检索结果-南通市图书馆

NIR-Ⅱ responsive Janus nanoparticles amplify immunogenic cell death for enhanced cancer immunotherapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第1期67卷 321-329页

作者： CHEN BeiBei GUO KangLi WANG haoran XU fu-Jian WANG JuLin ZHAO NaNa State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials Sciences and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical TechnologyBeijing 100029China

Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor cells.However,insufficient immunogenicity and low immune response rate greatly limit antitumor immunity.Herein,by optimizing the composition and morphology,the rational design of Janus nanoparticles composed of Fe_(3)O_(4) nanospheres and SiO_(2)nanorods was realized for enhanced cancer immunotherapy through amplified ICD.After glucose oxidase(GOx)was loaded by the Janus nanoparticles,the resultant M-FS-GOx consumes glucose at tumor sites to generate gluconic acid and hydrogen peroxide(H_(2)O_(2))for starvation therapy while the H_(2)O_(2)supply promotes the production of highly toxic·OH to achieve effective chemodynamic therapy(CDT).Under a 1064 nm light irradiation,the photothermal effect of M-FS-GOx enhances the enzyme activity of GOx for improved starvation therapy.furthermore,both tumor-associated antigens released during the process of ICD and the intrinsic immunoadjuvant property of M-FS-GOx stimulate dendritic cell maturation to activate antitumor immune responses.This work provides a promising strategy for the construction of Janus nanoparticles to achieve enhanced cancer immunotherapy through combination therapy-amplified ICD.

关键词： Janus nanoparticles immunogenic cell death cancer immunotherapy

Role of tannin pretreatment in flotation separation of magnesite and dolomite

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 452-461页

作者： Xiufeng Gong Jin Yao Jun Guo Bin Yang haoran Sun Wanzhong Yin Yulian Wang Yafeng fu School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Solid Waste Treatment and Resource Utilization of the Ministry of Education Southwest University of Science and TechnologyMianyang 621010China School of Chemical Engineering China University of Mining and TechnologyXuzhou 221116China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Ansteel Beijing Research Institute Co. Ltd.Beijing 102200China

Flotation separation of magnesite and its calcium-containing carbonate minerals is a difficult problem.Recently,new regulat-ors have been proposed for magnesite flotation decalcification,although traditional regulators such as tannin,water glass,sodium carbon-ate,and sodium hexametaphosphate are more widely used in industry.However,they are rarely used as the main regulators in research because they perform poorly in magnesite and dolomite single-mineral flotation tests.Inspired by the limonite presedimentation method and the addition of a regulator to magnesite slurry mixing,we used a tannin pretreatment method for separating magnesite and dolomite.Microflotation experiments confirmed that the tannin pretreatment method selectively and largely reduces the flotation recovery rate of dolomite without affecting the flotation recovery rate of magnesite.Moreover,the contact angles of the tannin-pretreated magnesite and dolomite increased and decreased,respectively,in the presence of NaOl.Zeta potential and Fourier transform infrared analyses showed that the tannin pretreatment method efficiently hinders NaOl adsorption on the dolomite surface but does not affect NaOl adsorption on the magnesite surface.X-ray photoelectron spectroscopy and density functional theory calculations confirmed that tannin interacts more strongly with dolomite than with magnesite.

关键词： tannin pretreatment selective inhibition flotation separation magnesite dolomite

Impact of extreme climate and train traffic loads on the performance of high-speed railway geotechnical infrastructures

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第3期24卷 189-205页

作者： Ying WU haoran fu Xuecheng BIAN Yunmin CHEN MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China Department of Civil Engineering Zhejiang UniversityHangzhou 310058China

High-speed railways are very important in global transportation.However,the railway subgrade is significantly affected by the environment due to its exposure to the atmosphere.At present,global warming is the primary trend in world climate change and seriously damages railway infrastructure.Owing to the coupling effect of extreme environmental and train loads,various subgrade problems tend to arise,such as settlement,ballast fouling,and mud pumping,thus inducing frequent railway accidents and reducing travel safety.Insights into the problems triggered by extreme climate and train loads are critical to the design and long-term operation of high-speed railway subgrades.This study therefore presents a detailed survey of recent advances in typical subgrade problems through analyzing the problem formation mechanisms and influences.Traditional and emerging detection/monitoring technologies in respect of subgrade problems are discussed in detail,as well as pre-accident and post-accident maintenance methods.Finally,according to the existing challenges in long-term subgrade shakedown assessment,an outlook on open opportunities is provided for future research.

关键词： High-speed railways Subgrade performance Train loads Extreme climate

Rapid report of seismic damage to buildings in the 2022 M 6.8 Luding earthquake,China

在线全文

学校读者我要写书评

暂无评论

Earthquake Research Advances 2023年第1期3卷 11-30页

作者： Zhe Qu Baijie Zhu Yuteng Cao haoran fu Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationNo.1 Chaobai StreetYanjiaoSanheHebei065201China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementChina

The report summarizes the observed damage to a variety of buildings near the epicenter of the M6.8 Luding earthquake in Sichuan Province,China.They include base-isolated buildings,multi-story reinforced concrete(RC)frame buildings,and masonry buildings.The near-field region is known to be tectonically highly active,and the local intensity level is the highest,that is,0.4g peak ground acceleration(PGA)for the design basis earthquake,in the Chinese zonation of seismic ground motion parameters.The extent of damage ranged from the weak-story collapse that claimed lives to the extensive nonstructural damage that suspended occupancy.The report highlights the first observation of the destruction of rubber bearings and viscous dampers in the isolation layer of Chinese seismically isolated buildings.It also features the rare observation of the brittle shear failure of RC columns in moment-resisting frames in a region of such a high seismic design requirement.Possible reasons that may have attributed to the reported damage are suggested by providing facts observed in the field.However,careful forensic analyses are needed before any conclusive judgment can be made.

关键词： Base isolation Rubber bearing Viscous damper Reinforced concrete frame Masonry structure Weak-story collapse Near-fault area Terrace riser Nonstructural element

Failure mechanisms in flexible electronics

在线全文

学校读者我要写书评

暂无评论

International Journal of Smart and Nano Materials 2023年第4期14卷 510-565页

作者： Zhehui Zhao haoran fu Ruitao Tang Bocheng Zhang Yunmin Chen Jianqun Jiang MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhouChina Department of Civil Engineering Zhejiang UniversityHangzhouChina R&D department Wuxi Innosonics Medical Technology CoLtdWuxiChina R&D Department of devices and processes Jiashan Fudan InstituteJiaxingChina

The rapid evolution of flexible electronic devices promises to revolutionize numerous fields by expanding the applications of smart devices.Nevertheless,despite this vast potential,the reliability of these innovative devices currently falls short,especially in light of demanding operation environment and the intrinsic challenges associated with their fabrication techniques.The heterogeneity in these processes and environments gives rise to unique failure modes throughout the devices'lifespan.To significantly enhance the reliability of these devices and assure long-term performance,it is paramount to comprehend the underpinning failure mechanisms thoroughly,thereby,enabling,optimal design solutions.A myriad of investigative efforts have been dedicated to unravel these failure mechanisms,utilizing a spectrum of tools from analytical models,numerical methods,to advanced characterization methods.This review delves into the root causes of device failure,scrutinizing both the fabrication process and the operation environment.Next,We subsequently address the failure mechanisms across four commonly observed modes:strength failure,fatigue failure,interfacial failure,and electrical failure,followed by an overview of targeted characterization methods associated with each mechanism.Concluding with an outlook,we spotlight ongoing challenges and promising directions for future research in our pursuit of highly resilient flexible electronic devices.

关键词： Flexible electronic devices failure mechanisms characterization methods

Advances in sodium-ion batteries at low-temperature: Challenges and strategies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第3期90卷 518-539,I0012页

作者： haoran Bai Xiaohui Zhu Huaisheng Ao Guangyu He Hai Xiao Yinjuan Chen Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation CenterChangzhou UniversityChangzhou 213164JiangsuChina Department of Chemistry Tsinghua UniversityBeijing 100084China

With the continuing boost in the demand for energy storage,there is an increasing requirement for batteries to be capable of operation in extreme environmental conditions.Sodium-ion batteries(SIBs) have emerged as a highly promising energy storage solution due to their promising performance over a wide range of temperatures and the abundance of sodium resources in the earth's crust.Compared to lithiumion batteries(LIBs),although sodium ions possess a larger ionic radius,they are more easily desolvated than lithium ions.fu rthermore,SIBs have a smaller Stokes radius than lithium ions,resulting in improved sodium-ion mobility in the electrolyte.Nevertheless,SIBs demonstrate a significant decrease in performance at low temperatures(LT),which constrains their operation in harsh weather conditions.Despite the increasing interest in SIBs,there is a notable scarcity of research focusing specifically on their mechanism under LT conditions.This review explores recent research that considers the thermal tolerance of SIBs from an inner chemistry process perspective,spanning a wide temperature spectrum(-70 to100℃),particularly at LT conditions.In addition,the enhancement of electrochemical performance in LT SIBs is based on improvements in reaction kinetics and cycling stability achieved through the utilization of effective electrode materials and electrolyte components.furthermore,the safety concerns associated with SIBs are addressed and effective strategies are proposed for mitigating these issues.Finally,prospects conducted to extend the environmental frontiers of commercial SIBs are discussed mainly from three viewpoints including innovations in materials,development and research of relevant theoretical mechanisms,and intelligent safety management system establishment for larger-scale energy storage SIBs.

关键词： Low-temperature Sodium-ion batteries Reaction kinetics Cycle stability Safety concerns of Sodium-ion batteries

渤海湾盆地黄骅坳陷乌马营地区断盖配置对上古生界天然气向孔店组运移的控制

在线全文

学校读者我要写书评

暂无评论

天然气地球科学 2024年第6期35卷 938-948页

作者：蒋飞付广张姣王浩然东北石油大学地球科学学院黑龙江大庆163318

渤海湾盆地黄骅坳陷乌马营地区孔店组气藏的发现,带来了天然气成藏层系的新突破,开辟了新的勘探领域。为探究孔店组天然气富集规律和资源潜力,推动黄骅坳陷古近系气藏的勘探,以天然气供给为核心,利用井震资料,通过定量表征方式,研究乌... 详细信息

渤海湾盆地黄骅坳陷乌马营地区孔店组气藏的发现,带来了天然气成藏层系的新突破,开辟了新的勘探领域。为探究孔店组天然气富集规律和资源潜力,推动黄骅坳陷古近系气藏的勘探,以天然气供给为核心,利用井震资料,通过定量表征方式,研究乌马营地区断盖配置对上古生界煤系烃源岩生成的天然气向孔店组运移的控制作用。结果表明:①输导断层为天然气向孔店组垂向运移提供通道,且断层在成藏期活动速率大于3.6 m/Ma的部位是优势输导通道;②孔三段—中生界盖层的断盖配置垂向封闭性控制天然气运聚层位,盖层断接厚度小于34 m的部位垂向渗漏,有利于天然气穿过盖层向孔店组运移;③断层输导与断盖配置封闭性共同控制天然气向孔店组的供给部位,且断层优势输导通道与断盖配置垂向渗漏区的重叠部位是天然气向孔店组运移的有利部位。

关键词：天然气输导断层盖层断盖配置煤系烃源岩孔店组黄骅坳陷

在线全文

学校读者我要写书评

暂无评论

机器人冲击、产业结构转型与就业正规性

中国经济问题 2024年第2期 182-196页

作者：朱峰李浩然傅志明四川大学经济学院

本文利用中国家庭追踪调查2012年至2018年数据,使用Probit模型考察了机器人冲击和产业结构转型对就业正规性转换的影响。研究表明,机器人冲击仅单向推动劳动者从正规就业转向非正规就业,不影响其反方向的就业正规性转换,而产业结构转型... 详细信息

本文利用中国家庭追踪调查2012年至2018年数据,使用Probit模型考察了机器人冲击和产业结构转型对就业正规性转换的影响。研究表明,机器人冲击仅单向推动劳动者从正规就业转向非正规就业,不影响其反方向的就业正规性转换,而产业结构转型不影响其就业正规性选择。异质性分析表明,机器人冲击通过就业替代效应实现这一单向作用,表现为第二产业的正规就业者被挤出到第三产业的非正规部门,且其主要影响低技能水平和居于较小规模城市劳动者的就业决策。本文为正确理解我国就业正规性问题和实现共同富裕目标提供了新的事实依据。

关键词：机器人渗透度产业结构转型非正规就业

在线全文

学校读者我要写书评

暂无评论

具有对抗鲁棒性的人脸活体检测方法

计算机科学 2024年第S1期51卷 975-981页

作者：王春东李泉付浩然浩庆波天津理工大学计算机科学与工程学院天津300384 天津理工大学“智能计算及软件新技术”天津市重点实验室天津300384

现有人脸活体检测方法在深度神经网络的支持下已获得优秀的检测能力,但面临对抗样本攻击时仍呈现脆弱性。针对此问题,引入胶囊网络(Capsule Network,CapsNet)提出一种具有对抗鲁棒性的人脸活体检测方法FAS-CapsNet:通过CapsNet及其图像... 详细信息

现有人脸活体检测方法在深度神经网络的支持下已获得优秀的检测能力,但面临对抗样本攻击时仍呈现脆弱性。针对此问题,引入胶囊网络(Capsule Network,CapsNet)提出一种具有对抗鲁棒性的人脸活体检测方法FAS-CapsNet:通过CapsNet及其图像重建机制保留特征间关联,过滤样本中的对抗扰动;根据皮肤与平面介质的反射性质差异,以Retinex算法增强图像光照特征,增大活体与非活体人脸类间距离的同时破坏对抗扰动模式,进而提升模型准确性与鲁棒性。在CASIA-SURF数据集上进行实验可知:FAS-CapsNet对正负样本的检测准确率为87.344%,对比模型中最高准确率为78.917%,说明FAS-CapsNet具备充分的常规活体检测能力。为进一步验证模型鲁棒性,基于CASIA-SURF测试集生成两种对抗样本数据集并进行实验:FAS-CapsNet在两数据集上的检测准确率分别为84.552%和79.042%,较常规检测准确率下降3.197%和9.505%;对比模型在两数据集上的最高准确率分别为74.938%和41.667%,较常规检测下降5.042%和47.201%。可见FAS-CapsNet受对抗扰动影响更小,具有显著的对抗鲁棒性优势。

关键词：人脸活体检测对抗鲁棒性胶囊网络 Retinex 对抗样本