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Additive manufactured osseointegrated screws with hierarchical design

Bio-Design and Manufacturing 2024年第2期7卷 206-235页

作者： Wenbo Yang Hao Chen haotian bai Yifu Sun Aobo Zhang Yang Liu Yuchao Song Qing Han Jincheng Wang Department of Orthopedics Second Hospital of Jilin UniversityChangchun 130022China College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China School of Materials Science and Engineering Jilin UniversityChangchun 130022China

Bone screws are devices used to fix implants or bones to ***,conventional screws are mechanically fixed with thread and often face long-term failure due to poor *** improve osseointegration,screws are evolving from solid and smooth to porous and *** manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and *** paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw ***,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing *** the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore *** addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi *** the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated ***,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated *** osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.

关键词： Bone screws Additive manufacturing Architecture design Surface modification

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Bioinspired Hollow Mesoporous Silica Nanoparticles Coating on Titanium Alloy with Hierarchical Structure for Modulating Cellular Functions

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Journal of Bionic Engineering 2024年第3期21卷 1427-1441页

作者： Jiaxin Zhang He Liu Jincheng Wang Jing Shang Mingwei Xu Xiujie Zhu Chao Xu haotian bai Xin Zhao Orthopedic Institute of Jilin Province Orthopedic Medical CenterThe Second Hospital of Jilin UniversityChangchun130041China Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun130025China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang110167China

3D-printed Porous Titanium Alloy Implants(pTi),owing to their biologically inertness and relatively smooth surface morphology,adversely affect the biological functions of surrounding *** address the challenges,constructing a bioinspired interface that mimics the hierarchical structure of bone tissue can enhance the cellular functions of *** this context,Hollow Mesoporous Silica Nanoparticles(HMSNs),renowned for their unique physicochemical properties and superior biocompatibility,offer a promising direction for this *** this research,the initially synthesized HMSNs were used to construct a“hollow-mesoporous-macroporous”hierarchical bioinspired coating on the pTi surface through the Layer-by-Layer ***,diverse morphologies of coatings were established by adjusting the deposition strategy of PDDA/HMSNs on the pTi surface(pTi-HMSN-2,pTi-HMSN-4,pTi-HMSN-6).A range of techniques were employed to investigate the physicochemical properties and regulation of cellular biological functions of the diverse HMSN coating ***,the pTi-HMSN-4 and pTi-HMSN-6 groups exhibited the uniform coatings,leading to a substantial enhancement in surface roughness and ***,the coating constructed strategy of pTi-HMSN-4 possessed commendable *** on the aforementioned findings,both pTi-HMSN-4 and pTi-HMSN-6 facilitated the adhesion,spreading,and pseudopodia extension of BMSCs,which led to a notable upsurge in the expression levels of vinculin protein in *** analysis indicates that the coating,when PDDA/HMSNs are deposited four times,possesses favorable overall *** research will provide a solid theoretical basis for the translation of HMSN bioinspired coatings for orthopedic implants.

关键词： Hollow mesoporous silica nanoparticles Bioinspired coating Titanium alloy Hierarchical structure Cellular functions

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党内巡视制度演绎的行动逻辑与价值指向

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西昌学院学报（社会科学版） 2024年第4期36卷 1-10,128页

作者：白浩天四川大学马克思主义学院

党内巡视制度是推进全面从严治党、强化党内政治监督的战略性安排。其在党的百年历史中出现四个重大的制度变迁节点,据此演绎为衍生、中断、发展、调适、深化五大阶段。党内巡视制度的演进深刻呈现出刺激回应、断续绵延、收缩调适的制... 详细信息

党内巡视制度是推进全面从严治党、强化党内政治监督的战略性安排。其在党的百年历史中出现四个重大的制度变迁节点,据此演绎为衍生、中断、发展、调适、深化五大阶段。党内巡视制度的演进深刻呈现出刺激回应、断续绵延、收缩调适的制度发展逻辑,更为加强党的集中统一领导、增强制度执行力、明确人民至上的价值导向、理解制度的时代局限等方面提供丰富的经验价值。针对新形势下反腐败斗争的现实问题与党的建设新要求,巡视制度充分发挥“政治利剑”作用,就要完善全面从严治党的党内法规体系,将巡视制度作为党的监督体系的首要制度;以上下结合的方式延展监督路径,依靠人民群众强化巡视监督;规范专职的高素质干部队伍,做好人才培育工作,把好人员“出入口”;以组织体系实现压力的传递与转换,充分发挥中国共产党组织形态的显著优势。

关键词：巡视制度制度演进党内监督党的建设

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前哨淋巴结活检联合保乳术治疗早期乳腺癌的效果观察

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中国医学创新 2024年第5期21卷 1-5页

作者：冯影刘震白浩天徐州医科大学附属徐州市立医院甲乳科江苏徐州221000

目的:探讨早期乳腺癌患者在经前哨淋巴结活检联合保乳术治疗后的效果。方法:选取2015年4月—2020年6月徐州医科大学附属徐州市立医院收治的102例早期乳腺癌患者作为研究对象,随机分为对照组和联合组,每组51例。对照组仅接受保乳术治疗,... 详细信息

目的:探讨早期乳腺癌患者在经前哨淋巴结活检联合保乳术治疗后的效果。方法:选取2015年4月—2020年6月徐州医科大学附属徐州市立医院收治的102例早期乳腺癌患者作为研究对象,随机分为对照组和联合组,每组51例。对照组仅接受保乳术治疗,联合组接受前哨淋巴结活检和保乳术联合治疗,比较两组患者在手术指标、复发率、并发症发生率、乳房美容效果和创伤后应激障碍自评量表(PTSD checklist-civilian version,PCL-C)评分。结果:联合组总出血量、总引流量和住院时间均优于对照组(P0.05);联合组并发症发生率明显低于对照组(P<0.05);联合组乳房美容效果优良率高于对照组(P<0.05);术后2周,联合组PCL-C评分明显低于对照组(P<0.05)。结论:前哨淋巴结活检联合保乳术在早期乳腺癌治疗中取得良好效果,可明显降低癌症复发率和并发症发生率,乳房美容效果好,患者心理受癌症影响更小,社会认同和接受度更高。

关键词：乳腺癌前哨淋巴结活检保乳术乳房美容效果应激障碍

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添加氮磷与菌根抑菌剂对荒漠草原草地净初级生产力的影响

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中国草地学报 2024年第4期46卷 25-32页

作者：丁琴何嘉郭文龙白皓天张建军杨鑫沈月宁夏大学林业与草业学院宁夏银川750021 宁夏生态草牧业工程技术研究中心宁夏银川750021

采用原位控制试验的方法,以宁夏东部温性荒漠草原植物群落为研究对象,解析氮、磷添加与菌根抑菌剂对草原植物净初级生产力(NPP)的影响。结果表明:氮、磷添加与菌根抑菌剂显著提高地上净初级生产力(ANPP)、地下净初级生产力(BNPP)与NPP(P... 详细信息

采用原位控制试验的方法,以宁夏东部温性荒漠草原植物群落为研究对象,解析氮、磷添加与菌根抑菌剂对草原植物净初级生产力(NPP)的影响。结果表明:氮、磷添加与菌根抑菌剂显著提高地上净初级生产力(ANPP)、地下净初级生产力(BNPP)与NPP(P<0.01)。磷与菌根抑菌剂添加的拮抗效应显著改变ANPP与NPP;施磷处理下菌根抑菌剂添加极显著增加ANPP与NPP(P<0.01);不施磷处理下菌根抑菌剂添加对ANPP与NPP无显著影响。氮、磷添加对ANPP、BNPP与NPP无显著交互作用。氮添加显著增加10~30 cm土层BNPP(P<0.01)。磷添加显著促进0~10 cm、10~30 cm与30~40 cm土层BNPP(P<0.01)。施磷处理下菌根抑菌剂添加显著增加深根型植物地上生物量(P<0.01)。深根型植物地上生物量占比与BNPP呈极显著正相关关系(P<0.01)。磷添加通过提高深根型植物地上生物量占比,进而促进BNPP增加。本研究结果表明,宁夏东部温性荒漠草原初级生产力受到氮、磷添加与菌根抑菌剂的影响;与氮、菌根抑菌剂添加相比,磷添加对NPP的作用强度更高。

关键词：荒漠草原氮磷丛枝菌根真菌净初级生产力

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Conjugated Polymer Nanomaterials for Phototherapy of Cancer

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Chemical Research in Chinese Universities 2020年第2期36卷 237-242页

作者： FU Xuancheng bai haotian LYU Fengting LIU Libing WANG Shu Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China College of Chemistry University of Chinese Academy of SciencesBeijing 100049P.R.China

Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past *** to the developed anticancer systems based on conjugated polymer nanomaterials,it could be summarized into three main cancer therapy strategies:photodynamic therapy(PDT),photothermal therapy(PTT)and combination *** this mini review,we provide a brief introduction to three different cancer therapy modes,their mechanisms and potential biological ***,some perspectives on the further development of conjugated polymer nanomaterials are proposed in the territory of anticancer precision medicine.

关键词： Conjugated polymer nanomaterial Cancer therapy Photodynamic therapy Photothermal therapy Combi nation therapy

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Research on combustion characteristics of scramjet combustor with different flight dynamic pressure conditions

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Propulsion and Power Research 2023年第1期12卷 69-82页

作者： Junlong Zhang Guangjun Feng haotian bai Kangshuai Lv Wen Bao Harbin Institute of Technology Heilongjiang 150001China

Combustion characteristics in a scramjet combustor equipped with a thin strut were observed and discussed in this paper.A series of numerical simulations were carried out under different flight dynamic pressure *** parameters of cold flow field and combustion field were used to analyze the combustion *** on the basic data,the mixing efficiency,characteristics of flame establishment and propagation as well as combustion field characteristics were discussed in this *** influence laws of lower dynamic pressure conditions were further revealed to optimize combustor *** indicated that properly reducing the flight dynamic pressure can enhance the mixing of *** diffusion of kerosene determined the distribution of combustion zone and heat ***,the influencing factor that affected the chemical reaction rate was revealed to shorten chemical reaction *** the higher flight Mach number made the flame propagation velocity faster and the combustion stability *** fuel mixing became the main factor and low dynamic pressure had little effect on laminar flame propagation velocity under high Mach number *** investigations in this paper are helpful for understanding the combustion characteristics under low dynamic pressure conditions.

关键词： Low flight dynamic pressure Fuel mixing characteristics Flame propagation characteristics Combustion characteristics

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Polymer Materials Synthesized through Cell-Mediated Polymerization Strategies for Regulation of Biological Functions

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Accounts of Materials Research 2023年第1期4卷 57-70页

作者： Qi Shen Yiming Huang haotian bai Fengting Lv Shu Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China

CONSPECTUS:As essential components of living organisms,biomacromolecules construct cell scaffolds and regulate cell activities and biological functions through chemical transformations in biological *** by the functional evolution in the formation of natural structures,in situ polymerization methods have been developed to create functional synthetic macromolecules inside or on the surface of living *** the diversity of cell species and the complexity of biological pathways,selected strategies can be employed to control the synthesis of functional polymers that utilize the dynamic cellular *** this Account,we summarize recent work in the field of designing cell-mediated in situ polymerization methods,with which we demonstrate their application prospects including tumor cell labeling and treatment,microbial photosynthetic efficiency regulation,and hydrogel *** purpose of these efforts is to design polymerization reactions in response to endogenous or exogenous stimuli and to describe the underlying response *** reasonable design of molecular structures,in situ synthesized polymers in the cell microenvironment implement regulation of biological *** example,using specific redox activity combined with light irradiation,bacteria can mediate the generation of functional polymers as the encapsulating matrix or with antibacterial *** polymers synthesized on the microalgae surface expanded the spectral absorption and improved photosynthetic ***,characteristics of the cellular microenvironment could initiate various polymerization reactions inside living cells,including oxidative thiol cross-linking,condensation polymerization,and free radical *** reactions can be selectively conducted with reactive species generated in tumor cells,and the resulting polymers showed prolonged retention inside cells for modulating cell *** development of cell-mediate

关键词： functions. polymerization utilize

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Synthesis of easily-processable collagen bio-inks using ionic liquid for 3D bioprinted liver tissue models with branched vascular networks

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Science China Chemistry 2023年第5期66卷 1489-1499页

作者： Zhiqiang Gao Xin Liu Hao Zhao Shengpeng Xia Wenli Liu haotian bai Fengting Lv Xiongfei Zheng Yiming Huang Qi Gu Shu Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China College of Chemistry University of Chinese Academy of SciencesBeijing 100049China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110169China

Bioprinting has been a flouring way to fabricate complex tissue and organ mimics via precisely depositing printable cell-laden ***,there is a limited number of biomaterials that fulfill the mechanical property of printing while meeting the responsive environment desired for the *** excellent cell compatibility and bioactivity,collagen suffers from difficulties in processing and printability which inhibited its utilization in three-dimensional(3D)***,we address this limitation by using ionic liquid as the solvent in the modification process,enabling collagens modified with quantified norbornene for chemical crosslink and extrusion-based 3D *** improved solubility and rheological properties,norbornene-functionalized collagen(Col-Nor)exhibited better shape fidelity in extrusion-based 3D printing compared with the one before ***-crosslinked Col-Nor hydrogel provided structural support and promoted the adhesion,proliferation,and differentiation of various types of cells,which afforded a centimeter-scale liver tissue *** highly generalizable methodology expands printable,versatile,and tunable hydrogels developed from the natural extracellular matrix,allowing the biofabrication of 3D liver tissue model with branched vascular networks.

关键词： bioprinting functionalized collagen rheological properties photo-crosslinking 3D tissue model

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Unexpected Photocatalytic Degeneration of NAD^(+) for Inducing Apoptosis of Hypoxia Cancer Cells

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CCS Chemistry 2023年第10期5卷 2324-2333页

作者： Shengpeng Xia haotian bai Endong Zhang Wen Yu Zhiqiang Gao Fengting Lv Yiming Huang Daoben Zhu Shu Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 College of Chemistry University of Chinese Academy of SciencesBeijing 100049

Developing customized chemical reactions that could regulate a specific biological process on demand is regarded as an advanced and promising strategy for treating ***,conventional chemical reactions become challenging in complex physiological environments,which demand mild reaction conditions,high efficiency,good biocompatibility,and strong ***,the effects of the achieved reactions on the real biological system are usually further ***,we describe an advanced photocatalytic reaction that irreversibly converted nicotinamide adenine dinucleotide(NAD+)to nicotinamide and adenosine diphosphate(ADP)-ribose by the cationic conjugated poly(fluorene-co-phenylene)(PFP).This reaction was introduced to tumor cells and triggered cell *** white-light illumination,the photocatalytic reaction decreased the NAD+ratio in tumor cells,disrupted the mitochondrial membrane potential,inhibited the synthesis of adenosine triphosphate(ATP),and effectively induced *** propose a mechanism of the reaction where PFP is photoexcited to PFP*,and the obtained photoelectrons are transferred from PFP*to NAD+to produce nicotinamide and another unstable intermediate,ADP-ribosyl ***-ribosyl radical quickly reacts with triethanolamine to form *** intracellular utilization of a specific photocatalytic reaction could offer a new approach to affect biological function for efficient cancer treatment.

关键词： photocatalysis conjugated polymer intracellular catalysis hypoxic tumor apoptosis

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