Hydroxycitric acid does not promote inflammation or liver toxicity

作     者：Dallas L Clouatre Harry G Preuss 

作者机构：Glykon Technologies Group LLC SeattleWA 98109 United States Department of Physiology Georgetown University Medical Center Washington DC 20057 United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第44期

页      面：8160-8162页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Garcinia cambogia Hepatic collagen Hepatic inflammation Hepatic oxidative stress Hydroxycitric acid Metabolic syndrome Tumor necrosis factor-α Weight loss 

摘      要：Garcinia cambogia extract(GC)with its active component consisting of hydroxycitric acid(HCA)is widely utilized for weight *** HCA salts are available,including calcium,magnesium,potassium and mixtures of ***,these salts exhibit different properties with some,but not all,improving glucose tolerance and blood ***,obesity-prone C57BL/6J mice were fed a high-fat diet(HFD,45 kcal%fat)with or without GC(1%,w/w)for 16 *** active arm reduced visceral fat,adipocyte size and serum glucose,yet purportedly also exhibited hepatic collagen accumulation,lipid peroxidation and increased mRNA levels of genes related to oxidative *** latter findings are at odds with a large body of animal and human studies that have been conducted on the safety and efficacy of *** literature shows HCA to be protective against the liver toxicity associated with ethanol and dexamethasone administration,and to maintain serum aspartate aminotransferase,alanine aminotransferase and alkaline phosphatase at near normal *** both animal and clinical literature,elevated intakes of HCA per se have not led to signs of inflammation or *** compound has been found to reduce markers of inflammation in brain,intestines,kidney and serum.