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Chinese Medical Journal 2022年第18期135卷 2253-2255页

作者： haoyao cao Tinghui Zheng Da Li Jing Liu Zhan Liu Liqing Peng Department of Applied Mechanics Sichuan UniversityChengduSichuan 610065China Sichuan University Yibin Park/Yibin Institute of Industrial Technology YibinSichuan 644000China Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:Coronary artery aneurysms(CAAs),one of the complications of Kawasaki disease(KD),can cause myocardial ischemia,infarction,and even sudden death.[1]Accurate thrombotic risk stratification in KD patients w... 详细信息

关键词： patients aneurysm coronary

Influence of morphology and hemodynamics on thrombosis in kawasaki disease patients

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Medicine in Novel Technology and Devices 2023年第2期18卷 91-101页

作者： haoyao cao Zhuxiang Xiong Zhan Liu Yan Li Huaxia Pu Jing Liu Liqing Peng Tinghui Zheng Department of Mechanics Sichuan UniversityChengdu610065China Sichuan University Yibin Park Yibin Institute of Industrial TechnologyYibin644000China Department of Radiology West China HospitalSichuan UniversityChengdu610041China Med-X Center for Informatics Sichuan UniversityChengdu610041China

Kawasaki Disease(KD)patients with co-occurrent coronary artery aneurysms(CAAs)are prone to *** study explores the thrombotic influence of morphology and hemodynamics in KD patients with ***-specific computed tomography angiogram images of 9 patients were used to rebuild coronary models(including 23 aneurysms;10 in thrombosed group,and 13 in non-thrombosed group)and perform computational simulations to obtain the hemodynamic *** thrombosed and non-thrombosed groups were compared in terms of six parameters,namely,the maximum diameter(D_(max)),aspect ratio(R_(l/d)),shape,time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),and relative residence time(RRT).The results showed that:(1)In thrombosed aneurysms,there were several vortex structures(eddy zone),of which the position changed continuously in a cardiac *** non-thrombosed aneurysms,the streamlines showed a large streaming zone.(2)Abnormal hemodynamic areas of aneurysms with thrombosis tended to appear in the same region(especially the proximal and near myocardial side of aneurysms).(3)In the non-thrombosed group,there was a correlation between the morphological and hemodynamic *** thrombosed aneurysms,the flow pulsatility has a significant impact on the flow *** thrombosed coronary aneurysms exhibited more risk factors and the co-location of hemodynamic abnormalities was consistent with the position of thrombosis.A score of risk factors could provide the thrombotic information of coronary aneurysms,which might be helpful for long-term clinical management of KD patients.

关键词： Coronary artery aneurysms Kawasaki disease Thrombotic risk stratification Morphology Hemodynamics

The exploration of flow pattern in the superior vena cava of healthy adults:A 4D flow magnetic resonance imaging study

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Medicine in Novel Technology and Devices 2023年第2期18卷 159-168页

作者： Huaxia Pu haoyao cao Yubo Fan Jinge Zhang Simeng Wang Zhan Liu Xiaoyue Zhou Ning Jin Tinghui Zheng Liqing Peng Department of Radiology West China HospitalSichuan UniversityChengdu610041China Department of Applied Mechanics Sichuan UniversityChengdu610065China Sichuan University Yibin Park Yibin Institute of Industrial TechnologyYibin644000China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China MR Collaboration Siemens Healthineers Ltd.Shanghai201318China Siemens Medical Solutions USA Inc.ChicagoIL60611USA Med-X Center for Informatics Sichuan UniversityChengdu610041China

Our study sought to investigate the blood flow pattern in the superior vena cava(SVC)of healthy adults and to describe the development and characteristics of the flow pattern using 4D flow magnetic resonance imaging(MRI).4D flow MRI data with full coverage of SVC and brachiocephalic veins(BVs)were acquired with a 3-Testa MRI in thirty healthy adults(age:28.70±9.09).Hemodynamic parameters in the SVC,including velocity,velocity vector,flow visualization(pathlines,streamlines),flow waveform and energy loss,were obtained with specialized commercial post-processing software based on 4D flow MRI *** study found that:(1)The SVC has a pulsating flow waveform with double peaks.(2)Based on BVs flow of the SVC pathline visualization,flow patterns could be divided into three development types:twining(n=14),untwining(n=)and no helical flow(n=7).(3)With the decreasing blood velocity,helical flow areas tended to gradually extend.(4)There were no significant differences in most hemodynamic parameters among the three *** exploration of the blood flow characteristics of normal SVC may be the first step for capturing pathogenic features before the patients develop symptoms with a certain positive *** potential physiological significance of these phenomena deserves more exploration in future studies.

关键词： Superior vena cava 4D flow magnetic resonance imaging Blood flow Circulation

瘤颈角度对腹主动脉瘤腔内修复术后支架位移的影响

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医用生物力学 2023年第3期38卷 472-478页

作者：赵一鸣曹皓瑶岳键金王家嵘袁丁魏泳涛郑庭辉四川大学建筑与环境学院成都610041 四川大学华西医院血管外科成都610041

目的研究瘤颈角度对腹主动脉瘤腔内修复术后支架位移的影响。方法选用28名患者CT影像分别建立术前腹主动脉瘤(abdominal aortic aneurysm,AAA)模型、术后两次随访(postoperative follow-up)AAA模型和覆膜支架模型,并根据术前瘤颈角度将... 详细信息

目的研究瘤颈角度对腹主动脉瘤腔内修复术后支架位移的影响。方法选用28名患者CT影像分别建立术前腹主动脉瘤(abdominal aortic aneurysm,AAA)模型、术后两次随访(postoperative follow-up)AAA模型和覆膜支架模型,并根据术前瘤颈角度将模型分为非严重成角组(n=14)和严重成角组(n=14)。测量每个模型的几何形态,分析手术前后AAA几何参数、术后支架位移变化。通过血流动力学模拟计算术后第1次随访模型的位移力。结果两组患者在瘤长度、最大直径、位移力、瘤颈长度变化和瘤体积变化有明显差异(P0.05)。在内漏发生情况上,未严重成角组中有2例,严重成角组中有4例(P>0.05)。结论严重的瘤颈成角可导致支架位移力显著增加以及近端锚固区减小,进而增加支架位移发生的可能性。建议在临床方面医生应加强对严重瘤颈成角患者的术后随访,警惕远期内漏的发生。

关键词：腹主动脉瘤腹主动脉瘤腔内修复术瘤颈角血流动力学

维生素C对危重心脏手术患者心血管系统的保护机制研究

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中国医药科学 2021年第19期11卷 62-65,84页

作者：韩沃华彭晓鹏袁昊尧刘文高陈启明黄振辉曹卫东东莞市人民医院心胸外科广东东莞523059

近年来,维生素C的生物多效性和抗氧化功能成为人们研究关注的焦点,其对多脏器功能具有一定的保护作用,在临床上也应用于危重心脏手术患者心血管功能障碍的治疗。笔者回顾相关文献资料得知,有大量证据表明,维生素C对各种急性应激事件(如... 详细信息

近年来,维生素C的生物多效性和抗氧化功能成为人们研究关注的焦点,其对多脏器功能具有一定的保护作用,在临床上也应用于危重心脏手术患者心血管功能障碍的治疗。笔者回顾相关文献资料得知,有大量证据表明,维生素C对各种急性应激事件(如脓毒症、休克、创伤、烧伤、缺血再灌注损伤)的病理生理反应都有积极的影响。本文主要阐述有关维生素C在危重心脏手术患者心血管系统中应用的最新知识,包括危重心脏手术患者应用维生素C的益处以及维生素C在炎症和氧化应激期间对心血管系统功能的影响及保护作用,强调其在危重心脏手术患者炎症抑制及心律失常方面的应用效果,以期更好的指导临床工作。

关键词：维生素C 心脏手术氧化应激心血管功能障碍心肌缺血再灌注损伤

1例突发血流动力学不稳定的老年钙化性重度主动脉瓣狭窄治疗体会

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中国现代医生 2022年第13期60卷 172-174,182页

作者：黄振辉刘文高彭晓鹏袁昊尧陈启明邓港浩曹卫东广东省东莞市人民医院心胸外科广东东莞523059

钙化性主动脉瓣狭窄(calcific aortic stenosis,CAS)当发展为重度时,主动脉瓣置换术是最为有效的干预手段。结合这种病例的具体特点,探讨围术期合并心力衰竭时正性肌力药物的正确使用及合并感染时潜在血管麻痹症综合征的处理和优化容量... 详细信息

钙化性主动脉瓣狭窄(calcific aortic stenosis,CAS)当发展为重度时,主动脉瓣置换术是最为有效的干预手段。结合这种病例的具体特点,探讨围术期合并心力衰竭时正性肌力药物的正确使用及合并感染时潜在血管麻痹症综合征的处理和优化容量管理等方面对麻醉诱导可能造成的影响进行经验总结。本研究报道1例突发血流动力学不稳定的老年钙化性重度主动脉瓣狭窄的治疗,并分析心得体会。

关键词：主动脉瓣狭窄脓血症正性肌力药物心力衰竭血管麻痹综合征