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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang he Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Recent progress in constructing fluorinated solid–electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 270-291页

作者： Di Zhang Pengfei Lv Wei Qin Xin he Yuanhua he Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of China School of Chemical Engineering Sichuan University

Lithium metal batteries(LMBs) are emerging as a promising energy storage solution owing to their high energy density and specific capacity. However, the non-uniform plating of lithium and the potential rupture of the solid–electrolyte interphase(SEI) during extended cycling use may result in dendrite growth, which can penetrate the separator and pose significant short-circuit risks. Forming a stable SEI is essential for the long-term operation of the batteries. Fluorine-rich SEI has garnered significant attention for its ability to effectively passivate electrodes, regulate lithium deposition, and inhibit electrolyte corrosion. Understanding the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode performance. This paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal anodes. It focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI performance. For instance, combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the SEI. Integrating metals with LiF significantly improves electrochemical performance at the SEI/anode interface, with a necessary focus on reducing electron tunneling risks. Additionally, incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity, though maintaining structural stability over long cycles remains a critical area for future research. Although alloys combined with LiF increase surface energy and lithium affinity, challenges such as dendrite growth and volume expansion persist. In summary, this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

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T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui he Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

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FeCrNiCoCu合金疲劳性能及缺陷演变的分子动力学研究

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原子与分子物理学报 2025年第4期42卷 81-86页

作者：朱和军常州工业职业技术学院常州213164

疲劳失效是机械构件的重要失效形式之一,因此本文通过分子动力学模拟方法在应变量ε=0.08下,对高熵合金FeCrNiCoCu合金进行20次循环加载模拟,以探究了高熵合金FeCrNiCoCu合金的疲劳力学性能和组织演变.结果发现,在循环加载过程中,FeCrNi... 详细信息

疲劳失效是机械构件的重要失效形式之一,因此本文通过分子动力学模拟方法在应变量ε=0.08下,对高熵合金FeCrNiCoCu合金进行20次循环加载模拟,以探究了高熵合金FeCrNiCoCu合金的疲劳力学性能和组织演变.结果发现,在循环加载过程中,FeCrNiCoCu模型存在明显的循环软化和循环硬化现象,且循环软化和循环硬化交替出现.通过对模型组织分析发现每个循环周期结束后,有残余位错和层错,这些缺陷直接影响到下一周期的疲劳应力.通过对模型中总能量和无序原子百分比的统计分析可知,模型的总能量呈升高的趋势.模型中无序原子的百分比逐渐升高,最后稳定在0.09左右,无序原子对位错的生成和湮灭有直接的影响,进而影响循环硬化和循环软化.

关键词：循环加载分子动力学疲劳变形微观缺陷演化

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拥有兄弟姐妹如何影响青少年的认知能力和主观幸福感?

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华东师范大学学报（教育科学版） 2025年第1期43卷 81-95页

作者：梁文艳何茜北京师范大学教育学部北京100875 北京师范大学首都教育经济研究基地北京100875

本研究对兄弟姐妹数量与青少年成长之间的关系进行了全面的理论探讨,并利用2010—2018年中国家庭追踪调查数据,为识别兄弟姐妹对青少年认知能力和主观幸福感的影响提供了微观证据。实证研究结果表明:拥有1个兄弟姐妹对青少年的主观幸福... 详细信息

本研究对兄弟姐妹数量与青少年成长之间的关系进行了全面的理论探讨,并利用2010—2018年中国家庭追踪调查数据,为识别兄弟姐妹对青少年认知能力和主观幸福感的影响提供了微观证据。实证研究结果表明:拥有1个兄弟姐妹对青少年的主观幸福感有积极影响,这种影响效应随年龄增长而加强,并且在成年后依旧保持稳定;拥有兄弟姐妹可能对青少年的数学类认知能力产生负向影响,这种影响主要体现在较低学段样本中,并随年龄增长逐渐消失。本研究为父母制定生育决策时更有效地开展成本收益分析提供了支持,也为缓解养育焦虑、完善生育政策以及促进人口可持续发展提供了政策启示。

关键词：资源稀释群聚理论同胞互动模型认知能力主观幸福感

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian he Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Breaking new ground in photocatalysis: lutetium texaphyrin as a trigger for pyroptosis through biomolecular photoredox reactions

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Science China Chemistry 2025年第01期 1-2页

作者： Qihang Ding Mengrong he Meijia Gu Department of Chemistry Korea University Department of Ultrasound Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) School of Pharmaceutical Sciences Wuhan University

Malignant neoplasms consistently pose a significant threat to global public health [1,2]. In recent years, immunotherapy has demonstrated remarkable clinical success; however, its efficacy is limited by the scarcity of immune cell infiltration within tumor microenvironments. Cell pyroptosis, a gasdermin-mediated process characterized by cellular swelling,rupture, and the release of intracellular contents such as IL-1β, IL-18, ATP, HMGB1, plays a crucial role in this context[3,4].

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李家壕煤矿31114工作面上覆岩层裂隙发育规律研究

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煤矿现代化 2025年第1期34卷 84-90页

作者：孙赫中煤科工集团沈阳研究院有限公司辽宁抚顺113122 煤矿安全技术国家重点实验室辽宁抚顺113122

为了弄清楚浅埋深近距离煤层群条件下,上部煤层开采后形成的采空区已基本被上覆岩层压实,而开采下部煤层时是如何对上部采空区的压实区造成影响的。本文采用相似材料模拟实验的方法模拟李家壕煤矿2-2煤层及其下部3-1煤层的开采,最终得出... 详细信息

为了弄清楚浅埋深近距离煤层群条件下,上部煤层开采后形成的采空区已基本被上覆岩层压实,而开采下部煤层时是如何对上部采空区的压实区造成影响的。本文采用相似材料模拟实验的方法模拟李家壕煤矿2-2煤层及其下部3-1煤层的开采,最终得出2-2煤层和3-1煤层开采的应力场演化规律、位移场演化规律、顶板垮落结构及裂隙演化导通规律,对于矿井的长期安全、稳定生产具有重要意义。

关键词：近距离煤层相似材料模拟应力场裂隙演化

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The current role of dendritic cells in the progression and treatment of colorectal cancer

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Cancer Biology & Medicine 2024年第9期21卷 769-783页

作者： Yuanci Zhang Songtao Ji Ge Miao Shuya Du haojia Wang Xiaohua Yang Ang Li Yuanyuan Lu Xin Wang Xiaodi Zhao State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers National Clinical Research Center for Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi'an 710032China Department of Gastroenterology Tangdu HospitalFourth Military Medical UniversityXi'an 710038China Department of Experimental Surgery Xijing HospitalFourth Military Medical UniversityXi'an 710032China Department of Gastroenterology the 988th Hospital of PLA Joint Logistics Support ForceZhengzhou 450042China

Colorectal cancer(CRC)is the third most common cancer and the second leading cause of cancer-related deaths *** cells(DCs)constitute a heterogeneous group of antigen-presenting cells that are important for initiating and regulating both innate and adaptive immune *** a crucial component of the immune system,DCs have a pivotal role in the pathogenesis and clinical treatment of *** cross-present tumor-related antigens to activate T cells and trigger an antitumor immune ***,the antitumor immune function of DCs is impaired and immune tolerance is promoted due to the presence of the tumor *** review systematically elucidates the specific characteristics and functions of different DC subsets,as well as the role that DCs play in the immune response and tolerance within the CRC ***,how DCs contribute to the progression of CRC and potential therapies to enhance antitumor immunity on the basis of existing data are also discussed,which will provide new perspectives and approaches for immunotherapy in patients with CRC.

关键词： Colorectal cancer dendritic cells tumor progression treatment strategies

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Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第01期 26-33页

作者： Tiantian Tang Jiaying he Huihang Sun Jingjia Luo Institute for Climate and Application Research (ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and Technology

2013年底至2016年初,东北太平洋上发生了历史上罕见的极端海洋热浪事件(称为“Blob”事件),形成了从海表延伸至海洋深处300m的强烈且持续的海温暖异常.本文利用南京信息工程大学全球气候预测系统1.0版本(NUISTCFS 1.0),采用两种海洋资... 详细信息

2013年底至2016年初,东北太平洋上发生了历史上罕见的极端海洋热浪事件(称为“Blob”事件),形成了从海表延伸至海洋深处300m的强烈且持续的海温暖异常.本文利用南京信息工程大学全球气候预测系统1.0版本(NUISTCFS 1.0),采用两种海洋资料同化方案,探究海洋资料同化差异对这一极端海洋热浪事件季节预测的影响.本文采用的一种同化方案为仅同化海表面温度(Surface sea temperature, SST)的SST-nudging方案,而另一种方案为在前一种方案的基础上加入确定性集合卡尔曼滤波(Deterministic Ensemble Kalman Filter, DEn KF),同化更多海洋观测数据的EnKF方案.主要结论为,利用EnKF方案可显著提高对“Blob”期间次表层温度异常预测的准确性,这主要源于En KF方案在预测次表层的水平和垂直热传输方面表现出色.该研究有助于更好地理解海洋热浪事件潜在物理机制及其季节预测水平.

关键词：季节预测海洋资料同化海洋热浪事件次表层海温

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