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Chinese Journal of Chemistry 2015年第7期33卷 756-764页

作者： haoyun zhu weizhi wang State Key Laboratory of Molecular Engineering of Polymers Collaborative Innovation Center of Polymers and Polymer Composite Materials Department of Maeromoleeular Science Fudan University Shanghai 200433 China

We report a considerably promising method based on agarose gel electrophoresis （AGE） to separate single-walled carbon nanotubes by adding a water-soluble polyfluorene （w-PFO） as surfactant into the agarose gel. In this effective method, the AGE/w-PFO gel network will trap more semiconducting single-walled carbon nanotubes （SWNTs） with the assistance ofw-PFO, for the strong interaction between w-PFO and semiconducting species. The optical absorbance, photoluminescence emission and resonant Raman scattering characterization were used to ver- ify the separation effect. The purity of separated semiconducting species is as high as （98±1）%. The demonstrated field effect transistors give the on/off ratio and mobility about 27000 and 10.2 cm^2·V^-1·s^-1, respectively.

关键词： agarose gel electrophoresis field effect transistors semiconducting single-walled carbon nanotubes water-soluble polyfluorene

Graphene Nanoribbons from Tetraphenylethene-Based Polymeric Precursor： Chemical Synthesis and Application in Thin-Film Field-Effect Transistor

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Chinese Journal of Chemistry 2015年第12期33卷 1380-1388页

作者： Ji Ma haoyun zhu Wei Huang Tingting Lin Xiaoyong Pan weizhi wang State Key Laboratory of Molecular Engineering of Polymers Collaborative Innovation Center of Polymers andPolymer Composite Materials Department of Macromolecular Science Fudan University Shanghai 200433 China Institute of Materials Research and Engineering A ＊STAR (Agency for Science Technology and Research) 2 Fusionopolis Way Innovis #08-03 Singapore 138634 Singapore

Graphene nanoribbons （GNRs） with a non-zero bandgap are regarded as a promising candidate for the fabrica- tion of electronic devices. In this study, large-scale solution synthesis of narrow GNRs was firstly achieved by the intramolecular cyclodehydrogenation of kinked tetraphenylethene （TPE） polymer precursors prepared by A2B2-type Suzuki-Miyaura polymerization. After the cyclization reaction, the nanoribbons have a better conjugation than the twisted polymer precursor, resulting in obvious red shift in UV/vis absorption and photoluminescence （PL） spectra. The efficient formation of conjugated nanoribbons was also investigated by Raman, FTIR spectroscopy, and micro- scopic studies. Furthermore, such structurally well-defined GNRs have been successfully developed for top-gated field-effect transistor （FET） by directly solution processing. The AFM images show that the prepared-GNRs thin films form crystalline fibrillar intercalating networks, which can effectively facilitate the charge transport. These FET devices with ion-gel gate dielectrics exhibit low-voltage operation （〈5 V） with excellent mobility up to 0.41 cm2·V-1·s-1 and an on-off ratio of 3 × 104, thus opening up new opportunities for flexible GNRs-based electronic devices.

关键词： graphene nanoribbons transistor tetraphenylethene device

Validation and correction of sea surface salinity retrieval from SMAP

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Acta Oceanologica Sinica 2020年第3期39卷 148-158页

作者： Sisi Qin Hui wang Jiang zhu Liying Wan Yu Zhang haoyun wang National Meteorological Center Beijing 100081China Numerical Weather Prediction Center of China Meteorological Administration Beijing 100081China Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterBeijing 100081China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of the Chinese Academy of Sciences Beijing 100049China

In this study, sea surface salinity(SSS) Level 3(L3) daily product derived from soil moisture active passive(SMAP)during the year 2016, was validated and compared with SSS daily products derived from soil Moisture and ocean salinity(SMOS) and in-situ measurements. Generally, the root mean square error(RMSE) of the daily SSS products is larger along the coastal areas and at high latitudes and is smaller in the tropical regions and open oceans. Comparisons between the two types of daily satellite SSS product revealed that the RMSE was higher in the daily SMOS product than in the SMAP, whereas the bias of the daily SMOS was observed to be less than that of the SMAP when compared with Argo floats data. In addition, the latitude-dependent bias and RMSE of the SMAP SSS were found to be primarily influenced by the precipitation and the sea surface temperature(SST). Then, a regression analysis method which has adopted the precipitation and SST data was used to correct the larger bias of the daily SMAP product. It was confirmed that the corrected daily SMAP product could be used for assimilation in high-resolution forecast models, due to the fact that it was demonstrated to be unbiased and much closer to the in-situ measurements than the original uncorrected SMAP product.

关键词： sea surface salinity(SSS) soil moisture active passive(SMAP) soil moisture and ocean salinity(SMOS) validation correction

Memory bandwidth optimization of SpMV on GPGPUs

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Frontiers of Computer Science 2015年第3期9卷 431-441页

作者： Chenggang Clarence YAN Hui YU weizhi XU Yingping ZHANG Bochuan CHEN zhu TIAN Yuxuan wang Jian YIN Key Lab of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China Institute of Microelectronics Tsinghua University Beijing 100084 China Automation Department Tsinghua University Beijing 100084 China State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China State Grid Information & Communication Company of Hunan EPC Changsha 410007 China Department of Computer Shandong University Weihai 250101 China

It is an important task to improve performance for sparse matrix vector multiplication （SpMV）, and it is a difficult task because of its irregular memory access. Gen- eral purpose GPU （GPGPU） provides high computing abil- ity and substantial bandwidth that cannot be fully exploited by SpMV due to its irregularity. In this paper, we propose two novel methods to optimize the memory bandwidth for SpMV on GPGPU. First, a new storage format is proposed to exploit memory bandwidth of GPU architecture more effi- ciently. The new storage format can ensure that there are as many non-zeros as possible in the format which is suitable to exploit the memory bandwidth of the GPU. Second, we pro- pose a cache blocking method to improve the performance of SpMV on GPU architecture. The sparse matrix is partitioned into sub-blocks that are stored in CSR format. With the block- ing method, the corresponding part of vector x can be reused in the GPU cache, so the time to access the global memory for vector x is reduced heavily. Experiments are carried out on three GPU platforms, GeForce 9800 GX2, GeForce GTX 480, and Tesla K40. Experimental results show that both new methods can efficiently improve the utilization of GPU mem- ory bandwidth and the performance of the GPU.

关键词： GPGPU performance tuning SpMV cacheblocking memory bandwidth

硅纳米线和聚3-十二烷基噻吩混合薄膜在场效应晶体管中的应用研究

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化学学报 2016年第5期74卷 429-434页

作者：朱昊云黄威黄宇立汪伟志聚合物分子工程国家重点实验室高分子及其先进复合材料协同创新中心复旦大学高分子科学系上海200433

为了提高聚3-十二烷基噻吩的场效应迁移率,将硅纳米线混入聚3-十二烷基噻吩的溶液中制成薄膜.退火后的聚3-十二烷基噻吩能够自组装成有序的微晶结构,有利于电子传输.聚3-十二烷基噻吩薄膜在场效应晶体管中能够获得0.015 cm2·V^(-1)·s^... 详细信息

为了提高聚3-十二烷基噻吩的场效应迁移率,将硅纳米线混入聚3-十二烷基噻吩的溶液中制成薄膜.退火后的聚3-十二烷基噻吩能够自组装成有序的微晶结构,有利于电子传输.聚3-十二烷基噻吩薄膜在场效应晶体管中能够获得0.015 cm2·V^(-1)·s^(-1)的迁移率,而混合薄膜能够获得高达0.68 cm2·V^(-1)·s^(-1)的迁移率.这是因为硅纳米线优异的电子传输性能使得电子通过硅纳米线就像通过快速通道一样,从而能够缩短电子在场效应晶体管中的传输时间,提高传输速度.此外,使用离子胶作为介电层也能够提升场效应晶体管的性能,混合薄膜能够获得高达6.2 cm2·V^(-1)·s^(-1)的迁移率.

关键词：硅纳米线聚3-十二烷基噻吩共轭聚合物场效应晶体管离子胶

Long-read sequencing and de novo assembly of the cynomolgus macaque genome

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Journal of Genetics and Genomics 2022年第10期49卷 975-978页

作者： Bing Bai Yi wang Ran zhu Yaolei Zhang Hong wang Guangyi Fan Xin Liu Hong Shi Yuyu Niu weizhi Ji State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266555China Translational Immunology Group Department of Biotechnology and BiomedicineTechnical University of DenmarkLyngbyDenmark State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnnan 650500China BGI-Shenzhen ShenzhenGuangdong 518083China China National GeneBank BGI-ShenzhenShenzhenGuangdong 518120China Faculty of Life Science and Technology Kunming University of Science and TechnologyKunmingYunnan 650500China Ji1 2

Cynomolgus macaques(Macaca fascicularis)belong to the genus *** are the most widespread nonhuman primate(NHP)and share a common ancestor with humans from about 25 million years ago(Kumar and Hedges,1998).Because of their phylogenetic proximity to humans,macaques are an attractive NHP research model for a wide range of biomedical research(Yan et al.,2011).

关键词： widespread attractive proximity

The role of corneal endothelium in macular corneal dystrophy development and recurrence

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Science China(Life Sciences) 2024年第2期67卷 332-344页

作者： Bi-Ning Zhang Benxiang Qi Chunxiao Dong Bin Zhang Jun Cheng Xin wang Suxia Li Xiaoyun zhuang Shijiu Chen haoyun Duan Dewei Li Sujie zhu Guoyun Li Yihai Cao Qingjun Zhou Lixin Xie Eye Institute of Shandong First Medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdao 266071China State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdao 266071China School of Ophthalmology Shandong First Medical UniversityQingdao 250021China Department of Medicine Qingdao UniversityQingdao 266071China Eye Institute of Shandong First Medical University Eye Hospital of Shandong First Medical University(Shandong Eye Hospital)Jinan 250021China Department of Ophthalmology School of Clinical MedicineWeifang Medical UniversityWeifang 261072China Institute of Translational Medicine College of MedicineQingdao UniversityQingdao 266071China Key Laboratory of Marine Drugs of Ministry of Education Shandong Provincial Key Laboratory of Glycoscience and GlycotechnologySchool of Medicine and PharmacyOcean University of ChinaQingdao 266071China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China Department of Microbiology Tumor and Cell BiologyBiomedicumKarolinska InstitutetStockholm 17177Sweden

Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for MCD ***,postoperative recurrence remains a significant *** conducted a retrospective review of a clinical cohort comprising 102 MCD patients with 124 eyes that underwent either penetrating keratoplasty(PKP)or deep anterior lamellar keratoplasty(DALK).Our results revealed that the recurrence rate was nearly three times higher in the DALK group(39.13%,9/23 eyes)compared with the PKP group(10.89%,11/101 eyes),suggesting that surgical replacement of the corneal endothelium for treating MCD is advisable to prevent postoperative *** experimental data confirmed the robust m RNA and protein expression of CHST6 in human corneal endothelium and the rodent homolog CHST5 in mouse *** knockdown of wild-type Chst5 in mouse corneal endothelium(AC^(siChst5)),but not in the corneal stroma,induced experimental MCD with similar extracellular matrix synthesis impairments and corneal thinning as observed in MCD *** carrying Chst5 point mutation also recapitulated clinical phenotypes of MCD,along with corneal endothelial *** injection of wild-type Chst5 rescued the corneal impairments in AC^(siChst5)mice and retarded the disease progression in Chst5 mutant ***,our study provides new mechanistic insights and therapeutic approaches for MCD treatment by highlighting the role of corneal endothelium in MCD development.

关键词： macular corneal dystrophy recurrence corneal endothelium keratan sulfate penetrating keratoplasty

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Long-term in vivo chimeric cells tracking in non-human primate

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Protein & Cell 2024年第3期15卷 207-222页

作者： Junmo Wu Yu Kang Xiang Luo Shaoxing Dai Yuxi Shi zhuoyao Li Zengli Tang Zhenzhen Chen Ran zhu Pengpeng Yang Zifan Li Hong wang Xinglong Chen Ziyi Zhao weizhi ji Yuyu Niu State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research Kunming 650500China Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming 650500China

Non-human primates(NHPs)are increasingly used in preclinical trials to test the safety and efficacy of biotech-nology ***,given the ethical issues and costs associated with this model,it would be highly advantageous to use NHP cellular models in clinical ***,developing and maintaining the naive state of primate pluripotent stem cells(PSCs)remains difficult as does in vivo detection of PSCs,thus limiting biotech-nology application in the cynomolgus ***,we report a chemically defined,xeno-free culture system for culturing and deriving monkey PSCs in *** cells display global gene expression and genome-wide hypometh-ylation patterns distinct from monkey-primed *** also found expression of signaling pathways components that may increase the potential for chimera *** for biomedical applications,we were also able to integrate bioluminescent reporter genes into monkey PsCs and track them in chimeric embryos in vivo and in *** engineered cells retained embryonic and extra-embryonic developmental ***,we generated a chimeric monkey carrying bioluminescent cells,which were able to track chimeric cells for more than 2 years in living *** study could have broad utility in primate stem cell engineering and in utilizing chimeric monkey models forclinical studies.

关键词： pluripotent stem cells bioluminescence imaging non-human primates

叶型对马尾松幼苗生长及叶绿素荧光特征的影响

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林业科学 2019年第3期55卷 183-192页

作者：王好运吴峰朱小坤谢维斌贵州大学林学院贵阳550025 贵州大学贵州省森林资源与环境研究中心贵阳550025 贵州都匀国家马尾松良种基地都匀558000

【目的】研究叶型对马尾松幼苗生长及叶绿素荧光特征的影响,以期为马尾松苗木选择及栽培提供参考。【方法】以出圃时呈现为全初生条形叶、全次生针形叶和中间型的马尾松1年生幼苗为试验材料,分析其生长指标、光合色素含量及叶绿素荧光参... 详细信息

【目的】研究叶型对马尾松幼苗生长及叶绿素荧光特征的影响,以期为马尾松苗木选择及栽培提供参考。【方法】以出圃时呈现为全初生条形叶、全次生针形叶和中间型的马尾松1年生幼苗为试验材料,分析其生长指标、光合色素含量及叶绿素荧光参数,研究初生叶和次生叶叶绿素荧光特征差异及对幼苗生长的影响。【结果】全次生叶幼苗出圃时苗木质量指数(QI)、干物质积累量及造林1年后净生长量均显著高于全初生叶幼苗;次生叶的叶长、体积和表面积等指标均显著大于初生叶;初生叶中叶绿素a、叶绿素b和总叶绿素含量均显著高于次生叶,两者间的类胡萝卜素含量无显著差异。初生叶的F_m、F_v/F_m、F_v/F_o均显著高于次生叶,F_o在2种叶型间无显著差异;初生叶的PSⅡ反应中心参数Y(Ⅱ)和F_v’/F_m’、淬灭参数q_P和NPQ、能量耗散参数Y(NPQ)和Y(NO)及光响应参数ETR_(max)、α、β和I_k也均高于次生叶,在高光强条件下,初生叶的非光化学淬灭和调节性能量耗散能力增强。由于次生针叶叶长、体积和表面积等形态指标均显著大于初生叶,因而具有次生针叶的幼苗的光合作用面积更大,干物质量积累较多,出圃时的苗木质量以及造林后的生长表现均高于全初生叶的幼苗。【结论】与次生叶相比,初生叶拥有较高的叶绿素含量,较耐光抑制,有较高的光能转化效率,但高光强条件下会通过热耗散的形式来减少多余光能对光合系统的损害;拥有次生叶的幼苗表现出较好的苗木质量及生长特性。

关键词：马尾松初生条叶次生针叶叶绿素荧光苗木质量

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季冻区低路堤土基强度与影响因素相关性

吉林大学学报（地球科学版） 2015年第3期45卷 869-875页

作者：战高峰朱福董伟智王静吉林大学建设工程学院长春130026 吉林建筑大学交通科学与工程学院长春130118

对吉林省高等级低路堤公路填土高度与最大冻深进行了调研,该地区低路堤填土高度为0.0~2.2m,钻孔数据表明路基最大冻深为距路表1.6~2.4m。选取3种不同塑性指数的路基土,采用正交表L16（45）进行了试验设计,应用静力成型法,使得土体在设... 详细信息

对吉林省高等级低路堤公路填土高度与最大冻深进行了调研,该地区低路堤填土高度为0.0~2.2m,钻孔数据表明路基最大冻深为距路表1.6~2.4m。选取3种不同塑性指数的路基土,采用正交表L16（45）进行了试验设计,应用静力成型法,使得土体在设定的含水率和压实度的水平下成型,并经历不同的冻融循环次数后,分别测试土体的无侧限抗压回弹模量。试验结果表明：1）对同一种土质,影响因素的大小排序为：含水率〉冻融次数〉压实度。2）随着含水率增大,土基强度接近线性减小;随着冻融次数的增加,土基强度逐渐减小,前2次冻融影响较大,之后幅度变小趋于稳定;随着压实度的增大,土基强度逐渐增大,增大幅度较小。3）采用指数函数对3种土的室内试验数据进行多元非线性拟合,拟合结果较好。

关键词：季冻区低路堤土基强度影响因素吉林省塑性指数