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Leukemoid reaction in a patient with COVID-19 infection: A case report

Journal of Acute Disease 2022年第3期11卷 120-122页

作者： Prabhat Agrawal Ashish Gautam Anjana Pandey Harendra Kumar Nikhil Pursnani Departments of Medicine S.N.Medical CollegeAgraIndia Departments of PathologyS.N.Medical CollegeAgraIndia

Rationale:COVID-19 usually presents with flu-like symptoms and signs,but some rare presentations like leukemoid symptoms cannot be ignored.Patient’s concerns:A 37-year-old female presented to the outpatient department with flu-like symptoms.Diagnosis:The RT-PCR test for SARS-CoV-2 infection was positive,while complete blood cell and peripheral blood smear showed leukemoid reaction.Intervention:Paracetamol and fexofenadine for flu-like symptoms and leukemoid presentation.Outcomes:On the 10th day,the patient was asymptomatic and RT-PCR was negative.So the patient was discharged and leukemoid presentation subsided after clearance of viral disease.Lessons:COVID-19 has a myriad of presentations,and unusual symptoms/signs especially in this pandemic could be induced by COVID-19 infection.

关键词： COVID-19 Leukemoid reaction Atypical presentation Abnormal total leucocyte count Leukocytosis

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Prospects of diagnostic and prognostic biomarkers of pyometra in canine

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Asian pacific Journal of Reproduction 2020年第4期9卷 166-173页

作者： Laishram Kipjen Singh Manas kumar Patra Girish kumar Mishra Abhishek Chandra Saxena Ujjwal kumar De Sanjay kumar Singh Harendra Kumar Krishnaswamy Narayanan Animal Reproduction Division Indian Veterinary Research InstituteIzatnagarU.P.243122India Animal Reproduction Gynaecology and Obstetrics Division ICAR-National Dairy Research InstituteKarnal-132001India Department of Veterinary Gynaecology andObstetrics College of Veterinary Sciences and Animal HusbandryAnjoraDurg(C.G.)India Referral Veterinary Polyclinic ICAR-Indian Veterinary Research InstituteIzatnagarU.P.243122India ICAR-Indian Veterinary Reseach Institute HebbalBangaluru 560024India

Pyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening systemic inflammatory response syndrome. Ultrasonographic examination of the uterus aids in the diagnosis, although it has limitation in ascertaining the clinical severity of pyometra. Moreover, differentiation of cystic endometrial hyperplasia from pyometra could not be discerned with greater accuracy. Therefore, false negative diagnosis of pyometra patients leads to development of systemic inflammatory response, which delays administration of therapies and results in deaths during early course of treatment. Further, indiscriminate use of broad-spectrum antimicrobials at higher dose in false positive cases considerably contributes to the rising pool of drug resistant pathogens, thereby increasing the risk of case fatality due to sepsis in a long-term. Monitoring the circulating pro-inflammatory cytokines, acute phase proteins, endotoxin, growth factors and inflammatory mediators is the current trend in pyometra research, especially for developing diagnostic and prognostic biomarkers. The present review deals with the prospects of developing diagnostic and prognostic biomarkers in the canine pyometra.

关键词： Pyometra Systemic inflammatory response Acute-phase proteins Prostaglandin F metabolite Canine

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Assessment of glacier stored water in Karakoram Himalaya using satellite remote sensing and field investigation

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Journal of Mountain Science 2019年第4期16卷 836-849页

作者： Kamal Kant SINGH harendra Singh NEGI Dhiraj kumar SINGH Snow and Avalanche Study Establishment

Karakoram Himalaya(KH) has continental climatic conditions and possesses largest concentration of glaciers outside the polar regions. The melt water from these glaciers is a major contributor to the Indus river. In this study, various methods have been used to estimate the ice volume in the Karakoram Range of glaciers such as Coregistration of Optically Sensed Images and Correlation(COSI-Corr) method and Area-Volume relations. Landsat 8 satellite data has been used to generate the ice displacement, velocity and thickness map. Our study for 558 Karakoram glaciers revealed that the average ice thickness in Karakoram is 90 m. Ground Penetrating Radar(GPR) survey has been conducted in one of the KH glacier i.e. Saser La glacier and the collected GPR data is used for the validation of satellite derived thickness map. GPR measured glacier thickness values are found comparable with satellite estimated values with RMSE of 4.3 m. The total ice volume of the Karakoram glaciers is estimated to be 1607±19 km3(1473±17 Gt), which is equivalent to 1473±17 km3 of water equivalent. Present study also covers the analysis of glacier surface displacement, velocity and ice thickness values with reference to glacier mean slope.

关键词： Glacier COSI-Corr Karakoram Range Ground Penetrating Radar GPR Volume-Area

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Evaluation of “Indigenous Vaccine” Developed Using “Indian Bison Type” Genotype of <i>Mycobacterium avium subspecies paratuberculosis</i>Strain “S5” of Goat Origin in a Sheep Flock Endemic for Johne’s Disease: A Three Years Trial in India

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World Journal of Vaccines 2013年第2期3卷 52-59页

作者： Shoor Vir Singh Ajay Vir Singh Pravin kumar Singh Saurabh Gupta harendra Singh Brajesh Singh Omalur Rajendran Vinodh kumar Aripudur Sellappan Rajendiran Narendra Nath Swain Jagdip Singh Sohal Central Institute for Research on Goats Mathura Indi Central Institute for Research on Goats Mathura India Southern Regional Research Centre Central Sheep and Wool Research Institute Kodaikanal India

“Indigenous vaccine” developed from native “Indian Bison Type” strain (“S5”) of Mycobacterium avium subspecies paratuberculosis (MAP) of “goat origin” was first time evaluated in a sheep flock of Bharat Merino breed located in Mannavanur town of Tamil Nadu in South India. Therapeutic efficacy of the vaccine was evaluated for 3 years between 2008 and 2010, on the basis of improvements in productivity (body weights, reproductive efficiency and survivability), physical condition, clinical symptoms (weakness, diarrhea, wool quality), immune response (sero-conversion) and infection load in feces (shedding). After immunization of the flock in 2008, the successive progenies of 112 and 53 lambs born in 2009 and 2010, respectively were vaccinated. Whereas, 40 lambs born to control animals were kept as unvaccinated controls. Though gain in body weights in vaccinated versus controls were not significant in 2008, growth rates were distinctly superior in Ist and IInd generations of vaccinated lambs. Reproductive performance (tupping percent) and survivability of lambs and adult sheep improved significantly. There was overall reduction in yearly morbidity (diarrhea) and mortality rates of the flock in post vaccination years. Shedding of MAP in feces was reduced in vaccinated sheep by 6.2%, 14.3% and 27.3% in 2008, 2009 and 2010 respectively, whereas shedding increased in the control sheep. Seromonitoring of the animals by “indigenous ELISA kit” showed enhanced “flock immunity” in successive generations. “Indigenous vaccine” reduced clinical disease and shedding and improved immunity and productivity of Bharat Merino flock, endemic for Johne’s disease.

关键词： Paratuberculosis Indigenous Vaccine Indian Bison Type Bharat Merino Sheep India

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