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Mechanism of hepatocellular damage in rat caused by low serum selenium

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Frontiers of Medicine 2008年第3期2卷 255-258页

作者： Yi LU Bo QU Chang LIU Liang YU Xuemin LIU haohua wang An JIANG Xiaogang ZHANG Department of Hepatobiliary Surgery The First Affiliated HospitalSchool of MedicineXi’an Jiaotong UniversityXi’an 710061China

The aim of this paper is to investigate the mechanism of hepatocellular damage in rats caused by low serum *** six rats were randomly divided into 2 groups:group A(fed with low-selenium diet from the Keshan Disease area with the content of selenium being 0.017 mg/kg);group B[fed with sel-enium-supplemented diet and 0.3 mg/L selenium(Na_(2)SeO_(3))was added to the drinking water].Both were respectively fed for 12 *** the end of the 12th week,the levels of serum selenium,glutathione peroxidase(GPX)and malondialdehyde(MDA)in hepatic tissue were measured;the hepatocellular ultrastructure and apoptosis were observed as *** levels of serum sel-enium and GPX in group A were markedly lower than those in group *** level in group A was significantly higher than that in group *** the electron micro-scope(EM),the mitochondria were remarkably changed in group *** rate of liver cell apoptosis appeared much higher in group A as *** indicated that the damage caused by selenium deficiency was through the process of *** deficiency led to apoptosis of hepa-tocytes where oxidative damage to mitochondria might be the cause.

关键词： low-selenium hepatocyte oxidative damage mitochondria apoptosis

Intravoxel incoherent motion and dynamic contrast-enhanced MRI for assessing abnormalities of brucellosis spondylitis without conventional MRI changes

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中国医学影像技术 2024年第8期40卷 1226-1230页

作者： wang haohua ZHAO Pengfei QIAO Pengfei Department of Imaging Diagnosis Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010050China

Objective To observe the value of intravoxel incoherent motion(IVIM)and dynamic contrast-enhanced MRI(DCE-MRI)for assessing abnormalities of brucellosis spondylitis(BS)without conventional MRI *** Data of 36 brucellosis patients with definite spinal lesions displayed on conventional MRI(BS 1 group),14 cases without brucellosis infection nor abnormal spinal signals on MRI(control group)and 36 brucellosis patients without definite spinal lesions on conventional MRI(BS 2 group)were retrospectively *** values of IVIM parameters,including perfusion fraction(f),pure water diffusion coefficient(D)and pseudo-diffusion coefficient(D*),also of DCE-MRI parameters,including time-intensity curve(TIC)type,volume transport constant(K trans),the rate constant(K ep)and volume fraction of extravascular extracellular space per unit tissue volume(V e)were compared among *** and multivariate logistic regression were used to screen independent factors for discriminating BS 1 and BS *** operating characteristic curves were drawn,and the areas under the curve(AUC)were calculated to evaluate the efficiency of the above parameters for discriminating BS 1 and BS *** Among IVIM parameters,compared with control group,D*values decreased but D values increased in BS 1 group,while D*values increased in BS 2 group(all adjusted P<0.05).Compared with BS 2 group,BS 1 group had higher values of f and D and lower D*(all adjusted P<0.05).In BS 1 group,the TIC types were predominantly typeⅠ(23/36,63.89%),which were wholly or predominantly typeⅢin BS 2 group and control group,and of the former was significantly different with latter 2(both adjusted P<0.05).Compared with control group,K trans increased progressively in both BS 1 and BS 2 groups(both adjusted P<0.05).BS 1 group had lower K ep and higher V e than BS 2 and control groups(all adjusted P<0.05).Among univariate logistic regression models,the model including only f had lower capability for discrimina

关键词： brucellosis spondylitis early diagnosis magnetic resonance imaging

Adhesive anastomosis for organ transplantation

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Bioactive Materials 2022年第7期7卷 260-268页

作者： Kang Liu Hang Yang Gaobo Huang Aihua Shi Qiang Lu Shanpei wang Wei Qiao haohua wang Mengyun Ke Hongfan Ding Tao Li Yanchao Zhang Jiawei Yu Bingyi Ren Rongfeng wang Kailing wang Hui Feng Zhigang Suo Jingda Tang Yi Lv National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine Department of Hepatobiliary SurgeryFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061Shaanxi ProvinceChina State Key Lab for Strength and Vibration of Mechanical Structures International Center for Applied MechanicsDepartment of Engineering MechanicsXi’an Jiaotong UniversityXi’an710049China John A.Paulson School of Engineering and Applied Science Kavli Institute for Bionano Science and TechnologyHarvard UniversityCambridgeMA02138USA Hepatobiliary Surgery Department Shaanxi Provincial People’s HospitalXi’an710068Shaanxi ProvinceChina

The recent development of tough tissue adhesives has stimulated intense interests among material scientists and medical ***,these adhesives have seldom been tested in clinically demanding *** we demonstrate adhesive anastomosis in organ *** is commonly conducted by dense sutures and takes a long time,during which all the vessels are *** occlusion may damage organs and even cause *** formulate a tough,biocompatible,bioabsorbable adhesive that can sustain tissue tension and pressurized *** expose the endothelial surface of vessels onto a gasket,press two endothelial surfaces to the adhesive using a pair of magnetic rings,and reopen the bloodstream *** time for adhesive anastomosis is shortened compared to the time for sutured *** have achieved adhesive anastomosis of a great vein in transplanting the liver of a *** the surgery,the adhesive is absorbed,the vein heals,and the pig lives for over one month.

关键词： Magnet Hydrogel Adhesive Anastomosis Liver transplantation

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典型分布式发电市场化交易机制分析与建议

电力系统自动化 2019年第4期43卷 1-8页

作者：林俐许冰倩王皓怀新能源电力系统国家重点实验室(华北电力大学) 北京市102206 中国南方电网电力调度控制中心广东省广州市510623

中国于2017年11月发布了《关于开展分布式发电市场化交易试点的通知》(简称《通知》),拉开分布式发电市场化交易帷幕。但分布式交易在中国仍处于试点阶段,交易模式、交易机制等问题还需进一步探索。文中首先阐述了分布式交易的基本概念... 详细信息

中国于2017年11月发布了《关于开展分布式发电市场化交易试点的通知》(简称《通知》),拉开分布式发电市场化交易帷幕。但分布式交易在中国仍处于试点阶段,交易模式、交易机制等问题还需进一步探索。文中首先阐述了分布式交易的基本概念和特点,总结了国外主要三种分布式交易机制及其应用和发展现状,对比分析了《通知》给出的试点交易模式,进而重点分析了分别位于英国、德国和美国的三个具有代表性的对等(P2P)电能交易平台。最后,对中国未来分布式交易的发展进行了探讨,希望能为中国电力交易发展提供一定的借鉴。

关键词：分布式交易分布式发电交易模式对等(P2P)电能交易

Xenogeneic hepatic progenitor cell transplantation ameliorate CCl_4 /partial hepatectomy-induced rat acute liver failure

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Journal of Medical Colleges of PLA(China) 2013年第6期28卷 355-367页

作者： WAN Zhen Lü Yi ZHANG Xiaogang ZHENG Xing-long WU Wanquan MA Jia wang haohua Department of Hepatobiliary Surgery the First Affiliated Hospital Medical School of Xi'an Jiaotong University Institute of Advanced Surgical Techniques and Tissue Engineering Research Xi'an Jiaotong University

Objective： Hepatic progenitor cell transplantation has shed light on the treatment of liver failure. The present study was designed to evaluate whether xenogeneic liver epithelial progenitor cells （LEPCs） transplantation could promote liver recovery in a rat model of acute liver failure. The engraftment and hepatocytic differentiation of transplanted hepatic progenitor cells in the rat spleen was also investigated. Methods： LEPCs were propagated in vitro for long and transduced with lentiviral vector carrying mCherry gene. Intraperitoneal injection of CC14 followed by 2/3 partial hepatectomy three days later were used to establish rat models of acute liver failure. Rats were intrasplenically injected with mCherry modified LEPCs （n=20, 1× 107 cells/0.5 mL） or the same volume of medium （n=20）. Serum liver enzymes （ALT, AST） and liver histology were evaluated for 21 days after transplantation. The engraftment of transplanted LEPCs in the spleens was tested by polymerase chain reaction （PCR） amplification targeting mCherry gene. The differentiation into hepatocytic lineage of transplanted LEPCs was investigated usingimmunohistochemistry staining against Alb. Results： LEPCs were effectively transduced with lentiviral vector showing a transduction efficiency of 90%. Compared with control, cell-injected group displayed significantly lower levels of ALT and AST （P〈0.05） and better histological features including less swelling change and hepatocyte death. PCR amplification of mCherry sequences confirmed the engraftment of LEPCs in the spleens. Alb-positive cells first appeared 5 days after cell transplantation and the number of Alb-positive cells increased substantially （P〈0.05）, which revealed the hepatocytic differentiation process Conclusion： Xenogeneic hepatic progenitor cells can engraft and differentiate into hepatocytes in the splenic parenchyma. Intrasplenic delivery of hepatic progenitor cells ameliorates CCh/partial hepatectomy-induced liver injury in rats

关键词： Acute liver failure Engraftment Hepatic progenitor cells Intrasplenic transplantation

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农村社会治理联动范式:理论阐释及实践路径

中州学刊 2019年第8期 73-78页

作者：李俊清王浩骅中央民族大学管理学院

社会发展转型加剧、政策制度优化变迁、现有主流范式局限凸显,使得探索和构建新的农村社会治理范式势在必行。农村社会治理联动范式以治理有效为目标指引、以家国文化和关联主义为价值基础、以多元主体共建共治共享为核心原则,通过党的... 详细信息

社会发展转型加剧、政策制度优化变迁、现有主流范式局限凸显,使得探索和构建新的农村社会治理范式势在必行。农村社会治理联动范式以治理有效为目标指引、以家国文化和关联主义为价值基础、以多元主体共建共治共享为核心原则,通过党的引领整合、关联权益强化、道德情感支撑重塑社会联结机制,进而培育“使命—责任”型党组织、权益关联型农民群体、公益型农村社会组织等积极联动主体,推动农村社会治理体系的“联”与治理能力的“动”相统一。

关键词：农村社会治理联动范式理论阐释实践路径

颈动脉体瘤的无术前栓塞手术切除的疗效分析:附单中心65例报告

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中国普通外科杂志 2020年第12期29卷 1445-1452页

作者：王浩骅杨斌张承磊昆明医科大学第一附属医院血管外科云南昆明650032

背景与目的:颈动脉体瘤(CBT)是临床上非常罕见的疾病,目前外科手术是治疗CBT的金标准,由于该病变血供极其丰富,是否行术前栓塞目前国内外存在争议,支持术前栓塞者认为其可减少术中失血,反对者认为成本和卒中风险大于收益,本文总结我院CB... 详细信息

背景与目的:颈动脉体瘤(CBT)是临床上非常罕见的疾病,目前外科手术是治疗CBT的金标准,由于该病变血供极其丰富,是否行术前栓塞目前国内外存在争议,支持术前栓塞者认为其可减少术中失血,反对者认为成本和卒中风险大于收益,本文总结我院CBT无术前栓塞的外科手术治疗经验及术后随访结果,为临床无术前栓塞切除瘤体的安全性提供数据参考。方法:回顾性分析昆明医科大学第一附属医院血管外科自2017年1月—2020年1月间行手术治疗的65例CBT患者临床与随访资料(其中2例双侧CBT患者选择第一次手术侧的数据)。肿块大小为1.0 cm×0.5 cm×1.0 cm^8.0 cm×6.5 cm×8.5 cm。患者Shamblin分型分别为I型13例,II型33例,III型19例。结果:65例患者均顺利完成外科手术切除,其中单纯瘤体切除51例(78.46%),瘤体切除联合单纯颈外动脉结扎8例(12.31%),瘤体切除联合颈内动脉、颈外动脉切除并颈内动脉重建6例(9.23%);术中发现术野内淋巴结的患者行淋巴结摘除;术中失血量为10~1800 mL,平均247 mL。2例双侧病变者均建议择期行对侧手术。病理检查结果,65例均为颈动脉副神经节瘤。围术期1例(1.54%)出现术后脑梗塞死亡。术后14例患者(21.54%)出现迷走神经损伤症状,表现为声音嘶哑、饮水呛咳;5例患者出现舌下神经损伤症状,表现为伸舌偏斜、吞咽困难。2例颈内动脉重建的III型患者(3.08%)术后随访过程中发现颈内动脉闭塞。结论:CBT确诊后应首选手术治疗,无术前栓塞情况下切除肿瘤安全有效。

关键词：颈动脉体瘤血管外科手术手术后并发症

一维圣维南方程差分数值算法中稀疏矩阵求解方法比较及优选研究

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灌溉排水学报 2021年第3期40卷 116-124页

作者：王浩骅管光华肖昌诚武汉大学水资源与水电工程科学国家重点实验室武汉430072 中国电建集团华东勘测设计研究院有限公司杭州310014

【目的】寻找高效、稳定的大型稀疏线性方程组求解算法以提高圣维南方程组求解速度。【方法】归纳了4种基于四点偏心格式的圣维南方程组求解算法并加以改进,并通过仿真试验,对比了不同算法的计算效率。【结果】计算断面数较少时(小于50... 详细信息

【目的】寻找高效、稳定的大型稀疏线性方程组求解算法以提高圣维南方程组求解速度。【方法】归纳了4种基于四点偏心格式的圣维南方程组求解算法并加以改进,并通过仿真试验,对比了不同算法的计算效率。【结果】计算断面数较少时(小于500),所有方法的运算时间基本一致;当计算断面数较大时(大于500),4种算法的速度较传统算法有了一定的提高,在计算断面数为1520时,4种算法的计算速度是传统算法的4倍,在计算断面数为3040时,计算速度更是达到了10倍以上。【结论】改进后的高斯消元法和PM算法在计算断面数较大时计算速度较快,计算效率较高。该方法可应用于MPC控制、LQR控制等渠系自动化控制技术中,以提高仿真程序运算速度。

关键词：明渠一维非恒定流圣维南方程组大型稀疏矩阵单个断面运算时间

妇女民间组织参与农村社区治理研究——基于河南省D村“嫁娶帮扶会”的个案

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新疆广播电视大学学报 2019年第1期23卷 51-54页

作者：王浩骅中央民族大学管理学院

妇女民间组织在激发农村社区治理活力中发挥着独特的作用。文章通过河南省D村“嫁娶帮扶会”的个案考察,梳理归纳其多元精细化服务的发展路径和实践经验,以期为推动妇女民间组织深度有效参与农村社区治理提供参考。

关键词：妇女民间组织农村社区治理 “嫁娶帮扶会”