad de Ingenieria Universidad Tecnologica del Choco Carrera 22 No.18B-10 Quibdo Colombia Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo (CIIEMAD) Instituto Politecnico Nacional (IPN) Calle 30 de junio de 1520 Barrio la Laguna Ticomdn Del. Gustavo A. Madero C.P.07340 Ciudad de Mexico Mexico Department of Marine Science University of Calcutta 35 Ballygunge Circular Road Calcutta 700 019 India Instituto de Investigaciones Ambientales del Pacifico (IIAP) Carrera 6 No. 37-39 quibdo Colombia Facultad de Ingenieria Uniuersidad de Medellin Carrera 87 No. 30-65 Medellin Colombia

A biomonitoring study was carried out to examine the adverse impacts of total mercury in the blood（HgB）, urine（Hg U） and human scalp hair（HgH） on the residents of a mining district in Colombia. Representative biological samples（scalp hair, urine and blood） were collected from volunteered participants（n = 63） to estimate the exposure levels of THg using a Direct mercury analyzer. The geometric mean of THg concentrations in the hair,urine and blood of males were 15.98 μg/g, 23.89 μg/L and 11.29 μg/L respectively, whereas the females presented values of 8.55 μg/g, 5.37 μg/L and 8.80 μg/L. Chronic urinary Hg（HgU）levels observed in male workers（32.53 μg/L） are attributed to their long termed exposures to inorganic and metallic mercury from gold panning activities. On an average, the levels of THg are increasing from blood（10.05 μg/L） to hair（12.27 μg/g） to urine（14.63 μg/L）.Significant positive correlation was found between hair and blood urinary levels in both male and female individuals. Thus the present biomonitoring investigation to evaluate the Hg levels and associated health issues would positively form a framework for further developmental plans and policies in building an ecofriendly ecosystem.

关键词： Humans Mercury Gold panning Biomarkers Toxicity Colombia

A NEW METHOD TO CALCUlaTE INDOOR NATURAL LIGHTING BY IMPROVING “ LUMEN MODELS”

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A NEW METHOD TO CALCULATE INDOOR NATURAL LIGHTING BY IMPROVI...

巨星的上升与陨落:经济失衡与全球环境限制(英文)

2007世界太阳能大会：太阳能与人类居住

作者： Fakra Ali Hamada harry Boyer Eddy lafosse Philippe lauret laboratoire de Physique du Btiment et des Systèmes Faculté des Sciences de l’Homme et de l’Environnement 117 rue du général Ailleret 97430 Tampon Université de La Réunion (France)

Many researches were undertaken in order to set up models which enable to calculate indoor daylighting [1-3].There are three of type’s method to calculate the daylight luminance through windows and large openings inside the *** others,‘simplified methods’ (Lumen method,Split Flux System method,etc...),‘numerical simulation method’ (Radiosity,Ray Tracing,etc...) and finally ‘experimental method’ (scale model,building experimental,etc...) are described in *** put some specific interest in the ‘simplified methods’ because they are easy to use and don’t need a lot of inputs for *** big disadvantage for most of these models is these models depend on restricted *** example,if we considered " Split Flux System method", we see that the models can be used only to overcast *** example,the " lumen method" applied for any skies,but the models gives only five values in the *** they can only work under precise and limited *** this present paper,we purpose to see how we can circumvent these difficulties by improving the "Lumen Model".Indeed,we will to introduce the notion of " Equivalent Deep" (E) into the " Lumen method".This " Equivalent Deep" will calculate any values and any types of skies instead of the original " Lumen method";that only calculate five values.

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巨星的上升与陨落:经济失衡与全球环境限制(英文)

中国有效定价与基于贫困转移的环境政策(英文)

北京论坛（2010）文明的和谐与共同繁荣——为了我们共同的家园：责任与行动

作者： harry Clarke School of Economics and Finance.la Trobe University.Melbourne.Australia

Introduction Classic arguments for laissez faire in economic management are based on two ***. that markets work efficiently to allocate resources ***,that there are no significant concerns regardingthe distribution of *** arguments apply intra-nationally and,with increasing integration of the world economy,globally as *** the global level the implication is that countries can develop economically in an efficient and equitable way without major interventionist policy regulations provided that there are no global distributional concerns and provided there are no globally important distortions in such areas as financial or in environmental *** this case,for example,global environmental problems can be addressed by levying uniform global taxes on the relevant externalities and by making resource transfers from wealthy to poor countries to address equity concerns.

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中国有效定价与基于贫困转移的环境政策(英文)