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Estimating the Size of an Open Population with Massive Datasets Based on a Generalized Varying-Coefficient Model

Journal of Systems Science & Complexity 2022年第3期35卷 1116-1136页

作者： li haoqi li Yuan School of Economics and Statistics Guangzhou UniversityGuangzhou 510006China School of Mathematics and Statistics Yangtze Normal UniversityChongqing 408100China

A generalized varying-coefficient model is proposed to estimate a population size at a specific time from multiple lists of an open *** research datasets have millions of records with a very long time span(38 years),bringing challenges to *** authors develop a regularization iterative algorithm to overcome this *** asymptotic distribution of the proposed estimators is *** studies show that the procedure works *** method is applied to estimate the number of drug abusers in Hong Kong,China over the period 1977–2014.

关键词： Drug abusers generalized varying-coefficient multiple-list open population

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Safe formation control of multiple unmanned aerial vehicles:control design and safety-stability analysis

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Control Theory and Technology 2024年第3期22卷 442-454页

作者： haoqi li Jiangping Hu Qingrui Zhou Bijoy K.Ghosh School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313000ZhejiangChina Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China Department of Mathematics and Statistics Texas Tech UniversityLubbockTX 79409-1042USA

Both safety and stability are primary performance criteria for multi-unmanned aerial vehicle(multi-UAV)systems in many coordination *** approaches often consider safety and stability *** is necessary and urgent to develop a safety-stability control strategy to merge these two performance *** this paper,a unified approach is developed to consider safety and stability for multi-UAV formation *** stability criterion is represented by a Lyapunov function and safety criterion is represented by a barrier function and then a relaxed converse control Lyapunov-barrier theorem is *** the help of a relaxed converse control Lyapunov-barrier function(RCCLBF),a distributed safety-stability formation control strategy is proposed for the multi-UAV *** transforming the solution of RCCLBF to a Lyapunovlike stabilization problem,we show that the proposed formation control strategy can drive the UAVs staying within a specified safe *** results are provided to validate the proposed safety-stability formation control strategy.

关键词： Multi-UAV system Formation control Lyapunov function Barrier function Stability with safety guarantee

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Adaptive Consensus Quantized Control for a Class of High-Order Nonlinear Multi-Agent Systems With Input Hysteresis and Full State Constraints

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IEEE/CAA Journal of Automatica Sinica 2022年第9期9卷 1574-1589页

作者： Guoqiang Zhu haoqi li Xiuyu Zhang Chenliang Wang Chun-Yi Su Jiangping Hu the School of Automation Engineering Northeast Electric Power UniversityJilin 132012 the Jilin Province International Research Center of Precision Drive and Intelligent Control Jilin 132012China the School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China the Department of Mechanical and Industrial Engineering Concordia UniversityQCMontrealH3B 1R6Canada the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China(

For a class of high-order nonlinear multi-agent systems with input hysteresis,an adaptive consensus output-feedback quantized control scheme with full state constraints is *** major properties of the proposed control scheme are:1)According to the different hysteresis input characteristics of each agent in the multi-agent system,a hysteresis quantization inverse compensator is designed to eliminate the influence of hysteresis characteristics on the system while ensuring that the quantized signal maintains the desired value.2)A barrier Lyapunov function is introduced for the first time in the hysteretic multi-agent *** constructing state constraint control strategy for the hysteretic multi-agent system,it ensures that all the states of the system are always maintained within a predetermined range.3)The designed adaptive consensus output-feedback quantization control scheme allows the hysteretic system to have unknown parameters and unknown disturbance,and ensures that the input signal transmitted between agents is the quantization value,and the introduced quantizer is implemented under the condition that only its sector bound property is *** stability analysis has proved that all signals of the closed-loop are semi-globally uniformly *** Star Sim hardware-in-the-loop simulation certificates the effectiveness of the proposed adaptive quantized control scheme.

关键词： Adaptive quantized control barrier Lyapunov function input hysteresis multi-agent systems

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Estimating population size of heterogeneous populations with massive data sets and a large number of parameters

Estimating population size of heterogeneous populations with...

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第十届海峡两岸统计与概率研讨会

作者： haoqi li Southwestern University of Finance and Economics

A generalized partial linear regression model is proposed to estimate population size at a specific time from multiple lists of a time-varying and heterogeneous population. The challenge is that we have millions of records and hundreds of parameters for a long period of time. This presents a challenge for data analysis, mainly due to the limitation of computer memory, computational convergence and infeasibility. In this paper, we propose an analytical methodology suitable for modeling a massive data set with a large number of parameters. The basic idea is to apply the maximum likelihood estimator to data observed at each time separately, and then combine these results via weighted averages so that the final estimator is the maximum likelihood estimator of the whole data set(full MLE). The asymptotic distribution and inference of the proposed estimators is derived. Simulation studies show that the proposed procedure gives exactly the same performance as the full MLE, but our method is computationally feasible while the full MLE is not, and our method has much lower computational cost than the full MLE if both methods work. The proposed method is applied to estimate the number of drug-abusers in Hong Kong over the period 1977-2014.

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Construction of an intranasal drug delivery system with hypothalamus-targeting nanoparticles

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SusMat 2024年第4期4卷 65-76页

作者： Qianru Rao Yujie Xu Xiaorong Wang Hang Luo haoqi li Jingyuan Xiong Huile Gao Guo Cheng Laboratory of Molecular Translational Medicine Center for Translational MedicineKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationMaternal&Child Nutrition CenterWest China Second University HospitalSichuan UniversityChengduChina Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengduChina Healthy Food Evaluation Research Center West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduChina

Dysfunction of the hypothalamus is associated with endocrine imbalances,growth abnormalities,and reproductive ***,there is a lack of targeted treatment strategies focused on the *** this study,we constructed a multifunctional nanocarrier system(S@ANP)to directly target the hypothalamic neurokinin receptor 3(NK3R)via an intranasal delivery *** system could overcome the primary obstacles in drug delivery for hypothalamus-related *** the guidance of a modified(Trp7,β-Ala8)-neurokinin A(4-10)peptide with cysteine,nanoparticles encapsulated with SB222200,an NK3R inhibitor,were found to readily penetrate hypothalamic cells with substantial loading capacity,encapsulation efficiency,and sustained release in ***,intranasal delivery represents an optimal delivery strategy that allows for a significant reduction in oral dosage and enables nanoparti-cles to bypass the blood-brain barrier and target relevant parts of the *** mucolytic agent N-acetyl-L-cysteine(NAC)was loaded into the nanopar-ticles(S@ANP+NAC)to increase mucosal solubility and intranasal delivery *** vivo evaluations showed that S@ANP+NAC could effectively tar-get the hypothalamus and modulate NK3R-regulated hypothalamic functions in *** to its high hypothalamic targeting efficiency and low toxicity,this intranasal nanoparticle drug delivery system may serve as a potential strategy for precision therapy of hypothalamic disorders.

关键词： hypothalamus intranasal delivery nanoparticles neurokinin receptor 3

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Guaranteeing Stability and Safety in Safety-Critical Systems: A Relaxed Converse Lyapunov-Barrier Theorem

Guaranteeing Stability and Safety in Safety-Critical Systems...

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第43届中国控制会议

作者： haoqi li Jiangping Hu School of Automation Engineering University of Electronic Science and Technology of China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China

This study investigates the unification of stability and safety in safety-critical systems and proposes a relaxed converse Lyapunov-barrier theorem. This theorem offers the opportunity for the flexible relaxation of stability and safety conditions by clarifying and using the relationships between significant sets in the system. Subsequently, a design procedure for relaxed converse control Lyapunov-barrier functions(RCCLBFs) is introduced. Notably, this design process provides an RCCLBF framework that enables designers to construct RCCLBFs based on stability and safety conditions at their discretion. Furthermore,a method utilizing a backstepping technique to solve Lyapunov-like stabilization problems defined by RCCLBFs to obtain safetystability control strategies is proposed. Finally, the effectiveness of the proposed method is validated using a mechanical system.

关键词： Barrier functions Lyapunov functions Safety-critical system Stability with safety guarantees Nonlinear control

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Investigation of the epidemiology,pathogenicity and immunogenicity of Bordetella bronchiseptica isolated from cats and dogs in China from 2021 to 2023

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Animal Diseases 2024年第3期4卷 156-172页

作者： Qinghua Shang Wenhui Gao Xiangting Zhang Jianqing Zhao Ying Wu haoqi li Ming Zhou Zhen F.Fu Chengguang Zhang ling Zhao National Key Laboratory of Agricultural Microbiology Huazhong AgriculturalUniversityWuhan 430070China. Key Laboratory of Preventive VeterinaryMedicine of Hubei Province College of Veterinary MedicineHuazhongAgricultural UniversityWuhan 430070China. Hubei Hongshan Laboratory Wuhan 430070China.

Bordetella bronchiseptica(Bb)is recognized as a leading cause of respiratory diseases in dogs and ***,epidemiological data on Bb in dogs and cats in China are still limited,and there is no commercially available *** vaccines containing Bb that are widely used abroad are generally efective but can establish latency and potentially reactivate to cause illness in some immunodefcient vaccinated recipients,raising safety *** this study,34 canine-derived and two feline-derived Bb strains were isolated from 1809 canine and 113 feline nasopharyngeal swab samples collected from eight provinces in China from 2021 to *** PCR results showed that the percentage of positive Bb was 22.94%(441/1922),and more than 90%of the Bb isolates had four virulence factor-encoding genes(VFGs),namely,fhaB,prn,betA and *** the isolated strains displayed a multidrug-resistant *** virulence of 10 Bb strains isolated from dogs with respiratory symptoms was tested in mice,and we found that eight isolates were highly ***,the eight Bb isolates with high virulence were inactivated and intramuscularly injected into mice,and three Bb strains(WH1218,WH1203 and WH1224)with the best protective efcacy were *** immunized with these three strains exhibited strong protection against challenge with the Bb feld strain ***,the WH1218 strain with the greatest protection in dogs was selected as the vaccine *** and cats that received a vaccine containing 109 CFU of the inactivated WH1218 strain showed complete protection against challenge with the Bb feld strain *** study revealed that Bb is an important pathogen that causes respiratory diseases in domestic dogs and cats in China,and all the isolates exhibited multidrug *** present work contributes to the current understanding of the prevalence,antimicrobial resistance,and virulence genes of Bb in domestic dogs and ***,our results suggest

关键词： Bordetella bronchiseptica Epidemiological investigation Pathogenicity Immunogenicity Inactivated vaccine

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Dual-Class Leader-Following Modeling for Collective Motion of Multi-Agent Systems

Dual-Class Leader-Following Modeling for Collective Motion o...

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第43届中国控制会议

作者： Bo Zhang haoqi li Bin Meng Jiangping Hu Bijoy Kumar Ghosh School of Automation Engineering University of Electronic Science and Technology of China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Department of Mathematics and Statistics Texas Tech University

Leader–follower collective motion is a key multi-agent network ***,conventional methods struggle with high dynamics or communication interferences and fail to maintain consistent *** address this issue,a resilient dual-class cooperative following(DCCF) model is *** model uses two movement strategies for the different follower ***-connected followers use a single-tracking control based on velocity or direction,whereas leader-disjoint followers employ a modified relative speed for single *** DCCF model may be more suitable for practical use than existing *** under degraded conditions demonstrate its superior tracking performance and robustness over traditional methods.

关键词： Multi-agent network collective motion leader-follower tracking dual-class cooperative following

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基于混合效应模型的群体数目估计

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统计与决策 2018年第7期34卷 28-31页

作者：白永娟李好奇长江师范学院数学与统计学院

对于多重列表的开放群体数目估计问题,文章提出了广义混合效应回归模型,估计出了异质性开放群体的规模,并证明了所提出估计量的渐近分布,利用随机模拟说明了所提方法效果良好。

关键词：随机效应模型开放群体多维列表

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京津冀一体化中的公证人

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中国公证 2021年第1期 19-22页

作者：李浩旗天津市滨海公证处

蝴蝶效应对于一家上市公司来说,业绩报表、对外形象关乎着企业的生存与发展。2018年的夏天,对于河北省某基业股份有限公司来说是至关重要的一个夏天。河北省某基业股份有限公司是在河北省廊坊市创立的民营企业,整合优质资产完成了资产上... 详细信息

蝴蝶效应对于一家上市公司来说,业绩报表、对外形象关乎着企业的生存与发展。2018年的夏天,对于河北省某基业股份有限公司来说是至关重要的一个夏天。河北省某基业股份有限公司是在河北省廊坊市创立的民营企业,整合优质资产完成了资产上市,公司总资产有四千多亿元。该公司以地产为核心产品,在全国多个地区建立项目产品。但是,随着近年来国家连续出台房屋限购政策,公司发展步调减缓。

关键词：京津冀一体化民营企业限购政策蝴蝶效应河北省廊坊市上市公司优质资产总资产

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