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视网膜母细胞瘤脉络膜浸润的组织学分期与转移和预后的关系

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中华眼底病杂志 1999年第2期15卷 88-90页

作者：杨红 harald,s 同济医科大学附属同济医院眼科德国埃森综合大学眼科医院

目的探讨视网膜母细胞瘤（ｒｅｔｉｎｏｂｌａｓｔｏｍａ，ＲＢ）脉络膜浸润的组织学分期及与预后的关系。方法光镜下复习观察１９８５年６月到１９９５年６月期间２９７只ＲＢ眼摘除眼球的组织病理切片。为估量此病患者预后的危险因素... 详细信息

目的探讨视网膜母细胞瘤（ｒｅｔｉｎｏｂｌａｓｔｏｍａ，ＲＢ）脉络膜浸润的组织学分期及与预后的关系。方法光镜下复习观察１９８５年６月到１９９５年６月期间２９７只ＲＢ眼摘除眼球的组织病理切片。为估量此病患者预后的危险因素，着重对患眼脉络膜浸润进行分级，并对患者进行随访。结果根据肿瘤细胞对眼内组织结构的影响，以脉络膜为中心将其分为５期：０期：视网膜色素上皮反应前期（１４４／２９７，４８．４８％）；Ⅰ期：视网膜色素上皮反应期（８１／２９７，２７．２７％）；Ⅱ期：脉络膜浸润早期（２９／２９７，９．７６％）；Ⅲ期：脉络膜浸润中期（１７／２９７，５．７２％）；Ⅳ期：脉络膜浸润晚期（２６／２９７，８．７５％）。Ⅱ～Ⅳ期为脉络膜浸润期。２４．２４％的切片中发现有脉络膜浸润。患者经平均５１．８个月的随访，０～Ⅲ期的患者死亡率为０．４％，Ⅳ期患者为１２．０％。结论脉络膜浸润晚期（大范围的脉络膜浸润）肿瘤细胞转移率较高，患者预后差。

关键词：视网膜母细胞瘤肿瘤浸润预后肿瘤转移肿瘤分期

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《发展心理语言学》介绍

当代语言学 2012年第1期14卷 95-98页

作者： Irina A.sekerina Eva M.Fernndez harald Clahsen 姚岚中国计量学院外国语学院

2006年3月在美国纽约城市大学举办了一次“儿童语言加工的在线研究方法研讨会”。2008年John benjamins出版社出版了《发展心理语言学——儿童语言加工的在线研究方法》（Developmental Psycholinguistics：On—line Methods in Childre... 详细信息

2006年3月在美国纽约城市大学举办了一次“儿童语言加工的在线研究方法研讨会”。2008年John benjamins出版社出版了《发展心理语言学——儿童语言加工的在线研究方法》（Developmental Psycholinguistics：On—line Methods in Children＇s Language Processing）。

关键词：发展心理语言学 Language 语言加工 2008年城市大学出版社在线儿童

金属注射成形微小齿轮光学全齿扫描测量技术研究

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现代制造工程 2022年第6期 90-96,104页

作者：王青云王训伟邱耀弘 harald Lowe 雷保珍北京联合大学北京市信息服务工程重点实验室北京100020 北京联合大学北京市智能机械创新设计服务工程技术研究中心北京100020 昆山耀德企业咨询有限公司昆山215300 德国布伦瑞克工业大学布伦瑞克38106

金属注射成形(Metal Injection Molding,MIM)微小齿轮由于存在各向异性收缩的成形特性和微小尺寸特征,使得传统的二维小样本和极值检测方法无法体现其三维成形特点。结合MIM微小齿轮的特点,提出MIM微小齿轮光学全齿扫描测量方法。通过... 详细信息

金属注射成形(Metal Injection Molding,MIM)微小齿轮由于存在各向异性收缩的成形特性和微小尺寸特征,使得传统的二维小样本和极值检测方法无法体现其三维成形特点。结合MIM微小齿轮的特点,提出MIM微小齿轮光学全齿扫描测量方法。通过将测量点云网格与理论数模进行比对,获得整个微小齿轮的三维偏差;通过在测量点云网格上构建截面,实现对截面上齿廓基本尺寸、齿距偏差和齿厚偏差等的自动测量。试验证明,所提出的光学全齿扫描测量方法可以实现对MIM微小齿轮快速、高精度自动检测,并获得全齿信息,为MIM微小齿轮注射模具的主动设计和制造参数的优化提供必要依据。该测量方法同样适用于注塑齿轮、粉末冶金齿轮、锻造齿轮和金属切削齿轮,有助于推动齿轮制造业向全齿检测的方向发展,提升齿轮制造质量。

关键词：金属注射成形微小齿轮光学测量全齿测量理论数模

Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis

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World Journal of Gastroenterology 2012年第32期18卷 4288-4299页

作者： sander van der Marel Anna Majowicz Karin Kwikkers Richard van Logtenstein Anje A te Velde Anne s De Groot sybren L Meijer sander J van Deventer harald Petry Daniel W Hommes Valerie Ferreira Department of Research and Development uniQure B.V.1105 BA AmsterdamThe Netherlands Department of Gastroenterology and Hepatology Leiden University Medical Center2333 ZA LeidenThe Netherlands Tytgat Institute for Liver and Intestinal Research Academic Medical CenterUniversity of Amsterdam1105 BK AmsterdamThe Netherlands EpiVax Inc. ProvidenceRI 02903United States The Institute for Immunology and Informatics University of Rhode IslandKingstonRI 02881United States Department of Pathology Academic Medical CenterUniversity of Amsterdam1105 AZ AmsterdamThe Netherlands Center for Inflammatory bowel Diseases UCLA Health SystemLos AngelesCA 90095United States

AIM:To explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of Tregitope 167 in an experimental colitis ***:The trinitrobenzene sulfonate(TNbs) model of induced colitis was used in balb/c *** after intravenous adeno-associated virusmediated regulatory T-cell epitopes(Tregitope) delivery,acute colitis was initiated by intra-rectal administration of 1.5 mg TNbs in 40% ethanol followed by a second treatment with TNbs(0.75 mg in 20% ethanol) 8 d *** groups included mice not treated with TNbs(healthy control group) and mice treated by TNbs only(diseased group).At the time of sacrifice colon weight,the disease activity index and histology damage score were *** staining of the colonic tissues was performed to asses the cellular infiltrate and the presence of transcription factor forkhead box-P3(Foxp3).Thymus,mesenteric lymph nodes,liver and spleen tissue were collected and the corresponding lymphocyte populations were further assessed by flow cytometry analysis for the expression of CD4+ T cell and regulatory T cell associated ***:The Tregitope 167 treated mice gained an average of 4% over their initial body weight at the time of *** contrast,the mice treated with TNbs alone(no Tregitope) developed colitis,and lost 4% of their initial body weight at the time of sacrifice(P body weight increase that had been observed in the mice pre-treated with Tregitope 167 was substantiated by a lower disease activity index and a decreased colon weight as compared to the diseased control group(P spectively).Immunohistochemical staining of the colonic tissues for CD4+ showed that inflammatory cell infiltrates were present in TNbs treated mice with or without administration with tregitope 167 and that these cellular infiltrates consisted mainly of CD4+ *** both TNbs treated groups CD4+ T cell infiltrates were observed in the sub-epithelia

关键词： Adeno-associated virus Regulatory T cell epitope Inflammatory bowel diseases Adeno-associated virus

市政饮用水供应中的污染物输移:一种估计速率和不确定性的稳态方法

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AMbIO－人类环境杂志 2007年第6期36卷 486-492页

作者： Martin bergvall harald Grip Jan sjstrm Hjalmar Laudon 丁莉瑞典农业大学瑞典国防研究署于默奥大学生态和环境科学系

污染物迁移通常是污染区域环境风险评估与分级中的一个关键因素。在本研究中,我们使用一种稳态方法来对一个污染市政饮用水供应的地点的农药代谢物bAM(2,6-二氯苯腈)的迁移时间和含量进行了评估。另外还使用一种蒙特卡洛模拟技术来量化... 详细信息

污染物迁移通常是污染区域环境风险评估与分级中的一个关键因素。在本研究中,我们使用一种稳态方法来对一个污染市政饮用水供应的地点的农药代谢物bAM(2,6-二氯苯腈)的迁移时间和含量进行了评估。另外还使用一种蒙特卡洛模拟技术来量化结果的不确定性并且估计所使用参数的敏感性。采用的方法产生的评估表明bAM从污染地点到达水供应的迁移时间的中值为10年。非饱和区域的土壤有机碳含量和饱和区域的水力导度分别解释了迁移时间的估计中44%和23%的不确定性。敏感度分析表明由于受污染地点整个地区的地下水流以及土壤有机碳含量造成的稀释因子分别解释了含量估计的53%和31%的不确定性。总之,可以使用这里采用的稳态方法来获得关于迁移时间和含量的可靠的初步估计,但是可能需要一个动态模型来提高对降解的污染物含量的预测。

关键词：污染物输移不确定性水供应估计稳态饮用市政环境风险评估

Minor antennae are not a prerequisite for energy transfer from major antenna to the photosystemⅡcore

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Minor antennae are not a prerequisite for energy transfer fr...

Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas

2013全国植物生物学大会

作者： sUN Ruixue LIU Kun DONG Liangqian PAULsEN harald YANG Chunhong Key Laboratory of Photobiology Institute of BotanyChinese Academy of Sciences

The three minor antennae of photosystemⅡ(PsⅡ),located between PsⅡcore complexes and the major light-harvesting chlorophyll(Chl) a/b complex(LHCⅡ),are important components for the structural and functional integrity of PsⅡ*** this work,two types of PsⅡpreparations containing different antenna compositions,namely, 1) PsⅡcrude core complex(PsⅡCC) containing all of the minor antennae and a small amount of major antennae and 2) purified PsⅡdimeric core complexes(PsⅡDE) without any Chl a/b proteins,were isolated from pea,and incorporated,together with LHCⅡ,into liposomes composed of thylakoid membrane *** spectroscopic and functional characteristics of the different proteoliposomes were measured.77 K fluorescence emission spectra revealed efficient energy transfer from major antennae to PsⅡcore also in the proteoliposomes without any minor *** indicates that the minor antennae are not a prerequisite for energy migration from LHCⅡto the PsⅡ*** result was further confirmed by Chl a fluorescence induction kinetics of different *** incorporation of LHCⅡtogether with PsⅡcore complexes markedly increased the antenna cross section of the PsⅡ*** DCPIP photoreduction rates of different proteoliposomes demonstrated that the major antennae efficiently transferred their excitation to the PsⅡcore under blue light and triggered charge separation. The structural and functional roles of minor antennae are discussed in view of their functions during the assembly of PsⅡsupercomplexes and for energy transfer.

关键词： photosystemⅡ minor antennae solar energy

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World Journal of Gastroenterology 2013年第36期19卷 6020-6025页

作者： harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters Internal Medicine Marien Hospital Department of Gastroenterology Radboud University Nijmegen Medical Center Division of biostatistics German Cancer Research Center Department of Clinical Pharmacology Technical University of Dresden

AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic ***:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione s-transferase(GsT)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal *** were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)*** storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GsT)as ***:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by *** activities were expressed as nmol/mg per minute protein for the GsT and as pmol/mg per minute protein for the *** of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer *** means±sD were smaller for cancer patients:GsT for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for ***:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range.

关键词： Glutathione s-transferase UDP-glucuronosyltransferase Detoxification Colon adenoma Colon carcinoma

英国曼切斯特Davyhulme污泥中心采用高级厌氧消化实现低碳排放的污泥战略

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给水排水 2013年第8期39卷 I0022-I0024页

作者：廖足良 bill barber Richard Lancaster Keith Panter harald Kleiven Martin Jolly CambiAs 挪威 Aecom 澳大利亚 United UtiIitiesLtd 英国 Ebcor Ltd 英国 bLACK&VEATCH 英国青岛理工大学青岛

介绍了英国曼切斯特Davyhulme污泥中心在部分污泥采用传统厌氧消化和焚烧和部分采用污泥石灰稳定的基础上，经过对比扩建焚烧的A方案和对现有消化采用预处理升级到高级厌氧消化的b方案，决策采用高级厌氧消化为核心的扩容升级战略，使... 详细信息

介绍了英国曼切斯特Davyhulme污泥中心在部分污泥采用传统厌氧消化和焚烧和部分采用污泥石灰稳定的基础上，经过对比扩建焚烧的A方案和对现有消化采用预处理升级到高级厌氧消化的b方案，决策采用高级厌氧消化为核心的扩容升级战略，使该项目实现充分利用现有焚烧设施提高焚烧能力、取消现有石灰稳定、大幅度扩容升级消化能力、大幅度提高沼气产量、全面升级到A级生物固体品质、实现生物固体土地利用和焚烧的多出路策略、大幅度减少新污泥战略的碳排放，全面实现低碳、绿色、可持续发展的污泥战略。

关键词：污泥中心高级厌氧消化焚烧扩容升级改造污泥战略 A级生物固体碳排放

Computational Design of Rare-Earth Reduced Permanent Magnets

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Engineering 2020年第2期6卷 148-153页

作者： Alexander Kovacs Johann Fischbacher Markus Gusenbauer harald Oezelt Heike C.Herper Olga Yu.Vekilova Pablo Nieves sergiu Arapan Thomas schrefl Department for Integrated sensor systems Danube University KremsWiener Neustadt 2700Austria Department of Physics and Astronomy Uppsala UniversityUppsala 75120Sweden International Research Centre in Critical Raw Materials for Advanced Industrial Technologies University of BurgosBurgos 09001Spain IT4Innovations VSB-Technical University of OstravaOstrava-Poruba 70833Czech Republic

Multiscale simulation is a key research tool in the quest for new permanent *** with first principles methods,a sequence of simulation methods can be applied to calculate the maximum possible coercive field and expected energy density product of a magnet made from a novel magnetic material ***(Fe)-rich magnetic phases suitable for permanent magnets can be found by means of adaptive genetic *** intrinsic properties computed by ab initio simulations are used as input for micromagnetic simulations of the hysteresis properties of permanent magnets with a realistic *** machine learning techniques,the magnet’s structure can be optimized so that the upper limits for coercivity and energy density product for a given phase can be *** property relations of synthetic permanent magnets were computed for several candidate hard magnetic *** following pairs(coercive field(T),energy density product(kJ·m^-3))were obtained for iron-tin-antimony(Fe3sn0.75sb0.25):(0.49,290),L10-ordered iron-nickel(L10 FeNi):(1,400),cobalt-iron-tantalum(CoFe6Ta):(0.87,425),and manganese-aluminum(MnAl):(0.53,80).

关键词： Rare-earth Permanent magnets Micromagnetics