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Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy

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Cancer Biology & Medicine 2024年第2期21卷 125-131页

作者： Jilong Yang Jin Xu haotian liu Wanyi Xiao Gengpu Zhang Department of Bone and Soft Tissue Tumor Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Molecular Cancer EpidemiologyTianjin 300060China Department of Anaesthesiology Tianjin University Tianjin HospitalTianjin 300211China

Bod et al.1 recently published a study in Nature that garnered attention to B cell-associated anti-tumor immunity and immunotherapy of melanoma and other tumors1.As a promising supplemental immunotherapy to mainstream... 详细信息

关键词： immunotherapy immunity

Reynolds-number scaling analysis on lift generation of a flapping and passive rotating wing with an inhomogeneous mass distribution

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Chinese Journal of Aeronautics 2024年第2期37卷 259-269页

作者： Suyang QIN haotian HANG Yang XIANG Hong liu J.C.Wu center for aerodynamics school of aeronautics and astronauticsshanghai jiao tong universityshanghai 200240china

Insects usually fly by passively rotating wings,which has been applied to the design of flapping-wing Micro-Air Vehicles(MAVs)to reduce mechanical complexity.In this paper,a robotic passive rotating-wing model is designed to investigate wing kinematics and lift generation,which are measured by a high-speed camera and a force transducer,respectively.In addition,flow fields are measured using the Particle Image Velocimetry(PIV).Experimental results demonstrate that passive rotating motion has a coordinative relationship with actively stroking motion.As the stroke amplitude or frequency increases,the rotating amplitude is enlarged.To characterize the active stroking motion,a driving Reynolds number Redrivingis defined,which varies from 68 to 366 in this study.Moving the gravity center of the wing towards trailing ed ge induces the increase of additional torque M,which decreases the wing rotating amplitude and promotes the advance of wing rotation.We find that the timing of wing rotation is gradually delayed and the mean lift coefficient C^(-)_(L)monotonously decreases as Redrivingincreases.By increasing the additional torque M,C^(-)_(L)is slightly improved and approaches to the lift coefficient of a real fruit fly at driving Re approximately equal to 230.The instantaneous lifts combined with the vortical structures further demonstrate that the lift generation associated with wing rotation is mainly attributed to the growth of the LeadingEdge Vortex(LEV)and the passive wake capture mechanism.Passive wake capture is influenced by LEV,reversal stroke motion and wing additional torque together,which can only maintain the lift at a high level for a considerable period.The high-lift generation mechanisms of flapping and passive rotating flight could shed light on the simplified design of MAVs and the improvement of their aerodynamic performance.

关键词： Flapping flight Unsteady lift Passive rotation Vortex flow Leading-edge vortex

Additive manufactured osseointegrated screws with hierarchical design

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Bio-Design and Manufacturing 2024年第2期7卷 206-235页

作者： Wenbo Yang Hao Chen haotian Bai Yifu Sun Aobo Zhang Yang liu Yuchao Song Qing Han Jincheng Wang Department of Orthopedics Second Hospital of Jilin UniversityChangchun 130022China College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China School of Materials Science and Engineering Jilin UniversityChangchun 130022China

Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,screws are evolving from solid and smooth to porous and rough.Additive manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and rough.This paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw breakage.Next,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing osseointegration.At the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore shape.In addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi structure.At the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated screws.Simultaneously,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated screws.AM osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.

关键词： Bone screws Additive manufacturing Architecture design Surface modification

Modeling of Large-Scale Hydrogen Storage System Considering Capacity Attenuation and Analysis of Its Efficiency Characteristics

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Energy Engineering 2024年第2期121卷 291-313页

作者： Junhui Li haotian Zhang Cuiping Li Xingxu Zhu Ruitong liu Fangwei Duan Yongming Peng Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of Education(Northeast Electric Power University)Jilin132012China Ministry of Science and Technology Electric Power Research Institute of State Grid Liaoning Electric Power Co.Ltd.Shenyang110006China Northeast Electric Power Dispatching Control Center Northeast Branch of State Grid Corporation of ChinaShenyang110180China

In the existing power system with a large-scale hydrogen storage system,there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system.In order to improve the hydrogen utilization rate of hydrogen storage system in the process of participating in the power grid operation,and speed up the process of electric-hydrogen-electricity conversion.This article provides a detailed introduction to the mathematical and electrical models of various components of the hydrogen storage unit,and also establishes a charging and discharging efficiency model that considers the temperature and internal gas partial pressure of the hydrogen storage unit.These models are of great significance for studying and optimizing gas storage technology.Through these models,the performance of gas storage units can be better understood and improved.These studies are very helpful for improving energy storage efficiency and sustainable development.The factors affecting the charge-discharge efficiency of hydrogen storage units are analyzed.By integrating the models of each unit and considering the capacity degradation of the hydrogen storage system,we can construct an efficiency model for a large hydrogen storage system and power conversion system.In addition,the simulation models of the hydrogen production system and hydrogen consumption system were established in MATLAB/Simulink.The accuracy and effectiveness of the simulation model were proved by comparing the output voltage variation curve of the simulation with the polarization curve of the typical hydrogen production system and hydrogen consumption system.The results show that the charge-discharge efficiency of the hydrogen storage unit increases with the increase of operating temperature,and H2 and O2 partial voltage have little influence on the charge-discharge efficiency.In the process of power conversion system converter rectification operation,its efficiency decreases with the increase of temperature,while in the proc

关键词： Hydrogen storage system simulation modeling electrolyzer fuel cell capacity loss

Underestimated benefits of NO_(x) control in reducing SNA and O_(3) based on missing heterogeneous HONO sources

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 57-67页

作者： Shuping Zhang haotian Zheng Jun liu Yao Shi Tianzeng Chen Chaoyang Xue Fenfen Zhang Yueqi Jiang Xiangping Zhang Shovan Kumar Sahu Biwu Chu Jia Xing State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China China Academy of Civil Aviation Science and Technology Beijing 100028China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Yellow River Institute of Hydraulic Research Zhengzhou 450003China Centre for Climate Research Singapore Meteorological Service SingaporeSingapore 537054Singapore

Substantial NO_(x) emission mitigation is crucial for the synergistic reduction of particulate matter and ozone(O_(3))pollution in China.The traditional air quality model does not consider heterogeneous HONO chemistry,leading to uncertainties in estimating the benefits of NO_(x) control.Previous studies have shown that the parameterization of heterogeneous HONO formation increases both the simulated value of sulfate–nitrate–ammonium(SNA)and that of O_(3),thus adding the heterogeneous reactions of HONO into air quality models inevitably leads to changes in the estimated benefits of NO_(x) abatement.Here we investigated the changes in SNA and O_(3)concentrations from NO_(x) emission reduction before and after adding heterogeneous HONO reactions in the Community Multi-Scale Air Quality(CMAQ)model.Including heterogeneous HONO reactions in the simulation improved the benefits of NO_(x) reduction in terms of SNA control in winter.With 80%NO_(x) reduction,the reduction in SNA increased from 36.9%without considering heterogeneous HONO reactions to 42.8%with heterogeneous HONO chemistry.The reduction in the maximum daily 8h average(MDA8)O_(3)in summer caused by NO_(x) reduction increased slightly from 4.7%to 5.2%after adding heterogeneous HONO reactions.The results in this study highlight the enhanced effectiveness of NO_(x) controls for the reduction of SNA and O_(3)after considering heterogeneous HONO formation in a complex chemical ambient,demonstrating the importance of NO_(x) controls in reducing PM2.5 and O_(3)pollution in China.

关键词： Heterogeneous HONO NO_(x) reduction PM_(2.5) O_(3)

Hierarchical model updating strategy of complex assembled structures with uncorrelated dynamic modes

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Chinese Journal of Aeronautics 2022年第3期35卷 281-296页

作者： Chengwei FEI haotian liu Rhea PATRICIA LIEM Yatsze CHOY Lei HAN Department of Aeronautics and Astronautics Fudan UniversityShanghai 200433China Department of Mechanical and Aerospace Engineering Hong Kong University of Science and TechnologyHong Kong 999077China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHong Kong 999077China

In structural simulation and design,an accurate computational model directly determines the effectiveness of performance evaluation.To establish a high-fidelity dynamic model of a complex assembled structure,a Hierarchical Model Updating Strategy(HMUS)is developed for Finite Element(FE)model updating with regard to uncorrelated modes.The principle of HMUS is first elaborated by integrating hierarchical modeling concept,model updating technology with proper uncorrelated mode treatment,and parametric modeling.In the developed strategy,the correct correlated mode pairs amongst the uncorrelated modes are identified by an error minimization procedure.The proposed updating technique is validated by the dynamic FE model updating of a simple fixed–fixed beam.The proposed HMUS is then applied to the FE model updating of an aeroengine stator system(casings)to demonstrate its effectiveness.Our studies reveal that(A)parametric modeling technique is able to build an efficient equivalent model by simplifying complex structure in geometry while ensuring the consistency of mechanical characteristics;(B)the developed model updating technique efficiently processes the uncorrelated modes and precisely identifies correct Correlated Mode Pairs(CMPs)between FE model and experiment;(C)the proposed HMUS is accurate and efficient in the FE model updating of complex assembled structures such as aeroengine casings with large-scale model,complex geometry,high-nonlinearity and numerous parameters;(D)it is appropriate to update a complex structural FE model parameterized.The efforts of this study provide an efficient updating strategy for the dynamic model updating of complex assembled structures with experimental test data,which is promising to promote the precision and feasibility of simulation-based design optimization and performance evaluation of complex structures.

关键词： Aeroengine casings Assembled structures Correlated mode pair Hierarchical model updating Objective function Uncorrelated modes

Enabling an Inorganic-Rich Interface via Cationic Surfactant for High-Performance Lithium Metal Batteries

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Nano-Micro Letters 2024年第8期16卷 1-17页

作者： Zejun Sun Jinlin Yang Hongfei Xu Chonglai Jiang Yuxiang Niu Xu Lian Yuan liu Ruiqi Su Dayu liu Yu Long Meng Wang Jingyu Mao haotian Yang Baihua Cui Yukun Xiao Ganwen Chen Qi Zhang Zhenxiang Xing Jisheng Pan Gang Wu Wei Chen Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore Agency for Science Technology and Research(A*STAR)Institute of High-Performance Computing1 Fusionopolis Way#16‑16 ConnexisSingapore 138632Singapore Department of Physics National University of Singapore2 Science Drive 3Singapore 117542Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207People’s Republic of China Agency for Science Technologyand Research(A*STAR)Institute of Materials Research and EngineeringInnovis2 Fusionopolis Way#08‑03Singapore 138634Singapore

An anion-rich electric double layer(EDL)region is favorable for fabricating an inorganic-rich solid-electrolyte interphase(SEI)towards stable lithium metal anode in ester electrolyte.Herein,cetyltrimethylammonium bromide(CTAB),a cationic surfactant,is adopted to draw more anions into EDL by ionic interactions that shield the repelling force on anions during lithium plating.In situ electrochemical surface-enhanced Raman spectroscopy results combined with molecular dynamics simulations validate the enrichment of NO_(3)^(−)/FSI−anions in the EDL region due to the positively charged CTA^(+).In-depth analysis of SEI structure by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry results confirmed the formation of the inorganic-rich SEI,which helps improve the kinetics of Li^(+)transfer,lower the charge transfer activation energy,and homogenize Li deposition.As a result,the Li||Li symmetric cell in the designed electrolyte displays a prolongated cycling time from 500 to 1300 h compared to that in the blank electrolyte at 0.5 mA cm^(-2) with a capacity of 1 mAh cm^(-2).Moreover,Li||LiFePO_(4) and Li||LiCoO_(2) with a high cathode mass loading of>10 mg cm^(-2) can be stably cycled over 180 cycles.

关键词： Cationic surfactant Lithium nitrate additive Solid-electrolyte interphase Electric double layer Lithium metal batteries

A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy

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Cancer Communications 2024年第3期44卷 438-442页

作者： Yingqiang liu Linjiang Tong Mengge Zhang Qi Zhang Qiupei liu Fang Feng Yan Li Mengzhen Lai haotian Tang Yi Chen Meiyu Geng Wenhu Duan Jian Ding Hua Xie Division of Antitumor Pharmacology&State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China University of Chinese Academy of Sciences BeijingP.R.China Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingboZhejiangP.R.China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdongP.R.China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandongP.R.China Small-Molecule Drug Research Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China

Oncogenes are critical factors in tumorigenesis of diverse cancer types and play essential roles in tumor immune escape.Mutations in Kirsten rat sarcoma viral oncogene homolog(KRAS)and epidermal growth factor receptor(EGFR)are among the most frequent gain-of-function alterations[1].After many years of in-depth research,inhibitors targeting EGFR or KRAS mutations have been successfully developed,however,their clinical benefit is relatively limited,and they will inevitably encounter the challenge of drug resistance.The emergence of resistance is attributed to secondary mutations in driver genes and other complicated factors.

关键词： alterations KRAS sarcoma

Prophylactic treatment of Lacticaseibacillus paracasei K56 ameliorates asthma by regulating short-chain fatty acid production and Treg differentiation

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Food Science and Human Wellness 2024年

作者： Jiaqi Cui Yanfei Hong Wei-Hsien liu Wen Zhao Xinmei Nan Xuekai Shang Yalan Li haotian Feng Qiuyue Jiang Weilian Hung Guiying Peng Inner Mongolia Yili Industrial Group Co. Ltd. Department of Immunology and Microbiology School of Life Sciences Beijing University of Chinese Medicine

Many studies have shown that the development of allergic asthma is associated with intestinal microbiota dysbiosis. Based on the gut-lung axis theory， probiotic intervention may be a potential strategy for respiratory diseases. Lacticaseibacillus paracasei K56 was reported to regulate gut microbiota in mice. However， its effect on allergic asthma has not been reported. In this study， we investigated the effect of the K56 on ovalbumin-induced asthma and its possible mechanisms. Our results showed that K56 reduced asthma symptoms and inflammatory cell infiltration in the lung of asthmatic mice. And K56 regulated the differentiation of helper T cells in the lung and intestine. Results from 16S rRNA gene sequencing showed that K56 prophylaxis significantly elevated the richness of Akkermansia and Burkholderia. Meanwhile， K56 abrogated the decrease in the levels of short-chain fatty acids (SCFAs) in the feces. In addition， a rebound in the mRNA expression of the SCFA receptors was observed after K56 prophylaxis. Notably， the regulatory T cell (Treg) frequencies and the FFAR3 levels were positively correlated. These results suggest that K56 could attenuate asthma， possibly by modulating the intestinal microbiota and regulating Treg differentiation through SCFA metabolized. Our study showed that K56 may be used as a probiotic to prevent pulmonary inflammation and dysbiosis of the intestinal microbiota in allergic asthma.

关键词：