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A Meta-Analysis of the Genome-Wide Association Studies on Two Genetically Correlated Phenotypes Suggests Four New Risk loci for Headaches

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Phenomics 2023年第1期3卷 64-76页

作者： Weihua Meng Parminder S.Reel Charvi Nangia Aravind lathika Rajendrakumar harry l.hebert Qian Guo Mark J.Adams Hua Zheng Zen Haut lu Me Research Team Debashree Ray lesley A.Colvin Colin N.A.Palmer Andrew M.McIntosh Blair H.Smith Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315100China Division of Population Health and Genomics Ninewells Hospital and Medical SchoolUniversity of DundeeDundee DD24BFUK Division of Psychiatry Edinburgh Medical SchoolUniversity of EdinburghEdinburgh EH105HFUK Department of Anaesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China PAPRSB Institute of Health Sciences Universiti Brunei DarussalamBandar Seri Begawan BE1410Brunei Darussalam andMe Inc.SunnyvaleCA 94086USA Department of Epidemiology Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA Department of Biostatistics Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA

Headache is one of the commonest complaints that doctors need to address in clinical *** genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reported headache and self-reported migraine were genetically *** this study,we performed a meta-analysis of genome-wide association studies(GWAS)on the self-reported headache phenotype from the UK Biobank and the self-reported migraine phenotype from the 23andMe using the Unified Score-based Association Test(metaUSAT)software for genetically correlated phenotypes(N=397,385).We identified 38 loci for headaches,of which 34 loci have been reported before and four loci were newly *** lDl receptor related protein 1(lRP1)-Signal Transducer and Activator of Transcription 6(STAT6)-Short chain Dehydrogenase/Reductase family 9C member 7(SDR9C7)region in chromosome 12 was the most significantly associated locus with a leading p value of 1.24×10^(-62)of *** One Cut homeobox 2(ONECUT2)gene locus in chromosome 18 was the strongest signal among the four new loci with a p value of 1.29×10^(-9)of *** study demonstrated that the genetically correlated phenotypes of self-reported headache and self-reported migraine can be meta-analysed together in theory and in practice to boost study power to identify more variants for *** study has paved way for a large GWAS meta-analysis involving cohorts of different while genetically correlated headache phenotypes.

关键词： Headache Migraine Unified Score-based Association Test Correlated phenotypes Meta-analysis Genome-wide association study

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Propulsive matrix of a helical flagellum

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Chinese Physics B 2014年第11期23卷 51-56页

作者：张何朋刘斌 Bruce Rodenborn harry l.Swinney Department of Physics and Astronomy and Institute of Natural Sciences School of Natural Sciences University of California Department of Physics and Center for Nonlinear Dynamics University of Texas at Austin

We study the propulsion matrix of bacterial flagella numerically using slender body theory and the regularized Stokeslet method in a biologically relevant parameter regime. All three independent elements of the matrix are measured by computing propulsive force and torque generated by a rotating flagellum, and the drag force on a translating flagellum. Nu- merical results are compared with the predictions of resistive force theory, which is often used to interpret micro-organism propulsion. Neglecting hydrodynamic interactions between different parts of a flagellum in resistive force theory leads to both qualitative and quantitative discrepancies between the theoretical prediction of resistive force theory and the numerical results. We improve the original theory by empirically incorporating the effects of hydrodynamic interactions and propose new expressions for propulsive matrix elements that are accurate over the parameter regime explored.

关键词： low-Reynolds-number flows micro-organism dynamics bacterial swimming

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Hydroxycitric acid does not promote inflammation or liver toxicity

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World Journal of Gastroenterology 2013年第44期19卷 8160-8162页

作者： Dallas l Clouatre harry G Preuss Glykon Technologies Group LLC SeattleWA 98109 United States Department of Physiology Georgetown University Medical Center Washington DC 20057 United States

Garcinia cambogia extract(GC)with its active component consisting of hydroxycitric acid(HCA)is widely utilized for weight *** HCA salts are available,including calcium,magnesium,potassium and mixtures of ***,these salts exhibit different properties with some,but not all,improving glucose tolerance and blood ***,obesity-prone C57Bl/6J mice were fed a high-fat diet(HFD,45 kcal%fat)with or without GC(1%,w/w)for 16 *** active arm reduced visceral fat,adipocyte size and serum glucose,yet purportedly also exhibited hepatic collagen accumulation,lipid peroxidation and increased mRNA levels of genes related to oxidative *** latter findings are at odds with a large body of animal and human studies that have been conducted on the safety and efficacy of *** literature shows HCA to be protective against the liver toxicity associated with ethanol and dexamethasone administration,and to maintain serum aspartate aminotransferase,alanine aminotransferase and alkaline phosphatase at near normal *** both animal and clinical literature,elevated intakes of HCA per se have not led to signs of inflammation or *** compound has been found to reduce markers of inflammation in brain,intestines,kidney and serum.

关键词： Garcinia cambogia Hepatic collagen Hepatic inflammation Hepatic oxidative stress Hydroxycitric acid Metabolic syndrome Tumor necrosis factor-α Weight loss

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Critical flow-storm approach to total maximum daily load (TMDl) development:an analytical conceptual model

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Frontiers of Environmental Science & Engineering 2008年第3期2卷 267-273页

作者： harry X.ZHANG Shaw l.YU CH2M HIll 15010 Conference Center DriveChantillyVA 20151–3801USA Department of Civil and Environmental Engineering Thornton HallUniversity of VirginiaCharlottesvilleVA 22904–4742USA

One of the key challenges in the total maximum daily load(TMDl)development process is how to define the critical condition for a receiving *** main concern in using a continuous simulation approach is the absence of any guarantee that the most critical condition will be captured during the selected representative hydrologic period,given the scarcity of long-term continuous *** objectives of this paper are to clearly address the critical condition in the TMDl development process and to compare continuous and event-based approaches in defining critical condition during TMDl development for a waterbody impacted by both point and nonpoint source pollution.A practical,event-based critical flow-storm(CFS)approach was developed to explicitly addresses the critical condition as a combination of a low stream flow and a storm event of a selected magnitude,both having certain frequencies of *** paper illustrated the CFS concept and provided its theoretical basis using a derived analytical conceptual *** CFS approach clearly defined a critical condition,obtained reasonable results and could be considered as an alternative method in TMDl development.

关键词： critical condition critical flow-storm(CFS)approach total maximum daily load(TMDl) conceptual model derived analytical model nonpoint source pollution

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Capturing the value of biosurveillance“big data”through natural capital accounting

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Big Earth Data 2021年第3期5卷 352-367页

作者： David Castle Paul D.N.hebert Elizabeth l.Clare Ian D.Hogg Crystal Tremblay School Public Administration and Gustavason School of Business University of VictoriaCanada Centre for Biodiversity Genomics University of GuelphGuelphCanada Ecology and Evolutionary Biology York UniversityTorontoCanada Ecosystem Science Polar Knowledge CanadaOttawa and Cambridge BayCanada Department of Geography University of VictoriaCanada

Global biodiversity is in *** of the scale and pace of biodiversity loss is leading to rapid technological development in biodiversity science to identify species,their interactions,and eco-system *** and international policy developments to stimulate mitigation and remediation actions are escalating to meet the biodiversity *** can take advantage of biosurveil-lance“big data”as evidence for more sweeping and impactful policy *** critical factor is translating biosurveillance data into the value-based frameworks underpinning new policy *** approach to this integration process,using natural capital accounting frameworks is developed.

关键词： Biodiversity biosurveillance big data SDGs policy natural capital accounting digital twins modelling

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A new cryptand/paraquat [2]pseudorotaxane

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Science China Chemistry 2010年第4期53卷 858-862页

作者： ZAKHAROV lev N. SlEBODNICK Carla RHEINGOlD Arnold l. GIBSON harry W. Department of Chemistry and Biochemistry University of California Department of Chemistry Virginia Polytechnic Institute and State University

A new cryptand/paraquat [2]pseudorotaxane and its crown ether analog were synthesized and characterized by proton NMR, mass spectrometry, and single crystal X-ray analysis. The Job plots based on proton NMR data demonstrated that both the complex between cryptand 1 and paraquat derivative 2a and the complex between bis(p-phenylene)-34-crown-10 (3) and paraquat derivative 2b have 1:1 stoichiometry in solution. The apparent association constants (Ka,exp) of 1·2a and 3·2b calculated for 1:1 complexes were 1.4 (±0.2) × 104 and 4.7 (± 0.5) × 102 M-1, respectively. X-ray analysis showed that 1·2a is stabilized by ten hydrogen bonds and face-to-face π-stacking interactions in the solid state, while 3·2b is stabilized by four hydrogen bonds and face-to-face π-stacking interactions. As well as in the X-ray structure of 1·2c, a water molecule acts as a hydrogen bridge between the β-pyridinium protons of 2a and the ether oxygen atoms of 1 in 1·2a. The successful preparation of 1·2a demonstrated that the tert-butyl group is not big enough to be a stopper for rotaxanes based on 1.

关键词： host-guest system self-assembly pseudorotaxane cryptand paraquat

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Development and Validation of a Deep learning Based Automated Minirhizotron Image Analysis Pipeline

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Plant Phenomics 2022年第1期4卷 247-260页

作者： Felix Maximilian Bauer lena lärm Shehan Morandage Guillaume lobet Jan Vanderborght harry Vereecken Andrea Schnepf Institute of Bio-and Geosciences Agrosphere(IBG-3)Forschungszentrum Jülich GmbH52425 JülichGermany Institute of Soil Science and land Evaluation University of Hohenheim7055978 StuttgartGermany

Root systems of crops play a significant role in *** root system is essential for water and nutrient uptake,plant stability,symbiosis with microbes,and a good soil *** have shown to be effective to noninvasively inves... 详细信息

关键词： structure crops soil

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Environmental factors affecting degradation of perfluorooctanoic acid(PFOA) by In2O3 nanoparticles

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Journal of Environmental Sciences 2020年第7期32卷 48-56页

作者： Weilan Zhang harry Efstathiadis lingyun li Yanna liang Department of Environmental and Sustainable Engineering University at AlbanySUNYAlbanyNY 12222USA Department of Nanoengineering SUNY Polytechnic InstituteAlbanyNY 12203USA New York State Department of Health Division of Environmental Health SciencesWadsworth CenterAlbanyNY 12237USA

Nanophotocatalysts have shown great potential for degrading poly-and perfluorinated substances(PFAS).In light of the fact that most of these catalysts were studied in pure water,this study was designed to elucidate effects from common environmental factors on decomposing and defluorinating perfluorooctanoic acid(PFOA)by In2O3 *** from this work demonstrated that among the seven parameters,pH,sulfate,chloride,H2O2,In2O3 dose,NOM and O2,the first four had statistically significant negative effects on PFOA *** PFOA is a strong acid,the best condition leading to the highest PFOA removal was identified for two pH *** pH was between 4 and 8,the optimal condition was:pH=4.2;sulfate=5.00 mg/l;chloride=20.43 mg/l;H2O2=0 mmol/*** this condition,PFOA decomposition and defluorination were 55.22 and 23.56%,*** pH was between 2 and 6,the optimal condition was:pH=2;sulfate=5.00 mg/l;chloride=27.31 mg/l;H2O2=0 mmol/*** this condition,the modeled PFOA decomposition was 97.59%with a defluorination of approximately 100%.These predicted results were all confirmed by experimental ***,In2O3 nanoparticles can be used for degrading PFOA in aqueous *** approach works best when the target contaminated water contains low concentrations of NOM,sulfate and chloride and at a low pH.

关键词： Perfluorooctanoic acid(PFOA) Nanophotocatalyst Degradation Defluorination Optimization

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Synthesis, Mechanism of Formation and Insecticidal Activity of Novel Fluorinated Organophosphorus Compounds

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Chinese Journal of Chemistry 2002年第12期20卷 1598-1601,1464页

作者：吴军 HUDSON harry R. Department of Chemistry Zhejiang University Hangzhou Zhejiang 310027 China Division of Chemistry School of Biological and Applied Sciences University of North London London N7 8DB UK Email: Jun Wu (wujunwu@***)

The major products of the interaction between triethyl phosphite and 3-fluoropropanoyl chloride at room temperature are diethyl (E)-1-(3-fluoropropanoyloxy)-3-fluoroprop-1-enylphosphonate (3) and diethyl l-(diethoxyphosphoryl)-3-fluoropropyl phosphate (4). The compounds 3 and 4 were separated by chromatography, and structurally characterized by elemental analysis, NMR spectroscopy (1H, 13C, 19F and 31P) and mass spectrometry. Possible reaction mechanisms are proposed. The major products 3 and 4 were tested for insecticidal activity. 3 gave 100% control of Musca domestica l. and Phaedon cochledriae Fab. at a dose of 20 μg/per insect.

关键词： synthesis reaction mechanism insecticidal activity fluorinated organophosphonate

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Towards efficient near-infrared fluorescent organic light-emitting diodes

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light(Science & Applications) 2021年第2期10卷 166-175页

作者： Alessandro Minotto Ibrahim Bulut Alexandras G.Rapidis Giuseppe Carnicella Maddalena Patrini Eugenio lunedei harry l.Andersonand Franco Cacialli Department of Physics and Astronomy and london Centre for Nanotechnology University College LondonLondon WC1E 6BTUK Department of Chemistry Chemistry Research LaboratoryUniversity of OxfordMansfield RoadOxford OX13TAUK Dipartimento di Fisica University degli Studi di PaviaVia A.Bassi6Pavia 27100Italy. CNR-ISMN Istituto per lo Studio dei Materiali NanostrutturatiConsiglio Nazionale delle RicercheVia P Gobetti 101Bologna 40129Italy

The energy gap law(E_(G)-law)and aggregation quenching are the main limitations to overcome in the design of near-infrared(NIR)organic ***,we achieve unprecedented results by synergistically addressing both of these ***,we propose porphyrin oligomers with increasing length to attenuate the effects of the E_(G)-law by suppressing the non-radiative rate growth,and to increase the radiative rate via enhancement of the oscillator ***,we design side chains to suppress aggregation *** find that the logarithmic rate of variation in the non-radiative rate vs.E_(G)is suppressed by an order of magnitude with respect to previous studies,and we complement this breakthrough by demonstrating organic light-emitting diodes with an average external quantum efficiency of-1.1%,which is very promising for a heavy-metal-free 850 nm *** also present a novel quantitative model of the internal quantum efficiency for active layers supporting triplet-to-singlet *** results provide a general strategy for designing high-luminance NIR emitters.

关键词： radiative limitations aggregation

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