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Entropically favoured through space charge transfer‘lighted’photosensitizing assemblies for‘metal free’regulated photooxidation of alcohols and aldehydes

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Aggregate 2022年第2期3卷 143-153页

作者： Gurpreet kaur harpreet kaur Mandeep kaur Manoj Kumar Vandana Bhalla Department of Chemistry Centre of Advance Studies-IIGuru Nanak Dev UniversityAmritsarIndia

Strong acceptor-weak acceptor system FN-TPy has been designed and synthesized,which undergoes solvent dependent self-assembly in mixed aqueous media to generate through space intermolecular charge transfer *** as-prepared entropically favoured assemblies of FN-TPy exhibit excellent photostability and photosensitizing properties in the assembled state to activate aerial oxygen for efficient generation of reactive oxygen species through Type-I and Type-II *** FN-TPy exhibits excellent potential for regulated oxidation of alcohols and aldehydes under mild reaction conditions(visible light irradiation,aqueous media,room temperature)using aerial oxygen as the‘oxidant’.The present study demonstrates the potential of FN-TPy assemblies to catalyse controlled oxidation of benzyl alcohol to benzoic acid.

关键词： aggregated assemblies molecular oxygen activation oxidations photosensitizer through space charge transfer

Improved offline multi-objective routing and wavelength assignment in optical networks

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Frontiers of Optoelectronics 2019年第4期12卷 433-444页

作者： harpreet kaur Munish RATTAN Research Scholar Electronics EngineeringI.K.Gujral Punjab Technical University JalandharKapurthalaPunjab 144603India Department of Electronics and Communication Baba Banda Singh Bahadur Engineering CollegeFatehgarh SahibPunjab 140407India Department of Electronics&Communication Guru Nanak Dev Engineering CollegeLudhianaPunjab 141006India

Optical networks act as a backbone for coming generation high speed *** applications demand a very high bandwidth which can be exploited with the use of wavelength division multiplexing(WDM)*** issue of setting light paths for the traffic demands is routing and wavelength assignment(RWA)*** on the type of traffic patterns,it can be categorized as offline or online *** this paper,an effective solution to offline(static)routing and wavelength assignment is presented considering multiple objectives ***,the flower pollination(FP)technique is *** the problem is extended with the parallel hybrid technique with flower pollination and intelligent water drop algorithm(FPIWDA).Further,FPIWD is hybrid in parallel with simulated annealing(SA)algorithm to propose a parallel hybrid algorithm *** results obtained through extensive simulation show the superiority of FPIWD as compared to ***,the results in terms of blocking probability with respect to wavelengths and load of FPIWDSA are more propitious than FP and FPIWD.

关键词： offline online flower pollination(FP) intelligent water drop(IWD) simulated annealing(SA) blocking probability static robustness flexibility heuristic wavelength division multiplexing(WDM)

Clinical Validation of Global Coagulation Tests to Guide Blood Component Transfusions in Cirrhosis and ACLF

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 210-219页

作者： Madhumita Premkumar Rohit Mehtani Smita Divyaveer Kamal Kajal Anand VKulkarni Syed Ahmed Harmanpreet kaur harpreet kaur Radhakrishna Dhiman Ajay Duseja Arka De Departments of Hepatology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Nephrology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Anesthesia and Intensive CarePostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Hepatology Asian Institute of GastroenterologyHyderabadIndia Medicine Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Background and Aims:Patients with cirrhosis and acuteon-chronic liver failure(ACLF)may have bleeding complications and need for invasive ***-of-care(POC)coagulation tests like thromboelastography(TEG)and Sonoclot may be better for guiding patient management than the standard coagulation tests(SCTs),like prothrombin time,platelet count and international normalized ***:We prospectively compared and validated the POC tests and SCTs in 70 persons with ACLF and 72 persons with decompensated cirrhosis who had clinical bleeding and checked for episodes of re-bleeding and transfusion *** assessed pre-procedure requirement of blood components when correction was done based on an SCT or POC ***:Episodes of bleeding were seen in 45%and 28%of ACLF and cirrhosis patient,respectively(p=0.036),with the major site of bleeding being gastrointestinal(31%and 16%,respectively).Platelet counts correlated with TEG-maximum amplitude in cirrhosis(p=0.045)and prothrombin time correlated positively with TEG-reaction(R)time(p=0.032),TEG-Clot kinetics(K)time(p=0.042),Son-activated clotting time(p=0.038)and negatively with clot rate(p=0.043)in ACLF,making these correctable target variables in POC transfusion *** 223 procedures,transfusion of fresh frozen plasma and platelet concentrate was reduced by 25%(p=0.035)and 20.8%(p=0.045)by using a POC strategy in 76 *** of deranged Son-activated clotting time and TEG-reaction time was noted in 68%and 72%after 24 h of fresh frozen plasma transfusion in ACLF and 85%and 80%in cirrhosis,***:Our study clinically validates that POC tests can better detect coagulation defects and transfusion thresholds in ACLF and cirrhosis,whereas use of conventional tests appear to be less suitable in patients with clinical *** Registration:NCT04332484.

关键词： Coagulation Cirrhosis ACLF Validation Sonoclot Thromboelastography

Body Composition, Dietary Intake and Physical Activity Level of Sedentary Adult Indian Women

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Food and Nutrition Sciences 2012年第11期3卷 1577-1585页

作者： Gurpreet kaur Kiran Bains harpreet kaur Punjab Agricultural University Ludhiana Punjab India.

Age related changes in body composition are associated with long term dietary intake profiles. Age related increase in body fat is primarily attributed to decline in physical activity and basal metabolic rate as well as dietary intake. The study was designed to assess the body composition, dietary intake and physical activity level of sedentary adult women of different age groups. A cross-sectional study was conducted on 152 sedentary adult women comprised of students and faculty from Punjab Agricultural University, Ludhiana. The relationship of body composition with dietary factors and physical activity level of women in four age groups i.e. 21 - 30, 31 - 40, 41 - 50 and 51 - 60 years was determined. A gradual increase (p ≤ 0.05) in anthropometric and body composition parameters such as weight, waist circumference, hip circumference, body mass index, fat mass and visceral fat rating was observed with the advancement of age. The lean body mass was decreased significantly (p ≤ 0.05) as the age progressed, the values for four age groups being 74.9, 68.9, 62.8 and 60.9%, respectively. Contrary to this fat mass increased with age, the corresponding values for four age groups being 15.7, 21.4, 26.6 and 29.2 kg, respectively. The percent adequacy of protein by four age groups was 69.6, 78.2, 80.0 and 66.3, respectively when compared to RDA while fat intake was much higher i.e. 245.5, 271.8, 288.4 and 250.8%, respectively. The energy intake was inadequate among all age groups, however, a significant (p ≤ 0.05) differ- ence was observed in daily energy consumption between the age groups. The mean physical activity level (PAL) of the subjects ranged between 1.49 - 1.60. The physical activity level values showed that majority of the subjects (87% - 94%) were having sedentary life style. Age is a crucial factor associated with body composition. A high fat mass and low lean body mass of the subjects was observed. Their diets were low in protein but high in fat. Majority of the

关键词： Lean Body Mass Fat Mass Dietary Factors Physical Activity Level

Feasibility and efficacy of gentamicin for treating neonatal sepsis in community-based settings:a systematic review

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World Journal of Pediatrics 2016年第4期12卷 408-414页

作者： Nishant Jaiswal Meenu Singh Ritika Kondel Navjot kaur Kiran K.Thumburu Ajay Kumar harpreet kaur Neelima Chadha Neeraj Gupta Amit Agarwal Samir Malhotra Nusrat Shafiq ICMR Advanced Centre for Evidence Based Child Health Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Pharmacology Postgraduate Institute of Medical Education and ResearchChandigarh160012India Department of Pediatrics Postgraduate Institute of Medical Education and ResearchChandigarhIndia Dr.Tulsi Das Library Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Library University Business SchoolPunjab UniversityChandigarhIndia Department of Pediatrics AIIMSJodhpurRajasthanIndia

Background:Neonatal sepsis is a leading cause of neonatal deaths in developing *** current recommended in-hospital treatment is parenteral ampicillin(or penicillin)and gentamicin in young infants for 10-14 days;however,very few could access and *** current review is to evaluate the feasibility of gentamicin in community based ***:Both observational and randomized controlled trials were ***,Embase,Cochrane Central Register of Controlled Trials and Central Trial Register of India were searched until September *** assessed the risk of bias by Cochrane Collaboration’s"risk of bias"***:Two observational studies indicated feasibility ensuring coverage of population,decrease in case fatality rate in the group treated by community health *** an RCT,no significant difference was observed in the treatment failure rates[odds ratio(OR)=0.88],and the mortality in the first and second week(OR=1.53;OR=2.24)between gentamicin and ceftriaxone *** the gentamicin group,the combination of penicillin and gentamicin showed a lower rate of treatment failure(OR=0.44)and mortality at second week of life(OR=0.17)as compared to the combination of gentamicin and oral ***:Gentamicin for the treatment of neonatal sepsis is both feasible and effective in community-based settings and can be used as an alternative to the hospitalbased care in resource compromised *** there was less evidence in the management of neonatal sepsis in hospitals as was seen in this review in which we included only one RCT and three observational studies.

关键词： gentamicin neonatal sepsis neonates

Interconversion of two commonly used performance tools: An analysis of 5844 paired assessments in 1501 lung cancer patients

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World Journal of Clinical Oncology 2018年第7期9卷 140-147页

作者： Kuruswamy Thurai Prasad harpreet kaur Valliappan Muthu Ashutosh Nath Aggarwal Digambar Behera Navneet Singh Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER)

AIM To establish the Karnofsky performance status(KPS) categories which would facilitate the interconversion of the KPS scale to the Eastern Cooperative Oncology Group(ECOG) performance status(PS) *** This was a retrospective analysis of all patients attending the lung cancer clinic at a tertiary care center over a 5-year period(September 2009 to August 2014). All patients were assessed with both KPS and ECOG PS scales at each visit. Correlation between KPS and ECOG PS was assessed using Spearman's correlation coefficient. KPS categories equivalent to ECOG PS scores were compared using hit rate and weighted kappa(κw).RESULTS A total of 1501 patients were assessed over the study period, providing 5844 paired KPS and ECOG PS assessments. The study cohort had a mean(standard deviation; SD) age of 58.4(10.8) years, with the majority being current or ex-smokers(76.9%) and males(82.3%). Non-small cell lung cancer was the most common histological type(n = 1196, 79.7%) with the majority having advanced(stage ⅢB/Ⅳ) disease(83.4%). Mean baseline KPS and ECOG PS scores were 77.6(SD = 14.4) and 1.5(SD = 1) respectively. The most frequent KPS score was 80(29%), and the most frequent ECOG PS score was 1(43%). The overall correlation between KPS and ECOG PS was good(Spearman r =-0.84, P < 0.0001) but ranged from-0.727 to-0.972 between visits. KPS categories derived from our cohort [10-40(ECOG 4), 50-60(ECOG 3), 70(ECOG 2), 80-90(ECOG 1), 100(ECOG 0)] performed better [hit rate 78.1%, κw = 0.749(0.736-0.762) P < 0.0001] than those suggested in the past *** The current study provides the largest set of paired KPS-ECOG assessments to date. We suggest that the KPS categories 10-40, 50-60, 70, 80-90, and 100 are equivalent to ECOG PS categories of 4, 3, 2, 1, and 0 respectively.

关键词： Karnofsky performance status Eastern Cooperative Oncology Group Performance status Lung cancer Chemotherapy

Telemonitoring in heart failure patients:Systematic review and metaanalysis of randomized controlled trials

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World Journal of Cardiology 2022年第12期14卷 640-656页

作者： Chukwuemeka Anthony Umeh Adrian Torbela Shipra Saigal harpreet kaur Shadi Kazourra Rahul Gupta Shivang Shah Internal Medicine Hemet Global Medical CenterHemetCA 92543United States Department of Cardiology Loma Linda University School of MedicineLoma LindaCA 92350United States Department of Cardiology University of California Riverside School of MedicineRiversideCA 92507United States

BACKGROUND Home telemonitoring has been used as a modality to prevent readmission and improve outcomes for patients with heart ***,studies have produced conflicting outcomes over the *** To determine the aggregate effect of telemonitoring on all-cause mortality,heart failure-related mortality,all-cause hospitalization,and heart failure-related hospitalization in heart failure *** We conducted a systematic review and meta-analysis of 38 home telemonitoring randomized controlled trials involving 14993 *** also conducted a sensitivity analysis to examine the effect of telemonitoring duration,recent heart failure hospitalization,and age on telemonitoring *** Our study demonstrated that home telemonitoring in heart failure patients was associated with reduced all-cause[relative risk(RR)=0.83,95% confidence interval(CI):0.75-0.92,P=0.001]and cardiovascular mortality(RR=0.66,95%CI:0.54-0.81,P<0.001).Additionally,telemonitoring decreased the all-cause hospitalization(RR=0.87,95%CI:0.80-0.94,P=0.002)but did not decrease heart failurerelated hospitalization(RR=0.88,95%CI:0.77-1.01,P=0.066).However,prolonged home telemonitoring(12 mo or more)was associated with both decreased all-cause and heart failure hospitalization,unlike shorter duration(6 mo or less)*** Home telemonitoring using digital/broadband/satellite/wireless or blue-tooth transmission of physiological data reduces all-cause and cardiovascular mortality in heart failure *** addition,prolonged telemonitoring(≥12 mo)reduces all-cause and heart failure-related *** implication for practice is that hospitals considering telemonitoring to reduce heart failure readmission rates may need to plan for prolonged telemonitoring to see the effect they are looking for.

关键词： Telemonitoring Heart failure Telehealth Home monitoring Remote monitoring

Extrapulmonary small cell carcinoma of lymph node: Pooled analysis of all reported cases

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World Journal of Clinical Oncology 2016年第3期7卷 308-320页

作者： Inderpaul Singh Sehgal harpreet kaur Sahajal Dhooria Amanjit Bal Nalini Gupta Digambar Behera Navneet Singh Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Department of Histopathology Postgraduate Institute of Medical Education and Research Department of Cytology and Gynecological Pathology Postgraduate Institute of Medical Education and Research

AIM: To study clinical outcomes and management of lymph nodes extrapulmonary small cell carcinoma(LNEPSCC). METHODS: Herein, we perform a systematic search of published literature in the PubMed and EMBASE databases for studies describing LNEPSCC. For uniformity of reporting, LNEPSCC was staged as limited if it involved either single lymph node station or if surgery with curative intent had been undertaken. The disease was staged extensive if it involved two or more lymph node ***: The systematic literature review yielded eight descriptions(n = 14) involving cervical, submandibular and inguinal lymph nodes. Eleven(64.7%) patients had limited disease(LD) and six(35.3%) had extensive disease(ED) at presentation. Chemotherapy(n = 6, 35.3%) or surgery(n = 4, 23.5%) were the most common form of treatment given to these patients. Complete response was achieved in 12(70.6%) of the patients. Median(interquartile range) progression free survival and overall survival was 15(7-42) mo and 22(12.75-42) mo respectively. Of the three illustrative cases, two patients each had ED at presentation and achieved complete remission with platinum based combination ***: LNEPSCC is a rare disease with less than 15 reported cases in world literature. Surgical resection with curative intent is feasible in those with LD while platinum based combination chemoradiation is associated with favorable outcomes in patients with ED. Prognosis of LNEPSCC is better than that of small cell lung cancer in general.

关键词： Extrapulmonary Small cell Carcinoma Lymph node Small cell lung cancer

Effect of Jasmonic Acid on Photosynthetic Pigments and Stress Markers in <i>Cajanus cajan</i>(L.) Millsp. Seedlings under Copper Stress

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American Journal of Plant Sciences 2013年第4期4卷 817-823页

作者： Sharma Poonam harpreet kaur Sirhindi Geetika Department of Botany Punjabi University Patiala India Department of Botany Punjabi University Patiala India.

Jasmonates are class of plant growth regulators act as signal molecule that intercede various components in physiological and metabolic regulation, stress responses and possibly communication through signal transduction. Oxidative stress due to heavy metal exposure stimulates synthesis and activity of antioxidant metabolites and enhances antioxidant enzyme activities that could protect plant tissues. The aim of this study was to investigate the exogenous effect of JA at seed level which can transduce throughout seedling growth and regulate antioxidant activities such as superoxide dismutase (SOD;EC 1.***.1.1) and guaiacol peroxidase (POD;EC 1.***.1.7) in 12 days old seedlings of pigeon pea (Cajanus cajan (L.) Millsp.) in presence and/or absence of copper. The activity of SOD and POD increased significantly in presence of Cu2+ after seed priming with JA. JA also helps in chlorophyll and carotenoid accumulation and neutralizes the toxic effect of Cu2+ on seedlings. This is the first report of JA effect on photosynthetic pigment accumulation and H2O2 mitigating enzymes i.e. SOD and POD and it could be recommended that seed priming with JA help in ameliorating toxic effect of Cu2+.

关键词： Jasmonic Acid Copper Sulphate Lipid Peroxidation Superoxide Dismutase Guaiacol Peroxidase Total Chlorophyll Carotenoids