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Chinese Chemical Letters 2021年第5期32卷 1765-1769页

作者： haoyuan lv Shuai Ma Zhenbo Wang Xiaoting Ji Shaoping lv Caifeng Ding Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science Ministry of EducationShandong Key Laboratory of Biochemical AnalysisKey Laboratory of Analytical Chemistry for Life Science in Universities of ShandongCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Qingdao Central Hospital Qingdao 266042China

Nano material based drug delivery system have received great attention in clinical application due to their high therapeutic efficacy and lower side effects than classical method,multi-functional nanomaterial also have shown the excellent performance at cancer theranostic and durg tracking in vivo and in ***,most of these works are influenced by the bio-toxicity of applied nanomaterials,which could influence the diagnostic results and treatment ***,we have prepared a high biocompatibility porous carbon nanospheres(PCNs) based nano-system(PCN-siRNA-DOX-FA) for targeted drug delivery and the *** surface modifications have increased dispersion and stability of the PCNs,and folic acid(FA) had enhanced the active target ability for FA receptor positive cell ***,through the siRNA structure and doxorubicin(DOX) loading,biological and chemical combined multi-therapy was achieved in cancerous *** constructed nano-system could positively improve the biotoxicity problem of nanomaterial and provide a potential platform for clinical cancer theranostic applications.

关键词： Cell imaging analysis Drug delivery Biothiol sensing Low biotoxicity Porous carbon

Substituent position effect of Co porphyrin on oxygen electrocatalysis

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Chinese Chemical Letters 2021年第9期32卷 2841-2845页

作者： haoyuan lv Hongbo Guo Kai Guo Haitao Lei Wei Zhang Haoquan Zheng Zuozhong Liang Rui Cao Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China

Substituent effect of metal porphyrin molecular catalysts plays a crucial role in determining the catalytic activity of oxygen ***,substituent position effect of Co porphyrins on oxygen electrocatalysis,including the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER),was *** Co porphyrins,namely 2,4,6-OMe-CoP and 3,4,5-OMe-CoP,were selected as the research *** ORR and OER performance was evaluated by drop-coating molecular catalysts on carbon nanotubes(CNTs).The resulted 3,4,5-OMe-CoP/CNT exhibited high bifunctional electrocatalytic activities and better long-term stability for both ORR and OER than 2,4,6-OMe-CoP/***,when applied in the Zn-air battery,3,4,5-OMe-CoP/CNT exhibited comparable performance to that with precious metal-based *** enhanced catalytic activity may be attributed to the improved charge transfer rate,mass transfer and *** work provides an effective strategy to further enhance catalytic activity by introducing substituent position effect,which is of great importance for developing more efficient energy-related electrocatalysts.

关键词： Oxygen electrocatalysis Oxygen reduction reaction Oxygen evolution reaction Co porphyrin Substituent effect

A Cobalt(Ⅲ)Corrole with a Tethered Imidazole for Boosted Electrocatalytic Oxygen Reduction Reaction

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Chinese Journal of Chemistry 2023年第21期41卷 2866-2872页

作者： Yimei Gao Benxing Mei Yizhen Wu Qian Zhao Zijia Bao Haonan Qin Yuhan Xu haoyuan lv Xinyang Peng Yan He Ting Luo Ran Yao Wei Zhang Haitao Lei Rui Cao Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'anShaanxi710119 China Beihang School Beihang UniversityBeijing100191 China

Developing electrocatalysts with high activity and selectivity for the oxygen reduction reaction(ORR)is vital to promote the performance of the next-generation energy technologies,which depend on the efficiency of the catalytic reduction of *** the structure of cytochrome c oxidases(CcOs),a histidine imidazole residue binding to the axial position of Fe plays a crucial role in facilitating the selective reduction of O_(2)to *** by nature,we herein report on the synthesis of CoIII corrole 1 tethered with an imidazole ligand as well as its electrocatalytic ORR and O_(2)binding *** compared to the imidazolium-free analogue,complex 1 displayed remarkably boosted activity for the selective four-electron/four-proton(4e-/4H+)ORR with a half-wave potential of E1/2=0.82 V versus reversible hydrogen electrode(RHE)in 0.1 mol/L KOH ***,we demonstrate that the tethered axial imidazole ligand improves the O_(2)binding ability of 1 thermodynamically and dynamically,which is crucial to boost electrocatalytic ORR *** work presents an example to improve electrocatalytic ORR activity and selectivity of Co corroles by introducing an axial imidazole ligand to enhance the O_(2)binding and activation.

关键词： Molecular electrocatalysis Cobalt corrole Axial ligand effect Oxygen reduction reaction O_(2)binding

An optical DNA logic gate based on strand-displacement and magnetic separation, with response to multiple microRNAs in cancer cell lysates

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An optical DNA logic gate based on strand-displacement and m...

A DNA Nanotube-Peptide biocomplex for mRNA Detection and Its Application in Cancer Diagnosis and Targeted Therapy

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Xiaoting Ji haoyuan lv Minghui Ma Binglin lv Caifeng Ding Key Laboratory of Sensor Analysis of Tumor Marker Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science and Technology

A battery of logic gates, "YES", "AND" and "OR", are designed using magnetic beads(MBs) modified by DNA which consists of a substrate strand(S) and a signal strand on which the logic operates. Inputs stemming from micro-RNA(which represent three cancer biomarkers) take the place of signal DNA. The released signal strand self-assembles into the hemin-G-quadruplex complex(DNAzyme) that catalyzes a blue-green dye(ABTS+) from the precursor ABTS. This dye(quantified at a wavelength of 414 nm) represents the output signal for the various logic gates. The above-mentioned method allows for quantitative detection of microRNA of three kinds of logic gates in the range of 5 nM-500 nM with a detection limit of 3.8 nM, 4.9 nM, 5.4 nM. A Boolean logic circuitry is also achieved following the principles of multilevel strand displacement. Based on strand-displacement and magnetic separation, this work demonstrates the possibility of designing a logic system using micro-RNA in live cell lysate as inputs, in the hope of being potentially applied in DNA computation and cancer diagnosis.

关键词： Logic circuit Magnetic separation DNAzyme Spectrum Colorimetric

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A DNA Nanotube-Peptide biocomplex for mRNA Detection and Its...

中国化学会第十三届全国分析化学年会

作者： Xiaoting Ji haoyuan lv Jiayi Guo Caifeng Ding Key Laboratory of Sensor Analysis of Tumor Marker Ministry of Education College of Chemistry and Molecular Engineering Qingdao University of Science and Technology

A biocomplex of DNA nanotube-peptide,consisting of six concatenated DNA strands,three lock DNA strands and a cell-penetrating peptide was developed *** MUC-1 aptamer which is part of DNA nanotube can specially recognize MUC-1 on the surface of MCF-7 *** c RGD facilitates recruitment and uptake of targeting drugs by binding to integrin receptors (αvβ3) of cytomembrane ***-cancer drug doxorubicin(DOX) and paclitaxel (PTX) were loaded into the capsulated DNA nanotube-peptide (CDNP),which was used as co-drug cargo *** as-prepared biocomplex can be utilized not only to deliver drug but also to achieve the anticancer effect in *** system that was composed by DNA strands and peptide has good biocompatibility and ***,the system can readily achieve detection of target mRNA of MCF-7 cell in *** detection limits of mRNA are 9.7×10 M and 1.8×10 M by using CDNP/DOX and CDNP/PTX-FITC as a probe,respectively.

关键词： DNA nanotube cRGD mRNA nanocarrier targeted release

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智能预测在能源管理系统中的应用

电子测试 2017年第6X期28卷 69-69,71页

作者：吕灏源莱芜市莱城区凤城高级中学山东莱芜271100

对于能源的管理方面的问题,一直是众多企业所面临的很重要的功课。如何能够有效地解决企业能源管理建设中的问题,彻底解决功能缺失等一系列弊端,需要结合智能预测在能源管理系统中的具体应用,并且将其对号入座,实现其作用的最大化应用... 详细信息

对于能源的管理方面的问题,一直是众多企业所面临的很重要的功课。如何能够有效地解决企业能源管理建设中的问题,彻底解决功能缺失等一系列弊端,需要结合智能预测在能源管理系统中的具体应用,并且将其对号入座,实现其作用的最大化应用。本论文对此进行了具体的阐述与分析。

关键词：智能预测系统能源管理系统问题应用方式

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高立边不锈钢门角的成形工艺与模具设计

锻压装备与制造技术 2017年第2期52卷 58-61页

作者：吕浩源中车长春轨道客车股份有限公司吉林长春130062

介绍了一种高立边不锈钢门角的形状和结构特点。分析了该零件的成形工艺方法。阐述了拉延模具的工作过程和设计要点。通过试验,确定了合理的坯料尺寸和准确的压料力值,同时验证了凹模工作面"TD"强化处理具有显著效果。

关键词：冲压成形不锈钢门角成形工艺模具设计高立边

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立体连接板的成形工艺与模具设计

锻压装备与制造技术 2014年第1期49卷 77-79页

作者：吕浩源宋连芹长春轨道客车股份有限公司吉林长春130062

介绍了一种立体连接板的结构特点,分析了该零件的成形工艺方法,阐述了拉深模具的工作过程、调试过程和设计要点。

关键词：冲压成形工艺模具设计立体连接板

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基于通阳理论探讨新冠肺炎防治策略

亚太传统医药 2021年第9期17卷 107-110页

作者：周莉涵李桂珍吕浩源湖北中医药大学第一临床学院湖北武汉430060 湖北中医药大学附属武汉市中西医结合医院湖北武汉430022 湖北中医药大学黄家湖医院湖北武汉430065

自2019年底新冠肺炎暴发以来,在全国甚至全世界大范围流行,中医药在防治新冠肺炎中起到了重要作用。新冠病毒在中医学中当属"疫毒",宜以温病论治,通阳法作为被历代医家重用发展的重要治则,不仅仅是温通阳气,亦包含汗、下、和、温、清、... 详细信息

自2019年底新冠肺炎暴发以来,在全国甚至全世界大范围流行,中医药在防治新冠肺炎中起到了重要作用。新冠病毒在中医学中当属"疫毒",宜以温病论治,通阳法作为被历代医家重用发展的重要治则,不仅仅是温通阳气,亦包含汗、下、和、温、清、消、补七法之义,在新冠肺炎的诊疗中得到一定应用。围绕通阳法,以卫气营血辨证为切入点,以发汗祛邪、清解郁热、分消湿热、透热转气、豁痰开闭、清热养阴、扶养正气法来诠释拓展新冠肺炎的辨证思路。

关键词：新冠肺炎辨证论治通阳法卫气营血

健身气功五禽戏治疗老年性骨质疏松症Meta分析

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亚太传统医药 2019年第10期15卷 164-167页

作者：徐长力吕浩源张涛肖强兵湖北中医药大学第一临床学院湖北武汉430061 湖北中医药大学黄家湖医院湖北武汉430061

目的:评价健身气功五禽戏治疗老年性骨质疏松的疗效。方法:计算机检索有关健身气功治疗老年原发性骨质疏松症的随机对照试验(RCT),用Cochrane协作网提供的RevMan 5.3软件进行Meta分析。结果:筛选出8篇文献共765名患者,其中五禽戏组较对... 详细信息

目的:评价健身气功五禽戏治疗老年性骨质疏松的疗效。方法:计算机检索有关健身气功治疗老年原发性骨质疏松症的随机对照试验(RCT),用Cochrane协作网提供的RevMan 5.3软件进行Meta分析。结果:筛选出8篇文献共765名患者,其中五禽戏组较对照组的腰椎骨密度比较差异有统计学意义,MD=0.08,95%CI(0.04,0.12),P=0.000 2。五禽戏组较对照组的股骨颈骨密度比较差异有统计学意义,MD=0.12,95%CI(0.00,0.23),P=0.04。五禽戏组较对照组的VAS疼痛评分有统计学意义,MD=-0.93,95%CI(-1.12,-0.74),P<0.000 01。结论:健身气功五禽戏对于减缓老年性骨质疏松,降低患者疼痛有一定疗效。但由于纳入的研究对象数量有限,需要更多高质量治疗文献支持这一结论。

关键词：健身气功五禽戏骨质疏松 Meta分析