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3D-printed miniature spectrometer for the visible range with a 100×100μm^(2) footprint

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Light(Advanced Manufacturing) 2021年第1期2卷 12-22页

作者： Andrea Toulouse Johannes Drozella Simon Thiele harald Giessen Alois Herkommer Institute of Applied Optics(ITO) University of StuttgartPfaffenwaldring 970569 StuttgartGermany Research Center SCoPE University of StuttgartPfaffenwaldring 5770569 StuttgartGermany 4th Physics Institute(PI4) University of StuttgartPfaffenwaldring 5770569 StuttgartGermany

The miniaturisation of spectroscopic measurement devices opens novel information channels for size critical applications such as endoscopy or consumer *** spectrometers in the micrometre size range have been demonstrated,however,these are calibration sensitive and based on complex reconstruction *** we present an angle-insensitive 3D-printed miniature spectrometer with a direct separated spatial-spectral *** spectrometer was fabricated via two-photon direct laser writing combined with a super-fine inkjet *** has a volume of less than 100×100×300μm^(3).Its tailored and chirped high-frequency grating enables strongly dispersive *** miniature spectrometer features a wavelength range of 200 nm in the visible range from 490 nm to 690 *** has a spectral resolution of 9.2±1.1 nm at 532 nm and 17.8±1.7 nm at a wavelength of 633 *** this spectrometer directly onto camera sensors is feasible and can be replicated for use as a macro-pixel of a snapshot hyperspectral camera.

关键词： visible spectral spectrometer

Substantial pollution of drinking and river water in Beijing, China: serious threat for public health and local ecology

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吉林大学学报(地球科学版) 2015年第S1期 377-377页

作者： Marc Peters Qingjun Guo harald Strauss Guangxu Zhu Center for Environmental Remediation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Institut für Geologie und Pal?ontologie Westf?lische Wilhelms-Universit?t Münster Corrensstrasse 2448149 Münster Germany Institute of Geochemistry Chinese Academy of Sciences

The decline of the water quality in fast developing Asian megacities has become a matter of public concern. We analyzed a number of tap and river water samples collected in Beijing urban area on selected inorganic pollutants, such as specific anions(Cl-, NO-3, SO2-4, f-), heavy metals,and trace elements(Al, As, Co, Cr, Cu, fe, Mn, Ni, Pb, Se, V, Zn). 27% of the analyzed tap water samples show one or more constituents above the national guideline limits. 9% of the samples reveal concentrations above the official threshold value for NO-3, while 5% exceed the standard value for As, which makes this tap water unsuitable for daily consumption due to the serious health risk, especially for children and babies. Multiple stable isotopes(δ15N1nitrate, δ8Onitrate, δ34Ssulfate, δ18Osulfate, Δ33Ssulfate) of tap water indicate urban sewage as the major origin of anthropogenic pollutants probably released in large amount by pipe wastewater leaking to the local groundwater. Substantial pollution by urban sewage and industrial emissions could be also detected in Beijing rivers. 13% of the river water samples in the wet season(summer) and 30% in the dry season(winter) show class IV quality, whereas 8% of the summer samples and 21% of the winter samples do not even comply with the lowest category class V. The latter river water can be regarded as toxic waste, which is hazardous for human health and highly destructive for the water ecology in the respective rivers. Both drinking and river water are most affected by urban pollution in the highly industrialized areas of Beijing. The results of this combined geochemical and multiple stable isotope study point to a critical status of the local rivers and aquifers, caused by the rapid growth of Beijing accompanied by an irresponsible handling of urban effluents.

关键词： Drinking and river water Water quality Urban pollution Multiple stable isotopes Beijing

应用开放体系模型模拟岩浆房内微量元素的分配

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国外火山地质 1991年第2期 31-46页

作者： harald Hagen Else Ragnhild Neumann 张定源

随着应用于岩浆体系的地球化学资料的大量增加,不断需要更加精确的数学模型来描述岩浆房内微量元素的分配。一般认为,在岩浆房内存在着分离结晶、同化和补充等几种岩浆作用。以前发表的大多数数学模型,只是同时考虑到某一种或某两种岩... 详细信息

随着应用于岩浆体系的地球化学资料的大量增加,不断需要更加精确的数学模型来描述岩浆房内微量元素的分配。一般认为,在岩浆房内存在着分离结晶、同化和补充等几种岩浆作用。以前发表的大多数数学模型,只是同时考虑到某一种或某两种岩浆作用。本文提供的"批式补充模型"和"连续式补充模型",则同时考虑了并存的分离结晶、同化和补充等诸作用。分离度f和任意时t可被当作两个自变量。附录中的fORTRAN 77程序具体实现了这些模型。它可同时模拟岩浆房中多达十种微量元素在同时经历分离结晶、同化和补充等作用,或这些作用任意相结合的岩浆作用行为。

关键词：岩浆房岩浆作用岩浆体系地球化学资料方程地质作用旋回分离结晶作用

贵州瓮安生物群和磷矿形成的沉积地球化学研究

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矿物岩石地球化学通报 2003年第3期22卷 202-208页

作者：郭庆军杨卫东刘丛强 harald Strauss 王兴理赵元龙中国科学院地球化学研究所 Geologisch-Pal~ontologisches Institut Universit~t Mnster 贵州工业大学资源和环境工程学院贵阳550003

运用沉积学和元素地球化学的理论和方法 ,通过对瓮福磷矿陡山沱组地层古地理背景与沉积环境分析 ,进一步揭示沉积记录中热水作用的客观存在性。研究认为 ,上震旦统陡山沱组“瓮安生物群”繁盛及磷块岩富集与海底热水喷流活动存在联系 ,... 详细信息

运用沉积学和元素地球化学的理论和方法 ,通过对瓮福磷矿陡山沱组地层古地理背景与沉积环境分析 ,进一步揭示沉积记录中热水作用的客观存在性。研究认为 ,上震旦统陡山沱组“瓮安生物群”繁盛及磷块岩富集与海底热水喷流活动存在联系 ,热水活动在海洋生物的繁盛和海洋磷的运移过程中可能扮演了一个极其重要的角色 ,在缺氧带和亚氧化带的大量细菌对磷的分解和有影响力的铁硫酸盐的循环作用下 ,富集的磷在海底上升洋流作用下 ,运移到氧化还原界面上富集成矿。

关键词：瓮安生物群贵州磷矿床沉积学元素地球化学热水作用海底热水喷流活动晚震旦世

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Resistance to activated protein C is a risk factor for fibrostenosis in Crohn’s disease

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World Journal of Gastroenterology 2006年第37期12卷 6026-6031页

作者： Gottfried Novacek Wolfgang Miehsler Julia Palkovits Walter Reinisch Thomas Waldhr Center of Public Health Department of Epidemiology Medical University of Vienna Vienna Austria Stylianos Kapiotis Alfred Gangl harald Vogelsang Department of Internal Medicine Ⅳ Division of Gastroenterology andHepatology Medical University of Vienna Vienna Austria Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Vienna Vienna Austria

AIM: To evaluate the effect of resistance to activated protein C (aPCR), the most common known inherited thrombophilic disorder, on the risk of intestinal operation of fi brostenosis in patients with Crohn’s disease (CD). METHODS: In a previous study, we assessed the prevalence of aPCR in CD. In a retrospective case- controlled study, 8 of these CD patients with aPCR were now compared with 24 CD patients without aPCR, matched by gender, age at diagnosis and duration of disease in a 1:3 fashion. The primary end point was the occurrence of an intestinal CD-related operation with evidence of fibrostenosis in the bowel resection specimen. RESULTS: The Kaplan-Meier analysis revealed that patients with aPCR had a lower probability of remaining free of operation with f ibrostenosis than patients without aPCR (P = 0.0372; exact log-rank test) resulting in a signifi cantly shorter median time interval from diagnosis of CD to the fi rst operation with fi brostenosis (32 vs 160 mo). At 10 years, the likelihood of remaining free of operation with fi brostenosis was 25% for patients with aPCR and 57.8% for patients without aPCR. CONCLUSION: CD patients with aPCR are at higher risk to undergo intestinal operation of fi brostenosis than those without aPCR. This supports our hypothesis of aPCR being a possible risk factor for fi brostenosis in CD.

关键词： fibrostenosis Resistance to activated protein C factor V Leiden Intestinal surgery Crohn's disease

亚热带红壤地区水土流失的原因、后果和控制措施

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中国水土保持 2002年第7期 38-38页

作者： Zepp harald Ruhr-University Bochum D-44780 Bochum f.R.Germany Geographical Institute

叶绿素（a/b）捕光蛋白复合体（LHCIIb）可以从完全变性的脱辅基蛋白状态进行体外重组

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叶绿素（a/b）捕光蛋白复合体（LHCIIb）可以从完全变性的脱辅基...

Monitoring of Tumor Response to Neoadjuvant Radio-Chemotherapy of Esophageal Carcinoma by f-18-fDG-PET

中国植物生理学会全国学术年会暨成立40周年庆祝大会

作者：杨春虹 Ruth Horn harald Paulsen Institut f. Allgemeine Botanik der Johannes-Gutenberg-Universit?t M llerweg 6 D-55099 Mainz Germany Institut f. Allgemeine Botanik der Johannes-Gutenberg-Universit?t M llerweg 6 D-55099 Mainz Germany Institut f. Allgemeine Botanik der Johannes-Gutenberg-Universit?t M llerweg 6 D-55099 Mainz Germany

＜正＞与水溶性蛋白相比,关于膜蛋白的体外重组的特性所知较少。原因之一是迄今为止,可以成功的进行体外重组的膜蛋白相对较少。很多水溶性蛋白可以在尿素或盐酸肌（Gnd）溶液里完全变性,然后稀释变性条件,再行复性。一些主要含β-折...

＜正＞与水溶性蛋白相比,关于膜蛋白的体外重组的特性所知较少。原因之一是迄今为止,可以成功的进行体外重组的膜蛋白相对较少。很多水溶性蛋白可以在尿素或盐酸肌（Gnd）溶液里完全变性,然后稀释变性条件,再行复性。一些主要含β-折叠结构的膜蛋白,如细菌外膜上的OmpA,或Ompf也可以利用尿素或Gnd变性,然后借助表面活性剂形成的微束,或脂质体进行复性。有些主要含α-螺旋结构的膜蛋白:如半乳糖转运酶也可以利用相同的方法进行重组,但重组的产量很低。大多数主要含α-螺旋结构的膜蛋白不能从Gnd溶液中变性的蛋白进行重组。这些蛋白的重组主要通过将蛋白溶解于一种表面活性剂（SDS）溶液中,然后再进行重组。SDS可以稳定膜蛋白中一部分α-螺旋结构,比如LHCⅡb在SDS溶液中已经具有50%的所有的α-螺旋结构。因此,很容易推断,α-螺旋结构的存在,是某些膜蛋白进行体外重组的先决条件。

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The Chinese-German Journal of Clinical Oncology 2004年第4期3卷 257-262页

作者： Peter Theissen Paul M.Schneider Stephan E.Baldus Alexandra Jost Markus Dietlein Rolf P.Muller Arnulf H.Holscher harald Schicha Department of Nuclear Medicine University of CologneCologneGermany Department of Visceral-and Vascular Surgery University of CologneCologneGermany Department of Pathology University of CologneCologneGermany Department of Radiation Therapy University of CologneCologneGermany

Introduction: for clinical assessment of neoadjuvant radiochemotherapy of esophageal cancer reliable in-vivo methods are necessary. Therefore, the capabilities of f-18-fluorodesoxyglucose-PET in comparison to histomorphological grading of tumor regression were studied. Methods: In 33 patients with locally advanced esophageal carcinoma (uT3, uN0-1, cM0) f-18-fDG-PET was performed before and 2 weeks after radiochemotherapy. All tumors were resected by transthoracic en-bloc esophagectomy 3–4 weeks after induction therapy. A subgroup of 11 patients underwent weekly PET scan during neoadjuvant therapy. PET was performed in a dedicated scanner 1.3 h after administration of 370 MBq f-18-fDG. Data analysis based on maximum SUV data derived from individual regions of interest in pre- and posttherapeutic images. PET data were compared to histomorphological grading parameters for tumor regression whithin the resected tissues. Results: The comparison of histopathological tumor regression after neoadjuvant therapy and PET SUV di?erences showed a signi?cant χ2 P -value of 0.006. There was a signi?cant decrease 五笔字型计算机汉字输入技术 of the SUV data from 9.1±3.5 to 4.3±1.9 (P fter one and two weeks (P =0.021 and 0.003). Conclusion: The recent data of the fDG-PET follow-up after neoadjuvant therapy show that PET is able to predict therapy response. Longitudinal PET data advocate that it may be possible to recognize response also very early during radiochemotherapy.

关键词： PET esophageal cancer therapy response histomorphological regression early therapy effect

Monitoring of Tumor Response to Neoadjuvant Radio-Chemotherapy of Esophageal Carcinoma by f-18-fDG-PET

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Oncology and Translational Medicine 2004年第4期 64-69页

作者： Peter Theissen,Paul M. Schneider,Stephan E. Baldus,Alexandra Jost,Markus Dietlein,Rolf P. Mller,Arnulf H. Hlscher,harald Schicha Department of Nuclear Medicine University of Cologne Department of Visceral- and Vascular Surgery University of Cologne Department of Pathology University of Cologne Department of Nuclear Medicine University of Cologne Department of Nuclear Medicine University of Cologne Department of Radiation Therapy University of Cologne Department of Visceral- and Vascular Surgery University of Cologne Department of Nuclear Medicine University of Cologne Cologne Germany Cologne Germany Cologne Germany Cologne GermanyDepartment of Visceral- and Vascular Surgery University of CologneCologne Germany Cologne Germany Cologne Germany Cologne Germany Cologne Germany

关键词： PET esophageal cancer therapy response histomorphological regression early therapy e?ect